NO963213L - Endotelinreseptorantagonister - Google Patents
EndotelinreseptorantagonisterInfo
- Publication number
- NO963213L NO963213L NO963213A NO963213A NO963213L NO 963213 L NO963213 L NO 963213L NO 963213 A NO963213 A NO 963213A NO 963213 A NO963213 A NO 963213A NO 963213 L NO963213 L NO 963213L
- Authority
- NO
- Norway
- Prior art keywords
- unsubstituted
- coor6
- hal
- independently
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Quinoline Compounds (AREA)
Abstract
Nye forbindelser med formel I hvor -Y-Z- er -NR7-CO-, -N=C(OR7)- eller -N=CR8-; R1 er Ar; R2 er COOR6, (CH2)nCOOR6, CN, lH-tetrazol-5-yl eller CONHS02Ar; R3, R4 og R5 er uavhengig av hverandre R6, OR6, S(O),,R6, Hal, N02, NR6R6', NHCOR6, NHSO2R6, OCOR6, COR6, COOR6 eller CN, idet R3 og R4 til sammen også kan utgjøre en O(CH2)nO-gruppe; R6 og R6' er uavhengig av hverandre H, alkyl med 1-6 C-atomer, benzyl eller fenyl; R7 er (CH2)nAr; R8 er Ar eller OAr; Ar er usubstituert eller en, to eller tre ganger med R9, R10 eller R11 substituert fenyl, eller usubstituert naftyl eller en usubstituert eller i fenyldelen en eller to ganger med R9 eller R10 substituert D-gruppe eller en usubstituert eller i sykloheksadien- yldelen en eller to ganger med R9 eller substituert N X-gruppe, R9, R10 og R11 er uavhengig av hverandre R6, OR6, Hal, CF3, OCF3, OCHF2, OCH2F, N02, NR6R6', NHCOR6, CN, NHS02R6, COOR6, COR6, CONHS02Ar, O(CH2)nR2, 0(CH2)nOR6 eller S(0)nR6; E er CH2, S eller O; D er karbonyl eller [C(R6R6')]n; X er O eller S; Hal er F, Cl, Br eller I; m er O, l eller 2; og n er l, 2 eller 3; samt deres salter, utviser endotelin- reseptorantagonistiske egenskaper .
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19528418A DE19528418A1 (de) | 1995-08-02 | 1995-08-02 | Endothelin-Rezeptor-Antagonisten |
Publications (2)
Publication Number | Publication Date |
---|---|
NO963213D0 NO963213D0 (no) | 1996-08-01 |
NO963213L true NO963213L (no) | 1997-02-03 |
Family
ID=7768528
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO963213A NO963213L (no) | 1995-08-02 | 1996-08-01 | Endotelinreseptorantagonister |
Country Status (16)
Country | Link |
---|---|
US (1) | US5731321A (no) |
EP (1) | EP0757039A1 (no) |
JP (1) | JPH0940649A (no) |
KR (1) | KR970010746A (no) |
AR (1) | AR004675A1 (no) |
AU (1) | AU705959B2 (no) |
BR (1) | BR9603252A (no) |
CA (1) | CA2182469A1 (no) |
CZ (1) | CZ224096A3 (no) |
DE (1) | DE19528418A1 (no) |
HU (1) | HUP9602127A1 (no) |
MX (1) | MX9603199A (no) |
NO (1) | NO963213L (no) |
PL (1) | PL315479A1 (no) |
SK (1) | SK100296A3 (no) |
ZA (1) | ZA966552B (no) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6251861B1 (en) * | 1996-06-27 | 2001-06-26 | Takeda Chemical Industries, Ltd. | Treatment of cerebral infarction using cyclic hexapeptides |
DE19839499A1 (de) * | 1998-08-29 | 2000-03-02 | Merck Patent Gmbh | 2-Oxo-2H-chinolinderivate |
DE10155076A1 (de) * | 2001-11-09 | 2003-05-22 | Merck Patent Gmbh | Verwendung von Endothelin-Rezeptor-Antagonisten zur Behandlung von Tumorerkrankungen |
CA2539760C (en) * | 2003-09-23 | 2011-01-25 | Merck & Co., Inc. | Quinoline potassium channel inhibitors |
US7939545B2 (en) * | 2006-05-16 | 2011-05-10 | Boehringer Ingelheim International Gmbh | Inhibitors of human immunodeficiency virus replication |
WO2009023655A1 (en) * | 2007-08-16 | 2009-02-19 | Boehringer Ingelheim International Gmbh | Quinazolinedione chymase inhibitors |
PL2220076T3 (pl) * | 2007-11-15 | 2012-09-28 | Gilead Sciences Inc | Inhibitory replikacji ludzkiego wirusa niedoboru odporności |
UA100250C2 (uk) * | 2007-11-16 | 2012-12-10 | Гілеад Сайнсіз, Інк. | Інгібітори реплікації вірусу імунодефіциту людини |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1336714C (en) * | 1987-08-20 | 1995-08-15 | Yoshihiro Fujikawa | Quinoline type mevalonolactone inhibitors of cholesterol biosynthesis |
US5514691A (en) * | 1993-05-20 | 1996-05-07 | Immunopharmaceutics, Inc. | N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin |
RU2086544C1 (ru) * | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
GB9115153D0 (en) * | 1991-07-12 | 1991-08-28 | Patel Bipin C M | Sol-gel composition for producing glassy coatings |
DE4208304A1 (de) * | 1992-03-16 | 1993-09-23 | Merck Patent Gmbh | 2-oxochinolinderivate |
US5565472A (en) * | 1992-12-21 | 1996-10-15 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents |
ZA939516B (en) * | 1992-12-22 | 1994-06-06 | Smithkline Beecham Corp | Endothelin receptor antagonists |
DE69422742T2 (de) * | 1993-03-19 | 2000-08-17 | Merck & Co Inc | Phenoxyphenylessigsäurederivate |
JPH06340658A (ja) * | 1993-04-08 | 1994-12-13 | Kyowa Hakko Kogyo Co Ltd | ベンゾイミダゾール誘導体 |
JPH09501915A (ja) * | 1993-08-06 | 1997-02-25 | スミスクライン・ビーチャム・コーポレイション | エンドセリン受容体アンタゴニスト |
DE4341663A1 (de) * | 1993-12-07 | 1995-06-08 | Basf Ag | Anellierte 2-Oxopiperazine, ihre Herstellung und Verwendung |
-
1995
- 1995-08-02 DE DE19528418A patent/DE19528418A1/de not_active Withdrawn
-
1996
- 1996-07-29 AU AU60792/96A patent/AU705959B2/en not_active Ceased
- 1996-07-29 CZ CZ962240A patent/CZ224096A3/cs unknown
- 1996-07-31 EP EP96112347A patent/EP0757039A1/de not_active Withdrawn
- 1996-07-31 CA CA002182469A patent/CA2182469A1/en not_active Abandoned
- 1996-07-31 SK SK1002-96A patent/SK100296A3/sk unknown
- 1996-08-01 PL PL96315479A patent/PL315479A1/xx unknown
- 1996-08-01 NO NO963213A patent/NO963213L/no unknown
- 1996-08-01 BR BR9603252A patent/BR9603252A/pt not_active Application Discontinuation
- 1996-08-01 HU HU9602127A patent/HUP9602127A1/hu unknown
- 1996-08-01 KR KR1019960032224A patent/KR970010746A/ko not_active Application Discontinuation
- 1996-08-01 US US08/691,148 patent/US5731321A/en not_active Expired - Fee Related
- 1996-08-01 ZA ZA9606552A patent/ZA966552B/xx unknown
- 1996-08-02 MX MX9603199A patent/MX9603199A/es unknown
- 1996-08-02 JP JP8219113A patent/JPH0940649A/ja active Pending
