AR033659A1 - El compuesto 2-(3,5-bis -trifluormetil-fenil)-n-metil-n-(6-morfolin-4-il-4-o-tolil-piridin-3-il)-isobutiramida), su uso, un procedimiento para prepararlo y un medicamento que lo contiene - Google Patents
El compuesto 2-(3,5-bis -trifluormetil-fenil)-n-metil-n-(6-morfolin-4-il-4-o-tolil-piridin-3-il)-isobutiramida), su uso, un procedimiento para prepararlo y un medicamento que lo contieneInfo
- Publication number
- AR033659A1 AR033659A1 ARP000106217A ARP000106217A AR033659A1 AR 033659 A1 AR033659 A1 AR 033659A1 AR P000106217 A ARP000106217 A AR P000106217A AR P000106217 A ARP000106217 A AR P000106217A AR 033659 A1 AR033659 A1 AR 033659A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- bis
- phenyl
- prepare
- methyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- -1 3,5-BIS -TRIFLUORMETHYL-PHENYL Chemical class 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- ZGNPLCMMVKCTHM-UHFFFAOYSA-N 2-[3,5-bis(trifluoromethyl)phenyl]-n,2-dimethyl-n-[4-(2-methylphenyl)-6-morpholin-4-ylpyridin-3-yl]propanamide Chemical compound C=1N=C(N2CCOCC2)C=C(C=2C(=CC=CC=2)C)C=1N(C)C(=O)C(C)(C)C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 ZGNPLCMMVKCTHM-UHFFFAOYSA-N 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 102000002002 Neurokinin-1 Receptors Human genes 0.000 abstract 1
- 108010040718 Neurokinin-1 Receptors Proteins 0.000 abstract 1
- 206010047700 Vomiting Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
El compuesto 2-(3,5-bis-trifluorometil-fenil)-N-metil-N-(6-morfolin-4-il-4-o-tolil-piridin-3-il)-isobutiramida de fórmula (1) y sus sales de adición de ácido farmacéuticamente aceptables; su uso; un procedimiento para prepararlo; y un medicamento que lo contiene. Se ha encontrado que este compuesto tiene una alta afinidad al receptor NK-1 y es por tanto útil en el tratamiento de enfermedades relacionadas con este receptor, tales como trastornos del sistema nervioso central, por ejemplo trastornos depresivos, ansiedad o emesis.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99123685 | 1999-11-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR033659A1 true AR033659A1 (es) | 2004-01-07 |
Family
ID=8239481
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000106217A AR033659A1 (es) | 1999-11-29 | 2000-11-27 | El compuesto 2-(3,5-bis -trifluormetil-fenil)-n-metil-n-(6-morfolin-4-il-4-o-tolil-piridin-3-il)-isobutiramida), su uso, un procedimiento para prepararlo y un medicamento que lo contiene |
Country Status (49)
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1131212C (zh) | 1999-02-24 | 2003-12-17 | 弗·哈夫曼-拉罗切有限公司 | 苯基－和吡啶基衍生物 |
| DE60045564D1 (de) * | 1999-02-24 | 2011-03-03 | Hoffmann La Roche | 4-Phenylpyridinderivate und deren Verwendung als NK-1 Rezeptorantagonisten |
| CA2415890C (en) * | 2000-07-14 | 2009-04-07 | F. Hoffmann-La Roche Ag | N-oxides as nk1 receptor antagonist prodrugs of 4-phenyl-pyridine derivatives |
| TWI287003B (en) * | 2000-07-24 | 2007-09-21 | Hoffmann La Roche | 4-phenyl-pyridine derivatives |
| TWI259180B (en) * | 2000-08-08 | 2006-08-01 | Hoffmann La Roche | 4-Phenyl-pyridine derivatives |
| US20030083345A1 (en) * | 2001-07-10 | 2003-05-01 | Torsten Hoffmann | Method of treatment and/or prevention of brain, spinal or nerve injury |
| CA2473128A1 (en) * | 2002-01-31 | 2003-08-07 | F. Hoffmann-La Roche Ag | Genetic polymorphisms in the preprotachykinin gene |
| JP4490421B2 (ja) | 2003-07-03 | 2010-06-23 | エフ．ホフマン−ラ ロシュ アーゲー | 統合失調症を処置するデュアルｎｋ１／ｎｋ３アンタゴニスト |
| US7288658B2 (en) | 2003-07-15 | 2007-10-30 | Hoffmann-La Roche Inc. | Process for preparation of pyridine derivatives |
| EP1776342B1 (en) | 2004-07-06 | 2011-03-02 | F. Hoffmann-La Roche AG | Process for preparing carboxamide pyridine derivatives used as intermediates in the synthesis of nk-1 receptor antagonists |
| CN101128189A (zh) | 2005-02-25 | 2008-02-20 | 弗·哈夫曼-拉罗切有限公司 | 药物物质分散性改善的片剂 |
| RU2404969C2 (ru) * | 2005-03-23 | 2010-11-27 | Ф. Хоффманн-Ля Рош Аг | Метаболиты антагонистов nk-1 против рвоты |
| SI1928427T1 (sl) | 2005-09-23 | 2010-03-31 | Hoffmann La Roche | Nove formulacije za doziranje |
| JP2010516734A (ja) | 2007-01-24 | 2010-05-20 | グラクソ グループ リミテッド | ３，５−ジアミノ−６−（２，３−ジクロロフェニル）−１，２，４−トリアジンまたはｒ（−）−２，４−ジアミノ−５−（２，３−ジクロロフェニル）−６−フルオロメチルピリミジンを含む医薬組成物 |
| US8426450B1 (en) | 2011-11-29 | 2013-04-23 | Helsinn Healthcare Sa | Substituted 4-phenyl pyridines having anti-emetic effect |
| EP3919056B1 (en) | 2013-03-15 | 2024-08-28 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| CA2930008A1 (en) | 2013-11-08 | 2015-05-14 | Kissei Pharmaceutical Co., Ltd. | Carboxymethyl piperidine derivative |
| SG10201911662YA (en) | 2014-02-07 | 2020-02-27 | Global Blood Therapeutics Inc | Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde |
| TWI649307B (zh) | 2014-05-07 | 2019-02-01 | 日商橘生藥品工業股份有限公司 | Cyclohexylpyridine derivative |
| KR101948238B1 (ko) | 2016-08-19 | 2019-02-14 | (주)케어젠 | 미녹시딜과 펩타이드의 결합체 |
| KR102328682B1 (ko) | 2018-08-27 | 2021-11-18 | 주식회사 대웅제약 | 신규한 헤테로사이클릭아민 유도체 및 이를 포함하는 약학 조성물 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE195867T1 (de) * | 1991-09-20 | 2000-09-15 | Glaxo Group Ltd | Neue medizinische indikation für tachykinin- antagonisten |
| CA2099233A1 (en) * | 1992-06-29 | 1993-12-30 | Conrad P. Dorn | Morpholine and thiomorpholine tachykinin receptor antagonists |
| IL111960A (en) * | 1993-12-17 | 1999-12-22 | Merck & Co Inc | Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them |
| DE69428913T2 (de) * | 1993-12-29 | 2002-05-29 | Merck Sharp & Dohme Ltd., Hoddesdon | Substituierte morpholinderivate und ihre verwendung als arzneimittel |
| TW385308B (en) * | 1994-03-04 | 2000-03-21 | Merck & Co Inc | Prodrugs of morpholine tachykinin receptor antagonists |
| DE69628484T2 (de) * | 1995-03-24 | 2004-05-19 | Takeda Chemical Industries, Ltd. | Zyklische Verbindungen, ihre Herstellung und ihre Verwendung als Tachykininrezeptorantagonisten |
| US5972938A (en) * | 1997-12-01 | 1999-10-26 | Merck & Co., Inc. | Method for treating or preventing psychoimmunological disorders |
| DE60045564D1 (de) * | 1999-02-24 | 2011-03-03 | Hoffmann La Roche | 4-Phenylpyridinderivate und deren Verwendung als NK-1 Rezeptorantagonisten |
| US6303790B1 (en) * | 1999-11-29 | 2001-10-16 | Hoffman-La Roche Inc. | Process for the preparation of pyridine derivatives |
| CA2415890C (en) * | 2000-07-14 | 2009-04-07 | F. Hoffmann-La Roche Ag | N-oxides as nk1 receptor antagonist prodrugs of 4-phenyl-pyridine derivatives |
| TWI287003B (en) * | 2000-07-24 | 2007-09-21 | Hoffmann La Roche | 4-phenyl-pyridine derivatives |
| TWI259180B (en) * | 2000-08-08 | 2006-08-01 | Hoffmann La Roche | 4-Phenyl-pyridine derivatives |
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2000
- 2000-11-21 ES ES00125450T patent/ES2208205T3/es not_active Expired - Lifetime
- 2000-11-21 SI SI200030246T patent/SI1103545T1/xx unknown
- 2000-11-21 EP EP00125450A patent/EP1103545B1/en not_active Expired - Lifetime
- 2000-11-21 AT AT00125450T patent/ATE253561T1/de active
- 2000-11-21 TR TR2003/02077T patent/TR200302077T4/xx unknown
- 2000-11-21 DK DK00125450T patent/DK1103545T3/da active
- 2000-11-21 DE DE60006340T patent/DE60006340T2/de not_active Expired - Lifetime
- 2000-11-21 PT PT00125450T patent/PT1103545E/pt unknown
- 2000-11-23 GB GB0028566A patent/GB2356863A/en not_active Withdrawn
- 2000-11-23 CA CA002326529A patent/CA2326529C/en not_active Expired - Lifetime
- 2000-11-23 AU AU71787/00A patent/AU775292B2/en not_active Expired
- 2000-11-23 PE PE2000001254A patent/PE20010901A1/es not_active Application Discontinuation
- 2000-11-23 YU YU73400A patent/YU73400A/sh unknown
- 2000-11-23 IL IL139868A patent/IL139868A/en active IP Right Grant
- 2000-11-23 NZ NZ508386A patent/NZ508386A/xx unknown
- 2000-11-23 JO JO2000187A patent/JO2298B1/en active
- 2000-11-24 IS IS5725A patent/IS2212B/is unknown
- 2000-11-24 JP JP2000356833A patent/JP3480835B2/ja not_active Expired - Lifetime
- 2000-11-24 HR HR20000809A patent/HRP20000809A2/hr not_active Application Discontinuation
- 2000-11-24 CZ CZ20004399A patent/CZ299286B6/cs not_active IP Right Cessation
- 2000-11-24 SG SG200006945A patent/SG97171A1/en unknown
- 2000-11-24 DE DE10058310A patent/DE10058310A1/de not_active Withdrawn
- 2000-11-24 PA PA20008507201A patent/PA8507201A1/es unknown
- 2000-11-24 FR FR0015193A patent/FR2801590A1/fr not_active Withdrawn
- 2000-11-26 GC GCP20001052 patent/GC0000151A/xx active
- 2000-11-27 SK SK1793-2000A patent/SK285373B6/sk unknown
- 2000-11-27 CO CO00090625A patent/CO5251405A1/es active IP Right Grant
- 2000-11-27 AR ARP000106217A patent/AR033659A1/es unknown
- 2000-11-27 MX MXPA00011672A patent/MXPA00011672A/es active IP Right Grant
- 2000-11-27 GE GEAP20005644A patent/GEP20022763B/en unknown
- 2000-11-27 MY MYPI20005527A patent/MY127426A/en unknown
- 2000-11-27 HU HU0004725A patent/HU224703B1/hu active IP Right Grant
- 2000-11-27 ZA ZA200006964A patent/ZA200006964B/xx unknown
- 2000-11-28 UA UA2000116781A patent/UA70326C2/uk unknown
- 2000-11-28 MA MA26111A patent/MA26754A1/fr unknown
- 2000-11-28 SV SV2000000227A patent/SV2002000227A/es unknown
- 2000-11-28 ES ES200002839A patent/ES2171134A1/es not_active Withdrawn
- 2000-11-28 DO DO2000000106A patent/DOP2000000106A/es unknown
- 2000-11-28 BR BRPI0005616A patent/BRPI0005616B8/pt not_active IP Right Cessation
- 2000-11-28 UY UY26458A patent/UY26458A1/es not_active Application Discontinuation
- 2000-11-28 GT GT200000197A patent/GT200000197A/es unknown
- 2000-11-28 BG BG104992A patent/BG64622B1/bg unknown
- 2000-11-28 EA EA200001114A patent/EA004404B1/ru not_active IP Right Cessation
- 2000-11-28 PL PL344147A patent/PL195957B1/pl unknown
- 2000-11-28 NO NO20006012A patent/NO317264B1/no not_active IP Right Cessation
- 2000-11-28 KR KR10-2000-0071141A patent/KR100390117B1/ko not_active Expired - Lifetime
- 2000-11-29 OA OA1200000324A patent/OA11513A/fr unknown
- 2000-11-29 TN TNTNSN00226A patent/TNSN00226A1/fr unknown
- 2000-11-29 IT IT2000MI002575A patent/IT1320120B1/it active
- 2000-11-29 CN CNB001342606A patent/CN1152016C/zh not_active Expired - Lifetime
- 2000-11-29 ID IDP20001029D patent/ID28483A/id unknown
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