NO300304B1 - Fremgangsmåte for fremstilling av et farmasöytisk preparat i form av mikropartikler - Google Patents
Fremgangsmåte for fremstilling av et farmasöytisk preparat i form av mikropartikler Download PDFInfo
- Publication number
- NO300304B1 NO300304B1 NO903264A NO903264A NO300304B1 NO 300304 B1 NO300304 B1 NO 300304B1 NO 903264 A NO903264 A NO 903264A NO 903264 A NO903264 A NO 903264A NO 300304 B1 NO300304 B1 NO 300304B1
- Authority
- NO
- Norway
- Prior art keywords
- microparticles
- stated
- copolymer
- trp
- active substance
- Prior art date
Links
- 239000011859 microparticle Substances 0.000 title claims description 28
- 238000000034 method Methods 0.000 title claims description 24
- 238000002360 preparation method Methods 0.000 title description 5
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229920001577 copolymer Polymers 0.000 claims description 27
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 22
- 239000013543 active substance Substances 0.000 claims description 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 19
- 239000000203 mixture Substances 0.000 claims description 18
- 238000001125 extrusion Methods 0.000 claims description 17
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 16
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 claims description 12
- 238000004519 manufacturing process Methods 0.000 claims description 9
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 claims description 9
- 238000013270 controlled release Methods 0.000 claims description 8
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 claims description 7
- 235000014655 lactic acid Nutrition 0.000 claims description 7
- 239000004310 lactic acid Substances 0.000 claims description 7
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 claims description 7
- 230000006835 compression Effects 0.000 claims description 6
- 238000007906 compression Methods 0.000 claims description 6
- 229920002253 Tannate Polymers 0.000 claims description 5
- 230000002035 prolonged effect Effects 0.000 claims description 5
- 102000005157 Somatostatin Human genes 0.000 claims description 4
- 108010056088 Somatostatin Proteins 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 229940088679 drug related substance Drugs 0.000 claims description 4
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 claims description 4
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 4
- 238000010298 pulverizing process Methods 0.000 claims description 4
- 229960000553 somatostatin Drugs 0.000 claims description 4
- 239000008186 active pharmaceutical agent Substances 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 238000007873 sieving Methods 0.000 claims description 3
- 102000055006 Calcitonin Human genes 0.000 claims description 2
- 108060001064 Calcitonin Proteins 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 claims description 2
- 229960004015 calcitonin Drugs 0.000 claims description 2
- 101000904177 Clupea pallasii Gonadoliberin-1 Proteins 0.000 claims 2
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 claims 2
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 claims 2
- -1 GH-RH Chemical compound 0.000 claims 1
- 150000003839 salts Chemical class 0.000 description 9
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 8
- 102000004196 processed proteins & peptides Human genes 0.000 description 6
- 108700012941 GNRH1 Proteins 0.000 description 5
- 238000001727 in vivo Methods 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 239000006185 dispersion Substances 0.000 description 4
- 239000007943 implant Substances 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 229960003604 testosterone Drugs 0.000 description 4
- XBBVURRQGJPTHH-DKWTVANSSA-N 2-hydroxyacetic acid;(2s)-2-hydroxypropanoic acid Chemical compound OCC(O)=O.C[C@H](O)C(O)=O XBBVURRQGJPTHH-DKWTVANSSA-N 0.000 description 3
- 241000700159 Rattus Species 0.000 description 3
- 238000000227 grinding Methods 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 description 2
- 239000000095 Growth Hormone-Releasing Hormone Substances 0.000 description 2
- 102000038461 Growth Hormone-Releasing Hormone Human genes 0.000 description 2
- 101710142969 Somatoliberin Proteins 0.000 description 2
- 229920002988 biodegradable polymer Polymers 0.000 description 2
- 239000004621 biodegradable polymer Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 235000012438 extruded product Nutrition 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 239000012907 medicinal substance Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000000750 progressive effect Effects 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000007580 dry-mixing Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 239000011874 heated mixture Substances 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 150000002942 palmitic acid derivatives Chemical class 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000013557 residual solvent Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 229940075620 somatostatin analogue Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical class [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/31—Somatostatins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH2829/89A CH679207A5 (cs) | 1989-07-28 | 1989-07-28 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO903264D0 NO903264D0 (no) | 1990-07-23 |
| NO903264L NO903264L (no) | 1991-01-29 |
| NO300304B1 true NO300304B1 (no) | 1997-05-12 |
Family
ID=4242536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO903264A NO300304B1 (no) | 1989-07-28 | 1990-07-23 | Fremgangsmåte for fremstilling av et farmasöytisk preparat i form av mikropartikler |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5134122A (cs) |
| JP (1) | JPH0662427B2 (cs) |
| AT (1) | AT397197B (cs) |
| AU (1) | AU619996B2 (cs) |
| BE (1) | BE1003093A3 (cs) |
| CA (1) | CA2021767C (cs) |
| CH (1) | CH679207A5 (cs) |
| DE (1) | DE4023134C2 (cs) |
| DK (1) | DK175495B1 (cs) |
| ES (1) | ES2020890A6 (cs) |
| FI (1) | FI97688C (cs) |
| FR (1) | FR2650182B1 (cs) |
| GB (1) | GB2234169B (cs) |
| GR (1) | GR1001215B (cs) |
| IE (1) | IE65397B1 (cs) |
| IL (1) | IL95120A (cs) |
| IT (1) | IT1243357B (cs) |
| LU (1) | LU87772A1 (cs) |
| NL (1) | NL194858C (cs) |
| NO (1) | NO300304B1 (cs) |
| PT (1) | PT94842B (cs) |
| SE (1) | SE504279C2 (cs) |
| ZA (1) | ZA905654B (cs) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH30995A (en) * | 1989-07-07 | 1997-12-23 | Novartis Inc | Sustained release formulations of water soluble peptides. |
| US5538739A (en) * | 1989-07-07 | 1996-07-23 | Sandoz Ltd. | Sustained release formulations of water soluble peptides |
| CH681425A5 (cs) * | 1990-11-14 | 1993-03-31 | Debio Rech Pharma Sa | |
| DK0528978T3 (da) * | 1990-05-16 | 2003-02-17 | Southern Res Inst | Mikrokapsler til reguleret afgivelse og deres anvendelse i stimulering af nervefibervækst |
| US6517859B1 (en) | 1990-05-16 | 2003-02-11 | Southern Research Institute | Microcapsules for administration of neuroactive agents |
| CH683149A5 (fr) * | 1991-07-22 | 1994-01-31 | Debio Rech Pharma Sa | Procédé pour la préparation de microsphères en matériau polymère biodégradable. |
| US5470582A (en) * | 1992-02-07 | 1995-11-28 | Syntex (U.S.A.) Inc. | Controlled delivery of pharmaceuticals from preformed porous polymeric microparticles |
| US6013853A (en) * | 1992-02-14 | 2000-01-11 | The University Of Texas System | Continuous release polymeric implant carrier |
| US5876452A (en) * | 1992-02-14 | 1999-03-02 | Board Of Regents, University Of Texas System | Biodegradable implant |
| GB9211268D0 (en) * | 1992-05-28 | 1992-07-15 | Ici Plc | Salts of basic peptides with carboxyterminated polyesters |
| US5456917A (en) * | 1993-04-12 | 1995-10-10 | Cambridge Scientific, Inc. | Method for making a bioerodible material for the sustained release of a medicament and the material made from the method |
| DE4342092B4 (de) * | 1993-12-09 | 2007-01-11 | Zentaris Gmbh | Langwirkende Injektionssuspension und Verfahren zur Herstellung |
| CA2178592C (en) * | 1993-12-09 | 2009-07-28 | Jurgen Engel | Long-acting injection suspensions and a process for their preparation |
| US5417982A (en) * | 1994-02-17 | 1995-05-23 | Modi; Pankaj | Controlled release of drugs or hormones in biodegradable polymer microspheres |
| US5569468A (en) * | 1994-02-17 | 1996-10-29 | Modi; Pankaj | Vaccine delivery system for immunization, using biodegradable polymer microspheres |
| US5430021A (en) * | 1994-03-18 | 1995-07-04 | Pharmavene, Inc. | Hydrophobic drug delivery systems |
| US5595760A (en) * | 1994-09-02 | 1997-01-21 | Delab | Sustained release of peptides from pharmaceutical compositions |
| FR2748205A1 (fr) | 1996-05-06 | 1997-11-07 | Debio Rech Pharma Sa | Compositions pharmaceutiques pour la liberation controlee de principes actifs insolubles |
| US5945128A (en) * | 1996-09-04 | 1999-08-31 | Romano Deghenghi | Process to manufacture implants containing bioactive peptides |
| AU4571097A (en) * | 1996-10-09 | 1998-05-05 | Takeda Chemical Industries Ltd. | A method for producing a microparticle |
| AU5678398A (en) * | 1997-01-29 | 1998-08-18 | Takeda Chemical Industries Ltd. | Sustained-release microspheres, their production and use |
| US6071982A (en) * | 1997-04-18 | 2000-06-06 | Cambridge Scientific, Inc. | Bioerodible polymeric semi-interpenetrating network alloys for surgical plates and bone cements, and method for making same |
| EP1028746B1 (en) | 1997-11-07 | 2003-02-26 | Chiron Corporation | Method for producing igf-i sustained-release formulations |
| IT1304152B1 (it) * | 1998-12-10 | 2001-03-08 | Mediolanum Farmaceutici Srl | Composizioni comprendenti un peptide ed acido polilattico-glicolicoatte alla preparazione di impianti sottocutanei aventi un prolungato |
| US6455526B1 (en) | 1998-12-16 | 2002-09-24 | Aventis Pharmaceuticals, Inc. | Biodegradable polymer encapsulated pharmaceutical compositions and method for preparing the same |
| HK1041645B (zh) * | 1998-12-16 | 2005-07-29 | Aventisub Ii Inc. | 生物可降解聚合物包封的5-羟色胺受体拮抗剂及其制备方法 |
| ES2579783T3 (es) | 1999-02-26 | 2016-08-16 | Novartis Vaccines And Diagnostics, Inc. | Microemulsiones con macropartículas adsorbidas |
| US7713739B1 (en) * | 2000-11-17 | 2010-05-11 | Novartis Vaccines And Diagnostics, Inc. | Microparticle-based transfection and activation of dendritic cells |
| ES2169980B1 (es) | 1999-12-17 | 2003-11-01 | Lipotec Sa | Microcapsulas para la liberacion prolongada de farmacos. |
| US6362308B1 (en) * | 2000-08-10 | 2002-03-26 | Alkermes Controlled Therapeutics Inc. Ii | Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content |
| CN1520297A (zh) * | 2001-04-26 | 2004-08-11 | ���ߵ���Ƶϵͳ��˾ | 包含复合药物(codrugs)的缓释药物传递系统 |
| US20040022853A1 (en) * | 2001-04-26 | 2004-02-05 | Control Delivery Systems, Inc. | Polymer-based, sustained release drug delivery system |
| DE50210646D1 (de) * | 2001-05-23 | 2007-09-20 | Hexal Ag | Verfahren zur herstellung von implantaten mittels lösungsmittelfreier herstellung eines homogenisats |
| WO2003000156A1 (en) | 2001-06-22 | 2003-01-03 | Southern Biosystems, Inc. | Zero-order prolonged release coaxial implants |
| IN2014DN10834A (cs) * | 2001-09-17 | 2015-09-04 | Psivida Inc | |
| DK1532985T3 (en) * | 2002-06-25 | 2016-12-05 | Takeda Pharmaceuticals Co | PROCEDURE FOR PREPARING A COMPOSITION WITH LONG-TERM RELEASE |