- 1996-08-02 AR ARP960103850A patent/AR004675A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
PL315479A1 (en) | 1997-02-03 |
SK100296A3 (en) | 1997-03-05 |
NO963213D0 (no) | 1996-08-01 |
BR9603252A (pt) | 1998-04-28 |
HU9602127D0 (en) | 1996-09-30 |
MX9603199A (es) | 1997-07-31 |
KR970010746A (ko) | 1997-03-27 |
AU705959B2 (en) | 1999-06-03 |
DE19528418A1 (de) | 1997-02-06 |
US5731321A (en) | 1998-03-24 |
AR004675A1 (es) | 1999-03-10 |
AU6079296A (en) | 1997-02-06 |
CZ224096A3 (en) | 1997-02-12 |
HUP9602127A1 (hu) | 1998-05-28 |
ZA966552B (en) | 1997-02-18 |
EP0757039A1 (de) | 1997-02-05 |
CA2182469A1 (en) | 1997-02-03 |
JPH0940649A (ja) | 1997-02-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUP0400570A2 (hu) | Feniletenil- vagy feniletinil-heteroaril-származékok mint glutamát receptor antagonisták, alkalmazásuk, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
DK0862567T3 (da) | 5-azabicyclo[3.1.0]hexylalkyl-2-piperidoner og-glutarimider som neurokininreceptorantagonister | |
RS50378B (sr) | N-heterociklični derivati kao nos inhibitori | |
NZ511739A (en) | New esters derived from substituted phenyl-cyclohexyl compounds | |
KR950704313A (ko) | 5-아릴인돌 유도체 및 세로토닌(5-ht₁)작용물질로서의 그의 용도(5-arylindole derivatives and their use as serotonin(5-ht₁)agonists) | |
ATE282614T1 (de) | Phenylharnstoff und phenylthioharnstoffderivate | |
NO912739L (no) | Nye 3-arylindol- og 3-arylindazolderivater. | |
DE59610527D1 (de) | S-Triazinederivate als Lichtschutzmittel für Kosmetika | |
YU59601A (sh) | Derivati piridopiranoazepina, njihovo pripremanje i terapeutska primena | |
ATE359073T1 (de) | Benzylidenthiazolidindione und ihre verwendung als antimykotische mittel | |
NO963213L (no) | Endotelinreseptorantagonister | |
ATE182889T1 (de) | Bicyclische amidinderivate als no-synthetase inhibitoren | |
ATE374748T1 (de) | Phenylcyclohexylpropanolaminderivate, deren herstellung und therapeutsche anwendung | |
ATE137759T1 (de) | S'-adenosyl-methionin-decarboxylase-inhibitoren | |
NO943961L (no) | Sykliske aminderivater | |
ES2099180T3 (es) | Derivados del benzopirano y procedimientos para su preparacion. | |
MEP12408A (en) | Acyloxypyrrolidine derivatives and use thereof as ligands of v1b or both v1b and v1a receptors | |
DE60204668D1 (de) | Piperazinderivate und deren verwendung als 5-ht1b liganden | |
HRP20080501T3 (en) | Beta-lactams for the treatment of cns disorders | |
FI955680A (fi) | Psoraleenijohdannaiset, niiden valmistus ja käyttö | |
ES2154191A1 (es) | Nuevos acetales derivados de los 2-alquil-5-halo-3-(2'-(tetrazol-5-il)-bifenil-4-ilmetil)-3h-imidazol-4-carbaldehidos. | |
TH34361A (th) | สารประกอบ | |
MX9804482A (es) | Quinolinas y quinazolinas utiles en terapias. | |
AR003970A1 (es) | Nuevos compuestos antagonistas de receptores de endotelina, procedimiento para prepararlos, composiciones farmaceuticas que los contienen y procedimientopara preparar estas composiciones farmaceuticas. |