NO20064004L - Virale polymeraseinhibitorer - Google Patents
Virale polymeraseinhibitorerInfo
- Publication number
- NO20064004L NO20064004L NO20064004A NO20064004A NO20064004L NO 20064004 L NO20064004 L NO 20064004L NO 20064004 A NO20064004 A NO 20064004A NO 20064004 A NO20064004 A NO 20064004A NO 20064004 L NO20064004 L NO 20064004L
- Authority
- NO
- Norway
- Prior art keywords
- polymerase inhibitors
- viral polymerase
- viral
- polymerases
- compound
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 230000003612 virological effect Effects 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 241000710781 Flaviviridae Species 0.000 abstract 1
- 108060004795 Methyltransferase Proteins 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54621304P | 2004-02-20 | 2004-02-20 | |
| PCT/CA2005/000208 WO2005080388A1 (en) | 2004-02-20 | 2005-02-18 | Viral polymerase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20064004L true NO20064004L (no) | 2006-09-06 |
Family
ID=34886250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20064004A NO20064004L (no) | 2004-02-20 | 2006-09-06 | Virale polymeraseinhibitorer |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US7582770B2 (enExample) |
| EP (2) | EP1718608B1 (enExample) |
| JP (4) | JP4648333B2 (enExample) |
| KR (2) | KR20120091276A (enExample) |
| CN (6) | CN1922174A (enExample) |
| AR (2) | AR047706A1 (enExample) |
| AU (1) | AU2005215829C1 (enExample) |
| BR (1) | BRPI0507861A (enExample) |
| CA (1) | CA2553879C (enExample) |
| DK (1) | DK1718608T3 (enExample) |
| EA (3) | EA013207B1 (enExample) |
| EC (1) | ECSP066780A (enExample) |
| ES (1) | ES2431314T3 (enExample) |
| HR (1) | HRP20130971T1 (enExample) |
| IL (2) | IL177537A (enExample) |
| IN (1) | IN2012DN04853A (enExample) |
| MY (1) | MY144718A (enExample) |
| NO (1) | NO20064004L (enExample) |
| NZ (1) | NZ549079A (enExample) |
| PE (1) | PE20051141A1 (enExample) |
| PL (1) | PL1718608T3 (enExample) |
| PT (1) | PT1718608E (enExample) |
| RS (1) | RS52931B (enExample) |
| SG (2) | SG150511A1 (enExample) |
| SI (1) | SI1718608T1 (enExample) |
| TW (2) | TWI368507B (enExample) |
| UA (2) | UA94602C2 (enExample) |
| UY (1) | UY28758A1 (enExample) |
| WO (1) | WO2005080388A1 (enExample) |
| ZA (1) | ZA200605151B (enExample) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4080541B2 (ja) | 1996-10-18 | 2008-04-23 | バーテックス ファーマシューティカルズ インコーポレイテッド | セリンプロテアーゼ、特にc型肝炎ウイルスns3プロテアーゼの阻害因子 |
| SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
| EP2335700A1 (en) | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
| US20050075279A1 (en) * | 2002-10-25 | 2005-04-07 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
| US7098231B2 (en) * | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| US7223785B2 (en) * | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| TW201127828A (en) | 2003-09-05 | 2011-08-16 | Vertex Pharma | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease |
| ES2431314T3 (es) * | 2004-02-20 | 2013-11-26 | Boehringer Ingelheim International Gmbh | Inhibidores de polimerasa vírica |
| US7772271B2 (en) | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| AU2005275181A1 (en) | 2004-07-14 | 2006-02-23 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| US7868037B2 (en) | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| NZ553329A (en) | 2004-07-22 | 2010-09-30 | Ptc Therapeutics Inc | Thienopyridines for treating hepatitis C |
| US7153848B2 (en) | 2004-08-09 | 2006-12-26 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
| MY141025A (en) | 2004-10-29 | 2010-02-25 | Vertex Pharma | Dose forms |
| KR20140022796A (ko) * | 2005-02-11 | 2014-02-25 | 베링거 인겔하임 인터내셔날 게엠베하 | 2,3-이치환된 인돌의 제조방법 |
| US8076365B2 (en) | 2005-08-12 | 2011-12-13 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
| US7964624B1 (en) | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
| US7816348B2 (en) | 2006-02-03 | 2010-10-19 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| US8039475B2 (en) | 2006-02-27 | 2011-10-18 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
| CA2646229A1 (en) | 2006-03-16 | 2007-09-27 | Vertex Pharmaceuticals Incorporated | Deuterated hepatitis c protease inhibitors |
| GB0608928D0 (en) | 2006-05-08 | 2006-06-14 | Angeletti P Ist Richerche Bio | Therapeutic agents |
| EP2054388A4 (en) | 2006-08-17 | 2009-10-28 | Boehringer Ingelheim Int | VIRAL POLYMERASE INHIBITORS |
| CA2672290A1 (en) * | 2007-01-15 | 2008-07-24 | The United States Of America, As Represented By The Secretary Of The Arm Y, On Behalf Of The U.S. Army Research Institute Of Infectious Diseases | Antiviral compounds and methods of using thereof |
| HRP20120330T1 (hr) | 2007-02-27 | 2012-05-31 | Vertex Pharmaceuticals Incorporated | Sukristali i farmaceutski pripravci koji ih sadrže |
| WO2008106058A2 (en) | 2007-02-27 | 2008-09-04 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
| CN102872461A (zh) | 2007-05-04 | 2013-01-16 | 弗特克斯药品有限公司 | 用于治疗hcv感染的组合治疗 |
| WO2009010785A1 (en) | 2007-07-17 | 2009-01-22 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Macrocyclic indole derivatives for the treatment of hepatitis c infections |
| US8242140B2 (en) | 2007-08-03 | 2012-08-14 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| US8492546B2 (en) | 2007-08-30 | 2013-07-23 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
