NL194858B - Werkwijze voor de bereiding van een farmaceutisch preparaat in de vorm van microdeeltjes, en een werkwijze voor de bereiding van farmaceutisch preparaat in de vorm van een injecteerbare suspentie van microdeeltjes. - Google Patents

Werkwijze voor de bereiding van een farmaceutisch preparaat in de vorm van microdeeltjes, en een werkwijze voor de bereiding van farmaceutisch preparaat in de vorm van een injecteerbare suspentie van microdeeltjes.

Info

Publication number
NL194858B
NL194858B NL9001646A NL9001646A NL194858B NL 194858 B NL194858 B NL 194858B NL 9001646 A NL9001646 A NL 9001646A NL 9001646 A NL9001646 A NL 9001646A NL 194858 B NL194858 B NL 194858B
Authority
NL
Netherlands
Prior art keywords
preparation
microparticles
pharmaceutical preparation
pharmaceutical
injectable suspension
Prior art date
Application number
NL9001646A
Other languages
English (en)
Other versions
NL9001646A (nl
NL194858C (nl
Original Assignee
Debiopharm Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Debiopharm Sa filed Critical Debiopharm Sa
Publication of NL9001646A publication Critical patent/NL9001646A/nl
Publication of NL194858B publication Critical patent/NL194858B/nl
Application granted granted Critical
Publication of NL194858C publication Critical patent/NL194858C/nl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
NL9001646A 1989-07-28 1990-07-19 Werkwijze voor de bereiding van een farmaceutisch preparaat in de vorm van microdeeltjes, en een werkwijze voor de bereiding van farmaceutisch preparaat in de vorm van een injecteerbare suspentie van microdeeltjes. NL194858C (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH282989 1989-07-28
CH2829/89A CH679207A5 (nl) 1989-07-28 1989-07-28

Publications (3)

Publication Number Publication Date
NL9001646A NL9001646A (nl) 1991-02-18
NL194858B true NL194858B (nl) 2003-01-06
NL194858C NL194858C (nl) 2003-05-06

Family

ID=4242536

Family Applications (1)

Application Number Title Priority Date Filing Date
NL9001646A NL194858C (nl) 1989-07-28 1990-07-19 Werkwijze voor de bereiding van een farmaceutisch preparaat in de vorm van microdeeltjes, en een werkwijze voor de bereiding van farmaceutisch preparaat in de vorm van een injecteerbare suspentie van microdeeltjes.

Country Status (23)

Country Link
US (1) US5134122A (nl)
JP (1) JPH0662427B2 (nl)
AT (1) AT397197B (nl)
AU (1) AU619996B2 (nl)
BE (1) BE1003093A3 (nl)
CA (1) CA2021767C (nl)
CH (1) CH679207A5 (nl)
DE (1) DE4023134C2 (nl)
DK (1) DK175495B1 (nl)
ES (1) ES2020890A6 (nl)
FI (1) FI97688C (nl)
FR (1) FR2650182B1 (nl)
GB (1) GB2234169B (nl)
GR (1) GR1001215B (nl)
IE (1) IE65397B1 (nl)
IL (1) IL95120A (nl)
IT (1) IT1243357B (nl)
LU (1) LU87772A1 (nl)
NL (1) NL194858C (nl)
NO (1) NO300304B1 (nl)
PT (1) PT94842B (nl)
SE (1) SE504279C2 (nl)
ZA (1) ZA905654B (nl)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5538739A (en) * 1989-07-07 1996-07-23 Sandoz Ltd. Sustained release formulations of water soluble peptides
PH30995A (en) * 1989-07-07 1997-12-23 Novartis Inc Sustained release formulations of water soluble peptides.
CH681425A5 (nl) * 1990-11-14 1993-03-31 Debio Rech Pharma Sa
ATE226091T1 (de) * 1990-05-16 2002-11-15 Southern Res Inst Mikrokapseln mit gesteuerter freigabe sowie deren verwendung zur stimulierung des nervenfaserwachstums
US6517859B1 (en) 1990-05-16 2003-02-11 Southern Research Institute Microcapsules for administration of neuroactive agents
CH683149A5 (fr) * 1991-07-22 1994-01-31 Debio Rech Pharma Sa Procédé pour la préparation de microsphères en matériau polymère biodégradable.
WO1993015722A1 (en) * 1992-02-07 1993-08-19 Syntex (Usa) Inc. Controlled delivery of pharmaceuticals from preformed porous microparticles
US6013853A (en) * 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier
US5876452A (en) * 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
GB9211268D0 (en) * 1992-05-28 1992-07-15 Ici Plc Salts of basic peptides with carboxyterminated polyesters
US5456917A (en) * 1993-04-12 1995-10-10 Cambridge Scientific, Inc. Method for making a bioerodible material for the sustained release of a medicament and the material made from the method
CA2178592C (en) * 1993-12-09 2009-07-28 Jurgen Engel Long-acting injection suspensions and a process for their preparation
DE4342092B4 (de) * 1993-12-09 2007-01-11 Zentaris Gmbh Langwirkende Injektionssuspension und Verfahren zur Herstellung
US5417982A (en) * 1994-02-17 1995-05-23 Modi; Pankaj Controlled release of drugs or hormones in biodegradable polymer microspheres
US5569468A (en) * 1994-02-17 1996-10-29 Modi; Pankaj Vaccine delivery system for immunization, using biodegradable polymer microspheres
US5430021A (en) * 1994-03-18 1995-07-04 Pharmavene, Inc. Hydrophobic drug delivery systems
US5595760A (en) * 1994-09-02 1997-01-21 Delab Sustained release of peptides from pharmaceutical compositions
FR2748205A1 (fr) 1996-05-06 1997-11-07 Debio Rech Pharma Sa Compositions pharmaceutiques pour la liberation controlee de principes actifs insolubles
US5945128A (en) * 1996-09-04 1999-08-31 Romano Deghenghi Process to manufacture implants containing bioactive peptides
WO1998015263A2 (en) * 1996-10-09 1998-04-16 Takeda Chemical Industries, Ltd. A method for producing a microparticle
AU5678398A (en) * 1997-01-29 1998-08-18 Takeda Chemical Industries Ltd. Sustained-release microspheres, their production and use
US6071982A (en) * 1997-04-18 2000-06-06 Cambridge Scientific, Inc. Bioerodible polymeric semi-interpenetrating network alloys for surgical plates and bone cements, and method for making same
AU1384199A (en) 1997-11-07 1999-05-31 Chiron Corporation Method for producing igf-1 sustained-release formulations
IT1304152B1 (it) * 1998-12-10 2001-03-08 Mediolanum Farmaceutici Srl Composizioni comprendenti un peptide ed acido polilattico-glicolicoatte alla preparazione di impianti sottocutanei aventi un prolungato
EA004502B1 (ru) * 1998-12-16 2004-04-29 Авентис Фармасьютикалз Инк. Фармацевтическая композиция антагониста рецептора серотонина и способ ее получения
US6455526B1 (en) 1998-12-16 2002-09-24 Aventis Pharmaceuticals, Inc. Biodegradable polymer encapsulated pharmaceutical compositions and method for preparing the same
US8206749B1 (en) 1999-02-26 2012-06-26 Novartis Vaccines And Diagnostics, Inc. Microemulsions with adsorbed macromolecules and microparticles
US7713739B1 (en) 2000-11-17 2010-05-11 Novartis Vaccines And Diagnostics, Inc. Microparticle-based transfection and activation of dendritic cells
ES2169980B1 (es) 1999-12-17 2003-11-01 Lipotec Sa Microcapsulas para la liberacion prolongada de farmacos.
US6362308B1 (en) 2000-08-10 2002-03-26 Alkermes Controlled Therapeutics Inc. Ii Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content
US20040022853A1 (en) * 2001-04-26 2004-02-05 Control Delivery Systems, Inc. Polymer-based, sustained release drug delivery system
BR0209198A (pt) * 2001-04-26 2004-06-08 Control Delivery Sys Inc Métodos de sìntese de compostos contendo fenol
US8501056B2 (en) * 2001-05-23 2013-08-06 Hexal Ag Homogenized product for implants and microparticles
CA2451187C (en) 2001-06-22 2012-08-14 Southern Biosystems, Inc. Zero-order prolonged release coaxial implants
IN2014DN10834A (nl) * 2001-09-17 2015-09-04 Psivida Inc
DK1532985T3 (en) * 2002-06-25 2016-12-05 Takeda Pharmaceuticals Co PROCEDURE FOR PREPARING A COMPOSITION WITH LONG-TERM RELEASE
SG192300A1 (en) 2003-01-28 2013-08-30 Ironwood Pharmaceuticals Inc Methods and compositions for the treatment of gastrointestinal disorders
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
GB0304726D0 (en) * 2003-03-01 2003-04-02 Ardana Bioscience Ltd New Process
EP1617859A1 (en) * 2003-04-30 2006-01-25 Debiopharm S.A. Methods and compositions using gonadotropin hormone releasing hormone
US9149440B2 (en) * 2003-09-02 2015-10-06 University Of South Florida Nanoparticles for drug-delivery
EP1682537B1 (en) 2003-11-05 2012-03-28 SARcode Bioscience Inc. Modulators of cellular adhesion
WO2005063276A1 (en) * 2003-12-23 2005-07-14 Debiopharm S.A. Methods and compositions using gonadotropin hormone releasing hormone
FR2865938B1 (fr) * 2004-02-05 2006-06-02 Sod Conseils Rech Applic Formulation retard solide comprenant de l'acetate de triptoreline
WO2006078320A2 (en) 2004-08-04 2006-07-27 Brookwood Pharmaceuticals, Inc. Methods for manufacturing delivery devices and devices thereof
CA2578113A1 (en) * 2004-08-30 2006-03-09 Spineovations, Inc. Method of treating spinal internal disk derangement
EP1674082A1 (de) * 2004-12-22 2006-06-28 Zentaris GmbH Verfahren zur Herstellung von sterilen Suspensionen oder Lyophilisaten schwerlöslicher basischer Peptidkomplexe, diese enthaltende pharmazeutische Formulierungen sowie ihre Verwendung als Arzneimittel
DK2444079T3 (en) * 2005-05-17 2017-01-30 Sarcode Bioscience Inc Compositions and Methods for the Treatment of Eye Diseases
KR100722607B1 (ko) * 2006-05-11 2007-05-28 주식회사 펩트론 분산성 및 주사 투여능이 향상된 서방성 미립구의 제조방법
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
KR101631475B1 (ko) 2007-06-06 2016-06-20 데비오팜 리서치 ＆ 매뉴팩처링 에스아 마이크로 입자로 구성되는 저속 방출 약학 조성물
US20090155176A1 (en) 2007-10-19 2009-06-18 Sarcode Corporation Compositions and methods for treatment of diabetic retinopathy
EP2222281B1 (en) 2007-12-20 2018-12-05 Evonik Corporation Process for preparing microparticles having a low residual solvent volume
US20100010549A1 (en) * 2008-03-05 2010-01-14 Neville Alleyne device and method of minimally invasive extracapsular ligamentous augmentation for canine stifle ligament injuries
US8469961B2 (en) * 2008-03-05 2013-06-25 Neville Alleyne Methods and compositions for minimally invasive capsular augmentation of canine coxofemoral joints
US8080562B2 (en) 2008-04-15 2011-12-20 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
EP2276508A4 (en) * 2008-04-15 2011-12-28 Sarcode Bioscience Inc RELEASE OF LFA-1 ANTAGONISTS AGAINST THE GAS-DARM SYSTEM
CA2726917C (en) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2010009319A2 (en) 2008-07-16 2010-01-21 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
WO2010123563A2 (en) * 2009-04-23 2010-10-28 Sustained Nano Systems Llc Controlled release dispensing device
US8378105B2 (en) * 2009-10-21 2013-02-19 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
KR101411349B1 (ko) 2010-12-24 2014-06-25 주식회사 삼양바이오팜 생리활성 펩타이드를 포함하는 마이크로입자 및 그의 제조방법, 및 그를 포함하는 약제학적 조성물
AU2012250776B2 (en) 2011-05-04 2017-06-15 Balance Therapeutics, Inc. Pentylenetetrazole derivatives
EP2630964A1 (en) * 2012-02-22 2013-08-28 Immundiagnostik AG Method and medicament for treating patients in risk of prediabetes and type-2 diabetes
IN2014DN09621A (nl) * 2012-05-14 2015-07-31 Teijin Ltd
KR102157608B1 (ko) 2012-07-25 2020-09-18 에스에이알코드 바이오사이언스 인코포레이티드 Lfa-1 저해제 및 그의 다형체
US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
CA2926358A1 (en) * 2013-10-08 2015-04-16 Ferring B.V. Microparticles comprising gnrh made by pgss
US20160220630A1 (en) 2013-10-10 2016-08-04 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of opioid induced dysfunctions
JP2018505726A (ja) 2015-01-16 2018-03-01 スピネオベイションズ・インコーポレーテッド 脊椎円板を処置する方法
US10653744B2 (en) 2016-01-11 2020-05-19 Bausch Health Ireland Limited Formulations and methods for treating ulcerative colitis
EP3651800B1 (en) 2017-07-11 2024-04-10 Sustained Nano Systems LLC Hypercompressed pharmaceutical formulations
EP3651771B1 (en) 2017-07-11 2023-08-30 Sustained Nano Systems LLC Radiation sterilization of hypercompressed polymer dosage forms
WO2019066649A1 (en) 2017-09-26 2019-04-04 Nanomi B.V. PROCESS FOR THE PREPARATION OF MICROPARTICLES BY A DOUBLE EMULSION TECHNIQUE

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3976071A (en) * 1974-01-07 1976-08-24 Dynatech Corporation Methods of improving control of release rates and products useful in same
US3978203A (en) * 1974-07-12 1976-08-31 Dynatech Corporation Sustained release of pharmaceuticals from polyester matrices
US4107288A (en) * 1974-09-18 1978-08-15 Pharmaceutical Society Of Victoria Injectable compositions, nanoparticles useful therein, and process of manufacturing same
US4010125A (en) * 1975-06-12 1977-03-01 Schally Andrew Victor [D-Trp6 ]-LH-RH and intermediates therefor
US4622244A (en) * 1979-09-04 1986-11-11 The Washington University Process for preparation of microcapsules
US4675189A (en) * 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
PH19942A (en) * 1980-11-18 1986-08-14 Sintex Inc Microencapsulation of water soluble polypeptides
US4349530A (en) * 1980-12-11 1982-09-14 The Ohio State University Implants, microbeads, microcapsules, preparation thereof and method of administering a biologically-active substance to an animal
US4483807A (en) * 1981-01-27 1984-11-20 Japan Atomic Energy Research Institute Process for producing a slow release composite
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
CH661206A5 (fr) * 1983-09-23 1987-07-15 Debiopharm Sa Procede pour la preparation d'un medicament destine au traitement de maladies hormonodependantes.
JPS60181029A (ja) * 1984-02-29 1985-09-14 Toyo Jozo Co Ltd 徐放性製剤の製法
US4666704A (en) * 1985-05-24 1987-05-19 International Minerals & Chemical Corp. Controlled release delivery system for macromolecules
IL79134A (en) * 1985-07-29 1991-06-10 American Cyanamid Co Continuous release peptide implants for parenteral administration
US4962091A (en) * 1986-05-23 1990-10-09 Syntex (U.S.A.) Inc. Controlled release of macromolecular polypeptides
JPS63218632A (ja) * 1987-03-06 1988-09-12 Japan Atom Energy Res Inst ホルモンに徐放性機能を付与した生体分解型コポリ（グルコ−ル酸／ｌ−乳酸）複合体の製造方法
US4897268A (en) * 1987-08-03 1990-01-30 Southern Research Institute Drug delivery system and method of making the same
GB2209937B (en) * 1987-09-21 1991-07-03 Depiopharm S A Water insoluble polypeptides
DE3734223A1 (de) * 1987-10-09 1989-04-20 Boehringer Ingelheim Kg Implantierbares, biologisch abbaubares wirkstofffreigabesystem

Also Published As

Publication number Publication date
FI97688C (fi) 1997-02-10
US5134122A (en) 1992-07-28
FR2650182A1 (fr) 1991-02-01
AU619996B2 (en) 1992-02-06
GR1001215B (el) 1993-06-21
GB2234169B (en) 1993-02-10
IL95120A0 (en) 1991-06-10
SE9002522L (sv) 1991-01-29
SE9002522D0 (sv) 1990-07-27
DE4023134C2 (de) 1997-04-17
IE902592A1 (en) 1991-02-27
NO903264L (no) 1991-01-29
NO903264D0 (no) 1990-07-23
PT94842A (pt) 1991-03-20
CH679207A5 (nl) 1992-01-15
ATA154590A (de) 1993-07-15
LU87772A1 (fr) 1990-12-11
AT397197B (de) 1994-02-25
DK175495B1 (da) 2004-11-08
FR2650182B1 (fr) 1992-05-15
IE65397B1 (en) 1995-10-18
IT1243357B (it) 1994-06-10
AU5910390A (en) 1991-01-31
NL9001646A (nl) 1991-02-18
NO300304B1 (no) 1997-05-12
JPH0366625A (ja) 1991-03-22
GB9015722D0 (en) 1990-09-05
FI97688B (fi) 1996-10-31
IT9021019A0 (it) 1990-07-23
CA2021767A1 (en) 1991-01-29
SE504279C2 (sv) 1996-12-23
GB2234169A (en) 1991-01-30
PT94842B (pt) 1997-04-30
DK180790D0 (da) 1990-07-27
IL95120A (en) 1994-10-07
ZA905654B (en) 1991-05-29
IT9021019A1 (it) 1992-01-23
NL194858C (nl) 2003-05-06
DK180790A (da) 1991-01-29
JPH0662427B2 (ja) 1994-08-17
ES2020890A6 (es) 1991-10-01
DE4023134A1 (de) 1991-01-31
FI903643A0 (fi) 1990-07-19
GR900100568A (en) 1991-12-10
CA2021767C (en) 1996-10-22
BE1003093A3 (fr) 1991-11-19

Similar Documents

Publication Publication Date Title
NL194858B (nl) Werkwijze voor de bereiding van een farmaceutisch preparaat in de vorm van microdeeltjes, en een werkwijze voor de bereiding van farmaceutisch preparaat in de vorm van een injecteerbare suspentie van microdeeltjes.
NL186576C (nl) Werkwijze voor het bereiden van een chemisch-gemodificeerd hyaluronzuurpreparaat en chemisch-gemodificeerd hyaluronzuurpreparaat.
DE68902534D1 (de) Kapazitiver beschleunigungsmesser und verfahren zu seiner herstellung.
OA09458A (en) Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof.
DE3879320D1 (de) Copolyester und verfahren zu dessen herstellung.
NL194637B (nl) Werkwijze voor het vervaardigen van deeltjes, bedoeld voor het over een verloop van tijd afgeven van een effectieve hoeveelheid actief bestanddeel.
NL193132B (nl) Werkwijze voor de bereiding van een preparaat dat tryptofan en/of threonine omvat.
ATE126007T1 (de) Tiererkennungssender und verfahren zu dessen herstellung.
DE3787628D1 (de) Pulver aus tetrafluoroaethylen-copolymer und verfahren zu dessen herstellung.
NL187486C (nl) Werkwijze voor de hydroxy-alkylering van een polysaccharide.
DE3867724D1 (de) Modifiziertes feinpulveriges polytetrafluoraethylen und verfahren zu seiner herstellung.
DE3770956D1 (de) Flavonglycosid, verfahren zur herstellung und pharmazeutische zusammensetzung, welche dieses produkt enthaelt.
NL8601838A (nl) Distamycinederivaten, werkwijze voor de bereiding ervan, alsmede farmaceutische preparaten, die deze derivaten bevatten.
DE68908374D1 (de) Propenonoximether, verfahren zu dessen herstellung sowie diese enthaltende arzneinmittel.
DE69002355D1 (de) Nahrungsmittel und verfahren zu seiner herstellung.
NL186638C (nl) Werkwijze voor het bereiden van een injecteerbaar chondroitine-polysulfaat, produkt verkrijgbaar met deze werkwijze alsmede een farmaceutisch preparaat.
ATA247489A (de) Festes pharmazeutisches piroxicam-präparat und verfahren zu seiner herstellung
DE3873086D1 (de) Plattenartig geformter katalysator und verfahren zu dessen herstellung.
DE58904666D1 (de) Hartmetallverbundkoerper und verfahren zu seiner herstellung.
DE3776983D1 (de) Aschenbecherpulver und verfahren zu dessen herstellung.
NL8601837A (nl) Poly-4-aminopyrrool-2-carboxamidoderivaten, werkwijze ter bereiding ervan, farmaceutische preparaten, die deze derivaten bevatten alsmede werkwijze voor de bereiding van de farmaceutische preparaten.
ZA976967B (en) Device and process for separating magnetic materials from pharmaceutical preparations, their starting or intermediate products, as well as agents that are produced with the of said device.
DE68905585D1 (de) 2-imino-benzothiazolin-derivate, verfahren zu deren herstellung und arzneimittel, die sie enthalten.
DE68906949D1 (de) Waschmittelpulver und verfahren zu deren herstellung.
NL181804C (nl) Sesquiterpeenderivaten met anticomplementwerking, werkwijze voor het winnen van een stof met anticomplementwerking en farmaceutische preparaten, die ze bevatten.

Legal Events

Date Code Title Description
BA A request for search or an international-type search has been filed
BB A search report has been drawn up
BC A request for examination has been filed
NP1 Patent granted (not automatically)
V4 Discontinued because of reaching the maximum lifetime of a patent

Effective date: 20100719