NO2014014I2 - Macitentan, propylsulfamsyre [5-(4-brom-fenyl)-6-[2-(5-brom-pyrimidin-2-yloksy)-etoksy]-pyrimidin-4-yl]-amid eller et farmasøytisk akseptabelt salt derav; blant annet kravene 1, 5, 6 og 10 I søknaden (se vedlegg) - Google Patents

Macitentan, propylsulfamsyre [5-(4-brom-fenyl)-6-[2-(5-brom-pyrimidin-2-yloksy)-etoksy]-pyrimidin-4-yl]-amid eller et farmasøytisk akseptabelt salt derav; blant annet kravene 1, 5, 6 og 10 I søknaden (se vedlegg)

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Publication number
NO2014014I2
NO2014014I2 NO2014014C NO2014014C NO2014014I2 NO 2014014 I2 NO2014014 I2 NO 2014014I2 NO 2014014 C NO2014014 C NO 2014014C NO 2014014 C NO2014014 C NO 2014014C NO 2014014 I2 NO2014014 I2 NO 2014014I2
Authority
NO
Norway
Prior art keywords
pyrimidin
bromo
macitentan
yloxy
ethoxy
Prior art date
Application number
NO2014014C
Other languages
English (en)
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8164206&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO2014014(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of NO2014014I2 publication Critical patent/NO2014014I2/no

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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
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    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
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  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO2014014C 2000-12-18 2014-06-05 Macitentan, propylsulfamsyre [5-(4-brom-fenyl)-6-[2-(5-brom-pyrimidin-2-yloksy)-etoksy]-pyrimidin-4-yl]-amid eller et farmasøytisk akseptabelt salt derav; blant annet kravene 1, 5, 6 og 10 I søknaden (se vedlegg) NO2014014I2 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP0012890 2000-12-18

Publications (1)

Publication Number Publication Date
NO2014014I2 true NO2014014I2 (no) 2015-08-31

Family

ID=8164206

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20032699A NO324952B1 (no) 2000-12-18 2003-06-13 Nye sulfonamider, fremstilling av disse, farmasoytiske preparater inneholdende slike,anvendelse av disse forbindelsene som medikament samt anvendelse av disse for fremstilling av medikament for behandling av lidelser.
NO2014014C NO2014014I2 (no) 2000-12-18 2014-06-05 Macitentan, propylsulfamsyre [5-(4-brom-fenyl)-6-[2-(5-brom-pyrimidin-2-yloksy)-etoksy]-pyrimidin-4-yl]-amid eller et farmasøytisk akseptabelt salt derav; blant annet kravene 1, 5, 6 og 10 I søknaden (se vedlegg)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20032699A NO324952B1 (no) 2000-12-18 2003-06-13 Nye sulfonamider, fremstilling av disse, farmasoytiske preparater inneholdende slike,anvendelse av disse forbindelsene som medikament samt anvendelse av disse for fremstilling av medikament for behandling av lidelser.

Country Status (27)

Country Link
US (2) US7094781B2 (no)
EP (2) EP1345920B1 (no)
JP (1) JP4245130B2 (no)
KR (1) KR100819668B1 (no)
CN (1) CN100432070C (no)
AR (1) AR035610A1 (no)
AT (1) ATE323079T1 (no)
AU (1) AU2002227984B8 (no)
BE (1) BE2014C019I2 (no)
BR (1) BRPI0116237B8 (no)
CA (1) CA2431675C (no)
CY (2) CY1105060T1 (no)
DE (1) DE60118782T2 (no)
DK (1) DK1345920T3 (no)
ES (1) ES2260318T3 (no)
FR (1) FR14C0017I2 (no)
HU (1) HU229403B1 (no)
IL (2) IL155805A0 (no)
LU (1) LU92381I2 (no)
MX (1) MXPA03004780A (no)
MY (1) MY129150A (no)
NL (1) NL300672I2 (no)
NO (2) NO324952B1 (no)
NZ (1) NZ525614A (no)
PT (1) PT1345920E (no)
WO (1) WO2002053557A1 (no)
ZA (1) ZA200303695B (no)

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EP1345920B1 (en) * 2000-12-18 2006-04-12 Actelion Pharmaceuticals Ltd. Novel sulfamides and their use as endothelin receptor antagonists
EP1474147B1 (en) * 2001-12-07 2010-05-05 Vertex Pharmaceuticals Incorporated Pyrimidine-based compounds useful as gsk-3 inhibitors
ES2320649T3 (es) * 2002-12-02 2009-05-27 Actelion Pharmaceuticals Ltd. Pirimidin-sulfamidas y su uso como antagonistas de receptores de endotelina.
CN1930135B (zh) 2004-03-05 2011-12-28 弗·哈夫曼-拉罗切有限公司 作为p2x3和p2x2/3拮抗剂的二氨基嘧啶
UA90269C2 (ru) 2004-04-02 2010-04-26 Мицубиси Танабе Фарма Корпорейшн Тетрагидрохинолиновые производные и способ их получения
TW200628467A (en) * 2004-11-11 2006-08-16 Actelion Pharmaceuticals Ltd Novel sulfamides
WO2007014924A1 (en) 2005-07-29 2007-02-08 Tibotec Pharmaceuticals Ltd. Macrocyclic inhibitors of hepatitis c virus
DK1912997T3 (da) 2005-07-29 2012-01-02 Tibotec Pharm Ltd Makrocycliske inhibitorer af hepatitis C virus
JP4850913B2 (ja) 2005-09-01 2012-01-11 エフ．ホフマン−ラ ロシュ アーゲー Ｐ２ｘ３及びｐ２ｘ２／３調節因子としてのジアミノピリジン
JP4850911B2 (ja) * 2005-09-01 2012-01-11 エフ．ホフマン−ラ ロシュ アーゲー Ｐ２ｘ３およびｐ２ｘ２／３モジュレーターとしてのジアミノピリミジン
BRPI0615613A2 (pt) 2005-09-01 2009-05-19 Hoffmann La Roche diaminopirimidinas como moduladores de p2x3 e p3x2/3
US20080233188A1 (en) * 2005-09-12 2008-09-25 Actelion Pharmaceuticals Ltd. Stable Pharmaceutical Compositions Comprising a Pyrimidine - Sulfamide
AR062501A1 (es) 2006-08-29 2008-11-12 Actelion Pharmaceuticals Ltd Composiciones terapeuticas
MX2010001837A (es) * 2007-08-17 2010-03-10 Actelion Pharmaceuticals Ltd Derivados de 4-pirimidinasulfamida.
WO2009041072A1 (ja) 2007-09-27 2009-04-02 Kowa Company, Ltd. テトラヒドロキノリン化合物を有効成分とする貧血の予防及び／又は治療剤
ES2446303T3 (es) 2008-02-20 2014-03-07 Actelion Pharmaceuticals Ltd. Combinación que comprende paclitaxel para el tratamiento del cáncer de ovarios
PL3300729T3 (pl) 2008-08-13 2020-04-30 Actelion Pharmaceuticals Ltd Kompozycje terapeutyczne zawierające macitentan
JP5572154B2 (ja) 2009-03-31 2014-08-13 興和株式会社 テトラヒドロキノリン化合物を有効成分とする貧血の予防及び／又は治療剤
NZ598078A (en) 2009-08-10 2013-07-26 Univ Texas Treatment of brain metastases with macitentan in combination with paclitacel and/or temozolomide and/or radiotherapy
AU2010284255B2 (en) 2009-08-17 2016-11-17 Memorial Sloan-Kettering Cancer Center Heat shock protein binding compounds, compositions, and methods for making and using same
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