| MX2010006210A (es) | 2007-12-05 | 2010-08-10 | Enanta Pharm Inc | Inhibidores de serina proteasa de hcv de tripeptido fluorado. |
| EA201000948A1 (ru) | 2007-12-19 | 2011-02-28 | Бёрингер Ингельхайм Интернациональ Гмбх | Ингибиторы вирусной полимеразы |
| AR072297A1 (es) | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
| UA103195C2 (uk) | 2008-08-11 | 2013-09-25 | Глаксосмитклайн Ллк | Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань |
| MX2011001662A (es) | 2008-08-11 | 2011-03-24 | Glaxosmithkline Llc | Derivados de purina para usarse en el tratamiento de enfermedades alergicas, inflamatorias e infecciosas. |
| KR101649881B1 (ko) | 2008-08-11 | 2016-08-30 | 글락소스미스클라인 엘엘씨 | 신규의 아데닌 유도체 |
| MY152824A (en) * | 2008-09-17 | 2014-11-28 | Boehringer Ingelheim Int | Combination of hcv ns3 protease inhibitor with interferon and ribavirin. |
| JP2012051803A (ja) * | 2008-12-25 | 2012-03-15 | Kyorin Pharmaceutical Co Ltd | 環状アミノ安息香酸エステル誘導体の製造方法 |
| MX2011007195A (es) | 2009-01-07 | 2013-07-12 | Scynexis Inc | Derivado de ciclosporina para el uso en el tratamiento de infección de virus de hepatitis c (vhc) y virus de inmunodeficiencia humana (vih). |
| EP2396028A2 (en) | 2009-02-12 | 2011-12-21 | Vertex Pharmceuticals Incorporated | Hcv combination therapies comprising pegylated interferon, ribavirin and telaprevir |
| CA2756870A1 (en) | 2009-03-31 | 2010-10-07 | Arqule, Inc. | Substituted indolo-pyridinone compounds |
| MX2011012155A (es) | 2009-05-13 | 2012-02-28 | Enanta Pharm Inc | Compuestos macrociclicos como inhibidores del virus de hepatitis c. |
| ES2414934T3 (es) * | 2009-06-11 | 2013-07-23 | Abbvie Bahamas Limited | Inhibidores del virus de la Hepatitis C |
| US8937150B2 (en) * | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
| WO2010149359A1 (en) * | 2009-06-26 | 2010-12-29 | Lonza Ltd | Process and intermediates for the preparation of benzimidazolecarboxylic acids |
| JP2012533569A (ja) * | 2009-07-16 | 2012-12-27 | ヴァーテックス ファーマシューティカルズ、 インコーポレイテッド | フラビウイルス感染症を治療又は予防するためのベンゾイミダゾール類似体 |
| NZ598465A (en) | 2009-10-30 | 2013-10-25 | Boehringer Ingelheim Int | Dosage regimens for hcv combination therapy comprising bi201335, interferon alpha and ribavirin |
| WO2011094489A1 (en) | 2010-01-29 | 2011-08-04 | Vertex Pharmaceuticals Incorporated | Therapies for treating hepatitis c virus infection |
| WO2011098451A1 (en) | 2010-02-10 | 2011-08-18 | Glaxosmithkline Llc | Purine derivatives and their pharmaceutical uses |
| EA021048B1 (ru) | 2010-02-10 | 2015-03-31 | ГЛАКСОСМИТКЛАЙН ЭлЭлСи | Малеат 6-амино-2-{[(1s)-1-метилбутил]окси}-9-[5-(1-пиперидинил)пентил]-7,9-дигидро-8н-пурин-8-она |
| WO2011156545A1 (en) | 2010-06-09 | 2011-12-15 | Vertex Pharmaceuticals Incorporated | Viral dynamic model for hcv combination therapy |
| US20120014912A1 (en) | 2010-07-14 | 2012-01-19 | Vertex Pharmaceuticals Incorporated | Palatable pharmaceutical composition |
| SG188618A1 (en) | 2010-09-21 | 2013-04-30 | Enanta Pharm Inc | Macrocyclic proline derived hcv serine protease inhibitors |
| JP2013543495A (ja) * | 2010-09-30 | 2013-12-05 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 強力なhcvインヒビターの固体形体 |
| AU2011310761A1 (en) * | 2010-09-30 | 2013-02-21 | Boehringer Ingelheim International Gmbh | Combination therapy for treating HCV infection |
| WO2012109646A1 (en) | 2011-02-11 | 2012-08-16 | Vertex Pharmaceuticals Incorporated | Treatment of hcv in hiv infection patients |
| US20130195797A1 (en) | 2012-01-31 | 2013-08-01 | Vertex Pharmaceuticals Incorporated | High potency formulations of vx-950 |
| WO2013147750A1 (en) | 2012-03-27 | 2013-10-03 | Boehringer Ingelheim International Gmbh | Oral combination therapy for treating hcv infection in specific patient sub-population |
| WO2013147749A1 (en) | 2012-03-27 | 2013-10-03 | Boehringer Ingelheim International Gmbh | Oral combination therapy for treating hcv infection in specific patient subgenotype populations |
| US20130261134A1 (en) * | 2012-03-30 | 2013-10-03 | Boehringer Ingelheim International Gmbh | Mesylate salt forms of a potent hcv inhibitor |
| WO2014138374A1 (en) | 2013-03-08 | 2014-09-12 | Boehringer Ingelheim International Gmbh | Oral combination therapy for treating hcv infection in specific patient sub-population |
| CN103408430B (zh) * | 2013-08-30 | 2014-09-17 | 南京理工大学 | 一种2-甲基-4-硝基苯甲酸的合成方法 |
| CA2938476A1 (en) | 2014-02-20 | 2015-08-27 | Glaxosmithkline Intellectual Property (No.2) Limited | Pyrrolo[3,2-d]pyrimidine derivatives as inducers of human interferon |
| CN104130143B (zh) * | 2014-08-06 | 2017-02-15 | 江苏鼎龙科技有限公司 | 3‑甲氨基‑4‑硝基苯氧乙醇的制备方法 |
| CN107108628A (zh) | 2014-11-13 | 2017-08-29 | 葛兰素史密丝克莱恩生物有限公司 | 可用于治疗变应性疾病或其它炎性病症的腺嘌呤衍生物 |
| WO2017093933A1 (en) | 2015-12-03 | 2017-06-08 | Glaxosmithkline Intellectual Property Development Limited | Cyclic purine dinucleotides as modulators of sting |
| SG10201900628RA (en) | 2016-04-07 | 2019-02-27 | Glaxosmithkline Ip Dev Ltd | Heterocyclic amides useful as protein modulators |
| ES2781474T3 (es) | 2016-04-07 | 2020-09-02 | Glaxosmithkline Ip Dev Ltd | Amidas heterocíclicas útiles como moduladores de proteínas |
| CN105884627A (zh) * | 2016-04-22 | 2016-08-24 | 成都东电艾尔科技有限公司 | 一种氧烯洛尔药物中间体邻氨基苯酚的合成方法 |
| EP3241830A1 (de) | 2016-05-04 | 2017-11-08 | Bayer CropScience Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
| BR112019003158B1 (pt) | 2016-08-15 | 2022-10-25 | Bayer Cropscience Aktiengesellschaft | Derivados de heterociclo bicíclico condensado, seu uso, formulação agroquímica, e método para controlar pragas animais |
| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| US20210238172A1 (en) | 2017-10-05 | 2021-08-05 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides useful as protein modulators and methods of using the same |
| EP3692034A1 (en) | 2017-10-05 | 2020-08-12 | GlaxoSmithKline Intellectual Property Development Limited | Modulators of stimulator of interferon genes (sting) |
| KR20200122353A (ko) | 2018-02-21 | 2020-10-27 | 바이엘 악티엔게젤샤프트 | 해충 방제제로서의 축합 바이시클릭 헤테로시클릭 유도체 |
| GB201807924D0 (en) | 2018-05-16 | 2018-06-27 | Ctxt Pty Ltd | Compounds |
| EP3969452A1 (en) | 2019-05-16 | 2022-03-23 | Stingthera, Inc. | Benzo[b][1,8]naphthyridine acetic acid derivatives and methods of use |
| CN114302875A (zh) | 2019-05-16 | 2022-04-08 | 斯汀塞拉股份有限公司 | 氧代吖啶基乙酸衍生物及使用方法 |
| GB201910305D0 (en) | 2019-07-18 | 2019-09-04 | Ctxt Pty Ltd | Compounds |
| GB201910304D0 (en) | 2019-07-18 | 2019-09-04 | Ctxt Pty Ltd | Compounds |
| WO2021119753A1 (en) | 2019-12-18 | 2021-06-24 | Ctxt Pty Limited | Compounds |
| US20230357125A1 (en) * | 2022-05-06 | 2023-11-09 | AMPAC Fine Chemicals | Process for Catalytic Reduction of Nitro Compounds to Amines |
| CN115304584B (zh) * | 2022-07-25 | 2023-05-26 | 云南大学 | 3-硫甲基-(5’-芳基-1h-吡唑)-吲哚类化合物及其制备方法和用途 |
Family Cites Families (215)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1094903A (en) | 1964-03-26 | 1967-12-13 | Smith Kline French Lab | Improvements in or relating to nitrofuran derivatives |
| FR1604809A (en) | 1965-11-26 | 1972-04-17 | Thiazolyl benzimidazoles - animal feed additives | |
| GB1186504A (en) | 1966-10-15 | 1970-04-02 | Fisons Pest Control Ltd | Substituted Heterocyclic Compounds |
| NL6917115A (enExample) | 1968-11-22 | 1970-05-26 | ||
| US3565912A (en) | 1969-01-27 | 1971-02-23 | Upjohn Co | 5-lower-alkanoyl-2,3-bis(p-methoxyphenyl)indoles |
| DE2346316C2 (de) | 1973-09-14 | 1985-02-14 | Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von 2-Furylbenzimidazolen |
| GB1521471A (en) | 1974-06-05 | 1978-08-16 | Randall & Son Ltd J | Token-deposit locks |
| FR2291749A1 (fr) | 1974-11-20 | 1976-06-18 | Delalande Sa | Nouveaux benzimidazoles acetiques, leur procede de preparation et leur application en therapeutique |
| US4003908A (en) | 1976-03-11 | 1977-01-18 | E. R. Squibb & Sons, Inc. | Derivatives of imidazo(4,5-b)pyridines |
| CH632628B (de) | 1976-07-26 | Ciba Geigy Ag | Verfahren zur herstellung von benzofuranyl-benzimidazolen und deren verwendung als optische aufheller. | |
| DE2641060A1 (de) | 1976-09-11 | 1978-03-16 | Hoechst Ag | Beta-lactamverbindungen und verfahren zu ihrer herstellung |
| US4264325A (en) | 1977-02-22 | 1981-04-28 | Ciba-Geigy Corporation | Phenyl-benzimidazolyl-furanes for optical brightening of organic materials |
| DE2720111A1 (de) | 1977-05-05 | 1978-11-16 | Agfa Gevaert Ag | Korrosionsschutzmittel fuer zweibad-stabilisatorbaeder |
| EP0010063B1 (de) | 1978-10-04 | 1982-12-29 | Ciba-Geigy Ag | Verfahren zur Herstellung von Furanyl-benzazolen |
| ZA795239B (en) | 1978-10-12 | 1980-11-26 | Glaxo Group Ltd | Heterocyclic compounds |
| DE2852531A1 (de) | 1978-12-05 | 1980-06-19 | Bayer Ag | Benzofuranyl-benzimidazole |
| DE2853765A1 (de) | 1978-12-13 | 1980-06-26 | Bayer Ag | Verfahren zur herstellung von benzimidazolylbenzofuranen |
| DE2904829A1 (de) | 1979-02-08 | 1980-08-14 | Bayer Ag | Verfahren zur herstellung von benzimidazolylbenzofuran |
| US4384121A (en) | 1979-11-01 | 1983-05-17 | Ciba-Geigy Corporation | Cationic fluorescent whitening agents |
| GR75101B (enExample) | 1980-10-23 | 1984-07-13 | Pfizer | |
| GB8707798D0 (en) | 1987-04-01 | 1987-05-07 | Ici Plc | Recovery of metals |
| ZA825413B (en) | 1981-08-26 | 1983-06-29 | Pfizer | Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them |
| GB2118552A (en) | 1982-04-15 | 1983-11-02 | Pfizer Ltd | Thromboxane synthetase inhibitors |
| JPS60149502A (ja) | 1984-01-12 | 1985-08-07 | Kuraray Co Ltd | インド−ル系農園芸用殺菌剤 |
| LU85544A1 (fr) | 1984-09-19 | 1986-04-03 | Cird | Derives heterocycliques aromatiques,leur procede de preparation et leur application dans les domaines therapeutique et cosmetique |
| DE3522230A1 (de) | 1985-06-21 | 1987-01-02 | Thomae Gmbh Dr K | Neue 2-arylimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| GB8707051D0 (en) | 1986-04-15 | 1987-04-29 | Ici America Inc | Heterocyclic carboxamides |
| GB8609175D0 (en) | 1986-04-15 | 1986-05-21 | Ici America Inc | Heterocyclic carboxamides |
| US4859684A (en) | 1986-09-15 | 1989-08-22 | Janssen Pharmaceutica N.V. | (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives and use thereof in treating androgen dependent disorders |
| CA1322005C (en) | 1987-11-25 | 1993-09-07 | Robert N. Young | Benzoheterazoles |
| JP2700475B2 (ja) | 1988-07-30 | 1998-01-21 | コニカ株式会社 | 非線形光学材料および非線形光学素子 |
| JPH03157646A (ja) | 1989-11-15 | 1991-07-05 | Konica Corp | ハロゲン化銀写真感光材料 |
| JPH03219232A (ja) | 1990-01-24 | 1991-09-26 | Konica Corp | 分光増感されたハロゲン化銀写真感光材料 |
| JPH05507469A (ja) | 1990-04-13 | 1993-10-28 | スミスクライン・ビーチャム・コーポレイション | 置換ベンズイミダゾール |
| JP2909645B2 (ja) | 1990-05-28 | 1999-06-23 | コニカ株式会社 | ハロゲン化銀カラー写真感光材料 |
| US5110494A (en) | 1990-08-24 | 1992-05-05 | Man-Gill Chemical Company | Alkaline cleaner and process for reducing stain on aluminum surfaces |
| DK0565634T3 (da) | 1990-12-14 | 1999-09-27 | Smithkline Beecham Corp | Angiotensin-II-receptorblokkersammensætninger |
| US5527819A (en) | 1991-09-06 | 1996-06-18 | Merck & Co., Inc. | Inhibitors of HIV reverse transcriptase |
| PT100905A (pt) | 1991-09-30 | 1994-02-28 | Eisai Co Ltd | Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem |
| GB9121463D0 (en) | 1991-10-10 | 1991-11-27 | Smithkline Beecham Corp | Medicament |
| GB9122590D0 (en) | 1991-10-24 | 1991-12-04 | Lilly Industries Ltd | Pharmaceutical compounds |
| JPH05165163A (ja) | 1991-12-11 | 1993-06-29 | Konica Corp | 色素画像形成方法 |
| JP3013124B2 (ja) | 1991-12-26 | 2000-02-28 | コニカ株式会社 | カラー画像形成方法 |
| US5216003A (en) | 1992-01-02 | 1993-06-01 | G. D. Searle & Co. | Diacid-containing benzimidazole compounds for treatment of neurotoxic injury |
| US5314796A (en) | 1992-04-02 | 1994-05-24 | Konica Corporation | Silver halide color photographic light sensitive material |
| US5387600A (en) | 1992-07-30 | 1995-02-07 | Fuji Photo Film Co., Ltd. | Treating arteriosclerosis using benzimidazole compositions |
| DE4237557A1 (de) | 1992-11-06 | 1994-05-11 | Bayer Ag | Substituierte Benzimidazole |
| DE4237617A1 (de) | 1992-11-06 | 1994-05-11 | Bayer Ag | Verwendung von substituierten Benzimidazolen |
| CA2400368A1 (en) | 1992-12-02 | 1994-06-09 | Allen J. Duplantier | Catechol diethers as selective pde iv inhibitors |
| JP3213426B2 (ja) | 1993-02-19 | 2001-10-02 | エーザイ株式会社 | 6,7−ジヒドロ−5H−シクロペンタ〔d〕ピリミジン誘導体 |
| EP0615159B1 (en) | 1993-03-04 | 2004-09-22 | Fuji Photo Film Co., Ltd. | Silver halide photographic material |
| DE4309969A1 (de) | 1993-03-26 | 1994-09-29 | Bayer Ag | Substituierte heteroanellierte Imidazole |
| US6169107B1 (en) | 1993-04-28 | 2001-01-02 | Sumitomo Pharmaceutical Co., Ltd. | Indoloylguanidine derivatives |
| JP3156444B2 (ja) | 1993-06-02 | 2001-04-16 | 松下電器産業株式会社 | 短波長レーザ光源およびその製造方法 |
| DE4330959A1 (de) | 1993-09-09 | 1995-03-16 | Schering Ag | Neue Benzimidazolderivate, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung |
| DE59509233D1 (de) | 1994-02-24 | 2001-06-13 | Haarmann & Reimer Gmbh | Kosmetische und dermatologische zubereitungen, enthaltend phenylen-1,4-bisbenzimidiazolesulfonsäuren |
| CA2124169A1 (en) | 1994-05-24 | 1995-11-25 | Richard Mcculloch Keenan | Chemical compounds |
| US5912260A (en) | 1994-05-27 | 1999-06-15 | James Black Foundation Limited | Gastrin and CCK antagonists |
| ES2159648T3 (es) | 1994-11-29 | 2001-10-16 | Dainippon Pharmaceutical Co | Derivado de indol. |
| EP0717143A1 (de) | 1994-12-16 | 1996-06-19 | Lignozym GmbH | Mehrkomponentensystem zum Verändern, Abbau oder Bleichen von Lignin, ligninhaltigen Materialien oder ähnlichen Stoffen sowie Verfahren zu seiner Anwendung |
| DE19507913C2 (de) | 1995-03-07 | 1998-04-16 | Agfa Gevaert Ag | Farbfotografisches Silberhalogenidmaterial |
| ATE219765T1 (de) | 1995-04-10 | 2002-07-15 | Fujisawa Pharmaceutical Co | Indolderivate als cgmp-pde inhibitoren |
| US6444694B1 (en) | 1995-06-06 | 2002-09-03 | Wyeth | Styryl benzimidazole derivatives |
| JP3544245B2 (ja) | 1995-06-09 | 2004-07-21 | 富士写真フイルム株式会社 | ハロゲン化銀カラー写真感光材料の処理方法 |
| EP0791582A4 (en) | 1995-08-04 | 1997-12-10 | Otsuka Kagaku Kk | DERIVATIVES OF INDOLE-2-CARBOXYLIC ACID ESTERS, AND BACTERICIDES FOR AGRICULTURE AND HORTICULTURE CONTAINING THEM AS ACTIVE INGREDIENTS |
| AU6966696A (en) | 1995-10-05 | 1997-04-28 | Warner-Lambert Company | Method for treating and preventing inflammation and atherosclerosis |
| ATE210116T1 (de) | 1995-10-05 | 2001-12-15 | Kyoto Pharma Ind | Neue heterozyklische derivate und ihre medizinische anwendung |
| JPH09124632A (ja) | 1995-10-31 | 1997-05-13 | Sankyo Co Ltd | ベンゾヘテロ環誘導体 |
| CA2241186C (en) | 1995-12-28 | 2006-02-14 | Fujisawa Pharmaceutical Co., Ltd. | Benzimidazole derivatives |
| GB9610811D0 (en) | 1996-05-23 | 1996-07-31 | Pharmacia Spa | Combinatorial solid phase synthesis of a library of indole derivatives |
| JP4373497B2 (ja) | 1996-06-19 | 2009-11-25 | ローン−プーラン・ロレ・リミテツド | 置換されたアザビシクロ化合物、ならびにtnfおよびサイクリックampホスホジエステラーゼ産生の阻害剤としてのそれらの使用 |
| GB9614347D0 (en) | 1996-07-09 | 1996-09-04 | Smithkline Beecham Spa | Novel compounds |
| AUPO118896A0 (en) | 1996-07-23 | 1996-08-15 | Fujisawa Pharmaceutical Co., Ltd. | New use |
| EP0923582B1 (en) | 1996-08-28 | 2006-09-20 | Pfizer Inc. | Substituted 6,5-hetero-bicyclic derivatives |
| JPH10114654A (ja) | 1996-10-09 | 1998-05-06 | Fujisawa Pharmaceut Co Ltd | 新規用途 |
| CA2276042C (en) | 1996-12-26 | 2002-10-08 | Michika Takano | N-hydroxyurea derivatives and medicinal compositions containing the same |
| JPH10204059A (ja) | 1997-01-22 | 1998-08-04 | Ono Pharmaceut Co Ltd | フェニルスルホンアミド誘導体 |
| CN1100777C (zh) | 1997-02-19 | 2003-02-05 | 伯莱克斯实验室公司 | 作为nos抑制剂的n-杂环衍生物 |
| AU6229298A (en) | 1997-02-20 | 1998-09-09 | Shionogi & Co., Ltd. | Indole dicarboxylic acid derivatives |
| DE69829381T2 (de) | 1997-08-11 | 2006-04-13 | Boehringer Ingelheim (Canada) Ltd., Laval | Hepatitis c inhibitor peptide |
| EP1012180B1 (en) | 1997-08-11 | 2004-12-01 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis c inhibitor peptide analogues |
| US5932743A (en) | 1997-08-21 | 1999-08-03 | American Home Products Corporation | Methods for the solid phase synthesis of substituted indole compounds |
| DE19753522A1 (de) | 1997-12-03 | 1999-06-10 | Boehringer Ingelheim Pharma | Substituierte Indole, ihre Herstellung und ihre Verwendung als Arzneimittel |
| SE9704545D0 (sv) | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
| SE9704544D0 (sv) | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
| JPH11177218A (ja) | 1997-12-12 | 1999-07-02 | Tamura Kaken Co Ltd | 電子回路用金属面具備部品及びその表面保護剤 |
| HUP0102128A3 (en) | 1998-05-22 | 2002-05-28 | Avanir Pharmaceuticals San Die | Mediciaments containing benzimidazole derivatives as modulators of ige |
| US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| CN1302293A (zh) | 1998-06-18 | 2001-07-04 | 诺瓦提斯公司 | 吲哚类化合物及其用途 |
| US7223879B2 (en) | 1998-07-10 | 2007-05-29 | Massachusetts Institute Of Technology | Ligands for metals and improved metal-catalyzed processes based thereon |
| US6445525B1 (en) * | 1998-07-16 | 2002-09-03 | Seagate Technology Llc | Disc drive performance by reducing areal data storage density |
| JP2003525200A (ja) | 1998-07-27 | 2003-08-26 | イスティトゥト ディ リチェルケ ディ ビオロジア モレコラーレ ピー.アンジェレッティ ソチエタ ペル アツィオニ | ポリメラーゼ阻害剤としてのジケト酸誘導体 |
| US6228868B1 (en) | 1998-07-27 | 2001-05-08 | Abbott Laboratories | Oxazoline antiproliferative agents |
| AU5227999A (en) | 1998-07-27 | 2000-02-21 | Abbott Laboratories | Substituted oxazolines as antiproliferative agents |
| GB9816654D0 (en) | 1998-07-30 | 1998-09-30 | Zeneca Ltd | Chemical compounds |
| AR022061A1 (es) | 1998-08-10 | 2002-09-04 | Boehringer Ingelheim Ca Ltd | Peptidos inhibidores de la hepatitis c, una composicion farmaceutica que los contiene, el uso de los mismos para preparar una composicion farmaceutica, el uso de un producto intermedio para la preparacion de estos peptidos y un procedimiento para la preparacion de un peptido analogo de los mismos. |
| US6323180B1 (en) | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
| ID27787A (id) | 1998-08-21 | 2001-04-26 | Viro Pharma Inc | Senyawa, komposisi dan metode untuk pengobatan atau pencegahan infeksi yang disebabkan oleh virus dan penyakit-penyakit yang berkaitan |
| MXPA01002253A (es) | 1998-09-04 | 2003-06-04 | Viropharma Inc | Metodo para tratar o prevenir infecciones virales y enfermedades asociadas. |
| JP2002525295A (ja) | 1998-09-25 | 2002-08-13 | バイロファーマ・インコーポレイテッド | ウイルス感染および関連疾患の治療または予防法 |
| GB9823871D0 (en) | 1998-10-30 | 1998-12-23 | Pharmacia & Upjohn Spa | 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents |
| WO2000027846A2 (en) | 1998-11-12 | 2000-05-18 | Neurocrine Biosciences, Inc. | Crf receptor antagonists and methods relating thereto |
| US6531475B1 (en) | 1998-11-12 | 2003-03-11 | Neurocrine Biosciences, Inc. | CRF receptor antagonists and methods relating thereto |
| US6358992B1 (en) | 1998-11-25 | 2002-03-19 | Cell Pathways, Inc. | Method of inhibiting neoplastic cells with indole derivatives |
| US6869950B1 (en) | 1998-12-24 | 2005-03-22 | Fujisawa Pharmaceutical Co., Ltd. | Benzimidazole derivatives |
| EP1175419B1 (en) | 1999-04-02 | 2003-05-28 | Bristol-Myers Squibb Pharma Company | Aryl sulfonyls as factor xa inhibitors |
| UA74546C2 (en) | 1999-04-06 | 2006-01-16 | Boehringer Ingelheim Ca Ltd | Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition |
| US6478874B1 (en) | 1999-08-06 | 2002-11-12 | Engelhard Corporation | System for catalytic coating of a substrate |
| DE19951360A1 (de) | 1999-10-26 | 2001-05-03 | Aventis Pharma Gmbh | Substituierte Indole |
| JP2001122855A (ja) | 1999-10-27 | 2001-05-08 | Japan Tobacco Inc | インドール化合物及びその医薬用途 |
| WO2001030744A1 (en) | 1999-10-28 | 2001-05-03 | Eoc Surfactants Nv | Process for the preparation of flowable concentrated betaine solution |
| US6455525B1 (en) | 1999-11-04 | 2002-09-24 | Cephalon, Inc. | Heterocyclic substituted pyrazolones |
| AU1262001A (en) | 1999-11-04 | 2001-05-14 | Biochem Pharma Inc. | Method for the treatment or prevention of flaviviridae viral infection using nucleoside analogues |
| EP1990343B1 (en) | 1999-12-24 | 2012-04-04 | Aventis Pharma Limited | Azaindoles |
| US6770666B2 (en) | 1999-12-27 | 2004-08-03 | Japan Tobacco Inc. | Fused-ring compounds and use thereof as drugs |
| IL145071A0 (en) * | 1999-12-27 | 2002-06-30 | Japan Tobacco Inc | Fused ring compounds and pharmaceutical compositions containing the same |
| JP2003519697A (ja) | 1999-12-28 | 2003-06-24 | ファイザー・プロダクツ・インク | 炎症性疾患、自己免疫疾患および呼吸器疾患の処置に有用な非ペプチド系のvla−4依存性細胞結合阻害薬 |
| GB0003397D0 (en) | 2000-02-14 | 2000-04-05 | Merck Sharp & Dohme | Therapeutic agents |
| MXPA02008078A (es) | 2000-02-18 | 2002-11-29 | Julio Javier Cristiani | Metodo para el tratamiento o prevencion de infecciones por flavivirus utilizando analogos de nucleosidos. |
| WO2001077091A2 (en) | 2000-04-05 | 2001-10-18 | Tularik Inc. | Ns5b hcv polymerase inhibitors |
| US6713502B2 (en) | 2000-05-05 | 2004-03-30 | Smithkline Beecham Corporation | Anti-infectives |
| EP1292310A1 (en) | 2000-05-10 | 2003-03-19 | SmithKline Beecham Corporation | Novel anti-infectives |
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| KR100372218B1 (ko) | 2000-06-29 | 2003-02-14 | 바이오인포메틱스 주식회사 | 유기산을 생산하는 균주 및 이를 이용한 유기산의 생산방법 |
| US6448281B1 (en) | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
| GB0017676D0 (en) | 2000-07-19 | 2000-09-06 | Angeletti P Ist Richerche Bio | Inhibitors of viral polymerase |
| US7244721B2 (en) | 2000-07-21 | 2007-07-17 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
| US20030008841A1 (en) | 2000-08-30 | 2003-01-09 | Rene Devos | Anti-HCV nucleoside derivatives |
| AU2001282528A1 (en) | 2000-09-01 | 2002-03-22 | Shionogi And Co., Ltd. | Compounds having anti-hepatitis c virus effect |
| US6846806B2 (en) | 2000-10-23 | 2005-01-25 | Bristol-Myers Squibb Company | Peptide inhibitors of Hepatitis C virus NS3 protein |
| AU2002248147B2 (en) | 2000-11-20 | 2006-04-06 | Bristol-Myers Squibb Company | Hepatitis C tripeptide inhibitors |
| CN1482914A (zh) | 2000-12-26 | 2004-03-17 | 三菱制药株式会社 | 丙型肝炎治疗剂 |
| CN1267446C (zh) | 2001-01-22 | 2006-08-02 | 默克公司 | 作为依赖于rna的rna病毒聚合酶的抑制剂的核苷衍生物 |
| GB0102109D0 (en) | 2001-01-26 | 2001-03-14 | Syngenta Ltd | Chemical process |
| WO2002069903A2 (en) | 2001-03-06 | 2002-09-12 | Biocryst Pharmaceuticals, Inc. | Nucleosides, preparation thereof and use as inhibitors of rna viral polymerases |
| IL157280A0 (en) | 2001-03-08 | 2004-02-19 | Boehringer Ingelheim Ca Ltd | Assay for identifying inhibitors of the rna dependent rna polymerase (ns5b) of hcv |
| KR100798579B1 (ko) | 2001-03-31 | 2008-01-28 | 동화약품공업주식회사 | 신규의 메톡시-1,3,5-트리아진 유도체 및 그를 포함하는약학적 조성물 |
| EP1256628A3 (en) | 2001-05-10 | 2003-03-19 | Agouron Pharmaceuticals, Inc. | Hepatitis c virus (hcv) ns5b rna polymerase and mutants thereof |
| GB0112617D0 (en) | 2001-05-23 | 2001-07-18 | Hoffmann La Roche | Antiviral nucleoside derivatives |
| AR036081A1 (es) | 2001-06-07 | 2004-08-11 | Smithkline Beecham Corp | Compuesto de 1,2-dihidroquinolina, su uso para preparar una composicion farmaceutica, metodos para prepararlo y compuestos del acido 2-aminobenzoico n-alquilado de utilidad como intermediarios en dichos metodos |
| US6887877B2 (en) | 2001-06-11 | 2005-05-03 | Virochem Pharma Inc. | Compounds and methods for the treatment or prevention of Flavivirus infections |
| CA2450007C (en) | 2001-06-11 | 2012-04-17 | Shire Biochem Inc. | Compounds and methods for the treatment or prevention of flavivirus infections |
| GB0114286D0 (en) | 2001-06-12 | 2001-08-01 | Hoffmann La Roche | Nucleoside Derivatives |
| JP2004534830A (ja) | 2001-06-21 | 2004-11-18 | グラクソ グループ リミテッド | Hcvにおけるヌクレオシド化合物 |
| GB0115109D0 (en) | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
| AR035543A1 (es) | 2001-06-26 | 2004-06-16 | Japan Tobacco Inc | Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con |
| KR100713137B1 (ko) | 2001-06-28 | 2007-05-02 | 동화약품공업주식회사 | 신규의 2,4-디플루오로벤즈아미드 유도체 |
| US6841566B2 (en) * | 2001-07-20 | 2005-01-11 | Boehringer Ingelheim, Ltd. | Viral polymerase inhibitors |
| EP2335700A1 (en) | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
| US7294457B2 (en) | 2001-08-07 | 2007-11-13 | Boehringer Ingelheim (Canada) Ltd. | Direct binding assay for identifying inhibitors of HCV polymerase |
| EP1423365A1 (en) | 2001-08-22 | 2004-06-02 | Ciba Specialty Chemicals Holding Inc. | Process for the preparation of indole derivatives |
| AU2002329970A1 (en) | 2001-09-04 | 2003-03-18 | Isis Pharmaceuticals, Inc. | Pyrrolo(2,3-d)pyrimidines for inhibiting rna-dependent rna viral polymerase |
| US20030134853A1 (en) | 2001-09-26 | 2003-07-17 | Priestley Eldon Scott | Compounds useful for treating hepatitis C virus |
| US7138376B2 (en) | 2001-09-28 | 2006-11-21 | Idenix Pharmaceuticals, Inc. | Methods and compositions for treating hepatitis C virus using 4'-modified nucleosides |
| EP1438054A4 (en) | 2001-09-28 | 2006-07-26 | Idenix Cayman Ltd | METHODS AND COMPOSITIONS FOR TREATING FLAVIVIRUS AND PESTIVIRUS USING MODIFIED NUCLEOSIDE AT 4 'POSITION |
| WO2003037262A2 (en) | 2001-10-29 | 2003-05-08 | Smithkline Beecham Corporation | Novel anit-infectives |
| AU2002365198A1 (en) | 2001-10-30 | 2003-07-30 | Smithkline Beecham Corporation | Novel anti-infectives |
| JP2005515172A (ja) | 2001-11-02 | 2005-05-26 | グラクソ グループ リミテッド | Hcv阻害剤としての4−(6−員)−ヘテロアリールアシルピロリジン誘導体 |
| EP1440070A1 (en) | 2001-11-02 | 2004-07-28 | Glaxo Group Limited | 4-(5-membered)-heteroaryl acyl pyrrolidine derivatives as hcv inhibitors |
| MY151199A (en) | 2001-11-02 | 2014-04-30 | Rigel Pharmaceuticals Inc | Substituted diphenyl heterocycles useful for treating hcv infection |
| US20050009873A1 (en) | 2001-11-02 | 2005-01-13 | Gianpaolo Bravi | Acyl dihydro pyrrole derivatives as hcv inhibitors |
| WO2003042265A1 (fr) | 2001-11-13 | 2003-05-22 | Toray Industries, Inc. | Polymere et lentilles ophthalmologiques realisees a l'aide de ce polymere |
| CA2466301A1 (en) | 2001-11-14 | 2003-10-23 | Biocryst Pharmaceuticals, Inc. | Nucleosides preparation thereof and use as inhibitors of rna viral polymerases |
| US6867185B2 (en) | 2001-12-20 | 2005-03-15 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus |
| EP1321463B1 (en) | 2001-12-21 | 2007-08-08 | Virochem Pharma Inc. | Thiazole derivatives and their use for the treatment or prevention of Flavivirus infections |
| EP1572705A2 (en) | 2002-01-17 | 2005-09-14 | Ribapharm, Inc. | Sugar modified nucleosides as viral replication inhibitors |
| WO2003062256A1 (en) | 2002-01-17 | 2003-07-31 | Ribapharm Inc. | 2'-beta-modified-6-substituted adenosine analogs and their use as antiviral agents |
| WO2003061385A1 (en) | 2002-01-17 | 2003-07-31 | Ribapharm Inc. | Tricyclic nucleoside library compounds, synthesis, and use as antiviral agents |
| GB0201179D0 (en) | 2002-01-18 | 2002-03-06 | Angeletti P Ist Richerche Bio | Therapeutic agents |
| CA2369711A1 (en) | 2002-01-30 | 2003-07-30 | Boehringer Ingelheim (Canada) Ltd. | Macrocyclic peptides active against the hepatitis c virus |
| CA2370396A1 (en) | 2002-02-01 | 2003-08-01 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis c inhibitor tri-peptides |
| CA2369970A1 (en) | 2002-02-01 | 2003-08-01 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis c inhibitor tri-peptides |
| CA2480583C (en) | 2002-04-01 | 2008-07-15 | Pfizer Inc. | Pyranon and pyrandion inhibitors of hepatitis c virus rna-dependent rna polymerase |
| KR100516434B1 (ko) | 2002-04-04 | 2005-09-22 | (주) 비엔씨바이오팜 | 6-(4-치환된-아닐리노)피리미딘 유도체, 그 제조방법 및 이를 포함하는 항바이러스용 약학적 조성물 |
| WO2003090674A2 (en) | 2002-04-23 | 2003-11-06 | Viropharma Incorporated | Compounds, compositions and methods for treating or preventing viral infections and associated diseases |
| US20040063658A1 (en) | 2002-05-06 | 2004-04-01 | Roberts Christopher Don | Nucleoside derivatives for treating hepatitis C virus infection |
| DOP2003000641A (es) | 2002-05-10 | 2003-11-15 | Pfizer | Inhibidores de las arn polimerasa dependiente de arn del virus de las hepatitis c y composiciones y tratamiento que los usan |
| GB0211418D0 (en) | 2002-05-17 | 2002-06-26 | Glaxo Group Ltd | Compounds |
| EP1505945B1 (en) | 2002-05-20 | 2008-11-05 | Bristol-Myers Squibb Company | Substituted cycloalkyl p1' hepatitis c virus inhibitors |
| MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
| JP4312718B2 (ja) | 2002-05-20 | 2009-08-12 | ブリストル−マイヤーズ スクイブ カンパニー | C型肝炎ウイルス阻害剤 |
| AU2003248535A1 (en) | 2002-05-20 | 2003-12-12 | Bristol-Myers Squibb Company | Heterocyclicsulfonamide hepatitis c virus inhibitors |
| TW200400818A (en) | 2002-05-21 | 2004-01-16 | Wyeth Corp | Method for the use of pyranoindole derivatives to treat infection with hepatitis C virus |
| TW200400963A (en) | 2002-05-21 | 2004-01-16 | Wyeth Corp | R-enantiomers of pyranoindole derivatives and the use thereof for the treatment of hepatitis C virus infection or disease |
| AU2003248566A1 (en) | 2002-05-24 | 2003-12-12 | Smithkline Beecham Corporation | Novel anti-infectives |
| MXPA04012245A (es) | 2002-06-04 | 2005-09-30 | Neogenesis Pharmaceuticals Inc | Compuestos de pirazolo[1,5a]pirimidina como agentes antivirales. |
| AU2003251524A1 (en) | 2002-06-17 | 2003-12-31 | Isis Pharmaceuticals, Inc. | Carbocyclic nucleoside analogs as RNA-antivirals |
| WO2004000242A1 (en) | 2002-06-25 | 2003-12-31 | Cosmeceutic Solutions Pty Ltd | Topical cosmetic compositions |
| WO2004003138A2 (en) | 2002-06-27 | 2004-01-08 | Merck & Co., Inc. | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
| RS114104A (sr) | 2002-06-28 | 2007-02-05 | Idenix (Cayman) Limited, | 2'i 3'-nukleozidni prolekovi za lečenje flaviviridae infekcija |
| AU2003247084B9 (en) | 2002-06-28 | 2018-07-26 | Centre National De La Recherche Scientifique | Modified 2' and 3'-nucleoside prodrugs for treating flaviridae infections |
| CA2489552A1 (en) | 2002-06-28 | 2004-01-08 | Idenix (Cayman) Limited | 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| WO2004002940A1 (en) | 2002-07-01 | 2004-01-08 | Pharmacia & Upjohn Company | Inhibitors of hcv ns5b polymerase |
| JP2006504643A (ja) | 2002-07-01 | 2006-02-09 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | Hcvns5bポリメラーゼ阻害剤 |
| GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
| CA2490666A1 (en) | 2002-07-16 | 2004-01-22 | Merck & Co., Inc. | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
| US20050075279A1 (en) | 2002-10-25 | 2005-04-07 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
| US7098231B2 (en) | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| US7223785B2 (en) | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| CA2515216A1 (en) | 2003-02-07 | 2004-08-26 | Enanta Pharmaceuticals, Inc. | Macrocyclic hepatitis c serine protease inhibitors |
| WO2004101602A2 (en) | 2003-03-05 | 2004-11-25 | Boehringer Ingelheim International Gmbh | Hepatitis c inhibitor peptide analogs |
| EP1601685A1 (en) | 2003-03-05 | 2005-12-07 | Boehringer Ingelheim International GmbH | Hepatitis c inhibiting compounds |
| GB0307891D0 (en) | 2003-04-04 | 2003-05-14 | Angeletti P Ist Richerche Bio | Chemical compounds,compositions and uses |
| ES2320771T3 (es) | 2003-04-16 | 2009-05-28 | Bristol-Myers Squibb Company | Inhibidores peptidicos de isoquinolina macrociclicos del virus de la hepatitis c. |
| PL1615613T3 (pl) | 2003-04-18 | 2010-04-30 | Enanta Pharm Inc | Chinoksalinylowe makrocykliczne inhibitory proteazy serynowej zapalenia wątroby typu C |
| MXPA05012316A (es) | 2003-05-12 | 2006-04-18 | Affymax Inc | Peptidos novedosos que se unen al receptor de la eritropoyetina. |
| UY28323A1 (es) | 2003-05-21 | 2004-12-31 | Boehringer Ingelheim Int | Compuestos inhibidores de la hepatitis c |
| EP1493440A1 (en) * | 2003-07-03 | 2005-01-05 | Rinoru Oil Mills Co., Ltd. | Prophylactic agent of hypertension containing a conjugated fatty acid as an effective ingredient and the use thereof |
| US7511145B2 (en) | 2003-08-01 | 2009-03-31 | Genelabs Technologies, Inc. | Bicyclic heteroaryl derivatives |
| WO2005014543A1 (ja) | 2003-08-06 | 2005-02-17 | Japan Tobacco Inc. | 縮合環化合物及びそのhcvポリメラーゼ阻害剤としての利用 |
| ES2431314T3 (es) | 2004-02-20 | 2013-11-26 | Boehringer Ingelheim International Gmbh | Inhibidores de polimerasa vírica |
| AU2005227289B2 (en) | 2004-03-08 | 2012-03-08 | Boehringer Ingelheim Pharmaceuticals, Inc. | Process for cross coupling indoles |
| CA2558051C (en) | 2004-03-16 | 2013-03-12 | Boehringer Ingelheim International Gmbh | Palladium catalyzed indolization of 2-bromo or chloroanilines |
| PE20060569A1 (es) | 2004-07-16 | 2006-06-22 | Boehringer Ingelheim Int | Compuestos de indol carbonilamino como inhibidores de la polimerasa ne5b del vhc |
| KR20140022796A (ko) | 2005-02-11 | 2014-02-25 | 베링거 인겔하임 인터내셔날 게엠베하 | 2,3-이치환된 인돌의 제조방법 |
-
2005
- 2005-02-18 ES ES05714457T patent/ES2431314T3/es not_active Expired - Lifetime
- 2005-02-18 HR HRP20130971TT patent/HRP20130971T1/hr unknown
- 2005-02-18 NZ NZ549079A patent/NZ549079A/en not_active IP Right Cessation
- 2005-02-18 TW TW094104764A patent/TWI368507B/zh not_active IP Right Cessation
- 2005-02-18 KR KR1020127014204A patent/KR20120091276A/ko not_active Abandoned
- 2005-02-18 CN CNA2005800055395A patent/CN1922174A/zh active Pending
- 2005-02-18 SG SG200900989-5A patent/SG150511A1/en unknown
- 2005-02-18 EA EA200601457A patent/EA013207B1/ru not_active IP Right Cessation
- 2005-02-18 CN CN2013102311710A patent/CN103304541A/zh active Pending
- 2005-02-18 DK DK05714457.8T patent/DK1718608T3/da active
- 2005-02-18 TW TW100123245A patent/TWI368508B/zh not_active IP Right Cessation
- 2005-02-18 RS RS20130350A patent/RS52931B/sr unknown
- 2005-02-18 PL PL05714457T patent/PL1718608T3/pl unknown
- 2005-02-18 US US11/062,305 patent/US7582770B2/en active Active
- 2005-02-18 KR KR1020067019382A patent/KR101320907B1/ko not_active Expired - Fee Related
- 2005-02-18 CN CN201310230892XA patent/CN103319464A/zh active Pending
- 2005-02-18 IN IN4853DEN2012 patent/IN2012DN04853A/en unknown
- 2005-02-18 EP EP05714457.8A patent/EP1718608B1/en not_active Expired - Lifetime
- 2005-02-18 EP EP12196121.3A patent/EP2626354A1/en not_active Withdrawn
- 2005-02-18 UA UAA200811052A patent/UA94602C2/ru unknown
- 2005-02-18 MY MYPI20050612A patent/MY144718A/en unknown
- 2005-02-18 PT PT57144578T patent/PT1718608E/pt unknown
- 2005-02-18 UA UAA200609971A patent/UA86962C2/ru unknown
- 2005-02-18 WO PCT/CA2005/000208 patent/WO2005080388A1/en not_active Ceased
- 2005-02-18 CN CN2013102406104A patent/CN103333162A/zh active Pending
- 2005-02-18 AU AU2005215829A patent/AU2005215829C1/en not_active Ceased
- 2005-02-18 CN CN2012102883700A patent/CN102911161A/zh active Pending
- 2005-02-18 CN CN200910166725A patent/CN101648944A/zh active Pending
- 2005-02-18 BR BRPI0507861-0A patent/BRPI0507861A/pt not_active IP Right Cessation
- 2005-02-18 UY UY28758A patent/UY28758A1/es not_active Application Discontinuation
- 2005-02-18 EA EA200901463A patent/EA200901463A1/ru unknown
- 2005-02-18 EA EA201301284A patent/EA201301284A1/ru unknown
- 2005-02-18 AR ARP050100580A patent/AR047706A1/es not_active Application Discontinuation
- 2005-02-18 CA CA2553879A patent/CA2553879C/en not_active Expired - Fee Related
- 2005-02-18 SG SG2012059374A patent/SG184700A1/en unknown
- 2005-02-18 PE PE2005000193A patent/PE20051141A1/es not_active Application Discontinuation
- 2005-02-18 JP JP2006553400A patent/JP4648333B2/ja not_active Expired - Fee Related
- 2005-02-18 SI SI200531780T patent/SI1718608T1/sl unknown
-
2006
- 2006-06-22 ZA ZA200605151A patent/ZA200605151B/en unknown
- 2006-08-17 IL IL177537A patent/IL177537A/en not_active IP Right Cessation
- 2006-08-21 EC EC2006006780A patent/ECSP066780A/es unknown
- 2006-09-06 NO NO20064004A patent/NO20064004L/no not_active Application Discontinuation
-
2009
- 2009-02-17 US US12/372,533 patent/US7879851B2/en not_active Expired - Lifetime
-
2010
- 2010-05-10 JP JP2010108526A patent/JP5394978B2/ja not_active Expired - Fee Related
- 2010-09-27 US US12/891,112 patent/US8030309B2/en not_active Expired - Lifetime
- 2010-09-30 JP JP2010221765A patent/JP2010280740A/ja not_active Withdrawn
-
2012
- 2012-04-15 IL IL219150A patent/IL219150A0/en unknown
-
2013
- 2013-09-02 JP JP2013181619A patent/JP2013237708A/ja not_active Withdrawn
- 2013-10-25 AR ARP130103893A patent/AR093144A2/es unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20064004L (no) | Virale polymeraseinhibitorer | |
| MX2007000007A (es) | Inhibidores de polimerasa viral. | |
| NO20053892L (no) | Virale polymeraseinhibitorer | |
| DE602004017126D1 (de) | Acylsulfonamid-verbindungen als inhibitoren der rna-abhängigen rna-polymerase | |
| NO20082934L (no) | Antivirale nukleotider | |
| NO20071162L (no) | Heterosykliske antivirale forbindelser | |
| DK1654261T3 (da) | Hepatitis C-inhibitorforbindelser | |
| NO20062185L (no) | Hepatitt C virus-inhibitorer | |
| WO2007103550A3 (en) | Substituted aminothiazole derivatives with anti-hcv activity | |
| NZ531229A (en) | Viral polymerase inhibitors | |
| NO20084637L (no) | Cyklopropyl-kondenserte indolobenzaepin HCV NS5B inhibitorer | |
| NO20062267L (no) | Hepatitt C virus inhibitorer | |
| NO20070751L (no) | Inhibitorer av HCV-replifikasjon | |
| ATE432922T1 (de) | Substituierte 5-carboxyamidpyrazoles und ä1,2, 4ütriazole als viruzide | |
| MX2011012541A (es) | Compuestos heterociclicos antivirales. | |
| EP1663105A4 (en) | CYCLOALKYL HETEROCYCLES FOR TREATING HEPATITIS C VIRUS | |
| NO20050871L (no) | 6-amino-1H-indazol- og 4-aminobenzofuranforbindelser som fosfodiesterase 4-inhibitorer | |
| ATE491706T1 (de) | Heterocyclische antivirale verbindungen | |
| CY1114456T1 (el) | Αναστολεις ιικης πολυμερασης | |
| TH86773A (th) | ตัวยับยั้ง hcv ns3 โปรตีเอส | |
| TH148534B (th) | ไซโคลโพรพิลฟิวสด์อินโดโลเบนซาซิพีนซึ่งคือตัวยับยั้งสำหรับ hcv ns5b |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |