YU46049B - Postopek za pripravo novih tieno-triazolo-1,4-diazepino-2-karboksilnih kislin - Google Patents

Postopek za pripravo novih tieno-triazolo-1,4-diazepino-2-karboksilnih kislin

Info

Publication number
YU46049B
YU46049B YU79987A YU79987A YU46049B YU 46049 B YU46049 B YU 46049B YU 79987 A YU79987 A YU 79987A YU 79987 A YU79987 A YU 79987A YU 46049 B YU46049 B YU 46049B
Authority
YU
Yugoslavia
Prior art keywords
carbon atoms
halogen
diazepino
triazolo
procedure
Prior art date
Application number
YU79987A
Other languages
English (en)
Other versions
YU79987A (en
Inventor
K.H. Weber
G. Walther
A. Harreus
J.C. Stenzel
G. Muacevic
W. Troeger
Original Assignee
Boehringer Ingelheim Kg.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg. filed Critical Boehringer Ingelheim Kg.
Publication of YU79987A publication Critical patent/YU79987A/xx
Publication of YU46049B publication Critical patent/YU46049B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

POSTOPEK ZA PRIPRAVO NOVIH TIENO-TRIAZOLO-1,4-DIAZEPINO-2-KARBOKSILNIH KISLIN , s splošno formulo v kateri pomenijo R1 vodik, ravno ali razvejeno alkilno skupino z 1 do 4 atomi ogljika, v danem primeru substituirano s halogenom ali hidroksi, ciklopropil, alkoksi z 1 do 3 atomi ogljika, halogen, in R4 fenil, pri čemer je lahko fenilov obroč v legi 2 ali v legi 2 in 6 substituiran z metilom, halogenom, nitro ali trifluormetilom, ali alfa-piridil in n eno od števil 1, 2, 3, 4, 5, 6, 7 in 8, označen s tem, da spojino s splošno formulo v kateri imata R4 in n spredaj navedeni pomen in R pomeni nižjo alkilno skupino, presnovimo s spojino s splošno formu R1 - CO - NH - NH2 v kateri ima R1 zgoraj navedeni pomen, in nato imilimo, ali spojino s splošno formulo v kateri imajo R, R4 in n preje navedeni pomen, presnovimo s spojino s splošno formulo R1 - COCl ali v kateri ima R1 zgoraj navedeni pomen, in nato imilimo, oz. umilimo spojino s splošno formulo kjer imajo R1, R4 in n zgoraj navedeni pomen in pomeni R nižjo alkilno skupino.
YU79987A 1985-01-25 1987-05-05 Postopek za pripravo novih tieno-triazolo-1,4-diazepino-2-karboksilnih kislin YU46049B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853502392 DE3502392A1 (de) 1985-01-25 1985-01-25 Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen

Publications (2)

Publication Number Publication Date
YU79987A YU79987A (en) 1988-06-30
YU46049B true YU46049B (sh) 1992-12-21

Family

ID=6260695

Family Applications (2)

Application Number Title Priority Date Filing Date
YU78/86A YU44280B (en) 1985-01-25 1986-01-20 Process for preparation new amides of thieno-triazolo-1,4-diazepino-2-carboxilic acid
YU79987A YU46049B (sh) 1985-01-25 1987-05-05 Postopek za pripravo novih tieno-triazolo-1,4-diazepino-2-karboksilnih kislin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
YU78/86A YU44280B (en) 1985-01-25 1986-01-20 Process for preparation new amides of thieno-triazolo-1,4-diazepino-2-carboxilic acid

Country Status (28)

