NO164029B - Analogifremgangsm te for fremstilling av terapeutisk aktive tieno-triazolo-1,4-diazepino-2-karboksylsyre-amider. - Google Patents
Analogifremgangsm te for fremstilling av terapeutisk aktive tieno-triazolo-1,4-diazepino-2-karboksylsyre-amider. Download PDFInfo
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- NO164029B NO164029B NO855260A NO855260A NO164029B NO 164029 B NO164029 B NO 164029B NO 855260 A NO855260 A NO 855260A NO 855260 A NO855260 A NO 855260A NO 164029 B NO164029 B NO 164029B
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- 230000007423 decrease Effects 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- -1 hydroxy, cyclopropyl Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Description
Pneumatiske dekk med asymmetrisk slitebaneprofilering.
Oppfinnelsen vedrorer pneumatisk dekk med en i forhold til slitebanens midtparti asymmetrisk slitebaneprofilering, hvorved profilrillene på den slitebaneside som vender mot den ytre dekkskulder, er orientert mere i dekkets omkretsretning enn de på den slitebaneside som vender mot den indre dekkskulder.
Kjente dekk av denne art har i området for den ene, særlig den ytre dekkskulder, en utpreget sommerprofil med gjennomlopende profilribber og i den ovrige del av slitebanen inklusive den andre skulder en M + S-profil som består av i omkretsretningen avbrutte ribber.
Ved disse kjente dekk er også slitebanen oppdelt i to sideområder som er tildelt bestemte forskjellige oppgaver. I< det vesentlige bidrar kun en liten del av slitebanebredden, nemlig kun det forholdsvis smale sommerprofil-sideområde,til den for optimale kjøre-egenskaper meget viktige sideforing, mens M + S-profil-sideområdet kun i begrenset grad er virksomt for overforing av driv- resp. bremsekrefter på vinterfore, særlig snedekte kjorebaner. Videre er den tillatte kjørehastighet ved disse kjente dekk forholdsvis begrenset, da det grovknastede M + S-profil-sideområdet ved hoye hastigheter kan forårsake en for sterk oppvarmning.
Formålet med oppfinnelsen er å tilveiebringe et dekk av den inn-ledningsvis nevnte art,som gir hoye kurve- og kjørehastigheter ved ombygning av en symmetrisk slitebaneprofilering, og det ikke ved en tilsiktet begrenset enkelt utformning av hvert slitebaneområde for oppnåelse av en bestemt dekkhovedegenskap som kun er egen for dette område og derfor virker begrenset, f.eks. hefting til bakken eller sideforing, men en med hensyn på slike egenskaper generell utformning av den totale slitebane for okning av de lokale enkeltbidrag for felles oppnåelse av disse hovedegenskåper ved dekket.
Dette oppnås ifolge oppfinnelsen ved at slitebaneprofileringen over den totale slitebane består av siksak- resp. bolgeformede profilspor som strekker seg over dekkets omkrets, og at amplitudene, sett i tverretning, for profilsporene er storre i området nær den indre dekk-skulder enn i området for den ytre dekkskulder.
Oppfinnelsen skal nærmere beskrives nedenfor ved hjelp av utforel-seseksempler under henvisning til tegningene, hvorpå
fig. 1-3 viser forskjellige slitebaneprofileringer ifolge oppfinnelsen, vist i grunnriss, hvorved A betegner dekkets utside og B dekkets innside.
Ifolge fig. 1 har slitebanen over bredden L tre bolge- respektive siksakformede profilspor 1,2 og 3 hvis amplituder, sett i tverr-retning, i området for den indre dekkskulder er storre enn i området for den ytre dekkskulder. Mellom profilsporet 1 og yttersiden A for slitebanen er det anordnet et relativt alle andre spor smalere profilspor 4 og korte fininnsnitt C. Breddene dl,
d2 og d3 for profilsporene 1,2 og 3, kan utgjore ca. 4,0 mm,
3,8 mm resp. 2,5 mm.
Slitebaneprofileringen ifolge fig. 2 har fire bolge- respektive siksak-formede profilspor 21,22,23,24, hvis amplituder, sett i tverretning, likelfdes tiltar fra yttersiden mot innsiden for dekket. Profilsporenes bredder d21,222,d23 og d24 utgjor ca.
3,5 mm, 3,5 mm, 3,0 mm resp. 2,0 mm. I området for den ytre dekkskulder er det dessuten anordnet korte fininnsnitt C.
Utforelseseksemplet ifolge fig. 3 har fire siksak-formede profilspor 31,32,33,34 som kan ha bredder d31,d32,d33 og d34 på ca.
3,0 mm, 2,5 mm, 2,0 mm resp. 1,5 mm og hvis tverramplituder vok-ser i retning fra den ytre dekkskulder mot den indre dekkskulder. Dessuten er det mellom dekkets ytterside og nevnte profilspor
et i forhold til disse smalere siksakspor 35, og over slitebanens hele bredde er det anordnet fininnsnitt C. I det slitebaneområde som ligger nærmest den indre dekkskulder, er nabo-profilsporene 3 3 og 34 forbundne med hverandre ved tverrspor 36.
Mens profilsporenes bredde, som allerede nevnt, er storre i området for den ytre dekkskulder enn i området for den indre dekk-skulder, er tverravstandene mellom nabo-profilspor i området ved den indre dekkskulder storre enn i området ved den ytre dekkskulder. Ved utforelseseksemplet ifolge fig. 3 utgjor tverravstandene mellom profilsporene 31 og 32 ca. 16 mm, mellom profilsporene 32 og 33 ca. 19 mm og mellom profilsporene 33 og 34 ca. 22 mm.
Claims (5)
1. Pneumatisk dekk med en i forhold til slitebanens midtparti asymmetrisk slitebaneprofilering, hvorved profilrillene på den slitebaneside som vender mot den ytre dekkskulder, er orientert mere i dekkets omkretsretning enn de på den slitebaneside som
vender mot den indre dekkskulder, karakterisert ved at slitebaneprofileringen over den totale slitebane består av siksak- respektive bolgeformede profilspor (1 til 3 resp. 21 til 24 resp. 31 til 34) som strekker seg over dekkets omkrets, og at amplitudene, sett i tverretning, for profilsporene er storre i området nær den indre dekkskulder enn i området for den ytre dekkskulder.
2. Dekk som angitt i krav 1, karakterisert ved at tverravstandene mellom nabo-profilspor er storre i området ved den indre dekkskulder enn i området ved den ytre dekkskulder.
3. Dekk som angitt i krav 1 eller 2, karakterisert ved at profilsporenes bredde i området ved den ytre dekkskulder er storre enn i området ved den indre dekkskulder.
4. Dekk som angitt i krav 1 eller 2, karakterisert ved at det profilspor (4 resp. 35) som ligger nærmest den ytre dekkskulder, har en mindre bredde enn alle ovrige profilspor, hvorved bredden for disse profilspor avtar mot området ved den indre dekkskulder.
5. Dekk som angitt i et av de foregående krav, karakterisert ved at i slitebaneområdet som ligger nærmest den indre dekkskulder, er nabo-profilsporene forbundne med hverandre med tverrspor (36).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NO894640A NO166646C (no) | 1985-01-25 | 1989-11-22 | Nye tieno-triazolo-1,4-diazepino-2-karboksylsyrer. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19853502392 DE3502392A1 (de) | 1985-01-25 | 1985-01-25 | Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen |
Publications (3)
Publication Number | Publication Date |
---|---|
NO855260L NO855260L (no) | 1986-07-28 |
NO164029B true NO164029B (no) | 1990-05-14 |
NO164029C NO164029C (no) | 1990-08-22 |
Family
ID=6260695
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO855260A NO164029C (no) | 1985-01-25 | 1985-12-23 | Analogifremgangsmaate for fremstilling av terapeutisk aktive tieno-triazolo-1,4-diazepino-2-karboksylsyre-amider. |
NO894640A NO166646C (no) | 1985-01-25 | 1989-11-22 | Nye tieno-triazolo-1,4-diazepino-2-karboksylsyrer. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO894640A NO166646C (no) | 1985-01-25 | 1989-11-22 | Nye tieno-triazolo-1,4-diazepino-2-karboksylsyrer. |
Country Status (28)
Country | Link |
---|---|
US (3) | US4968794A (no) |
EP (1) | EP0194416B1 (no) |
JP (2) | JPH0633278B2 (no) |
KR (1) | KR920010711B1 (no) |
AT (1) | ATE42556T1 (no) |
AU (1) | AU584663B2 (no) |
CA (1) | CA1269373A (no) |
CS (1) | CS254992B2 (no) |
CZ (1) | CZ410791A3 (no) |
DD (3) | DD265799A5 (no) |
DE (2) | DE3502392A1 (no) |
DK (2) | DK165323C (no) |
ES (3) | ES8704949A1 (no) |
FI (1) | FI86851C (no) |
GR (1) | GR860189B (no) |
HK (1) | HK75792A (no) |
HU (2) | HU193624B (no) |
IE (1) | IE58728B1 (no) |
IL (1) | IL77702A (no) |
MX (1) | MX9203258A (no) |
NO (2) | NO164029C (no) |
NZ (1) | NZ214926A (no) |
PL (1) | PL144948B1 (no) |
PT (1) | PT81898B (no) |
SG (1) | SG44292G (no) |
SU (1) | SU1402265A3 (no) |
YU (2) | YU44280B (no) |
ZA (1) | ZA86542B (no) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3502392A1 (de) * | 1985-01-25 | 1986-07-31 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen |
ES2037013T3 (es) * | 1986-01-21 | 1993-06-16 | Boehringer Ingelheim Kg | Procedimiento para preparar tieno-1,4-diazepinas. |
DE3610848A1 (de) * | 1986-04-01 | 1987-10-15 | Boehringer Ingelheim Kg | Neue 1,4-diazepine |
PH30676A (en) * | 1986-07-22 | 1997-09-16 | Boehringer Ingelhein Kg | Hetrazepine compounds which have useful pharmaceutical utility |
DE3745135C2 (de) * | 1986-10-21 | 1999-05-12 | Korth Ruth | Verwendung von hydrophilen Triazolothieno-diazepinen zur Behandlung von Arteriosklerose |
EP0268242B1 (en) * | 1986-11-17 | 1992-03-18 | Yoshitomi Pharmaceutical Industries, Ltd. | Paf-antagonistic thienotriazolodiazepine compounds and pharmaceutical uses thereof |
DE3725130C2 (de) * | 1987-07-29 | 1996-12-12 | Boehringer Ingelheim Kg | Tritium-oder ·1··4·C-markiertes 4-(2-Chlorphenyl)-9-methyl-2-[3-(4-morpholinyl)-3-propanon-1-yl]-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin, Verfahren zu deren Herstellung und deren Verwendung als Radiorezeptorassay sowie zu diagnostischen Zwecken |
US5895785A (en) * | 1987-10-20 | 1999-04-20 | Ruth Korth | Treatment and prevention of disorders mediated by LA-paf or endothelial cells |
US4959361A (en) * | 1987-12-18 | 1990-09-25 | Hoffmann-La Roche Inc. | Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists |
CA1324863C (en) * | 1988-01-30 | 1993-11-30 | Minoru Moriwaki | Thienotriazolodiazepine compounds and pharmaceutical uses thereof |
EP0338993A1 (en) * | 1988-04-21 | 1989-10-25 | Sandoz Ag | 6-Aryl-substituted-4h-thieno[2,3-e][1,2,4]triazolo [3,4-c][1,4]diazepines |
US5334592A (en) * | 1988-04-27 | 1994-08-02 | Schering Corporation | Certain PAF antagonist antihistamine combinations and methods |
ATE84724T1 (de) * | 1988-04-27 | 1993-02-15 | Schering Corp | Gewisse paf-antagonist/antihistamin-mischungen und verfahren. |
CA1322367C (en) * | 1988-05-17 | 1993-09-21 | Yoshitomi Pharmaceutical Industries Ltd. | Thienotriazolodiazepine compounds and pharmaceutical uses thereof |
US5382579A (en) * | 1988-10-31 | 1995-01-17 | Eisai Co., Ltd. | Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals |
FI95708C (fi) * | 1988-10-31 | 1996-03-11 | Eisai Co Ltd | Analogiamenetelmä 1,4-diatsepiinijohdannaisen ja sen farmaseuttisesti sopivan suolan valmistamiseksi |
US5221671A (en) * | 1988-10-31 | 1993-06-22 | Eisai Co., Ltd. | Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals |
US5468740A (en) * | 1988-10-31 | 1995-11-21 | Eisai Co., Ltd. | 1,4-diazepine derivative and its pharmaceutical use |
RU2117670C1 (ru) * | 1988-10-31 | 1998-08-20 | Эйсай Ко., Лтд. | Производные триазоло[1,4]диазепина и способы их получения |
US5304553A (en) * | 1988-10-31 | 1994-04-19 | Eisai Co., Ltd. | 1,4-diazepine derivative and its pharmaceutical use |
EP0387613A1 (de) * | 1989-03-03 | 1990-09-19 | Boehringer Ingelheim Kg | Neue Thienodiazepine |
DE4010528A1 (de) * | 1990-04-02 | 1991-10-17 | Boehringer Ingelheim Kg | Praeparativ chromatographisches trennverfahren zur herstellung enantiomerenreiner hetrazepine |
EP0532512B1 (en) * | 1990-05-31 | 1996-12-11 | Allergan, Inc. | Use of platelet activating factor antagonists as anti-pruritic agents |
DE4027470A1 (de) * | 1990-08-30 | 1992-03-05 | Boehringer Ingelheim Kg | Neue hetrazepinoide amide |
DE4128579A1 (de) * | 1991-08-28 | 1993-03-04 | Boehringer Ingelheim Kg | Verwendung von 4-(2-chlorphenyl)-9-methyl-2-(3(4-morpholinyl)-3-propanon-1-y1)-6h-thieno-(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepin zur behandlung der allergischen rhinitis |
ES2181665T3 (es) * | 1991-11-04 | 2003-03-01 | Ruth-Maria Korth | Tratamiento y prevencion de enfermedades mentales, acompañadas por unos elevados niveles de liso paf, con los antagonistas de paf. |
TW219935B (no) * | 1991-12-25 | 1994-02-01 | Mitsubishi Chemicals Co Ltd | |
DE4200619A1 (de) * | 1992-01-13 | 1993-07-15 | Boehringer Ingelheim Kg | Verwendung von 4-(2-chlorphenyl)-9-methyl-2-/3(4-morpholinyl)-3-propanon-1-yl/-6h-thieno-/3,2-f//1,2,4/ triazolo/4,3-a//1,4/diazepin zur behandlung der dysmenorrhes |
GB9207645D0 (en) * | 1992-04-08 | 1992-05-27 | Smithkline Beecham Corp | Methods |
EP0656004A1 (en) * | 1992-08-20 | 1995-06-07 | Cytomed, Inc. | Dual functional anti-inflammatory and immunosuppressive agents |
US5288514A (en) * | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
US5302590A (en) * | 1992-12-18 | 1994-04-12 | Hoffmann-La Roche Inc. | Compounds useful as dual antagonists of platelet activating factor and leukotriene D4 |
AU699354B2 (en) * | 1994-11-08 | 1998-12-03 | Takeda Chemical Industries Ltd. | Thienopyridine or thienopyrimidine derivatives useful as anti-inflammatory agents or in the treatment of osteoporosis |
WO1998058930A1 (fr) | 1997-06-25 | 1998-12-30 | Nikken Chemicals Co., Ltd. | Composes de triazolo-1,4-diazepine et composition medicinale les contenant |
CA2753318A1 (en) | 2003-05-30 | 2004-12-09 | Ranbaxy Laboratories Limited | Substituted pyrrole derivatives |
US7223167B2 (en) * | 2005-04-01 | 2007-05-29 | Cnh America Llc | Anti-wind wiper with adjustable extension |
SG166829A1 (en) | 2005-11-08 | 2010-12-29 | Ranbaxy Lab Ltd | Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt |
US9638493B2 (en) | 2011-11-26 | 2017-05-02 | Orval E. Bowman | Pointing devices, apparatus, systems and methods for high shock environments |
CA3200710A1 (en) | 2020-11-16 | 2022-05-19 | Boehringer Ingelheim International Gmbh | Cyclopentathiophene carboxamide derivatives as platelet activating factor receptor antagonists |
US11992494B2 (en) | 2021-12-22 | 2024-05-28 | Boehringer Ingelheim International Gmbh | Cyclopentathiophene carboxamide derivatives as platelet activating factor receptor antagonists |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PH12303A (en) * | 1973-02-08 | 1979-01-16 | Hoffmann La Roche | Thienotriazolodiazepine derivatives |
DE2503235A1 (de) * | 1975-01-27 | 1976-07-29 | Boehringer Sohn Ingelheim | Neues verfahren zur herstellung von 8-brom-thieno-triazolo-1,4-diazepinen |
US4201712A (en) * | 1975-07-16 | 1980-05-06 | Boehringer Ingelheim Gmbh | Process for preparation of 6-aryl-4H-s-triazolo-[3,4-c]-thieno-[2,3-e]-1,4-diazepines |
AU518438B2 (en) * | 1978-04-26 | 1981-10-01 | Boehringer Ingelheim International Gmbh | Substituted 6-aryl-4h-s-triazolo-3,4-c-thieno-2,3-e-1,4-diazepines |
AU520063B2 (en) * | 1978-07-13 | 1982-01-14 | Boehringer Ingelheim International Gmbh | Substituted 4h-s-triazolo(3,4-c)thieno(2,3-e)1,4-diazepines |
DE3435973A1 (de) * | 1984-10-01 | 1986-04-10 | Boehringer Ingelheim KG, 6507 Ingelheim | Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung |
DE3502392A1 (de) * | 1985-01-25 | 1986-07-31 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen |
ES2037013T3 (es) * | 1986-01-21 | 1993-06-16 | Boehringer Ingelheim Kg | Procedimiento para preparar tieno-1,4-diazepinas. |
ATE86256T1 (de) * | 1987-05-28 | 1993-03-15 | Yoshitomi Pharmaceutical | Thieno(triazolo)diazepinverbindungen, und medizinische verwendung derselben. |
US4959361A (en) * | 1987-12-18 | 1990-09-25 | Hoffmann-La Roche Inc. | Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists |
US4914096A (en) * | 1988-04-21 | 1990-04-03 | Sandoz Pharmaceuticals Corp. | 6-aryl-substituted-4H-thieno(2,3-e)(1,2,4)triazolo(3,4-c)(1,4)diazepines |
-
1985
- 1985-01-25 DE DE19853502392 patent/DE3502392A1/de not_active Withdrawn
- 1985-12-23 NO NO855260A patent/NO164029C/no unknown
-
1986
- 1986-01-16 SU SU864008368A patent/SU1402265A3/ru active
- 1986-01-20 AT AT86100656T patent/ATE42556T1/de not_active IP Right Cessation
- 1986-01-20 DE DE8686100656T patent/DE3663028D1/de not_active Expired
- 1986-01-20 YU YU78/86A patent/YU44280B/xx unknown
- 1986-01-20 EP EP86100656A patent/EP0194416B1/de not_active Expired
- 1986-01-21 CS CS86452A patent/CS254992B2/cs not_active IP Right Cessation
- 1986-01-22 FI FI860296A patent/FI86851C/fi not_active IP Right Cessation
- 1986-01-23 GR GR860189A patent/GR860189B/el not_active IP Right Cessation
- 1986-01-23 DD DD86311014A patent/DD265799A5/de not_active IP Right Cessation
- 1986-01-23 DD DD86311011A patent/DD265899A5/de not_active IP Right Cessation
- 1986-01-23 DD DD86286429A patent/DD263063A5/de unknown
- 1986-01-23 PL PL1986257602A patent/PL144948B1/pl unknown
- 1986-01-24 KR KR1019860000445A patent/KR920010711B1/ko not_active IP Right Cessation
- 1986-01-24 DK DK036786A patent/DK165323C/da not_active IP Right Cessation
- 1986-01-24 IE IE20986A patent/IE58728B1/en not_active IP Right Cessation
- 1986-01-24 HU HU86356A patent/HU193624B/hu not_active IP Right Cessation
- 1986-01-24 IL IL77702A patent/IL77702A/xx not_active IP Right Cessation
- 1986-01-24 NZ NZ214926A patent/NZ214926A/xx unknown
- 1986-01-24 ES ES551198A patent/ES8704949A1/es not_active Expired
- 1986-01-24 HU HU852044A patent/HU195821B/hu not_active IP Right Cessation
- 1986-01-24 ZA ZA85542A patent/ZA86542B/xx unknown
- 1986-01-24 JP JP61013605A patent/JPH0633278B2/ja not_active Expired - Fee Related
- 1986-01-24 CA CA000500345A patent/CA1269373A/en not_active Expired - Fee Related
- 1986-01-24 PT PT81898A patent/PT81898B/pt not_active IP Right Cessation
- 1986-01-24 AU AU52728/86A patent/AU584663B2/en not_active Ceased
-
1987
- 1987-01-21 ES ES557344A patent/ES8802523A1/es not_active Expired
- 1987-01-21 ES ES557343A patent/ES8802426A1/es not_active Expired
- 1987-05-05 YU YU79987A patent/YU46049B/sh unknown
-
1988
- 1988-10-03 US US07/252,725 patent/US4968794A/en not_active Expired - Lifetime
-
1989
- 1989-09-13 JP JP1238305A patent/JPH0651704B2/ja not_active Expired - Fee Related
- 1989-11-22 NO NO894640A patent/NO166646C/no unknown
-
1990
- 1990-06-15 US US07/539,416 patent/US5082839A/en not_active Expired - Lifetime
-
1991
- 1991-10-11 US US07/774,683 patent/US5155103A/en not_active Expired - Fee Related
- 1991-12-27 CZ CS914107A patent/CZ410791A3/cs unknown
-
1992
- 1992-04-06 DK DK92462A patent/DK46292D0/da not_active Application Discontinuation
- 1992-04-22 SG SG442/92A patent/SG44292G/en unknown
- 1992-06-24 MX MX9203258A patent/MX9203258A/es unknown
- 1992-10-01 HK HK757/92A patent/HK75792A/xx not_active IP Right Cessation
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