TR199801191T2 - Çogul ilaç direnci modülatörleri olarak kaynasik imidazol türevleri. - Google Patents

Çogul ilaç direnci modülatörleri olarak kaynasik imidazol türevleri.

Info

Publication number
TR199801191T2
TR199801191T2 TR1998/01191T TR9801191T TR199801191T2 TR 199801191 T2 TR199801191 T2 TR 199801191T2 TR 1998/01191 T TR1998/01191 T TR 1998/01191T TR 9801191 T TR9801191 T TR 9801191T TR 199801191 T2 TR199801191 T2 TR 199801191T2
Authority
TR
Turkey
Prior art keywords
drug resistance
multiple drug
modulators
imidazole derivatives
source
Prior art date
Application number
TR1998/01191T
Other languages
English (en)
Inventor
Eduard Janssens Frans
Elisabeth Leenaerts Joseph
Maria Sommen Francois
Louis Nestor Ghislaine Surleraux Dominique
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of TR199801191T2 publication Critical patent/TR199801191T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/04—Amoebicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

FORMÜL: Bu bulus formül (I) bilesiklerine, onlarin N- oksit biçimlerine, farmasötik olarak kabul edilebilir ilave tuzlarina ve stereokimyasal olarak izomerik biçimlerine iliskindir. Ayrica adi geçen ürünleri hazirlamaya yönelik islemlere,adi geçen ürünleri içeren formülasyonlarina ve özellikle çogul ilaç direnci etkilerini inhibe etmek veya tersine çevirmek üzere ilaç olarak kullanimlarina iliskindir.
TR1998/01191T 1996-03-19 1997-03-11 Çogul ilaç direnci modülatörleri olarak kaynasik imidazol türevleri. TR199801191T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96200755 1996-03-19

Publications (1)

Publication Number Publication Date
TR199801191T2 true TR199801191T2 (tr) 1998-10-21

Family

ID=8223797

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1998/01191T TR199801191T2 (tr) 1996-03-19 1997-03-11 Çogul ilaç direnci modülatörleri olarak kaynasik imidazol türevleri.

Country Status (30)

Country Link
US (3) US6218381B1 (tr)
EP (1) EP0888352B1 (tr)
JP (3) JP3630434B2 (tr)
KR (2) KR100330698B1 (tr)
CN (1) CN1083453C (tr)
AR (1) AR006271A1 (tr)
AT (1) ATE241626T1 (tr)
BG (1) BG62734B1 (tr)
BR (1) BR9708140A (tr)
CA (1) CA2237594C (tr)
CZ (1) CZ294060B6 (tr)
DE (1) DE69722389T2 (tr)
EA (1) EA001004B1 (tr)
EE (1) EE03773B1 (tr)
ES (1) ES2200159T3 (tr)
HK (1) HK1015769A1 (tr)
HR (1) HRP970161B1 (tr)
HU (1) HU224528B1 (tr)
ID (1) ID16375A (tr)
IL (1) IL124572A (tr)
MX (1) MX9804426A (tr)
MY (1) MY118282A (tr)
NO (1) NO310659B1 (tr)
NZ (1) NZ330466A (tr)
PL (1) PL193444B1 (tr)
SK (1) SK284434B6 (tr)
TR (1) TR199801191T2 (tr)
TW (1) TW527186B (tr)
WO (1) WO1997034897A1 (tr)
ZA (1) ZA972351B (tr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3775780B2 (ja) * 1997-09-18 2006-05-17 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 薬剤の経口的バイオアベイラビリテイを向上させるための縮合イミダゾール誘導体
AU756752B2 (en) * 1998-04-01 2003-01-23 Skyepharma Canada Inc. Anticancer compositions
US6743794B2 (en) 1999-12-22 2004-06-01 Eli Lilly And Company Methods and compounds for inhibiting MRP1
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
CN100491378C (zh) 2001-06-12 2009-05-27 詹森药业有限公司 新的取代四环咪唑衍生物,其制备方法,包含它们的药物组合物及它们作为药物的用途
CN100478031C (zh) * 2001-11-23 2009-04-15 詹森药业有限公司 抗组胺药快速降低高颅内压的用途
GB0301736D0 (en) * 2003-01-24 2003-02-26 Xenova Ltd Pharmaceutical compounds
US9682984B2 (en) * 2013-03-25 2017-06-20 Crystal Pharma S.A.U. Methods for the preparation of alcaftadine
CN103408549B (zh) * 2013-06-14 2016-01-20 苏州汇和药业有限公司 一种阿卡他定中间体的制备方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2418502C3 (de) * 1974-04-11 1980-04-24 Schering Ag, 1000 Berlin Und 4619 Bergkamen Dichlorbenzyl- [2-( a -imidazolylbutyl)-phenyl] -äther und -thioäther, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US4153719A (en) * 1977-09-06 1979-05-08 Sterling Drug Inc. Aromatic diketones
JPS56125326A (en) * 1980-03-07 1981-10-01 Asahi Kagaku Kogyo Kk Preparation of chlorinated phenoxytoluenes in high selectivity
US4778931A (en) 1982-12-01 1988-10-18 Usv Pharmaceutical Corporation Certain [3-(1-hydroxy hexyl-tetrahydro)naphthalenes], the corresponding naphthalenes having anti-inflammatory and anti-allergic activity
US4567184A (en) 1982-12-01 1986-01-28 Usv Pharmaceutical Corporation Certain aryl or hetero-aryl derivatives of 1-hydroxy-pentane or 1-hydroxy-hexane which are useful for treating inflammation and allergies
US4794188A (en) 1982-12-01 1988-12-27 Usv Pharmaceutical Corporation Certain unsymmetrical quinolinyl ethers having anti-inflammatory and anti-allergic activity
US4588722A (en) 1984-01-09 1986-05-13 Janssen Pharmaceutica N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
JPS61151176A (ja) * 1984-12-24 1986-07-09 Sumitomo Chem Co Ltd ベンズイミダゾール誘導体およびそれを有効成分とする殺虫、殺ダニ剤
US4631287A (en) * 1985-04-16 1986-12-23 Usv Pharmaceutical Corp. Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4840971A (en) * 1986-04-07 1989-06-20 Sumitomo Chemical Company, Limited Novel ether compound, a process for manufacturing the same, a composition containing the same and a use thereof
JPS6475441A (en) * 1987-09-16 1989-03-22 Sumitomo Chemical Co Production of optically active ether compound
JPH01254680A (ja) * 1988-04-01 1989-10-11 Sumitomo Chem Co Ltd 複素環化合物、その製造法およびそれを有効成分とする殺菌剤
CA2093797C (en) * 1990-10-10 1998-09-22 Richard J. Friary Substituted imidazobenzazepines and imidazopyridoazepines
IL101851A (en) 1991-06-13 1996-05-14 Janssen Pharmaceutica Nv History 01 -) 4 - Pipridinyl - and Pipridinylidene (- Imidazo] A-1,2 [Pirolo, Thiano or Purano (] 3,2 [Azpin, their preparation and pharmaceutical preparations containing them and composition
IL101850A (en) 1991-06-13 1996-01-31 Janssen Pharmaceutica Nv History 11-) 4-Pipridinyl (-Imidazo] B-1, 2 [] 3 [Benzazepine, their preparation and pharmaceutical preparations containing them
GB9122590D0 (en) * 1991-10-24 1991-12-04 Lilly Industries Ltd Pharmaceutical compounds
CA2129144C (en) 1992-02-06 1999-07-13 Jules Freedman Reversal of multi-drug resistance by triphenyl-azacycloalkane derivatives
ES2199224T3 (es) 1992-12-04 2004-02-16 Janssen Pharmaceutica N.V. Derivados de imidazo(1,2-a)tieno(2,3-d)azepina antialergicos.
ES2152310T3 (es) * 1993-03-29 2001-02-01 Basf Ag Derivados de 1-amino-3-fenoxipropano como moduladores de la resistencia a multiples a farmacos.
ES2155092T3 (es) 1993-07-13 2001-05-01 Janssen Pharmaceutica Nv Imidazoazepinas antialergicas.
US5486612A (en) * 1993-12-14 1996-01-23 Eli Lilly And Company N-benzyl dihydroindole LTD4 antagonists
US5596008A (en) * 1995-02-10 1997-01-21 G. D. Searle & Co. 3,4-Diaryl substituted pyridines for the treatment of inflammation
FR2731708B1 (fr) 1995-03-13 1997-04-30 Synthelabo Derives de piperidine, leur procede de preparation et leur application en therapeutique
TW382017B (en) 1995-12-27 2000-02-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives

Also Published As

Publication number Publication date
NO982124D0 (no) 1998-05-11
JP2002012594A (ja) 2002-01-15
AU2026997A (en) 1997-10-10
EP0888352B1 (en) 2003-05-28
CA2237594C (en) 2006-05-30
PL327985A1 (en) 1999-01-04
HRP970161B1 (en) 2002-06-30
HU224528B1 (hu) 2005-10-28
CN1083453C (zh) 2002-04-24
ZA972351B (en) 1998-09-18
HUP9900415A2 (hu) 1999-05-28
BG62734B1 (bg) 2000-06-30
EE03773B1 (et) 2002-06-17
CA2237594A1 (en) 1997-09-25
EE9800281A (et) 1999-02-15
AU709683B2 (en) 1999-09-02
IL124572A0 (en) 1998-12-06
MY118282A (en) 2004-09-30
NO310659B1 (no) 2001-08-06
EP0888352A1 (en) 1999-01-07
AR006271A1 (es) 1999-08-11
ID16375A (id) 1997-09-25
CN1211985A (zh) 1999-03-24
HUP9900415A3 (en) 2001-11-28
HK1015769A1 (en) 1999-10-22
IL124572A (en) 2002-03-10
EA199800586A1 (ru) 1998-12-24
JP2000505477A (ja) 2000-05-09
KR100330698B1 (ko) 2002-10-31
US20030087895A1 (en) 2003-05-08
JP4205319B2 (ja) 2009-01-07
WO1997034897A1 (en) 1997-09-25
PL193444B1 (pl) 2007-02-28
MX9804426A (es) 1998-09-30
KR20000064358A (ko) 2000-11-06
US6476018B1 (en) 2002-11-05
JP4251447B2 (ja) 2009-04-08
ATE241626T1 (de) 2003-06-15
JP3630434B2 (ja) 2005-03-16
DE69722389D1 (de) 2003-07-03
DE69722389T2 (de) 2009-09-24
KR100349500B1 (ko) 2002-08-21
US6218381B1 (en) 2001-04-17
NZ330466A (en) 1999-03-29
BG102459A (en) 1999-06-30
HRP970161A2 (en) 1998-04-30
TW527186B (en) 2003-04-11
NO982124L (no) 1998-09-18
BR9708140A (pt) 1999-07-27
ES2200159T3 (es) 2004-03-01
CZ152998A3 (cs) 1999-02-17
SK66298A3 (en) 1999-06-11
JP2004067701A (ja) 2004-03-04
CZ294060B6 (cs) 2004-09-15
EA001004B1 (ru) 2000-08-28
SK284434B6 (sk) 2005-04-01

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