NO300304B1 - Fremgangsmåte for fremstilling av et farmasöytisk preparat i form av mikropartikler - Google Patents

Fremgangsmåte for fremstilling av et farmasöytisk preparat i form av mikropartikler Download PDF

Info

Publication number
NO300304B1
NO300304B1 NO903264A NO903264A NO300304B1 NO 300304 B1 NO300304 B1 NO 300304B1 NO 903264 A NO903264 A NO 903264A NO 903264 A NO903264 A NO 903264A NO 300304 B1 NO300304 B1 NO 300304B1
Authority
NO
Norway
Prior art keywords
microparticles
stated
copolymer
trp
active substance
Prior art date
Application number
NO903264A
Other languages
English (en)
Norwegian (no)
Other versions
NO903264L (no
NO903264D0 (no
Inventor
Piero Orsolini
Original Assignee
Debiopharm Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Debiopharm Sa filed Critical Debiopharm Sa
Publication of NO903264D0 publication Critical patent/NO903264D0/no
Publication of NO903264L publication Critical patent/NO903264L/no
Publication of NO300304B1 publication Critical patent/NO300304B1/no

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • A61K38/09Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/23Calcitonins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/25Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/31Somatostatins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
NO903264A 1989-07-28 1990-07-23 Fremgangsmåte for fremstilling av et farmasöytisk preparat i form av mikropartikler NO300304B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH2829/89A CH679207A5 (cs) 1989-07-28 1989-07-28

Publications (3)

Publication Number Publication Date
NO903264D0 NO903264D0 (no) 1990-07-23
NO903264L NO903264L (no) 1991-01-29
NO300304B1 true NO300304B1 (no) 1997-05-12

Family

ID=4242536

Family Applications (1)

Application Number Title Priority Date Filing Date
NO903264A NO300304B1 (no) 1989-07-28 1990-07-23 Fremgangsmåte for fremstilling av et farmasöytisk preparat i form av mikropartikler

Country Status (23)

Country Link
US (1) US5134122A (cs)
JP (1) JPH0662427B2 (cs)
AT (1) AT397197B (cs)
AU (1) AU619996B2 (cs)
BE (1) BE1003093A3 (cs)
CA (1) CA2021767C (cs)
CH (1) CH679207A5 (cs)
DE (1) DE4023134C2 (cs)
DK (1) DK175495B1 (cs)
ES (1) ES2020890A6 (cs)
FI (1) FI97688C (cs)
FR (1) FR2650182B1 (cs)
GB (1) GB2234169B (cs)
GR (1) GR1001215B (cs)
IE (1) IE65397B1 (cs)
IL (1) IL95120A (cs)
IT (1) IT1243357B (cs)
LU (1) LU87772A1 (cs)
NL (1) NL194858C (cs)
NO (1) NO300304B1 (cs)
PT (1) PT94842B (cs)
SE (1) SE504279C2 (cs)
ZA (1) ZA905654B (cs)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5538739A (en) * 1989-07-07 1996-07-23 Sandoz Ltd. Sustained release formulations of water soluble peptides
PH30995A (en) * 1989-07-07 1997-12-23 Novartis Inc Sustained release formulations of water soluble peptides.
CH681425A5 (cs) * 1990-11-14 1993-03-31 Debio Rech Pharma Sa
WO1991017772A1 (en) * 1990-05-16 1991-11-28 Southern Research Institute Controlled release dopamine and its use to stimulate nerve fiber growth
US6517859B1 (en) 1990-05-16 2003-02-11 Southern Research Institute Microcapsules for administration of neuroactive agents
CH683149A5 (fr) * 1991-07-22 1994-01-31 Debio Rech Pharma Sa Procédé pour la préparation de microsphères en matériau polymère biodégradable.
US5470582A (en) * 1992-02-07 1995-11-28 Syntex (U.S.A.) Inc. Controlled delivery of pharmaceuticals from preformed porous polymeric microparticles
US6013853A (en) * 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier
US5876452A (en) * 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
GB9211268D0 (en) * 1992-05-28 1992-07-15 Ici Plc Salts of basic peptides with carboxyterminated polyesters
US5456917A (en) * 1993-04-12 1995-10-10 Cambridge Scientific, Inc. Method for making a bioerodible material for the sustained release of a medicament and the material made from the method
DE4342092B4 (de) * 1993-12-09 2007-01-11 Zentaris Gmbh Langwirkende Injektionssuspension und Verfahren zur Herstellung
CA2178592C (en) * 1993-12-09 2009-07-28 Jurgen Engel Long-acting injection suspensions and a process for their preparation
US5417982A (en) * 1994-02-17 1995-05-23 Modi; Pankaj Controlled release of drugs or hormones in biodegradable polymer microspheres
US5569468A (en) * 1994-02-17 1996-10-29 Modi; Pankaj Vaccine delivery system for immunization, using biodegradable polymer microspheres
US5430021A (en) * 1994-03-18 1995-07-04 Pharmavene, Inc. Hydrophobic drug delivery systems
US5595760A (en) * 1994-09-02 1997-01-21 Delab Sustained release of peptides from pharmaceutical compositions
FR2748205A1 (fr) 1996-05-06 1997-11-07 Debio Rech Pharma Sa Compositions pharmaceutiques pour la liberation controlee de principes actifs insolubles
US5945128A (en) * 1996-09-04 1999-08-31 Romano Deghenghi Process to manufacture implants containing bioactive peptides
CA2267930A1 (en) * 1996-10-09 1998-04-16 Nobuyuki Takechi A method for producing a microparticle
WO1998032423A1 (en) * 1997-01-29 1998-07-30 Takeda Chemical Industries, Ltd. Sustained-release microspheres, their production and use
US6071982A (en) * 1997-04-18 2000-06-06 Cambridge Scientific, Inc. Bioerodible polymeric semi-interpenetrating network alloys for surgical plates and bone cements, and method for making same
US6573238B2 (en) 1997-11-07 2003-06-03 Chiron Corporation Method for producing sustained-release formulations
IT1304152B1 (it) * 1998-12-10 2001-03-08 Mediolanum Farmaceutici Srl Composizioni comprendenti un peptide ed acido polilattico-glicolicoatte alla preparazione di impianti sottocutanei aventi un prolungato
HK1041645B (zh) * 1998-12-16 2005-07-29 Aventisub Ii Inc. 生物可降解聚合物包封的5-羟色胺受体拮抗剂及其制备方法
US6455526B1 (en) 1998-12-16 2002-09-24 Aventis Pharmaceuticals, Inc. Biodegradable polymer encapsulated pharmaceutical compositions and method for preparing the same
EP1156781B1 (en) 1999-02-26 2005-06-08 Chiron Corporation Microemulsions with adsorbed macromolecules and microparticles
US7713739B1 (en) 2000-11-17 2010-05-11 Novartis Vaccines And Diagnostics, Inc. Microparticle-based transfection and activation of dendritic cells
ES2169980B1 (es) 1999-12-17 2003-11-01 Lipotec Sa Microcapsulas para la liberacion prolongada de farmacos.
US6362308B1 (en) * 2000-08-10 2002-03-26 Alkermes Controlled Therapeutics Inc. Ii Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content
US20040022853A1 (en) * 2001-04-26 2004-02-05 Control Delivery Systems, Inc. Polymer-based, sustained release drug delivery system
EP2283845A1 (en) * 2001-04-26 2011-02-16 pSivida Inc. Sustained release drug delivery system containing codrugs
DK1392248T3 (da) * 2001-05-23 2007-11-12 Hexal Ag Fremgangsmåde til fremstilling af implantater ved oplösningsmiddelfri fremstilling af et homogenisat
WO2003000156A1 (en) 2001-06-22 2003-01-03 Southern Biosystems, Inc. Zero-order prolonged release coaxial implants
IN2014DN10834A (cs) * 2001-09-17 2015-09-04 Psivida Inc
KR101041767B1 (ko) * 2002-06-25 2011-06-17 다케다 야쿠힌 고교 가부시키가이샤 서방성 조성물의 제조 방법
AU2004210161B2 (en) 2003-01-28 2009-11-26 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
GB0304726D0 (en) * 2003-03-01 2003-04-02 Ardana Bioscience Ltd New Process
KR20060033859A (ko) * 2003-04-30 2006-04-20 데비오 팜 소시에떼 아노님 생식선 자극 호르몬 방출 호르몬을 이용한 방법 및 조성물
WO2005020933A2 (en) * 2003-09-02 2005-03-10 University Of South Florida Nanoparticles for drug-delivery
DK1682537T3 (da) 2003-11-05 2012-07-09 Sarcode Bioscience Inc Modulatorer af celleadhæsion
WO2005063276A1 (en) * 2003-12-23 2005-07-14 Debiopharm S.A. Methods and compositions using gonadotropin hormone releasing hormone
FR2865938B1 (fr) * 2004-02-05 2006-06-02 Sod Conseils Rech Applic Formulation retard solide comprenant de l'acetate de triptoreline
PT1781264E (pt) 2004-08-04 2013-10-16 Evonik Corp Métodos para o fabrico de dispositivis de administração e dispositivos para a mesma
WO2006026731A1 (en) 2004-08-30 2006-03-09 Spineovations, Inc. Method of treating spinal internal disk derangement
EP1674082A1 (de) * 2004-12-22 2006-06-28 Zentaris GmbH Verfahren zur Herstellung von sterilen Suspensionen oder Lyophilisaten schwerlöslicher basischer Peptidkomplexe, diese enthaltende pharmazeutische Formulierungen sowie ihre Verwendung als Arzneimittel
PL1881823T3 (pl) 2005-05-17 2015-05-29 Sarcode Bioscience Inc Kompozycje i sposoby leczenia chorób oczu
KR100722607B1 (ko) 2006-05-11 2007-05-28 주식회사 펩트론 분산성 및 주사 투여능이 향상된 서방성 미립구의 제조방법
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CN103601792B (zh) 2007-06-04 2016-06-29 协同医药品公司 有效用于胃肠功能紊乱、炎症、癌症和其他疾病治疗的鸟苷酸环化酶激动剂
ES2611020T3 (es) 2007-06-06 2017-05-04 Debiopharm Research & Manufacturing Sa Composición farmacéutica de liberación lenta hecha de micropartículas
US20090155176A1 (en) * 2007-10-19 2009-06-18 Sarcode Corporation Compositions and methods for treatment of diabetic retinopathy
EP2222281B1 (en) 2007-12-20 2018-12-05 Evonik Corporation Process for preparing microparticles having a low residual solvent volume
US8469961B2 (en) * 2008-03-05 2013-06-25 Neville Alleyne Methods and compositions for minimally invasive capsular augmentation of canine coxofemoral joints
US20100010549A1 (en) * 2008-03-05 2010-01-14 Neville Alleyne device and method of minimally invasive extracapsular ligamentous augmentation for canine stifle ligament injuries
CN102065893A (zh) * 2008-04-15 2011-05-18 萨可德公司 Lfa-1拮抗剂向胃肠系统的递送
US8080562B2 (en) * 2008-04-15 2011-12-20 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
WO2009149279A2 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2010009319A2 (en) 2008-07-16 2010-01-21 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
WO2010123563A2 (en) * 2009-04-23 2010-10-28 Sustained Nano Systems Llc Controlled release dispensing device
US8378105B2 (en) * 2009-10-21 2013-02-19 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
KR101411349B1 (ko) 2010-12-24 2014-06-25 주식회사 삼양바이오팜 생리활성 펩타이드를 포함하는 마이크로입자 및 그의 제조방법, 및 그를 포함하는 약제학적 조성물
WO2012151343A1 (en) 2011-05-04 2012-11-08 Balance Therapeutics, Inc. Pentylenetetrazole derivatives
EP2630964A1 (en) * 2012-02-22 2013-08-28 Immundiagnostik AG Method and medicament for treating patients in risk of prediabetes and type-2 diabetes
AU2013261308B2 (en) * 2012-05-14 2018-02-08 Km Biologics Co., Ltd. Sterilized composition
SI3715345T1 (sl) 2012-07-25 2024-07-31 Bausch + Lomb Ireland Limited Priprava zaviralca lfa-1
US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
EP3054968A1 (en) * 2013-10-08 2016-08-17 Ferring BV Microparticles comprising gnrh made by pgss
US20160220630A1 (en) 2013-10-10 2016-08-04 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of opioid induced dysfunctions
MX382085B (es) 2015-01-16 2025-03-13 Spineovations Inc Método de tratamiento de disco intervertebral
JP2019506383A (ja) 2016-01-11 2019-03-07 シナジー ファーマシューティカルズ インコーポレイテッド 潰瘍性大腸炎を治療するための製剤および方法
BR112020000504A2 (pt) 2017-07-11 2020-07-14 Sustained Nano Systems Llc esterilização por radiação de formas de dosagem de polímeros hipercomprimidos
IL271908B2 (en) 2017-07-11 2024-02-01 Sustained Nano Systems Llc Hypercompressed pharmaceutical formulations
WO2019066649A1 (en) 2017-09-26 2019-04-04 Nanomi B.V. PROCESS FOR THE PREPARATION OF MICROPARTICLES BY A DOUBLE EMULSION TECHNIQUE
WO2021185373A1 (zh) * 2020-03-20 2021-09-23 苏州医本生命科技有限公司 载药用微粒、载药微粒、蓄粒管及其植入系统
WO2024250012A2 (en) 2023-06-02 2024-12-05 33 Medical, Inc. Compositions for treatment of discogenic pain, and processes for making and using the same

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3976071A (en) * 1974-01-07 1976-08-24 Dynatech Corporation Methods of improving control of release rates and products useful in same
US3978203A (en) * 1974-07-12 1976-08-31 Dynatech Corporation Sustained release of pharmaceuticals from polyester matrices
US4107288A (en) * 1974-09-18 1978-08-15 Pharmaceutical Society Of Victoria Injectable compositions, nanoparticles useful therein, and process of manufacturing same
US4010125A (en) * 1975-06-12 1977-03-01 Schally Andrew Victor [D-Trp6 ]-LH-RH and intermediates therefor
US4622244A (en) * 1979-09-04 1986-11-11 The Washington University Process for preparation of microcapsules
PH19942A (en) * 1980-11-18 1986-08-14 Sintex Inc Microencapsulation of water soluble polypeptides
US4675189A (en) * 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
US4349530A (en) * 1980-12-11 1982-09-14 The Ohio State University Implants, microbeads, microcapsules, preparation thereof and method of administering a biologically-active substance to an animal
US4483807A (en) * 1981-01-27 1984-11-20 Japan Atomic Energy Research Institute Process for producing a slow release composite
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
CH661206A5 (fr) * 1983-09-23 1987-07-15 Debiopharm Sa Procede pour la preparation d'un medicament destine au traitement de maladies hormonodependantes.
JPS60181029A (ja) * 1984-02-29 1985-09-14 Toyo Jozo Co Ltd 徐放性製剤の製法
US4666704A (en) * 1985-05-24 1987-05-19 International Minerals & Chemical Corp. Controlled release delivery system for macromolecules
IL79134A (en) * 1985-07-29 1991-06-10 American Cyanamid Co Continuous release peptide implants for parenteral administration
US4962091A (en) * 1986-05-23 1990-10-09 Syntex (U.S.A.) Inc. Controlled release of macromolecular polypeptides
JPS63218632A (ja) * 1987-03-06 1988-09-12 Japan Atom Energy Res Inst ホルモンに徐放性機能を付与した生体分解型コポリ(グルコ−ル酸/l−乳酸)複合体の製造方法
US4897268A (en) * 1987-08-03 1990-01-30 Southern Research Institute Drug delivery system and method of making the same
GB2209937B (en) * 1987-09-21 1991-07-03 Depiopharm S A Water insoluble polypeptides
DE3734223A1 (de) * 1987-10-09 1989-04-20 Boehringer Ingelheim Kg Implantierbares, biologisch abbaubares wirkstofffreigabesystem

Also Published As

Publication number Publication date
NL194858B (nl) 2003-01-06
SE504279C2 (sv) 1996-12-23
FR2650182A1 (fr) 1991-02-01
AT397197B (de) 1994-02-25
NO903264L (no) 1991-01-29
SE9002522L (sv) 1991-01-29
GB2234169A (en) 1991-01-30
FI97688B (fi) 1996-10-31
FR2650182B1 (fr) 1992-05-15
DE4023134C2 (de) 1997-04-17
GB9015722D0 (en) 1990-09-05
LU87772A1 (fr) 1990-12-11
DE4023134A1 (de) 1991-01-31
IE65397B1 (en) 1995-10-18
ATA154590A (de) 1993-07-15
SE9002522D0 (sv) 1990-07-27
CH679207A5 (cs) 1992-01-15
IT9021019A1 (it) 1992-01-23
FI97688C (fi) 1997-02-10
CA2021767A1 (en) 1991-01-29
ES2020890A6 (es) 1991-10-01
BE1003093A3 (fr) 1991-11-19
CA2021767C (en) 1996-10-22
ZA905654B (en) 1991-05-29
JPH0662427B2 (ja) 1994-08-17
AU619996B2 (en) 1992-02-06
GR900100568A (en) 1991-12-10
IT1243357B (it) 1994-06-10
IL95120A (en) 1994-10-07
US5134122A (en) 1992-07-28
NL194858C (nl) 2003-05-06
DK180790D0 (da) 1990-07-27
DK180790A (da) 1991-01-29
FI903643A0 (fi) 1990-07-19
IL95120A0 (en) 1991-06-10
NL9001646A (nl) 1991-02-18
GR1001215B (el) 1993-06-21
NO903264D0 (no) 1990-07-23
JPH0366625A (ja) 1991-03-22
DK175495B1 (da) 2004-11-08
PT94842A (pt) 1991-03-20
AU5910390A (en) 1991-01-31
IT9021019A0 (it) 1990-07-23
PT94842B (pt) 1997-04-30
GB2234169B (en) 1993-02-10
IE902592A1 (en) 1991-02-27

Similar Documents

Publication Publication Date Title
NO300304B1 (no) Fremgangsmåte for fremstilling av et farmasöytisk preparat i form av mikropartikler
US5225205A (en) Pharmaceutical composition in the form of microparticles
US5439688A (en) Process for preparing a pharmaceutical composition
EP2015737B1 (en) A process of preparing microspheres for sustained release having improved dispersibility and syringeability
US4675189A (en) Microencapsulation of water soluble active polypeptides
CA2317411C (en) Controlled release delivery of peptide or protein
JP2594560B2 (ja) 巨大分子ポリペプチドの放出速度調節
AU2003217367B2 (en) Polymer-based compositions for sustained release
US5643604A (en) Parenteral dosage form
NO167752B (no) Biologisk nedbrytbare amfipatiske kopolymerer som er selv-dispergerbare, samt fremgangsmaate for fremstilling av slike kopolymerer.
NO301405B1 (no) Fremgangsmåte for fremstilling av mikrokapsler med forlenget frigjöring
NO180149B (no) Framgangsmåte for framstilling av en blanding for systemisk administrering gjennom slimhinner
NO326966B1 (no) Partikkelpreparat for terapeutisk anvendelse, egnet for administrering ved inhalasjon, anordning for pulmonal avlevering av et terapeutisk middel, og fremgangsmate for fremstilling av partiklene
AU710539B2 (en) Pharmaceutical compositions for the sustained release of insoluble active principles
JPH04288021A (ja) 薬用組成物の製造方法
EP1328250A2 (en) Method for determining the release of a peptide from a sustained release polylactide formulation
NO175135B (no) Frossen, vandig dispersjon for farmasöytisk eller veterinærmedisinsk bruk som bærer

Legal Events

Date Code Title Description
MK1K Patent expired