KR950700248A - 트리페닐-아자시클로알칸 유도체에 의한 다약물 내성의 역전(Reversal of Multi-drug Resistance by Triphenyl-azacycloalkane Derivatives) - Google Patents
트리페닐-아자시클로알칸 유도체에 의한 다약물 내성의 역전(Reversal of Multi-drug Resistance by Triphenyl-azacycloalkane Derivatives)Info
- Publication number
- KR950700248A KR950700248A KR1019940702687A KR19940702687A KR950700248A KR 950700248 A KR950700248 A KR 950700248A KR 1019940702687 A KR1019940702687 A KR 1019940702687A KR 19940702687 A KR19940702687 A KR 19940702687A KR 950700248 A KR950700248 A KR 950700248A
- Authority
- KR
- South Korea
- Prior art keywords
- integer
- tumors
- triphenyl
- reversal
- drug resistance
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83254092A | 1992-02-06 | 1992-02-06 | |
| PCT/US1993/000669 WO1993016044A1 (en) | 1992-02-06 | 1993-01-11 | Reversal of multi-drug resistance by triphenyl-azacycloalkane derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR950700248A true KR950700248A (ko) | 1995-01-16 |
Family
ID=25261950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019940702687A KR950700248A (ko) | 1992-02-06 | 1994-08-05 | 트리페닐-아자시클로알칸 유도체에 의한 다약물 내성의 역전(Reversal of Multi-drug Resistance by Triphenyl-azacycloalkane Derivatives) |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0643693B1 (ko) |
| JP (1) | JPH07503957A (ko) |
| KR (1) | KR950700248A (ko) |
| AT (1) | ATE182582T1 (ko) |
| AU (1) | AU662602B2 (ko) |
| CA (1) | CA2129144C (ko) |
| DE (1) | DE69325805T2 (ko) |
| DK (1) | DK0643693T3 (ko) |
| ES (1) | ES2135463T3 (ko) |
| GR (1) | GR3031557T3 (ko) |
| HU (1) | HUT70564A (ko) |
| NO (1) | NO942920L (ko) |
| NZ (1) | NZ249040A (ko) |
| WO (1) | WO1993016044A1 (ko) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3398748B2 (ja) * | 1993-01-21 | 2003-04-21 | メレルダウファーマスーティカルズ インコーポレイテッド | 多剤耐性腫瘍剤として有用なジアリールアルキルピペリジン類 |
| US5670521A (en) * | 1994-08-05 | 1997-09-23 | Merrell Pharmaceuticals Inc. | Reversal of multi-drug resistance by triphenyl-azacycloalkane derivatives |
| EP1129707A3 (en) | 1994-08-31 | 2002-02-27 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Methods for identifying and treating resistant tumors |
| TW527186B (en) | 1996-03-19 | 2003-04-11 | Janssen Pharmaceutica Nv | Fused imidazole derivatives as multidrug resistance modulators |
| GB0003685D0 (en) * | 2000-02-17 | 2000-04-05 | Univ Cardiff | Sensitisation of cellular material |
| CN110372571B (zh) * | 2018-04-12 | 2022-11-15 | 中国科学院大连化学物理研究所 | 一种2-(2,2-二芳基乙基)-环胺衍生物或盐及合成和应用与组合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1049377B (de) * | 1952-04-03 | 1959-01-29 | Abbott Laboratories, North Chicago, 111. (V. St. A.) | Verfahren zur Herstellung von substituierten Vinylpiperidinen |
| EP0228893A3 (en) * | 1985-12-20 | 1990-01-03 | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) | Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl group in allergy treatment |
| HUT59377A (en) * | 1989-06-19 | 1992-05-28 | Wellcome Found | Process for producing drugs containing new aromatic rings |
| GB9000305D0 (en) * | 1990-01-06 | 1990-03-07 | Pfizer Ltd | Anticholinergic agents |
| EP0467435A3 (en) * | 1990-07-19 | 1992-04-01 | Akzo N.V. | Benzhydryl derivatives having calmodulin inhibitor properties |
| JP3398748B2 (ja) * | 1993-01-21 | 2003-04-21 | メレルダウファーマスーティカルズ インコーポレイテッド | 多剤耐性腫瘍剤として有用なジアリールアルキルピペリジン類 |
-
1993
- 1993-01-11 DK DK93903678T patent/DK0643693T3/da active
- 1993-01-11 DE DE69325805T patent/DE69325805T2/de not_active Expired - Fee Related
- 1993-01-11 AT AT93903678T patent/ATE182582T1/de not_active IP Right Cessation
- 1993-01-11 NZ NZ249040A patent/NZ249040A/en unknown
