AR096865A1 - Proceso para la preparación de un intermediario de pirimidina - Google Patents
Proceso para la preparación de un intermediario de pirimidinaInfo
- Publication number
- AR096865A1 AR096865A1 ARP140102549A ARP140102549A AR096865A1 AR 096865 A1 AR096865 A1 AR 096865A1 AR P140102549 A ARP140102549 A AR P140102549A AR P140102549 A ARP140102549 A AR P140102549A AR 096865 A1 AR096865 A1 AR 096865A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- formula
- preparation
- pyrimidine
- intermediary
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Detergent Compositions (AREA)
- Magnetic Heads (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Manufacturing Cores, Coils, And Magnets (AREA)
- Extraction Or Liquid Replacement (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Reivindicación 1: Un proceso para la elaboración del compuesto de la fórmula (1) donde dicho proceso comprende la reacción del compuesto de la fórmula (2) donde G¹ representa halógeno, o una sal de dicho compuesto, con etilenglicol en presencia de una base, caracterizado porque, luego de obtener el compuesto de la fórmula (1), se realiza una extracción de líquido-líquido, donde se usa metil iso-butil cetona para extraer el compuesto de la fórmula (1) de una fase acuosa que contiene los productos de la reacción del compuesto de la fórmula (2) con etilenglicol.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13176374 | 2013-07-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR096865A1 true AR096865A1 (es) | 2016-02-03 |
Family
ID=48790244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140102549A AR096865A1 (es) | 2013-07-12 | 2014-07-10 | Proceso para la preparación de un intermediario de pirimidina |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9556125B2 (es) |
| EP (1) | EP3019479B1 (es) |
| JP (1) | JP6375374B2 (es) |
| KR (1) | KR102305298B1 (es) |
| CN (1) | CN105636940B (es) |
| AR (1) | AR096865A1 (es) |
| CA (1) | CA2915736C (es) |
| DK (1) | DK3019479T3 (es) |
| ES (1) | ES2636937T3 (es) |
| HR (1) | HRP20171166T1 (es) |
| HU (1) | HUE034071T2 (es) |
| IL (1) | IL243477B (es) |
| MX (1) | MX360768B (es) |
| PL (1) | PL3019479T3 (es) |
| PT (1) | PT3019479T (es) |
| TW (1) | TWI643848B (es) |
| WO (1) | WO2015004265A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA201605808B (en) | 2015-08-26 | 2017-08-30 | Cipla Ltd | Process for preparing an endothelin receptor antagonist |
| CN105461638A (zh) * | 2015-12-10 | 2016-04-06 | 合肥久诺医药科技有限公司 | 一种马西替坦晶型及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2431675C (en) * | 2000-12-18 | 2011-11-08 | Actelion Pharmaceuticals Ltd. | Novel sulfamides and their use as endothelin receptor antagonists |
| CN103724281A (zh) * | 2013-12-03 | 2014-04-16 | 镇江圣安医药有限公司 | N-[5-（4-溴苯基）-6-[2-[（5-溴-2-嘧啶基）氧基]乙氧基]-4-嘧啶基]-n′-丙基磺酰胺的新型衍生物及其应用 |
| CN103819411A (zh) * | 2014-03-14 | 2014-05-28 | 成都克莱蒙医药科技有限公司 | 一种马西替坦中间体新的制备方法 |
-
2014
- 2014-07-10 AR ARP140102549A patent/AR096865A1/es active IP Right Grant
- 2014-07-11 TW TW103124052A patent/TWI643848B/zh not_active IP Right Cessation
- 2014-07-11 JP JP2016524837A patent/JP6375374B2/ja active Active
- 2014-07-11 EP EP14737272.6A patent/EP3019479B1/en active Active
- 2014-07-11 DK DK14737272.6T patent/DK3019479T3/en active
- 2014-07-11 MX MX2016000386A patent/MX360768B/es active IP Right Grant
- 2014-07-11 KR KR1020167003201A patent/KR102305298B1/ko active IP Right Grant
- 2014-07-11 WO PCT/EP2014/064904 patent/WO2015004265A1/en active Application Filing
- 2014-07-11 HU HUE14737272A patent/HUE034071T2/en unknown
- 2014-07-11 US US14/904,657 patent/US9556125B2/en active Active
- 2014-07-11 PT PT147372726T patent/PT3019479T/pt unknown
- 2014-07-11 PL PL14737272T patent/PL3019479T3/pl unknown
- 2014-07-11 ES ES14737272.6T patent/ES2636937T3/es active Active
- 2014-07-11 CA CA2915736A patent/CA2915736C/en active Active
- 2014-07-11 CN CN201480039832.2A patent/CN105636940B/zh active Active
-
2016
- 2016-01-06 IL IL243477A patent/IL243477B/en active IP Right Grant
-
2017
- 2017-07-31 HR HRP20171166TT patent/HRP20171166T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2915736C (en) | 2021-07-27 |
| TW201536759A (zh) | 2015-10-01 |
| DK3019479T3 (en) | 2017-07-17 |
| EP3019479A1 (en) | 2016-05-18 |
| CN105636940B (zh) | 2018-02-27 |
| MX360768B (es) | 2018-11-15 |
| ES2636937T3 (es) | 2017-10-10 |
| KR102305298B1 (ko) | 2021-09-27 |
| CA2915736A1 (en) | 2015-01-15 |
| HRP20171166T1 (hr) | 2017-10-06 |
| PT3019479T (pt) | 2017-08-11 |
| TWI643848B (zh) | 2018-12-11 |
| IL243477B (en) | 2018-06-28 |
| PL3019479T3 (pl) | 2017-10-31 |
| WO2015004265A1 (en) | 2015-01-15 |
| HUE034071T2 (en) | 2018-01-29 |
| EP3019479B1 (en) | 2017-05-10 |
| US9556125B2 (en) | 2017-01-31 |
| JP6375374B2 (ja) | 2018-08-15 |
| JP2016525094A (ja) | 2016-08-22 |
| US20160145215A1 (en) | 2016-05-26 |
| KR20160030972A (ko) | 2016-03-21 |
| MX2016000386A (es) | 2016-04-29 |
| CN105636940A (zh) | 2016-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure | ||
| FG | Grant, registration |