Country Link
US (3) US4968794A (sh)
EP (1) EP0194416B1 (sh)
JP (2) JPH0633278B2 (sh)
KR (1) KR920010711B1 (sh)
AT (1) ATE42556T1 (sh)
AU (1) AU584663B2 (sh)
CA (1) CA1269373A (sh)
CS (1) CS254992B2 (sh)
CZ (1) CZ410791A3 (sh)
DD (3) DD265899A5 (sh)
DE (2) DE3502392A1 (sh)
DK (2) DK165323C (sh)
ES (3) ES8704949A1 (sh)
FI (1) FI86851C (sh)
GR (1) GR860189B (sh)
HK (1) HK75792A (sh)
HU (2) HU195821B (sh)
IE (1) IE58728B1 (sh)
IL (1) IL77702A (sh)
MX (1) MX9203258A (sh)
NO (2) NO164029C (sh)
NZ (1) NZ214926A (sh)
PL (1) PL144948B1 (sh)
PT (1) PT81898B (sh)
SG (1) SG44292G (sh)
SU (1) SU1402265A3 (sh)
YU (2) YU44280B (sh)
ZA (1) ZA86542B (sh)

Families Citing this family (40)

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DE3502392A1 (de) * 1985-01-25 1986-07-31 Boehringer Ingelheim KG, 6507 Ingelheim Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen
DE3778559D1 (de) * 1986-01-21 1992-06-04 Boehringer Ingelheim Kg Thieno-1,4-diazepine.
DE3610848A1 (de) * 1986-04-01 1987-10-15 Boehringer Ingelheim Kg Neue 1,4-diazepine
PH30676A (en) * 1986-07-22 1997-09-16 Boehringer Ingelhein Kg Hetrazepine compounds which have useful pharmaceutical utility
DE3745135C2 (de) * 1986-10-21 1999-05-12 Korth Ruth Verwendung von hydrophilen Triazolothieno-diazepinen zur Behandlung von Arteriosklerose
ES2039408T3 (es) * 1986-11-17 1993-10-01 Yoshitomi Pharmaceutical Industries, Ltd. Un procedimiento para preparar un compuesto de tienotriazolodiazepina.
DE3725130C2 (de) * 1987-07-29 1996-12-12 Boehringer Ingelheim Kg Tritium-oder ·1··4·C-markiertes 4-(2-Chlorphenyl)-9-methyl-2-[3-(4-morpholinyl)-3-propanon-1-yl]-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin, Verfahren zu deren Herstellung und deren Verwendung als Radiorezeptorassay sowie zu diagnostischen Zwecken
US5895785A (en) * 1987-10-20 1999-04-20 Ruth Korth Treatment and prevention of disorders mediated by LA-paf or endothelial cells
US4959361A (en) * 1987-12-18 1990-09-25 Hoffmann-La Roche Inc. Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists
CA1324863C (en) * 1988-01-30 1993-11-30 Minoru Moriwaki Thienotriazolodiazepine compounds and pharmaceutical uses thereof
EP0338993A1 (en) * 1988-04-21 1989-10-25 Sandoz Ag 6-Aryl-substituted-4h-thieno[2,3-e][1,2,4]triazolo [3,4-c][1,4]diazepines
US5334592A (en) * 1988-04-27 1994-08-02 Schering Corporation Certain PAF antagonist antihistamine combinations and methods
EP0402422A1 (en) * 1988-04-27 1990-12-19 Schering Corporation Certain paf antagonist antihistamine combinations and methods
CA1322367C (en) * 1988-05-17 1993-09-21 Yoshitomi Pharmaceutical Industries Ltd. Thienotriazolodiazepine compounds and pharmaceutical uses thereof
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RU2117670C1 (ru) * 1988-10-31 1998-08-20 Эйсай Ко., Лтд. Производные триазоло[1,4]диазепина и способы их получения
US5221671A (en) * 1988-10-31 1993-06-22 Eisai Co., Ltd. Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals
US5382579A (en) * 1988-10-31 1995-01-17 Eisai Co., Ltd. Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals
FI95708C (fi) * 1988-10-31 1996-03-11 Eisai Co Ltd Analogiamenetelmä 1,4-diatsepiinijohdannaisen ja sen farmaseuttisesti sopivan suolan valmistamiseksi
EP0387613A1 (de) * 1989-03-03 1990-09-19 Boehringer Ingelheim Kg Neue Thienodiazepine
DE4010528A1 (de) * 1990-04-02 1991-10-17 Boehringer Ingelheim Kg Praeparativ chromatographisches trennverfahren zur herstellung enantiomerenreiner hetrazepine
ATE146079T1 (de) * 1990-05-31 1996-12-15 Allergan Inc Verwendung von antagonisten des plättchen- aktivierenden faktors bei pruritus
DE4027470A1 (de) * 1990-08-30 1992-03-05 Boehringer Ingelheim Kg Neue hetrazepinoide amide
DE4128579A1 (de) * 1991-08-28 1993-03-04 Boehringer Ingelheim Kg Verwendung von 4-(2-chlorphenyl)-9-methyl-2-(3(4-morpholinyl)-3-propanon-1-y1)-6h-thieno-(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepin zur behandlung der allergischen rhinitis
ATE221779T1 (de) * 1991-11-04 2002-08-15 Ruth-Maria Korth Behandlung und vorbeugung von erhöhten lyso-paf- spiegel mediierten mentalen erkrankungen mit paf- antagonisten
TW219935B (sh) * 1991-12-25 1994-02-01 Mitsubishi Chemicals Co Ltd
DE4200619A1 (de) * 1992-01-13 1993-07-15 Boehringer Ingelheim Kg Verwendung von 4-(2-chlorphenyl)-9-methyl-2-/3(4-morpholinyl)-3-propanon-1-yl/-6h-thieno-/3,2-f//1,2,4/ triazolo/4,3-a//1,4/diazepin zur behandlung der dysmenorrhes
GB9207645D0 (en) * 1992-04-08 1992-05-27 Smithkline Beecham Corp Methods
EP0656004A1 (en) * 1992-08-20 1995-06-07 Cytomed, Inc. Dual functional anti-inflammatory and immunosuppressive agents
US5288514A (en) * 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5302590A (en) * 1992-12-18 1994-04-12 Hoffmann-La Roche Inc. Compounds useful as dual antagonists of platelet activating factor and leukotriene D4
EP0791000B1 (en) * 1994-11-08 2002-10-02 Takeda Chemical Industries, Ltd. Thienopyridine or thienopyrimidine derivatives and their use
EP0995752A4 (en) 1997-06-25 2001-08-16 Nikken Chemicals Co Ltd TRIAZOLO-1,4-DIAZEPINE COMPOUNDS AND MEDICINAL COMPOSITION CONTAINING THEM
JP4901474B2 (ja) 2003-05-30 2012-03-21 ランバクシー ラボラトリーズ リミテッド 置換ピロール誘導体
US7223167B2 (en) * 2005-04-01 2007-05-29 Cnh America Llc Anti-wind wiper with adjustable extension
SG166829A1 (en) 2005-11-08 2010-12-29 Ranbaxy Lab Ltd Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
US9638493B2 (en) 2011-11-26 2017-05-02 Orval E. Bowman Pointing devices, apparatus, systems and methods for high shock environments
KR20230109692A (ko) 2020-11-16 2023-07-20 베링거 인겔하임 인터내셔날 게엠베하 혈소판 활성화 인자 수용체 길항제로서의 시클로펜타티오펜 카복스아미드 유도체
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PH12303A (en) * 1973-02-08 1979-01-16 Hoffmann La Roche Thienotriazolodiazepine derivatives
DE2503235A1 (de) * 1975-01-27 1976-07-29 Boehringer Sohn Ingelheim Neues verfahren zur herstellung von 8-brom-thieno-triazolo-1,4-diazepinen
US4201712A (en) * 1975-07-16 1980-05-06 Boehringer Ingelheim Gmbh Process for preparation of 6-aryl-4H-s-triazolo-[3,4-c]-thieno-[2,3-e]-1,4-diazepines
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AU520063B2 (en) * 1978-07-13 1982-01-14 Boehringer Ingelheim International Gmbh Substituted 4h-s-triazolo(3,4-c)thieno(2,3-e)1,4-diazepines
DE3435973A1 (de) * 1984-10-01 1986-04-10 Boehringer Ingelheim KG, 6507 Ingelheim Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung
DE3502392A1 (de) * 1985-01-25 1986-07-31 Boehringer Ingelheim KG, 6507 Ingelheim Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen
DE3778559D1 (de) * 1986-01-21 1992-06-04 Boehringer Ingelheim Kg Thieno-1,4-diazepine.
DE3878833T2 (de) * 1987-05-28 1993-06-09 Yoshitomi Pharmaceutical Thieno(triazolo)diazepinverbindungen, und medizinische verwendung derselben.
US4959361A (en) * 1987-12-18 1990-09-25 Hoffmann-La Roche Inc. Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists
US4914096A (en) * 1988-04-21 1990-04-03 Sandoz Pharmaceuticals Corp. 6-aryl-substituted-4H-thieno(2,3-e)(1,2,4)triazolo(3,4-c)(1,4)diazepines

Also Published As

Publication number Publication date
HK75792A (en) 1992-10-09
DK36786A (da) 1986-07-26
US5155103A (en) 1992-10-13
ZA86542B (en) 1987-09-30
DD263063A5 (de) 1988-12-21
HU195821B (en) 1988-07-28
GR860189B (en) 1986-05-26
ATE42556T1 (de) 1989-05-15
ES8802426A1 (es) 1988-06-01
ES557344A0 (es) 1988-07-16
ES8802523A1 (es) 1988-07-16
DK165323B (da) 1992-11-09
NO164029B (no) 1990-05-14
PT81898B (pt) 1988-05-27
NO855260L (no) 1986-07-28
KR860005822A (ko) 1986-08-13
YU7886A (en) 1987-10-31
JPH02191281A (ja) 1990-07-27
FI860296A (fi) 1986-07-26
CA1269373A (en) 1990-05-22
DK36786D0 (da) 1986-01-24
ES557343A0 (es) 1988-06-01
US5082839A (en) 1992-01-21
DK46292A (da) 1992-04-06
FI860296A0 (fi) 1986-01-22
DD265899A5 (de) 1989-03-15
EP0194416A1 (de) 1986-09-17
JPH0633278B2 (ja) 1994-05-02
CZ410791A3 (en) 1993-04-14
PL257602A1 (en) 1987-05-04
PL144948B1 (en) 1988-07-30
NO164029C (no) 1990-08-22
YU79987A (en) 1988-06-30
DK165323C (da) 1993-03-29
HUT40441A (en) 1986-12-28
ES8704949A1 (es) 1987-04-16
SG44292G (en) 1992-09-04
DD265799A5 (de) 1989-03-15
FI86851C (fi) 1992-10-26
KR920010711B1 (ko) 1992-12-14
DK46292D0 (da) 1992-04-06
DE3663028D1 (en) 1989-06-01
EP0194416B1 (de) 1989-04-26
US4968794A (en) 1990-11-06
AU5272886A (en) 1986-07-31
JPS61176591A (ja) 1986-08-08
FI86851B (fi) 1992-07-15
IL77702A (en) 1989-02-28
NO894640D0 (no) 1989-11-22
ES551198A0 (es) 1987-04-16
IE860209L (en) 1986-07-25
PT81898A (de) 1986-02-01
JPH0651704B2 (ja) 1994-07-06
NO894640L (no) 1986-07-28
NO166646B (no) 1991-05-13
SU1402265A3 (ru) 1988-06-07
DE3502392A1 (de) 1986-07-31
MX9203258A (es) 1992-07-01
IE58728B1 (en) 1993-11-03
YU44280B (en) 1990-04-30
NO166646C (no) 1991-08-21
CS254992B2 (en) 1988-02-15
NZ214926A (en) 1989-04-26
AU584663B2 (en) 1989-06-01
HU193624B (en) 1987-11-30

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