- 1993-01-11 ES ES93903678T patent/ES2135463T3/es not_active Expired - Lifetime
- 1993-01-11 HU HU9402298A patent/HUT70564A/hu unknown
- 1993-01-11 AU AU34842/93A patent/AU662602B2/en not_active Ceased
- 1993-01-11 EP EP93903678A patent/EP0643693B1/en not_active Expired - Lifetime
- 1993-01-11 JP JP5514096A patent/JPH07503957A/ja active Pending
- 1993-01-11 CA CA002129144A patent/CA2129144C/en not_active Expired - Fee Related
- 1993-01-11 WO PCT/US1993/000669 patent/WO1993016044A1/en active IP Right Grant
-
1994
- 1994-08-05 KR KR1019940702687A patent/KR950700248A/ko not_active Application Discontinuation
- 1994-08-05 NO NO942920A patent/NO942920L/no unknown
-
1999
- 1999-10-15 GR GR990402651T patent/GR3031557T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ249040A (en) | 1997-06-24 |
| CA2129144C (en) | 1999-07-13 |
| NO942920D0 (ko) | 1994-08-05 |
| NO942920L (no) | 1994-08-05 |
| HU9402298D0 (en) | 1994-10-28 |
| DK0643693T3 (da) | 1999-11-29 |
| GR3031557T3 (en) | 2000-01-31 |
| DE69325805T2 (de) | 2000-03-16 |
| HUT70564A (en) | 1995-10-30 |
| DE69325805D1 (de) | 1999-09-02 |
| AU662602B2 (en) | 1995-09-07 |
| ES2135463T3 (es) | 1999-11-01 |
| CA2129144A1 (en) | 1993-08-19 |
| ATE182582T1 (de) | 1999-08-15 |
| EP0643693B1 (en) | 1999-07-28 |
| AU3484293A (en) | 1993-09-03 |
| JPH07503957A (ja) | 1995-04-27 |
| WO1993016044A1 (en) | 1993-08-19 |
| EP0643693A1 (en) | 1995-03-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO2014022I1 (no) | Rosuvastatin (som sink) og ezetimib | |
| AR020250A1 (es) | Compueto de isoxazolinona, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion | |
| DK0724566T3 (da) | 1,2-Diarylcyclopentenylforbindelser til behandling af inflammation | |
| DK0731796T3 (da) | 1,3,5-Trisubstituerede pyrozolforbindelser til behandling af inflammation | |
| DE60220188D1 (de) | Hemmer des phosphattransports | |
| DE69614270D1 (de) | 5-azabicyclo(3.1.0.)hexylalkyl-2-piperidone und - glutarimide als neurokinin receptor antagonisten. | |
| ID29452A (id) | 4-okso-1,4-dihidro-3-quinolinkarboksamida sebagai agen-agen antivirus | |
| KR950700248A (ko) | 트리페닐-아자시클로알칸 유도체에 의한 다약물 내성의 역전(Reversal of Multi-drug Resistance by Triphenyl-azacycloalkane Derivatives) | |
| SE8503415D0 (sv) | Novel isoindolinyl-alkyl-piperazines | |
| TR200400237T4 (tr) | Yeni karışımlar. | |
| SE8802412L (sv) | Tiokarbamidderivat | |
| KR920703056A (ko) | 항 바이러스제 | |
| DK581486D0 (da) | Antihypertensivt kombinationspraeparat | |
| CO5080754A1 (es) | Caspasas y apoptosis | |
| ATE401329T1 (de) | Neue antivirale makrocyclische derivate und metallkomplexe, in die verbrückte makrocyclen eingebaut sind | |
| NO963213L (no) | Endotelinreseptorantagonister | |
| DE60103129D1 (de) | Benzofurancarboxamide und deren therapeutische verwendung | |
| TR200100364T2 (tr) | Yeni bileşimler. | |
| DK0440324T3 (da) | Substiturede alfa-diketoner og deres anvendelse til behandling af inflammatorisk tarmsygdom | |
| RS50791B (sr) | Farmaceutske kombinacije zasnovane na derivatima piridoindolona | |
| DE69217148D1 (de) | Isoxazole derivate als lichtschutzmittel | |
| FI872110A0 (fi) | Antihypertensiviska aemnen, dessa innehaollande farmaceutiska blandningar och foerfarande foer framstaellning av aemnen och blandningar. | |
| TH76780A (th) | อนุพันธ์ของไดออกแซน-2-อิลแอลคิลคาร์บาเมท, สารเตรียมของสารเหล่านั้น และการใช้สารเหล่านั้นทางการรักษา | |
| TH13641A (th) | เบนโซไพรานและแอนทาโกนิสของ ltb4 ที่สัมพันธ์กัน | |
| TH13641EX (th) | เบนโซไพรานและแอนทาโกนิสของ ltb4 ที่สัมพันธ์กัน |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| E601 | Decision to refuse application |