DE60204668D1 - Piperazinderivate und deren verwendung als 5-ht1b liganden - Google Patents

Piperazinderivate und deren verwendung als 5-ht1b liganden

Info

Publication number
DE60204668D1
DE60204668D1 DE60204668T DE60204668T DE60204668D1 DE 60204668 D1 DE60204668 D1 DE 60204668D1 DE 60204668 T DE60204668 T DE 60204668T DE 60204668 T DE60204668 T DE 60204668T DE 60204668 D1 DE60204668 D1 DE 60204668D1
Authority
DE
Germany
Prior art keywords
sup
sub
alkyl
piperacetin
ht1b
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60204668T
Other languages
English (en)
Other versions
DE60204668T2 (de
Inventor
Mervyn Thompson
Adrian Wyman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of DE60204668D1 publication Critical patent/DE60204668D1/de
Application granted granted Critical
Publication of DE60204668T2 publication Critical patent/DE60204668T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
DE60204668T 2001-03-15 2002-03-11 Piperazinderivate und deren verwendung als 5-ht1b liganden Expired - Fee Related DE60204668T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0106419 2001-03-15
GBGB0106419.5A GB0106419D0 (en) 2001-03-15 2001-03-15 Novel compounds
PCT/EP2002/002632 WO2002074764A2 (en) 2001-03-15 2002-03-11 Piperazine derivatives and their use as 5-ht1b ligands

Publications (2)

Publication Number Publication Date
DE60204668D1 true DE60204668D1 (de) 2005-07-21
DE60204668T2 DE60204668T2 (de) 2005-10-06

Family

ID=9910758

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60204668T Expired - Fee Related DE60204668T2 (de) 2001-03-15 2002-03-11 Piperazinderivate und deren verwendung als 5-ht1b liganden

Country Status (9)

Country Link
US (1) US7109201B2 (de)
EP (1) EP1368337B1 (de)
JP (1) JP2004529124A (de)
AT (1) ATE297915T1 (de)
AU (1) AU2002257644A1 (de)
DE (1) DE60204668T2 (de)
ES (1) ES2240737T3 (de)
GB (1) GB0106419D0 (de)
WO (1) WO2002074764A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0316915D0 (en) 2003-07-18 2003-08-20 Glaxo Group Ltd Compounds
BRPI0513713A (pt) 2004-07-28 2008-05-13 Glaxo Group Ltd derivados de piperazina úteis para o tratamento de distúrbios gastrointestinais
AR060213A1 (es) 2006-03-31 2008-06-04 Glaxo Group Ltd Compuesto de piperazinil - piridinil -bencensulfonamida , su uso para fabricar un medicamento proceso para la preparacion del mismo composicion farmaceutica que lo comprende y proceso para prepararla
WO2020183011A1 (en) 2019-03-14 2020-09-17 Institut Curie Htr1d inhibitors and uses thereof in the treatment of cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69417427T2 (de) 1993-09-03 1999-11-25 Smithkline Beecham Plc Indol- und indolin-derivate als 5ht1d rezeptor antagonisten
HUP0001123A3 (en) * 1997-04-18 2002-04-29 Smithkline Beecham Plc Indole derivatives having combined 5ht1a, 5ht1b and 5ht1d receptor antagonist activity
GB9725931D0 (en) * 1997-12-05 1998-02-04 Smithkline Beecham Plc Novel compounds
TR200200795T2 (tr) 1999-09-25 2002-07-22 Smithkline Beecham P. L. C. 5-HT1B antagonistleri olarak piperazin türevleri

Also Published As

Publication number Publication date
JP2004529124A (ja) 2004-09-24
EP1368337B1 (de) 2005-06-15
WO2002074764A3 (en) 2002-11-14
AU2002257644A1 (en) 2002-10-03
ES2240737T3 (es) 2005-10-16
WO2002074764A2 (en) 2002-09-26
EP1368337A2 (de) 2003-12-10
GB0106419D0 (en) 2001-05-02
US20040142925A1 (en) 2004-07-22
US7109201B2 (en) 2006-09-19
ATE297915T1 (de) 2005-07-15
DE60204668T2 (de) 2005-10-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee