YU73400A - 2-(3,5-bis trifluorometil-fenil)-n-metil-n-(6-morfolin-4-il- 4-o-tolil-piridin-3-il)izobutiroamid - Google Patents

2-(3,5-bis trifluorometil-fenil)-n-metil-n-(6-morfolin-4-il- 4-o-tolil-piridin-3-il)izobutiroamid

Info

Publication number
YU73400A
YU73400A YU73400A YUP73400A YU73400A YU 73400 A YU73400 A YU 73400A YU 73400 A YU73400 A YU 73400A YU P73400 A YUP73400 A YU P73400A YU 73400 A YU73400 A YU 73400A
Authority
YU
Yugoslavia
Prior art keywords
isobutyramide
morpholin
pyridin
tolyl
trifluoromethyl
Prior art date
Application number
YU73400A
Other languages
English (en)
Inventor
Theresa Maria Ballard
Guy Andrew Higgins
Torsten Hoffmann
Sonia Maria Poli
Andrew Sleight
Original Assignee
F.Hoffmann-La Roche Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag. filed Critical F.Hoffmann-La Roche Ag.
Publication of YU73400A publication Critical patent/YU73400A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Ovaj pronalazak se odnosi na jedinjenje formule koje je 2-(3,5-bis-trifluormetil-fenl)-N-metil-N-(6-morfolin-4-il-4-o-tolil-piridin-3-il)-izobutiroamid. Nadjeno je da ovo jedinjenje ima visok afinitet prema receptoru NK-1 i otuda je podesno za lečenje bolesti koje su u vezi sa ovim receptorom.[This invention refers to the compound of the formula which is 2-(3,5-bis-trifluoromethyl-phenyl)-N-methyl-N-(6-morpholin-4-yl-4-o-tolyl-pyridin-3-yl)-isobutyramide. It has been found that this compound has great affinity towards NK-1 receptor and is therefore suitable for curing diseases involving this receptor.
YU73400A 1999-11-29 2000-11-23 2-(3,5-bis trifluorometil-fenil)-n-metil-n-(6-morfolin-4-il- 4-o-tolil-piridin-3-il)izobutiroamid YU73400A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99123685 1999-11-29

Publications (1)

Publication Number Publication Date
YU73400A true YU73400A (sh) 2003-02-28

Family

ID=8239481

Family Applications (1)

Application Number Title Priority Date Filing Date
YU73400A YU73400A (sh) 1999-11-29 2000-11-23 2-(3,5-bis trifluorometil-fenil)-n-metil-n-(6-morfolin-4-il- 4-o-tolil-piridin-3-il)izobutiroamid

Country Status (50)

Country Link
EP (1) EP1103545B1 (sh)
JP (1) JP3480835B2 (sh)
KR (1) KR100390117B1 (sh)
CN (1) CN1152016C (sh)
AR (1) AR033659A1 (sh)
AT (1) ATE253561T1 (sh)
AU (1) AU775292B2 (sh)
BG (1) BG64622B1 (sh)
BR (1) BRPI0005616B8 (sh)
CA (1) CA2326529C (sh)
CO (1) CO5251405A1 (sh)
CZ (1) CZ299286B6 (sh)
DE (2) DE60006340T2 (sh)
DK (1) DK1103545T3 (sh)
DO (1) DOP2000000106A (sh)
EA (1) EA004404B1 (sh)
ES (2) ES2208205T3 (sh)
FR (1) FR2801590A1 (sh)
GB (1) GB2356863A (sh)
GC (1) GC0000151A (sh)
GE (1) GEP20022763B (sh)
GT (1) GT200000197A (sh)
HK (1) HK1036759A1 (sh)
HR (1) HRP20000809A2 (sh)
HU (1) HU224703B1 (sh)
ID (1) ID28483A (sh)
IL (1) IL139868A (sh)
IS (1) IS2212B (sh)
IT (1) IT1320120B1 (sh)
JO (1) JO2298B1 (sh)
MA (1) MA26754A1 (sh)
MX (1) MXPA00011672A (sh)
MY (1) MY127426A (sh)
NO (1) NO317264B1 (sh)
NZ (1) NZ508386A (sh)
OA (1) OA11513A (sh)
PA (1) PA8507201A1 (sh)
PE (1) PE20010901A1 (sh)
PL (1) PL195957B1 (sh)
PT (1) PT1103545E (sh)
SG (1) SG97171A1 (sh)
SI (1) SI1103545T1 (sh)
SK (1) SK285373B6 (sh)
SV (1) SV2002000227A (sh)
TN (1) TNSN00226A1 (sh)
TR (1) TR200302077T4 (sh)
UA (1) UA70326C2 (sh)
UY (1) UY26458A1 (sh)
YU (1) YU73400A (sh)
ZA (1) ZA200006964B (sh)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1394150T3 (da) * 1999-02-24 2011-03-21 Hoffmann La Roche 4-phenylpyridinderivater og deres anvendelse som NK-1-receptorantagonister
WO2000050398A2 (en) * 1999-02-24 2000-08-31 F. Hoffmann-La Roche Ag Phenyl- and pyridinyl derivatives as neurokinin 1 antagonists
KR100501608B1 (ko) * 2000-07-14 2005-07-18 에프. 호프만-라 로슈 아게 4-페닐-피리딘 유도체의 ｎｋ1 수용체의 길항성선구약물로서의 ｎ-산화물
TWI287003B (en) * 2000-07-24 2007-09-21 Hoffmann La Roche 4-phenyl-pyridine derivatives
TWI259180B (en) * 2000-08-08 2006-08-01 Hoffmann La Roche 4-Phenyl-pyridine derivatives
US20030083345A1 (en) * 2001-07-10 2003-05-01 Torsten Hoffmann Method of treatment and/or prevention of brain, spinal or nerve injury
IL162733A0 (en) * 2002-01-31 2005-11-20 Hoffmann La Roche Genetic polymorphisms in the preprotachykinin gene
EP1643998B1 (en) 2003-07-03 2007-08-29 F. Hoffmann-La Roche Ag Dual nk1/nk3 antagonists for treating schizophrenia
TWI280239B (en) 2003-07-15 2007-05-01 Hoffmann La Roche Process for preparation of pyridine derivatives
DE602005026669D1 (de) 2004-07-06 2011-04-14 Hoffmann La Roche Herstellungsverfahren für carboxamid-pyridin-derivate als zwischenprodukte bei der synthese von nk-1-rezeptor-antagonisten
UA90708C2 (ru) 2005-02-25 2010-05-25 Ф. Хоффманн-Ля Рош Аг Таблетки с улучшенной дисперсностью лекарственного вещества
DK1863767T3 (da) * 2005-03-23 2009-05-04 Hoffmann La Roche Metabolitter til NK-I-antagonister til emesis
DK1928427T3 (da) * 2005-09-23 2010-03-08 Hoffmann La Roche Hidtil ukendt dosisformulering
EP2129381A1 (en) 2007-01-24 2009-12-09 Glaxo Group Limited Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or r (-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an nk1
US8426450B1 (en) 2011-11-29 2013-04-23 Helsinn Healthcare Sa Substituted 4-phenyl pyridines having anti-emetic effect
MY180206A (en) 2013-03-15 2020-11-25 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
JP5806420B1 (ja) 2013-11-08 2015-11-10 キッセイ薬品工業株式会社 カルボキシメチルピペリジン誘導体
DK3102208T3 (da) 2014-02-07 2021-03-08 Global Blood Therapeutics Inc Krystallinsk polymorf af den frie base af 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyd
TWI649307B (zh) 2014-05-07 2019-02-01 日商橘生藥品工業股份有限公司 Cyclohexylpyridine derivative
KR101948238B1 (ko) 2016-08-19 2019-02-14 (주)케어젠 미녹시딜과 펩타이드의 결합체

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2149767T5 (es) * 1991-09-20 2005-06-16 Glaxo Group Limited Nuevo uso medico para antagonistas de taquiquininas.
IL106142A (en) * 1992-06-29 1997-03-18 Merck & Co Inc Morpholine and thiomorpholine tachykinin receptor antagonists, their preparation and pharmaceutical compositions containing them
IL111960A (en) * 1993-12-17 1999-12-22 Merck & Co Inc Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them
SK283070B6 (sk) * 1993-12-29 2003-02-04 Merck Sharp & Dohme Limited Substituované morfolínové deriváty, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie
TW385308B (en) * 1994-03-04 2000-03-21 Merck & Co Inc Prodrugs of morpholine tachykinin receptor antagonists
ATE242243T1 (de) * 1995-03-24 2003-06-15 Takeda Chemical Industries Ltd Zyklische verbindungen, ihre herstellung und ihre verwendung als tachykininrezeptorantagonisten
US5972938A (en) * 1997-12-01 1999-10-26 Merck & Co., Inc. Method for treating or preventing psychoimmunological disorders
DK1394150T3 (da) * 1999-02-24 2011-03-21 Hoffmann La Roche 4-phenylpyridinderivater og deres anvendelse som NK-1-receptorantagonister
US6303790B1 (en) * 1999-11-29 2001-10-16 Hoffman-La Roche Inc. Process for the preparation of pyridine derivatives
KR100501608B1 (ko) * 2000-07-14 2005-07-18 에프. 호프만-라 로슈 아게 4-페닐-피리딘 유도체의 ｎｋ1 수용체의 길항성선구약물로서의 ｎ-산화물
TWI287003B (en) * 2000-07-24 2007-09-21 Hoffmann La Roche 4-phenyl-pyridine derivatives
TWI259180B (en) * 2000-08-08 2006-08-01 Hoffmann La Roche 4-Phenyl-pyridine derivatives

Also Published As

Publication number Publication date
UY26458A1 (es) 2001-05-31
CZ20004399A3 (cs) 2001-07-11
NO20006012D0 (no) 2000-11-28
ID28483A (id) 2001-05-31
EP1103545B1 (en) 2003-11-05
PA8507201A1 (es) 2002-02-21
DE10058310A1 (de) 2001-05-31
BG104992A (en) 2001-11-30
AR033659A1 (es) 2004-01-07
BR0005616A (pt) 2001-07-17
NO20006012L (no) 2001-05-30
GEP20022763B (en) 2002-08-26
AU7178700A (en) 2001-05-31
CN1297888A (zh) 2001-06-06
ATE253561T1 (de) 2003-11-15
DK1103545T3 (da) 2004-03-15
CA2326529A1 (en) 2001-05-29
NZ508386A (en) 2003-02-28
TR200302077T4 (tr) 2004-01-21
ZA200006964B (en) 2001-06-05
PL195957B1 (pl) 2007-11-30
EA004404B1 (ru) 2004-04-29
HU224703B1 (en) 2006-01-30
KR20010051983A (ko) 2001-06-25
JO2298B1 (en) 2005-09-12
SK285373B6 (sk) 2006-12-07
PT1103545E (pt) 2004-03-31
HUP0004725A2 (hu) 2002-04-29
SK17932000A3 (sk) 2001-11-06
DE60006340T2 (de) 2004-09-09
GC0000151A (en) 2005-06-29
SG97171A1 (en) 2003-07-18
GB0028566D0 (en) 2001-01-10
IS2212B (is) 2007-02-15
EA200001114A3 (ru) 2001-12-24
PL344147A1 (en) 2001-06-04
BRPI0005616B8 (pt) 2021-07-06
BRPI0005616B1 (pt) 2017-12-12
BG64622B1 (bg) 2005-09-30
TNSN00226A1 (fr) 2002-05-30
IS5725A (is) 2001-05-29
CA2326529C (en) 2009-12-22
JP3480835B2 (ja) 2003-12-22
IT1320120B1 (it) 2003-11-18
HK1036759A1 (en) 2002-01-18
GT200000197A (es) 2002-05-22
CO5251405A1 (es) 2003-02-28
MA26754A1 (fr) 2004-12-20
DE60006340D1 (de) 2003-12-11
NO317264B1 (no) 2004-09-27
AU775292B2 (en) 2004-07-29
ITMI20002575A1 (it) 2002-05-29
KR100390117B1 (ko) 2003-07-04
UA70326C2 (en) 2004-10-15
CZ299286B6 (cs) 2008-06-04
DOP2000000106A (es) 2002-07-30
SV2002000227A (es) 2002-02-05
HU0004725D0 (sh) 2001-02-28
JP2001151754A (ja) 2001-06-05
IL139868A (en) 2009-09-01
MY127426A (en) 2006-11-30
PE20010901A1 (es) 2001-09-20
HRP20000809A2 (en) 2001-12-31
ES2208205T3 (es) 2004-06-16
MXPA00011672A (es) 2002-08-20
ES2171134A1 (es) 2002-08-16
CN1152016C (zh) 2004-06-02
IL139868A0 (en) 2002-02-10
GB2356863A (en) 2001-06-06
EA200001114A2 (ru) 2001-08-27
EP1103545A1 (en) 2001-05-30
OA11513A (fr) 2004-02-03
SI1103545T1 (en) 2004-02-29
FR2801590A1 (fr) 2001-06-01

Similar Documents

Publication Publication Date Title
YU73400A (sh) 2-(3,5-bis trifluorometil-fenil)-n-metil-n-(6-morfolin-4-il- 4-o-tolil-piridin-3-il)izobutiroamid
UA74419C2 (uk) Заміщені піридини та їх застосування як антагоністів рецептору метаботропного глутамату
MY135333A (en) Modulators of the glucocorticoid receptor
TNSN01118A1 (en) 2-(4-PYRIDYL) AMINO-6-DIALKOXYPHENYL-PYRIDO [2,3-d]PYRIMIDIN-7- ONES
PT1671949E (pt) Piridinilaminas substituídas
MXPA03008135A (es) Combinacion de analogos de epotilona y agentes quimioterapeuticos para tratamiento de enfermedades proliferativas.
WO2001056990A3 (en) Pyridine derivates as potentiators of glutamate receptors
IL160872A0 (en) Pyrimidinones as melanin concentrating hormone receptor 1
SI1487444T1 (sl) Uporaba piridil-amidov kot inhibitorjev angiogeneze
MY131518A (en) 6-substituted pyrido-pyrimidines
TR199802241T2 (sh)
ATE256671T1 (de) 2-phenyl-substituierte 1-(n-phenylaminoalkyl)- piperazin-derivate
HK1080466A1 (zh) 用於治療過度增生疾病的稠合三環雜環
DE60230683D1 (de) 3,6-disubstituierte azabicyclo-3.1.0 hexan-derivat
PL371127A1 (en) 6-aminomorphinane derivatives, method for the production and use thereof
PL368563A1 (en) Processes for the production of substituted 2-(2-pyridylmethyl) sulfinyl-1h-benzimidazoles
EP1453812A4 (en) CYTOTOXIC AGENTS
PL396160A1 (pl) Pochodna heterocykliczna i jej zastosowanie
ATE298742T1 (de) Zykloalkenylsulfonamidderivate
EP1372648A4 (en) KIEASE TIE2 RECEPTOR INHIBITORS FOR THE TREATMENT OF ANGIOGENIC DISEASES
ECSP003783A (es) 2-(3,5-bis-trifluorometil-fenil) -N-metil-N- (6-morfolin-4-il-4-o-totil-piridin-3-il)-isobutiramida
UA83187C2 (en) Aryl- and heteroarylpiperazines
WO2002036546A3 (en) Alkynyl amides and their therapeutic applications