| DK1594517T3 (da) | 2003-01-28 | 2007-10-29 | Microbia Inc | Sammensætninger til behandlingen af gastrointestinale lidelser |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| GB0304726D0 (en) * | 2003-03-01 | 2003-04-02 | Ardana Bioscience Ltd | New Process |
| MXPA05011299A (es) * | 2003-04-30 | 2006-01-24 | Debiopharm Sa | Metodos y composiciones utilizando la hormona liberadora de la hormona gonadotropina. |
| WO2005020933A2 (en) * | 2003-09-02 | 2005-03-10 | University Of South Florida | Nanoparticles for drug-delivery |
| CN105820160B (zh) | 2003-11-05 | 2019-02-12 | 萨可德生物科学公司 | 细胞粘着调节剂 |
| WO2005063276A1 (en) * | 2003-12-23 | 2005-07-14 | Debiopharm S.A. | Methods and compositions using gonadotropin hormone releasing hormone |
| FR2865938B1 (fr) * | 2004-02-05 | 2006-06-02 | Sod Conseils Rech Applic | Formulation retard solide comprenant de l'acetate de triptoreline |
| EP1781264B1 (en) | 2004-08-04 | 2013-07-24 | Evonik Corporation | Methods for manufacturing delivery devices and devices thereof |
| WO2006026731A1 (en) | 2004-08-30 | 2006-03-09 | Spineovations, Inc. | Method of treating spinal internal disk derangement |
| EP1674082A1 (de) * | 2004-12-22 | 2006-06-28 | Zentaris GmbH | Verfahren zur Herstellung von sterilen Suspensionen oder Lyophilisaten schwerlöslicher basischer Peptidkomplexe, diese enthaltende pharmazeutische Formulierungen sowie ihre Verwendung als Arzneimittel |
| EP2444079B1 (en) * | 2005-05-17 | 2016-11-30 | SARcode Bioscience Inc. | Compositions and Methods for Treatment of Eye Disorders |
| KR100722607B1 (ko) | 2006-05-11 | 2007-05-28 | 주식회사 펩트론 | 분산성 및 주사 투여능이 향상된 서방성 미립구의 제조방법 |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| CN101772513B (zh) | 2007-06-04 | 2013-11-13 | 协同医药品公司 | 有效用于胃肠功能紊乱、炎症、癌症和其他疾病治疗的鸟苷酸环化酶激动剂 |
| KR101631475B1 (ko) * | 2007-06-06 | 2016-06-20 | 데비오팜 리서치 ＆ 매뉴팩처링 에스아 | 마이크로 입자로 구성되는 저속 방출 약학 조성물 |
| EP2209371B1 (en) * | 2007-10-19 | 2017-01-04 | SARcode Bioscience Inc. | Compositions and methods for treatment of diabetic retinopathy |
| WO2009085952A1 (en) | 2007-12-20 | 2009-07-09 | Brookwood Pharmaceuticals, Inc. | Process for preparing microparticles having a low residual solvent volume |
| US8469961B2 (en) * | 2008-03-05 | 2013-06-25 | Neville Alleyne | Methods and compositions for minimally invasive capsular augmentation of canine coxofemoral joints |
| US20100010549A1 (en) * | 2008-03-05 | 2010-01-14 | Neville Alleyne | device and method of minimally invasive extracapsular ligamentous augmentation for canine stifle ligament injuries |
| US8080562B2 (en) | 2008-04-15 | 2011-12-20 | Sarcode Bioscience Inc. | Crystalline pharmaceutical and methods of preparation and use thereof |
| WO2009128932A1 (en) * | 2008-04-15 | 2009-10-22 | Sarcode Corporation | Delivery of lfa-1 antagonists to the gastrointestinal system |
| EP2328910B1 (en) | 2008-06-04 | 2014-08-06 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| WO2010009319A2 (en) | 2008-07-16 | 2010-01-21 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| EP2421517A4 (en) * | 2009-04-23 | 2013-08-07 | Sustained Nano Systems Llc | DONATION DEVICE WITH CONTROLLED OUTPUT |
| US8378105B2 (en) | 2009-10-21 | 2013-02-19 | Sarcode Bioscience Inc. | Crystalline pharmaceutical and methods of preparation and use thereof |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| KR101411349B1 (ko) | 2010-12-24 | 2014-06-25 | 주식회사 삼양바이오팜 | 생리활성 펩타이드를 포함하는 마이크로입자 및 그의 제조방법, 및 그를 포함하는 약제학적 조성물 |
| JP6092849B2 (ja) | 2011-05-04 | 2017-03-08 | バランス セラピューティックス, インコーポレイテッドBalance Therapeutics, Inc. | ペンチレンテトラゾール誘導体 |
| EP2630964A1 (en) | 2012-02-22 | 2013-08-28 | Immundiagnostik AG | Method and medicament for treating patients in risk of prediabetes and type-2 diabetes |
| CN104284673B (zh) * | 2012-05-14 | 2018-02-13 | 帝人株式会社 | 灭菌组合物 |
| JP6607780B2 (ja) | 2012-07-25 | 2019-11-20 | サルコード・バイオサイエンス・インコーポレイテッド | Ｌｆａ−１阻害剤およびその多形 |
| EP2958577A2 (en) | 2013-02-25 | 2015-12-30 | Synergy Pharmaceuticals Inc. | Guanylate cyclase receptor agonists for use in colonic cleansing |
| WO2014151206A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| US9486494B2 (en) | 2013-03-15 | 2016-11-08 | Synergy Pharmaceuticals, Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| JP6534994B2 (ja) * | 2013-10-08 | 2019-06-26 | フェリング ベスローテン フェンノートシャップ | Ｐｇｓｓにより作製されるｇｎｒｈを含む微粒子 |
| EA201690732A1 (ru) | 2013-10-10 | 2016-12-30 | Синерджи Фармасьютикалз, Инк. | Агонисты гуанилатциклазы, используемые для лечения индуцированных опиоидами дисфункций |
| JP2018505726A (ja) | 2015-01-16 | 2018-03-01 | スピネオベイションズ・インコーポレーテッド | 脊椎円板を処置する方法 |
| EP3402804A1 (en) | 2016-01-11 | 2018-11-21 | Synergy Pharmaceuticals Inc. | Formulations and methods for treating ulcerative colitis |
| AU2018300080B2 (en) | 2017-07-11 | 2024-09-19 | Sustained Nano Systems Llc | Hypercompressed pharmaceutical formulations |
| US10500163B2 (en) | 2017-07-11 | 2019-12-10 | Sustained Nano Systems Llc | Radiation sterilization of hypercompressed polymer dosage forms |
| CN111315365A (zh) | 2017-09-26 | 2020-06-19 | 纳奥米有限公司 | 用于通过双乳液技术制备微粒的方法 |
| WO2021185373A1 (zh) * | 2020-03-20 | 2021-09-23 | 苏州医本生命科技有限公司 | 载药用微粒、载药微粒、蓄粒管及其植入系统 |
| WO2024250012A2 (en) | 2023-06-02 | 2024-12-05 | 33 Medical, Inc. | Compositions for treatment of discogenic pain, and processes for making and using the same |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3976071A (en) * | 1974-01-07 | 1976-08-24 | Dynatech Corporation | Methods of improving control of release rates and products useful in same |
| US3978203A (en) * | 1974-07-12 | 1976-08-31 | Dynatech Corporation | Sustained release of pharmaceuticals from polyester matrices |
| US4107288A (en) * | 1974-09-18 | 1978-08-15 | Pharmaceutical Society Of Victoria | Injectable compositions, nanoparticles useful therein, and process of manufacturing same |
| US4010125A (en) * | 1975-06-12 | 1977-03-01 | Schally Andrew Victor | [D-Trp6 ]-LH-RH and intermediates therefor |
| US4622244A (en) * | 1979-09-04 | 1986-11-11 | The Washington University | Process for preparation of microcapsules |
| US4675189A (en) * | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
| PH19942A (en) * | 1980-11-18 | 1986-08-14 | Sintex Inc | Microencapsulation of water soluble polypeptides |
| US4349530A (en) * | 1980-12-11 | 1982-09-14 | The Ohio State University | Implants, microbeads, microcapsules, preparation thereof and method of administering a biologically-active substance to an animal |
| US4483807A (en) * | 1981-01-27 | 1984-11-20 | Japan Atomic Energy Research Institute | Process for producing a slow release composite |
| IE52535B1 (en) * | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| CH661206A5 (fr) * | 1983-09-23 | 1987-07-15 | Debiopharm Sa | Procede pour la preparation d'un medicament destine au traitement de maladies hormonodependantes. |
| JPS60181029A (ja) * | 1984-02-29 | 1985-09-14 | Toyo Jozo Co Ltd | 徐放性製剤の製法 |
| US4666704A (en) * | 1985-05-24 | 1987-05-19 | International Minerals & Chemical Corp. | Controlled release delivery system for macromolecules |
| IL79134A (en) * | 1985-07-29 | 1991-06-10 | American Cyanamid Co | Continuous release peptide implants for parenteral administration |
| US4962091A (en) * | 1986-05-23 | 1990-10-09 | Syntex (U.S.A.) Inc. | Controlled release of macromolecular polypeptides |
| JPS63218632A (ja) * | 1987-03-06 | 1988-09-12 | Japan Atom Energy Res Inst | ホルモンに徐放性機能を付与した生体分解型コポリ（グルコ−ル酸／ｌ−乳酸）複合体の製造方法 |
| US4897268A (en) * | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
| GB2209937B (en) * | 1987-09-21 | 1991-07-03 | Depiopharm S A | Water insoluble polypeptides |
| DE3734223A1 (de) * | 1987-10-09 | 1989-04-20 | Boehringer Ingelheim Kg | Implantierbares, biologisch abbaubares wirkstofffreigabesystem |
-
1989
- 1989-07-28 CH CH2829/89A patent/CH679207A5/fr not_active IP Right Cessation
-
1990
- 1990-07-16 IE IE259290A patent/IE65397B1/en not_active IP Right Cessation
- 1990-07-17 GB GB9015722A patent/GB2234169B/en not_active Expired - Lifetime
- 1990-07-18 ZA ZA905654A patent/ZA905654B/xx unknown
- 1990-07-18 BE BE9000729A patent/BE1003093A3/fr not_active IP Right Cessation
- 1990-07-18 AU AU59103/90A patent/AU619996B2/en not_active Expired
- 1990-07-18 IL IL9512090A patent/IL95120A/en not_active IP Right Cessation
- 1990-07-19 NL NL9001646A patent/NL194858C/nl not_active IP Right Cessation
- 1990-07-19 FI FI903643A patent/FI97688C/fi active IP Right Grant
- 1990-07-20 FR FR909009333A patent/FR2650182B1/fr not_active Expired - Lifetime
- 1990-07-20 DE DE4023134A patent/DE4023134C2/de not_active Expired - Lifetime
- 1990-07-20 US US07/555,973 patent/US5134122A/en not_active Expired - Lifetime
- 1990-07-23 IT IT02101990A patent/IT1243357B/it active IP Right Grant
- 1990-07-23 NO NO903264A patent/NO300304B1/no not_active IP Right Cessation
- 1990-07-23 AT AT0154590A patent/AT397197B/de not_active IP Right Cessation
- 1990-07-23 CA CA002021767A patent/CA2021767C/en not_active Expired - Lifetime
- 1990-07-23 ES ES9001976A patent/ES2020890A6/es not_active Expired - Fee Related
- 1990-07-25 GR GR900100568A patent/GR1001215B/el not_active IP Right Cessation
- 1990-07-25 LU LU87772A patent/LU87772A1/fr unknown
- 1990-07-27 JP JP2201063A patent/JPH0662427B2/ja not_active Expired - Lifetime
- 1990-07-27 SE SE9002522A patent/SE504279C2/sv not_active IP Right Cessation
- 1990-07-27 DK DK199001807A patent/DK175495B1/da not_active IP Right Cessation
- 1990-07-27 PT PT94842A patent/PT94842B/pt not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO300304B1 (no) | Fremgangsmåte for fremstilling av et farmasöytisk preparat i form av mikropartikler | |
| US5225205A (en) | Pharmaceutical composition in the form of microparticles | |
| US5439688A (en) | Process for preparing a pharmaceutical composition | |
| EP2015737B1 (en) | A process of preparing microspheres for sustained release having improved dispersibility and syringeability | |
| US4675189A (en) | Microencapsulation of water soluble active polypeptides | |
| CA2317411C (en) | Controlled release delivery of peptide or protein | |
| JP2594560B2 (ja) | 巨大分子ポリペプチドの放出速度調節 | |
| US5643604A (en) | Parenteral dosage form | |
| NO167752B (no) | Biologisk nedbrytbare amfipatiske kopolymerer som er selv-dispergerbare, samt fremgangsmaate for fremstilling av slike kopolymerer. | |
| NO301405B1 (no) | Fremgangsmåte for fremstilling av mikrokapsler med forlenget frigjöring | |
| NO180149B (no) | Framgangsmåte for framstilling av en blanding for systemisk administrering gjennom slimhinner | |
| NO326966B1 (no) | Partikkelpreparat for terapeutisk anvendelse, egnet for administrering ved inhalasjon, anordning for pulmonal avlevering av et terapeutisk middel, og fremgangsmate for fremstilling av partiklene | |
| IL163218A (en) | Polymer-based preparations for prolonged release of the hormone FSH | |
| AU710539B2 (en) | Pharmaceutical compositions for the sustained release of insoluble active principles | |
| CN101007170A (zh) | 包虫病药物缓释制剂的制备方法 | |
| JPH04288021A (ja) | 薬用組成物の製造方法 | |
| WO2002030391A2 (en) | Method for determining the release of a peptide from a sustained release polylactide formulation | |
| NO175135B (no) | Frossen, vandig dispersjon for farmasöytisk eller veterinærmedisinsk bruk som bærer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |