ATE253561T1 - 2-(3,5-bis-trifluoromethyl-phenyl)-n-methyl-n-( - morpholin-4-yl-4-o-tolyl-pyridin-3-yl)- isobutyramid - Google Patents

2-(3,5-bis-trifluoromethyl-phenyl)-n-methyl-n-( - morpholin-4-yl-4-o-tolyl-pyridin-3-yl)- isobutyramid

Info

Publication number
ATE253561T1
ATE253561T1 AT00125450T AT00125450T ATE253561T1 AT E253561 T1 ATE253561 T1 AT E253561T1 AT 00125450 T AT00125450 T AT 00125450T AT 00125450 T AT00125450 T AT 00125450T AT E253561 T1 ATE253561 T1 AT E253561T1
Authority
AT
Austria
Prior art keywords
isobutyramide
tolyl
morpholine
trifluoromethyl
pyridine
Prior art date
Application number
AT00125450T
Other languages
English (en)
Inventor
Theresa Maria Ballard
Guy Andrew Higgins
Torsten Hoffmann
Sonia Maria Poli
Andrew Sleight
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE253561T1 publication Critical patent/ATE253561T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
AT00125450T 1999-11-29 2000-11-21 2-(3,5-bis-trifluoromethyl-phenyl)-n-methyl-n-( - morpholin-4-yl-4-o-tolyl-pyridin-3-yl)- isobutyramid ATE253561T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99123685 1999-11-29

Publications (1)

Publication Number Publication Date
ATE253561T1 true ATE253561T1 (de) 2003-11-15

Family

ID=8239481

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00125450T ATE253561T1 (de) 1999-11-29 2000-11-21 2-(3,5-bis-trifluoromethyl-phenyl)-n-methyl-n-( - morpholin-4-yl-4-o-tolyl-pyridin-3-yl)- isobutyramid

Country Status (50)

Country Link
EP (1) EP1103545B1 (de)
JP (1) JP3480835B2 (de)
KR (1) KR100390117B1 (de)
CN (1) CN1152016C (de)
AR (1) AR033659A1 (de)
AT (1) ATE253561T1 (de)
AU (1) AU775292B2 (de)
BG (1) BG64622B1 (de)
BR (1) BRPI0005616B8 (de)
CA (1) CA2326529C (de)
CO (1) CO5251405A1 (de)
CZ (1) CZ299286B6 (de)
DE (2) DE60006340T2 (de)
DK (1) DK1103545T3 (de)
DO (1) DOP2000000106A (de)
EA (1) EA004404B1 (de)
ES (2) ES2208205T3 (de)
FR (1) FR2801590A1 (de)
GB (1) GB2356863A (de)
GC (1) GC0000151A (de)
GE (1) GEP20022763B (de)
GT (1) GT200000197A (de)
HK (1) HK1036759A1 (de)
HR (1) HRP20000809A2 (de)
HU (1) HU224703B1 (de)
ID (1) ID28483A (de)
IL (1) IL139868A (de)
IS (1) IS2212B (de)
IT (1) IT1320120B1 (de)
JO (1) JO2298B1 (de)
MA (1) MA26754A1 (de)
MX (1) MXPA00011672A (de)
MY (1) MY127426A (de)
NO (1) NO317264B1 (de)
NZ (1) NZ508386A (de)
OA (1) OA11513A (de)
PA (1) PA8507201A1 (de)
PE (1) PE20010901A1 (de)
PL (1) PL195957B1 (de)
PT (1) PT1103545E (de)
SG (1) SG97171A1 (de)
SI (1) SI1103545T1 (de)
SK (1) SK285373B6 (de)
SV (1) SV2002000227A (de)
TN (1) TNSN00226A1 (de)
TR (1) TR200302077T4 (de)
UA (1) UA70326C2 (de)
UY (1) UY26458A1 (de)
YU (1) YU73400A (de)
ZA (1) ZA200006964B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2226622T3 (es) * 1999-02-24 2005-04-01 F. Hoffmann-La Roche Ag Derivados de 4-fenil piridina y su empleo como antagonistas del receptor nk-1.
JP4070957B2 (ja) * 1999-02-24 2008-04-02 エフ．ホフマン−ラ ロシュ アーゲー フェニルおよびピリジニル誘導体
CZ303639B6 (cs) * 2000-07-14 2013-01-23 F. Hoffmann-La Roche Ag N-Oxid derivátu 4-fenylpyridinu, zpusob jeho prípravy a lécivo s jeho obsahem
TWI287003B (en) * 2000-07-24 2007-09-21 Hoffmann La Roche 4-phenyl-pyridine derivatives
TWI259180B (en) * 2000-08-08 2006-08-01 Hoffmann La Roche 4-Phenyl-pyridine derivatives
US20030083345A1 (en) * 2001-07-10 2003-05-01 Torsten Hoffmann Method of treatment and/or prevention of brain, spinal or nerve injury
CN1625603A (zh) * 2002-01-31 2005-06-08 弗·哈夫曼-拉罗切有限公司 前速激肽原基因中的遗传多态性
PT1643998E (pt) 2003-07-03 2007-11-21 Hoffmann La Roche Antagonistas duplos dos receptores de nc1/nc3 para tratar a esquizofrenia
US7288658B2 (en) 2003-07-15 2007-10-30 Hoffmann-La Roche Inc. Process for preparation of pyridine derivatives
CN1984891B (zh) 2004-07-06 2012-08-08 弗·哈夫曼-拉罗切有限公司 用作合成nk-1受体拮抗剂的中间体的甲酰胺吡啶衍生物的制备方法
BRPI0606187A2 (pt) 2005-02-25 2009-06-09 Hoffmann La Roche comprimidos com capacidade de dispersão da substáncia do fármaco melhorada
CA2602445C (en) 2005-03-23 2013-08-20 F.Hoffmann-La Roche Ag Metabolites for nk-i antagonists for emesis
MY143784A (en) 2005-09-23 2011-07-15 Hoffmann La Roche Novel dosage formulation
KR20090112722A (ko) 2007-01-24 2009-10-28 글락소 그룹 리미티드 3,5-디아미노-6-(2,3-디클로로페닐)-1,2,4-트리아진 또는 ｒ(-)-2,4-디아미노-5-(2,3-디클로로페닐)-6-플루오로메틸 피리미딘 및 ｎｋ1을 포함하는 제약 조성물
US8426450B1 (en) * 2011-11-29 2013-04-23 Helsinn Healthcare Sa Substituted 4-phenyl pyridines having anti-emetic effect
EA033555B1 (ru) 2013-03-15 2019-10-31 Global Blood Therapeutics Inc Фармацевтические композиции для лечения серповидно-клеточного нарушения
CA2930008A1 (en) 2013-11-08 2015-05-14 Kissei Pharmaceutical Co., Ltd. Carboxymethyl piperidine derivative
MY189995A (en) 2014-02-07 2022-03-22 Global Blood Therapeutics Inc Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
TWI649307B (zh) 2014-05-07 2019-02-01 日商橘生藥品工業股份有限公司 Cyclohexylpyridine derivative
KR101948238B1 (ko) 2016-08-19 2019-02-14 (주)케어젠 미녹시딜과 펩타이드의 결합체

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1082959A1 (de) * 1991-09-20 2001-03-14 Glaxo Group Limited NK1 Antagonisten zur Behandlung von Depression
CA2099233A1 (en) * 1992-06-29 1993-12-30 Conrad P. Dorn Morpholine and thiomorpholine tachykinin receptor antagonists
IL111960A (en) * 1993-12-17 1999-12-22 Merck & Co Inc Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them
PL181214B1 (pl) * 1993-12-29 2001-06-29 Merck Sharp & Dohme Podstawione związki morfolinowe, sposób ich wytwarzania oraz zawierające je kompozycje farmaceutyczne
IL112778A0 (en) * 1994-03-04 1995-05-26 Merck & Co Inc Substituted heterocycles, their preparation and pharmaceutical compositions containing them
TW394773B (en) * 1995-03-24 2000-06-21 Takeda Chemical Industries Ltd Cyclic compounds for antagonizing tachykinin receptor, substance p receptor and neurokinin a receptor, their production and pharmaceutical composition
US5972938A (en) * 1997-12-01 1999-10-26 Merck & Co., Inc. Method for treating or preventing psychoimmunological disorders
ES2226622T3 (es) * 1999-02-24 2005-04-01 F. Hoffmann-La Roche Ag Derivados de 4-fenil piridina y su empleo como antagonistas del receptor nk-1.
US6303790B1 (en) * 1999-11-29 2001-10-16 Hoffman-La Roche Inc. Process for the preparation of pyridine derivatives
CZ303639B6 (cs) * 2000-07-14 2013-01-23 F. Hoffmann-La Roche Ag N-Oxid derivátu 4-fenylpyridinu, zpusob jeho prípravy a lécivo s jeho obsahem
TWI287003B (en) * 2000-07-24 2007-09-21 Hoffmann La Roche 4-phenyl-pyridine derivatives
TWI259180B (en) * 2000-08-08 2006-08-01 Hoffmann La Roche 4-Phenyl-pyridine derivatives

Also Published As

Publication number Publication date
DOP2000000106A (es) 2002-07-30
ES2208205T3 (es) 2004-06-16
PA8507201A1 (es) 2002-02-21
KR20010051983A (ko) 2001-06-25
EP1103545B1 (de) 2003-11-05
AU7178700A (en) 2001-05-31
OA11513A (fr) 2004-02-03
NZ508386A (en) 2003-02-28
SV2002000227A (es) 2002-02-05
CA2326529A1 (en) 2001-05-29
HU224703B1 (en) 2006-01-30
BG104992A (en) 2001-11-30
DE60006340T2 (de) 2004-09-09
GC0000151A (en) 2005-06-29
IT1320120B1 (it) 2003-11-18
EA004404B1 (ru) 2004-04-29
JP2001151754A (ja) 2001-06-05
MY127426A (en) 2006-11-30
JO2298B1 (en) 2005-09-12
CZ20004399A3 (cs) 2001-07-11
ITMI20002575A1 (it) 2002-05-29
EA200001114A3 (ru) 2001-12-24
MXPA00011672A (es) 2002-08-20
FR2801590A1 (fr) 2001-06-01
KR100390117B1 (ko) 2003-07-04
SK17932000A3 (sk) 2001-11-06
DE60006340D1 (de) 2003-12-11
BRPI0005616B8 (pt) 2021-07-06
EA200001114A2 (ru) 2001-08-27
HRP20000809A2 (en) 2001-12-31
BRPI0005616B1 (pt) 2017-12-12
MA26754A1 (fr) 2004-12-20
EP1103545A1 (de) 2001-05-30
ES2171134A1 (es) 2002-08-16
DK1103545T3 (da) 2004-03-15
UY26458A1 (es) 2001-05-31
GB2356863A (en) 2001-06-06
GEP20022763B (en) 2002-08-26
PL195957B1 (pl) 2007-11-30
HUP0004725A2 (hu) 2002-04-29
GT200000197A (es) 2002-05-22
YU73400A (sh) 2003-02-28
BR0005616A (pt) 2001-07-17
PE20010901A1 (es) 2001-09-20
CN1297888A (zh) 2001-06-06
NO20006012L (no) 2001-05-30
SI1103545T1 (en) 2004-02-29
IS2212B (is) 2007-02-15
UA70326C2 (en) 2004-10-15
HU0004725D0 (de) 2001-02-28
AR033659A1 (es) 2004-01-07
NO20006012D0 (no) 2000-11-28
SK285373B6 (sk) 2006-12-07
JP3480835B2 (ja) 2003-12-22
BG64622B1 (bg) 2005-09-30
CO5251405A1 (es) 2003-02-28
IL139868A (en) 2009-09-01
GB0028566D0 (en) 2001-01-10
IS5725A (is) 2001-05-29
SG97171A1 (en) 2003-07-18
PL344147A1 (en) 2001-06-04
CA2326529C (en) 2009-12-22
CN1152016C (zh) 2004-06-02
DE10058310A1 (de) 2001-05-31
PT1103545E (pt) 2004-03-31
AU775292B2 (en) 2004-07-29
HK1036759A1 (en) 2002-01-18
TR200302077T4 (tr) 2004-01-21
IL139868A0 (en) 2002-02-10
NO317264B1 (no) 2004-09-27
CZ299286B6 (cs) 2008-06-04
ZA200006964B (en) 2001-06-05
TNSN00226A1 (fr) 2002-05-30
ID28483A (id) 2001-05-31

Similar Documents

Publication Publication Date Title
ATE253561T1 (de) 2-(3,5-bis-trifluoromethyl-phenyl)-n-methyl-n-( - morpholin-4-yl-4-o-tolyl-pyridin-3-yl)- isobutyramid
PT1056759E (pt) Derivados do 2-(purin-9-il)-tetrahidrofurano-3,4-diolc
DE60012154D1 (de) Zange
ID23803A (id) Turunan-turunan 2-(4-aril atau heteroaril-piperazin-1-ilmetil)-1h-indola
ATA25299A (de) Scharnier
DE50107988D1 (de) Substituierte 1,2,3,4-tetrahydrochinolin-2-carbonsäurederivate
DE60025958D1 (de) 14,15-beta-methylen substituierte androgene
DE50006616D1 (de) Zange
NO20042980L (no) 3,4-dihydro-1H-isokinolin-2-yl-derivater
DE60029273D1 (de) Titan-Tinoxidfilme
DE50003869D1 (de) Kalander
DE50006120D1 (de) Scharnier
FR2796979B1 (fr) Gond
ATE525362T1 (de) 2-(3-(4-(2-t-butyl-6-trifluormethylpyrimidin-4-
DE50005314D1 (de) Kalander
DE50007103D1 (de) Scharnier
DE50007005D1 (de) Kalander
DE50005755D1 (de) Kalander
FI991185A0 (fi) Sarana
AR027974A1 (es) 1-aril-ciclopropilmetilamino-1,3,5-triazinas substituidas
IS7131A (is) Nýjar 2,4-díamínóþíasól afleiður
NO20015998D0 (no) Hengsel
FI19992637A (fi) Termotela
DE29906439U1 (de) Scharnier
FI990794A0 (fi) Kalanteri

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1103545

Country of ref document: EP