NO982124L - Kondenserte imidazolderivater som multilegemiddel resistanse modulatorer - Google Patents

Kondenserte imidazolderivater som multilegemiddel resistanse modulatorer

Info

Publication number
NO982124L
NO982124L NO982124A NO982124A NO982124L NO 982124 L NO982124 L NO 982124L NO 982124 A NO982124 A NO 982124A NO 982124 A NO982124 A NO 982124A NO 982124 L NO982124 L NO 982124L
Authority
NO
Norway
Prior art keywords
multidrug resistance
imidazole derivatives
condensed imidazole
resistance modulators
modulators
Prior art date
Application number
NO982124A
Other languages
English (en)
Other versions
NO982124D0 (no
NO310659B1 (no
Inventor
Frans Eduard Janssens
Joseph Elisabeth Leenaerts
Fran Ois Maria Sommen
Dominique Louis Nest Surleraux
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO982124D0 publication Critical patent/NO982124D0/no
Publication of NO982124L publication Critical patent/NO982124L/no
Publication of NO310659B1 publication Critical patent/NO310659B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/04—Amoebicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO19982124A 1996-03-19 1998-05-11 Kondenserte imidazolderivater som multilegemiddel resistanse modulatorer NO310659B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96200755 1996-03-19
PCT/EP1997/001264 WO1997034897A1 (en) 1996-03-19 1997-03-11 Fused imidazole derivatives as multidrug resistance modulators

Publications (3)

Publication Number Publication Date
NO982124D0 NO982124D0 (no) 1998-05-11
NO982124L true NO982124L (no) 1998-09-18
NO310659B1 NO310659B1 (no) 2001-08-06

Family

ID=8223797

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19982124A NO310659B1 (no) 1996-03-19 1998-05-11 Kondenserte imidazolderivater som multilegemiddel resistanse modulatorer

Country Status (30)

Country Link
US (3) US6218381B1 (no)
EP (1) EP0888352B1 (no)
JP (3) JP3630434B2 (no)
KR (2) KR100330698B1 (no)
CN (1) CN1083453C (no)
AR (1) AR006271A1 (no)
AT (1) ATE241626T1 (no)
BG (1) BG62734B1 (no)
BR (1) BR9708140A (no)
CA (1) CA2237594C (no)
CZ (1) CZ294060B6 (no)
DE (1) DE69722389T2 (no)
EA (1) EA001004B1 (no)
EE (1) EE03773B1 (no)
ES (1) ES2200159T3 (no)
HK (1) HK1015769A1 (no)
HR (1) HRP970161B1 (no)
HU (1) HU224528B1 (no)
ID (1) ID16375A (no)
IL (1) IL124572A (no)
MX (1) MX9804426A (no)
MY (1) MY118282A (no)
NO (1) NO310659B1 (no)
NZ (1) NZ330466A (no)
PL (1) PL193444B1 (no)
SK (1) SK284434B6 (no)
TR (1) TR199801191T2 (no)
TW (1) TW527186B (no)
WO (1) WO1997034897A1 (no)
ZA (1) ZA972351B (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3775780B2 (ja) * 1997-09-18 2006-05-17 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 薬剤の経口的バイオアベイラビリテイを向上させるための縮合イミダゾール誘導体
AU756752B2 (en) * 1998-04-01 2003-01-23 Skyepharma Canada Inc. Anticancer compositions
US6743794B2 (en) 1999-12-22 2004-06-01 Eli Lilly And Company Methods and compounds for inhibiting MRP1
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
CN100491378C (zh) 2001-06-12 2009-05-27 詹森药业有限公司 新的取代四环咪唑衍生物,其制备方法,包含它们的药物组合物及它们作为药物的用途
CN100478031C (zh) * 2001-11-23 2009-04-15 詹森药业有限公司 抗组胺药快速降低高颅内压的用途
GB0301736D0 (en) * 2003-01-24 2003-02-26 Xenova Ltd Pharmaceutical compounds
US9682984B2 (en) * 2013-03-25 2017-06-20 Crystal Pharma S.A.U. Methods for the preparation of alcaftadine
CN103408549B (zh) * 2013-06-14 2016-01-20 苏州汇和药业有限公司 一种阿卡他定中间体的制备方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2418502C3 (de) * 1974-04-11 1980-04-24 Schering Ag, 1000 Berlin Und 4619 Bergkamen Dichlorbenzyl- [2-( a -imidazolylbutyl)-phenyl] -äther und -thioäther, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US4153719A (en) * 1977-09-06 1979-05-08 Sterling Drug Inc. Aromatic diketones
JPS56125326A (en) * 1980-03-07 1981-10-01 Asahi Kagaku Kogyo Kk Preparation of chlorinated phenoxytoluenes in high selectivity
US4778931A (en) 1982-12-01 1988-10-18 Usv Pharmaceutical Corporation Certain [3-(1-hydroxy hexyl-tetrahydro)naphthalenes], the corresponding naphthalenes having anti-inflammatory and anti-allergic activity
US4567184A (en) 1982-12-01 1986-01-28 Usv Pharmaceutical Corporation Certain aryl or hetero-aryl derivatives of 1-hydroxy-pentane or 1-hydroxy-hexane which are useful for treating inflammation and allergies
US4794188A (en) 1982-12-01 1988-12-27 Usv Pharmaceutical Corporation Certain unsymmetrical quinolinyl ethers having anti-inflammatory and anti-allergic activity
US4588722A (en) 1984-01-09 1986-05-13 Janssen Pharmaceutica N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
JPS61151176A (ja) * 1984-12-24 1986-07-09 Sumitomo Chem Co Ltd ベンズイミダゾール誘導体およびそれを有効成分とする殺虫、殺ダニ剤
US4631287A (en) * 1985-04-16 1986-12-23 Usv Pharmaceutical Corp. Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4840971A (en) * 1986-04-07 1989-06-20 Sumitomo Chemical Company, Limited Novel ether compound, a process for manufacturing the same, a composition containing the same and a use thereof
JPS6475441A (en) * 1987-09-16 1989-03-22 Sumitomo Chemical Co Production of optically active ether compound
JPH01254680A (ja) * 1988-04-01 1989-10-11 Sumitomo Chem Co Ltd 複素環化合物、その製造法およびそれを有効成分とする殺菌剤
CA2093797C (en) * 1990-10-10 1998-09-22 Richard J. Friary Substituted imidazobenzazepines and imidazopyridoazepines
IL101851A (en) 1991-06-13 1996-05-14 Janssen Pharmaceutica Nv History 01 -) 4 - Pipridinyl - and Pipridinylidene (- Imidazo] A-1,2 [Pirolo, Thiano or Purano (] 3,2 [Azpin, their preparation and pharmaceutical preparations containing them and composition
IL101850A (en) 1991-06-13 1996-01-31 Janssen Pharmaceutica Nv History 11-) 4-Pipridinyl (-Imidazo] B-1, 2 [] 3 [Benzazepine, their preparation and pharmaceutical preparations containing them
GB9122590D0 (en) * 1991-10-24 1991-12-04 Lilly Industries Ltd Pharmaceutical compounds
CA2129144C (en) 1992-02-06 1999-07-13 Jules Freedman Reversal of multi-drug resistance by triphenyl-azacycloalkane derivatives
ES2199224T3 (es) 1992-12-04 2004-02-16 Janssen Pharmaceutica N.V. Derivados de imidazo(1,2-a)tieno(2,3-d)azepina antialergicos.
ES2152310T3 (es) * 1993-03-29 2001-02-01 Basf Ag Derivados de 1-amino-3-fenoxipropano como moduladores de la resistencia a multiples a farmacos.
ES2155092T3 (es) 1993-07-13 2001-05-01 Janssen Pharmaceutica Nv Imidazoazepinas antialergicas.
US5486612A (en) * 1993-12-14 1996-01-23 Eli Lilly And Company N-benzyl dihydroindole LTD4 antagonists
US5596008A (en) * 1995-02-10 1997-01-21 G. D. Searle & Co. 3,4-Diaryl substituted pyridines for the treatment of inflammation
FR2731708B1 (fr) 1995-03-13 1997-04-30 Synthelabo Derives de piperidine, leur procede de preparation et leur application en therapeutique
TW382017B (en) 1995-12-27 2000-02-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives

Also Published As

Publication number Publication date
NO982124D0 (no) 1998-05-11
JP2002012594A (ja) 2002-01-15
AU2026997A (en) 1997-10-10
EP0888352B1 (en) 2003-05-28
CA2237594C (en) 2006-05-30
PL327985A1 (en) 1999-01-04
HRP970161B1 (en) 2002-06-30
HU224528B1 (hu) 2005-10-28
CN1083453C (zh) 2002-04-24
ZA972351B (en) 1998-09-18
HUP9900415A2 (hu) 1999-05-28
BG62734B1 (bg) 2000-06-30
EE03773B1 (et) 2002-06-17
CA2237594A1 (en) 1997-09-25
EE9800281A (et) 1999-02-15
AU709683B2 (en) 1999-09-02
IL124572A0 (en) 1998-12-06
MY118282A (en) 2004-09-30
NO310659B1 (no) 2001-08-06
EP0888352A1 (en) 1999-01-07
AR006271A1 (es) 1999-08-11
ID16375A (id) 1997-09-25
CN1211985A (zh) 1999-03-24
HUP9900415A3 (en) 2001-11-28
HK1015769A1 (en) 1999-10-22
IL124572A (en) 2002-03-10
EA199800586A1 (ru) 1998-12-24
JP2000505477A (ja) 2000-05-09
KR100330698B1 (ko) 2002-10-31
US20030087895A1 (en) 2003-05-08
JP4205319B2 (ja) 2009-01-07
TR199801191T2 (xx) 1998-10-21
WO1997034897A1 (en) 1997-09-25
PL193444B1 (pl) 2007-02-28
MX9804426A (es) 1998-09-30
KR20000064358A (ko) 2000-11-06
US6476018B1 (en) 2002-11-05
JP4251447B2 (ja) 2009-04-08
ATE241626T1 (de) 2003-06-15
JP3630434B2 (ja) 2005-03-16
DE69722389D1 (de) 2003-07-03
DE69722389T2 (de) 2009-09-24
KR100349500B1 (ko) 2002-08-21
US6218381B1 (en) 2001-04-17
NZ330466A (en) 1999-03-29
BG102459A (en) 1999-06-30
HRP970161A2 (en) 1998-04-30
TW527186B (en) 2003-04-11
BR9708140A (pt) 1999-07-27
ES2200159T3 (es) 2004-03-01
CZ152998A3 (cs) 1999-02-17
SK66298A3 (en) 1999-06-11
JP2004067701A (ja) 2004-03-04
CZ294060B6 (cs) 2004-09-15
EA001004B1 (ru) 2000-08-28
SK284434B6 (sk) 2005-04-01

Similar Documents

Publication Publication Date Title
PT1019090E (pt) Derivados polimeros de camptotecina
DE69718179T2 (de) Radauswuchtvorrichtung
PT934320E (pt) Derivados de naftiridina
ID19609A (id) Senyawa-senyawa heterosiklik
ID19403A (id) Senyawa-senyawa heterosiklik
ID16152A (id) Senyawa-senyawa triaril
BR9708386A (pt) Derivados de 6-fenilpiridil-2-amina
PT1005446E (pt) Derivados de n-aroilfenilalanina
ID15904A (id) Senyawa-senyawa tiofenopirimidina
BR9710352A (pt) Compostos piridilpirrole
DE69716924T2 (de) Phosphonat-nukleotid-verbindungen
ID18685A (id) Senyawa trisiklik tersubstitusi
ATE255098T1 (de) Substituierte chromanderivate
PT1003719E (pt) Derivados microbicidas de n-sulfonil-glicinalquiniloxifenemetilamida
FI972660A (fi) Piperatsini-2,5-dionijohdannaiset monilääke resistanssi modulaattoreina
BR9709065A (pt) Derivados de alquilaminobenzotiazole e-benzoxazol
PT922050E (pt) Derivados de 3-descladinose-2,3-anidroeritromicina
ATE255099T1 (de) Substituierte chromanderivate
BR9705635A (pt) Compostos
NO982124L (no) Kondenserte imidazolderivater som multilegemiddel resistanse modulatorer
DK0923594T3 (da) Bromotiacumicinforbindelser
PT931087E (pt) Novos derivados de piranosido
PT906279E (pt) Derivados de pirrol
ATE211884T1 (de) Halopropargyl-einschlussverbindungen
BR9706980A (pt) Derivados de isooxacefem

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees