DE69722389D1 - Kondensierte imidazolderivate als modulatoren vielfacher medikamentenresistenz - Google Patents

Kondensierte imidazolderivate als modulatoren vielfacher medikamentenresistenz

Info

Publication number
DE69722389D1
DE69722389D1 DE69722389T DE69722389T DE69722389D1 DE 69722389 D1 DE69722389 D1 DE 69722389D1 DE 69722389 T DE69722389 T DE 69722389T DE 69722389 T DE69722389 T DE 69722389T DE 69722389 D1 DE69722389 D1 DE 69722389D1
Authority
DE
Germany
Prior art keywords
modulators
imidazole derivatives
multiple medicine
medicine resistance
condensed imidazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69722389T
Other languages
English (en)
Other versions
DE69722389T2 (de
Inventor
Eduard Janssens
Elisabeth Leenaerts
Maria Sommen
Louis Surleraux
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of DE69722389D1 publication Critical patent/DE69722389D1/de
Application granted granted Critical
Publication of DE69722389T2 publication Critical patent/DE69722389T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/04—Amoebicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69722389T 1996-03-19 1997-03-11 Kondensierte imidazolderivate als modulatoren vielfacher medikamentenresistenz Expired - Fee Related DE69722389T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP96200755 1996-03-19
EP96200755 1996-03-19
PCT/EP1997/001264 WO1997034897A1 (en) 1996-03-19 1997-03-11 Fused imidazole derivatives as multidrug resistance modulators

Publications (2)

Publication Number Publication Date
DE69722389D1 true DE69722389D1 (de) 2003-07-03
DE69722389T2 DE69722389T2 (de) 2009-09-24

Family

ID=8223797

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69722389T Expired - Fee Related DE69722389T2 (de) 1996-03-19 1997-03-11 Kondensierte imidazolderivate als modulatoren vielfacher medikamentenresistenz

Country Status (30)

Country Link
US (3) US6218381B1 (de)
EP (1) EP0888352B1 (de)
JP (3) JP3630434B2 (de)
KR (2) KR100330698B1 (de)
CN (1) CN1083453C (de)
AR (1) AR006271A1 (de)
AT (1) ATE241626T1 (de)
BG (1) BG62734B1 (de)
BR (1) BR9708140A (de)
CA (1) CA2237594C (de)
CZ (1) CZ294060B6 (de)
DE (1) DE69722389T2 (de)
EA (1) EA001004B1 (de)
EE (1) EE03773B1 (de)
ES (1) ES2200159T3 (de)
HK (1) HK1015769A1 (de)
HR (1) HRP970161B1 (de)
HU (1) HU224528B1 (de)
ID (1) ID16375A (de)
IL (1) IL124572A (de)
MX (1) MX9804426A (de)
MY (1) MY118282A (de)
NO (1) NO310659B1 (de)
NZ (1) NZ330466A (de)
PL (1) PL193444B1 (de)
SK (1) SK284434B6 (de)
TR (1) TR199801191T2 (de)
TW (1) TW527186B (de)
WO (1) WO1997034897A1 (de)
ZA (1) ZA972351B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999013871A2 (en) * 1997-09-18 1999-03-25 Janssen Pharmaceutica N.V. Fused imidazole derivatives for improving oral bioavailability of pharmaceutical agents
IL138767A0 (en) * 1998-04-01 2001-10-31 Rtp Pharma Inc Anticancer compositions
US6743794B2 (en) 1999-12-22 2004-06-01 Eli Lilly And Company Methods and compounds for inhibiting MRP1
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
WO2002100862A2 (en) 2001-06-12 2002-12-19 Janssen Pharmaceutica N.V. Novel substituted tetracyclic imidazole derivatives, processes for their preparation, pharmaceutical compositions comprising them and their use as a medicine
MXPA04004867A (es) * 2001-11-23 2004-07-30 Janssen Pharmaceutica Nv El uso de antihistaminicos para la reduccion aguda de presion intracraneal elevada.
GB0301736D0 (en) * 2003-01-24 2003-02-26 Xenova Ltd Pharmaceutical compounds
JP6400672B2 (ja) * 2013-03-25 2018-10-03 クリスタル ファーマ エセ．ア．ウ． アルカフタジンの製造方法
CN103408549B (zh) * 2013-06-14 2016-01-20 苏州汇和药业有限公司 一种阿卡他定中间体的制备方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2418502C3 (de) * 1974-04-11 1980-04-24 Schering Ag, 1000 Berlin Und 4619 Bergkamen Dichlorbenzyl- [2-( a -imidazolylbutyl)-phenyl] -äther und -thioäther, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US4153719A (en) * 1977-09-06 1979-05-08 Sterling Drug Inc. Aromatic diketones
JPS56125326A (en) * 1980-03-07 1981-10-01 Asahi Kagaku Kogyo Kk Preparation of chlorinated phenoxytoluenes in high selectivity
US4567184A (en) 1982-12-01 1986-01-28 Usv Pharmaceutical Corporation Certain aryl or hetero-aryl derivatives of 1-hydroxy-pentane or 1-hydroxy-hexane which are useful for treating inflammation and allergies
US4778931A (en) 1982-12-01 1988-10-18 Usv Pharmaceutical Corporation Certain [3-(1-hydroxy hexyl-tetrahydro)naphthalenes], the corresponding naphthalenes having anti-inflammatory and anti-allergic activity
US4794188A (en) 1982-12-01 1988-12-27 Usv Pharmaceutical Corporation Certain unsymmetrical quinolinyl ethers having anti-inflammatory and anti-allergic activity
US4588722A (en) 1984-01-09 1986-05-13 Janssen Pharmaceutica N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
JPS61151176A (ja) * 1984-12-24 1986-07-09 Sumitomo Chem Co Ltd ベンズイミダゾール誘導体およびそれを有効成分とする殺虫、殺ダニ剤
US4631287A (en) * 1985-04-16 1986-12-23 Usv Pharmaceutical Corp. Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
AU7100887A (en) * 1986-04-07 1987-10-08 Sumitomo Chemical Company, Limited Halogenated aromatic ethers and alcohol and aldehyde intermediates
JPS6475441A (en) * 1987-09-16 1989-03-22 Sumitomo Chemical Co Production of optically active ether compound
JPH01254680A (ja) * 1988-04-01 1989-10-11 Sumitomo Chem Co Ltd 複素環化合物、その製造法およびそれを有効成分とする殺菌剤
JPH089616B2 (ja) * 1990-10-10 1996-01-31 シェリング・コーポレーション 置換されたイミダゾベンズアゼピン類およびイミダゾピリドアゼピン類
IL101851A (en) 1991-06-13 1996-05-14 Janssen Pharmaceutica Nv History 01 -) 4 - Pipridinyl - and Pipridinylidene (- Imidazo] A-1,2 [Pirolo, Thiano or Purano (] 3,2 [Azpin, their preparation and pharmaceutical preparations containing them and composition
IL101850A (en) 1991-06-13 1996-01-31 Janssen Pharmaceutica Nv History 11-) 4-Pipridinyl (-Imidazo] B-1, 2 [] 3 [Benzazepine, their preparation and pharmaceutical preparations containing them
GB9122590D0 (en) * 1991-10-24 1991-12-04 Lilly Industries Ltd Pharmaceutical compounds
ES2135463T3 (es) 1992-02-06 1999-11-01 Merrell Pharma Inc Inversion de la resistencia multi-medicamento por medio de derivados de trifenil-piperidina.
RU2134269C1 (ru) 1992-12-04 1999-08-10 Жансен Фармасетика Н.В. Производные имидазо/1,2а/тиено/2,3-d/азепинов, способ их получения, промежуточные для их получения, фармацевтическая композиция и способ их получения
CA2155759A1 (en) * 1993-03-29 1994-10-13 Bernd Janssen 1-amino-3-phenoxy propane derivatives as modulators of multi-drug resistance
CN1042228C (zh) 1993-07-13 1999-02-24 詹森药业有限公司 抗过敏咪唑并吖庚因
US5486612A (en) * 1993-12-14 1996-01-23 Eli Lilly And Company N-benzyl dihydroindole LTD4 antagonists
US5596008A (en) * 1995-02-10 1997-01-21 G. D. Searle & Co. 3,4-Diaryl substituted pyridines for the treatment of inflammation
FR2731708B1 (fr) 1995-03-13 1997-04-30 Synthelabo Derives de piperidine, leur procede de preparation et leur application en therapeutique
TW382017B (en) 1995-12-27 2000-02-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives

Also Published As

Publication number Publication date
AU709683B2 (en) 1999-09-02
BG62734B1 (bg) 2000-06-30
CA2237594A1 (en) 1997-09-25
PL327985A1 (en) 1999-01-04
HK1015769A1 (en) 1999-10-22
IL124572A (en) 2002-03-10
HRP970161B1 (en) 2002-06-30
MX9804426A (es) 1998-09-30
AR006271A1 (es) 1999-08-11
HUP9900415A2 (hu) 1999-05-28
NO310659B1 (no) 2001-08-06
SK284434B6 (sk) 2005-04-01
KR100330698B1 (ko) 2002-10-31
NZ330466A (en) 1999-03-29
SK66298A3 (en) 1999-06-11
HRP970161A2 (en) 1998-04-30
TR199801191T2 (xx) 1998-10-21
AU2026997A (en) 1997-10-10
NO982124D0 (no) 1998-05-11
JP3630434B2 (ja) 2005-03-16
KR100349500B1 (ko) 2002-08-21
WO1997034897A1 (en) 1997-09-25
NO982124L (no) 1998-09-18
JP2002012594A (ja) 2002-01-15
US6476018B1 (en) 2002-11-05
US6218381B1 (en) 2001-04-17
IL124572A0 (en) 1998-12-06
ID16375A (id) 1997-09-25
US20030087895A1 (en) 2003-05-08
EP0888352A1 (de) 1999-01-07
CA2237594C (en) 2006-05-30
BG102459A (en) 1999-06-30
EP0888352B1 (de) 2003-05-28
JP2000505477A (ja) 2000-05-09
EE03773B1 (et) 2002-06-17
ZA972351B (en) 1998-09-18
JP4251447B2 (ja) 2009-04-08
KR20000064358A (ko) 2000-11-06
DE69722389T2 (de) 2009-09-24
HU224528B1 (hu) 2005-10-28
ATE241626T1 (de) 2003-06-15
JP4205319B2 (ja) 2009-01-07
CZ294060B6 (cs) 2004-09-15
CN1083453C (zh) 2002-04-24
CZ152998A3 (cs) 1999-02-17
EA001004B1 (ru) 2000-08-28
MY118282A (en) 2004-09-30
BR9708140A (pt) 1999-07-27
ES2200159T3 (es) 2004-03-01
EE9800281A (et) 1999-02-15
PL193444B1 (pl) 2007-02-28
HUP9900415A3 (en) 2001-11-28
EA199800586A1 (ru) 1998-12-24
JP2004067701A (ja) 2004-03-04
TW527186B (en) 2003-04-11
CN1211985A (zh) 1999-03-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee