DK36786D0 - Thieno-triazolo-1,4-diazepino-2-carbonsyreamider, deres fremstilling og anvendelse i farmaceutiske sammensaetninger - Google Patents

Thieno-triazolo-1,4-diazepino-2-carbonsyreamider, deres fremstilling og anvendelse i farmaceutiske sammensaetninger

Info

Publication number
DK36786D0
DK36786D0 DK36786A DK36786A DK36786D0 DK 36786 D0 DK36786 D0 DK 36786D0 DK 36786 A DK36786 A DK 36786A DK 36786 A DK36786 A DK 36786A DK 36786 D0 DK36786 D0 DK 36786D0
Authority
DK
Denmark
Prior art keywords
carbon atoms
diazepino
thieno
triazolo
halogen
Prior art date
Application number
DK36786A
Other languages
English (en)
Other versions
DK165323B (da
DK36786A (da
DK165323C (da
Inventor
Karl-Heinz Weber
Gerhard Walther
Albrecht Harreus
Jorge Casals-Stenzel
Gojki Muacevic
Wolfgang Troeger
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of DK36786D0 publication Critical patent/DK36786D0/da
Publication of DK36786A publication Critical patent/DK36786A/da
Publication of DK165323B publication Critical patent/DK165323B/da
Application granted granted Critical
Publication of DK165323C publication Critical patent/DK165323C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK036786A 1985-01-25 1986-01-24 Thieno-triazolo-1,4-diazepino-2-carboxylsyreamider, fremgangsmaader til fremstilling af forbindelserne, forbindelserne til anvendelse ved fremstilling af laegemidler med paf-antagonistisk virkning samt farmaceutiske praeparater indeholdende forbindelserne DK165323C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3502392 1985-01-25
DE19853502392 DE3502392A1 (de) 1985-01-25 1985-01-25 Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen

Publications (4)

Publication Number Publication Date
DK36786D0 true DK36786D0 (da) 1986-01-24
DK36786A DK36786A (da) 1986-07-26
DK165323B DK165323B (da) 1992-11-09
DK165323C DK165323C (da) 1993-03-29

Family

ID=6260695

Family Applications (2)

Application Number Title Priority Date Filing Date
DK036786A DK165323C (da) 1985-01-25 1986-01-24 Thieno-triazolo-1,4-diazepino-2-carboxylsyreamider, fremgangsmaader til fremstilling af forbindelserne, forbindelserne til anvendelse ved fremstilling af laegemidler med paf-antagonistisk virkning samt farmaceutiske praeparater indeholdende forbindelserne
DK046292A DK46292A (da) 1985-01-25 1992-04-06 Thieno-triazolo-1,4-diazepino-2-carboxylsyrer, samt fremgangsmaader til deres fremstilling

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK046292A DK46292A (da) 1985-01-25 1992-04-06 Thieno-triazolo-1,4-diazepino-2-carboxylsyrer, samt fremgangsmaader til deres fremstilling

Country Status (28)

Country Link
US (3) US4968794A (da)
EP (1) EP0194416B1 (da)
JP (2) JPH0633278B2 (da)
KR (1) KR920010711B1 (da)
AT (1) ATE42556T1 (da)
AU (1) AU584663B2 (da)
CA (1) CA1269373A (da)
CS (1) CS254992B2 (da)
CZ (1) CZ410791A3 (da)
DD (3) DD265899A5 (da)
DE (2) DE3502392A1 (da)
DK (2) DK165323C (da)
ES (3) ES8704949A1 (da)
FI (1) FI86851C (da)
GR (1) GR860189B (da)
HK (1) HK75792A (da)
HU (2) HU195821B (da)
IE (1) IE58728B1 (da)
IL (1) IL77702A (da)
MX (1) MX9203258A (da)
NO (2) NO164029C (da)
NZ (1) NZ214926A (da)
PL (1) PL144948B1 (da)
PT (1) PT81898B (da)
SG (1) SG44292G (da)
SU (1) SU1402265A3 (da)
YU (2) YU44280B (da)
ZA (1) ZA86542B (da)

Families Citing this family (40)

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Publication number Priority date Publication date Assignee Title
DE3502392A1 (de) * 1985-01-25 1986-07-31 Boehringer Ingelheim KG, 6507 Ingelheim Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen
ES2037013T3 (es) * 1986-01-21 1993-06-16 Boehringer Ingelheim Kg Procedimiento para preparar tieno-1,4-diazepinas.
DE3610848A1 (de) * 1986-04-01 1987-10-15 Boehringer Ingelheim Kg Neue 1,4-diazepine
PH30676A (en) * 1986-07-22 1997-09-16 Boehringer Ingelhein Kg Hetrazepine compounds which have useful pharmaceutical utility
DE3745135C2 (de) * 1986-10-21 1999-05-12 Korth Ruth Verwendung von hydrophilen Triazolothieno-diazepinen zur Behandlung von Arteriosklerose
DE3777541D1 (de) * 1986-11-17 1992-04-23 Yoshitomi Pharmaceutical Paf-antagonistische thienotriazoldiazepin-verbindungen und deren pharmazeutische anwendung.
DE3725130C2 (de) * 1987-07-29 1996-12-12 Boehringer Ingelheim Kg Tritium-oder ·1··4·C-markiertes 4-(2-Chlorphenyl)-9-methyl-2-[3-(4-morpholinyl)-3-propanon-1-yl]-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin, Verfahren zu deren Herstellung und deren Verwendung als Radiorezeptorassay sowie zu diagnostischen Zwecken
US5895785A (en) * 1987-10-20 1999-04-20 Ruth Korth Treatment and prevention of disorders mediated by LA-paf or endothelial cells
US4959361A (en) * 1987-12-18 1990-09-25 Hoffmann-La Roche Inc. Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists
CA1324863C (en) * 1988-01-30 1993-11-30 Minoru Moriwaki Thienotriazolodiazepine compounds and pharmaceutical uses thereof
EP0338993A1 (en) * 1988-04-21 1989-10-25 Sandoz Ag 6-Aryl-substituted-4h-thieno[2,3-e][1,2,4]triazolo [3,4-c][1,4]diazepines
US5334592A (en) * 1988-04-27 1994-08-02 Schering Corporation Certain PAF antagonist antihistamine combinations and methods
WO1989010143A1 (en) * 1988-04-27 1989-11-02 Schering Corporation Certain paf antagonist antihistamine combinations and methods
CA1322367C (en) * 1988-05-17 1993-09-21 Yoshitomi Pharmaceutical Industries Ltd. Thienotriazolodiazepine compounds and pharmaceutical uses thereof
FI95708C (fi) * 1988-10-31 1996-03-11 Eisai Co Ltd Analogiamenetelmä 1,4-diatsepiinijohdannaisen ja sen farmaseuttisesti sopivan suolan valmistamiseksi
US5221671A (en) * 1988-10-31 1993-06-22 Eisai Co., Ltd. Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals
US5468740A (en) * 1988-10-31 1995-11-21 Eisai Co., Ltd. 1,4-diazepine derivative and its pharmaceutical use
RU2117670C1 (ru) * 1988-10-31 1998-08-20 Эйсай Ко., Лтд. Производные триазоло[1,4]диазепина и способы их получения
US5304553A (en) * 1988-10-31 1994-04-19 Eisai Co., Ltd. 1,4-diazepine derivative and its pharmaceutical use
US5382579A (en) * 1988-10-31 1995-01-17 Eisai Co., Ltd. Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals
EP0387613A1 (de) * 1989-03-03 1990-09-19 Boehringer Ingelheim Kg Neue Thienodiazepine
DE4010528A1 (de) * 1990-04-02 1991-10-17 Boehringer Ingelheim Kg Praeparativ chromatographisches trennverfahren zur herstellung enantiomerenreiner hetrazepine
JP3142559B2 (ja) * 1990-05-31 2001-03-07 アラーガン、インコーポレイテッド 止痒剤としての血小板活性化因子拮抗剤の用途
DE4027470A1 (de) * 1990-08-30 1992-03-05 Boehringer Ingelheim Kg Neue hetrazepinoide amide
DE4128579A1 (de) * 1991-08-28 1993-03-04 Boehringer Ingelheim Kg Verwendung von 4-(2-chlorphenyl)-9-methyl-2-(3(4-morpholinyl)-3-propanon-1-y1)-6h-thieno-(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepin zur behandlung der allergischen rhinitis
DE69133083C5 (de) * 1991-11-04 2007-05-31 Korth, Ruth-Maria, Dr.med. Behandlung und Vorbeugung von erhöhten Lyso-PAF-Spiegel mediierten mentalen Erkrankungen mit PAF-Antagonisten
TW219935B (da) * 1991-12-25 1994-02-01 Mitsubishi Chemicals Co Ltd
DE4200619A1 (de) * 1992-01-13 1993-07-15 Boehringer Ingelheim Kg Verwendung von 4-(2-chlorphenyl)-9-methyl-2-/3(4-morpholinyl)-3-propanon-1-yl/-6h-thieno-/3,2-f//1,2,4/ triazolo/4,3-a//1,4/diazepin zur behandlung der dysmenorrhes
GB9207645D0 (en) * 1992-04-08 1992-05-27 Smithkline Beecham Corp Methods
EP0656004A1 (en) * 1992-08-20 1995-06-07 Cytomed, Inc. Dual functional anti-inflammatory and immunosuppressive agents
US5288514A (en) * 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5302590A (en) * 1992-12-18 1994-04-12 Hoffmann-La Roche Inc. Compounds useful as dual antagonists of platelet activating factor and leukotriene D4
CA2202985A1 (en) * 1994-11-08 1996-05-17 Haruhiko Makino Thienopyridine or thienopyrimidine derivatives and their use
EP0995752A4 (en) 1997-06-25 2001-08-16 Nikken Chemicals Co Ltd TRIAZOLO-1,4-DIAZEPINE COMPOUNDS AND MEDICINAL COMPOSITION CONTAINING THEM
UA82698C2 (uk) 2003-05-30 2008-05-12 Ранбакси Лабораториз Лимитед Заміщені похідні піролу та їх використання в якості інгібіторів hmg-co
US7223167B2 (en) * 2005-04-01 2007-05-29 Cnh America Llc Anti-wind wiper with adjustable extension
WO2007054896A1 (en) 2005-11-08 2007-05-18 Ranbaxy Laboratories Limited Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
US9638493B2 (en) 2011-11-26 2017-05-02 Orval E. Bowman Pointing devices, apparatus, systems and methods for high shock environments
CN117624188A (zh) 2020-11-16 2024-03-01 勃林格殷格翰国际有限公司 作为血小板活化因子受体拮抗剂的环戊烷并噻吩甲酰胺衍生物
WO2023117914A1 (en) 2021-12-22 2023-06-29 Boehringer Ingelheim International Gmbh Cyclopentathiophene carboxamide derivatives as platelet activating factor receptor antagonists

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
PH12303A (en) * 1973-02-08 1979-01-16 Hoffmann La Roche Thienotriazolodiazepine derivatives
DE2503235A1 (de) * 1975-01-27 1976-07-29 Boehringer Sohn Ingelheim Neues verfahren zur herstellung von 8-brom-thieno-triazolo-1,4-diazepinen
US4201712A (en) * 1975-07-16 1980-05-06 Boehringer Ingelheim Gmbh Process for preparation of 6-aryl-4H-s-triazolo-[3,4-c]-thieno-[2,3-e]-1,4-diazepines
AU518438B2 (en) * 1978-04-26 1981-10-01 Boehringer Ingelheim International Gmbh Substituted 6-aryl-4h-s-triazolo-3,4-c-thieno-2,3-e-1,4-diazepines
AU520063B2 (en) * 1978-07-13 1982-01-14 Boehringer Ingelheim International Gmbh Substituted 4h-s-triazolo(3,4-c)thieno(2,3-e)1,4-diazepines
DE3435973A1 (de) * 1984-10-01 1986-04-10 Boehringer Ingelheim KG, 6507 Ingelheim Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung
DE3502392A1 (de) * 1985-01-25 1986-07-31 Boehringer Ingelheim KG, 6507 Ingelheim Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen
ES2037013T3 (es) * 1986-01-21 1993-06-16 Boehringer Ingelheim Kg Procedimiento para preparar tieno-1,4-diazepinas.
WO1988009333A1 (en) * 1987-05-28 1988-12-01 Yoshitomi Pharmaceutical Industries, Ltd. Thieno(triazolo)diazepine compound and medicinal application of the same
US4959361A (en) * 1987-12-18 1990-09-25 Hoffmann-La Roche Inc. Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists
US4914096A (en) * 1988-04-21 1990-04-03 Sandoz Pharmaceuticals Corp. 6-aryl-substituted-4H-thieno(2,3-e)(1,2,4)triazolo(3,4-c)(1,4)diazepines

Also Published As

Publication number Publication date
ES551198A0 (es) 1987-04-16
DK165323B (da) 1992-11-09
KR920010711B1 (ko) 1992-12-14
FI86851B (fi) 1992-07-15
DK36786A (da) 1986-07-26
CS254992B2 (en) 1988-02-15
PL144948B1 (en) 1988-07-30
HU193624B (en) 1987-11-30
YU7886A (en) 1987-10-31
ZA86542B (en) 1987-09-30
DK46292D0 (da) 1992-04-06
CZ410791A3 (en) 1993-04-14
HU195821B (en) 1988-07-28
ES8704949A1 (es) 1987-04-16
PL257602A1 (en) 1987-05-04
JPH0651704B2 (ja) 1994-07-06
EP0194416A1 (de) 1986-09-17
ES8802426A1 (es) 1988-06-01
ATE42556T1 (de) 1989-05-15
NO166646C (no) 1991-08-21
AU584663B2 (en) 1989-06-01
NO894640D0 (no) 1989-11-22
EP0194416B1 (de) 1989-04-26
DE3663028D1 (en) 1989-06-01
ES557343A0 (es) 1988-06-01
NO855260L (no) 1986-07-28
DE3502392A1 (de) 1986-07-31
CA1269373A (en) 1990-05-22
ES557344A0 (es) 1988-07-16
IE58728B1 (en) 1993-11-03
FI86851C (fi) 1992-10-26
NO164029C (no) 1990-08-22
PT81898A (de) 1986-02-01
US5155103A (en) 1992-10-13
MX9203258A (es) 1992-07-01
NO164029B (no) 1990-05-14
AU5272886A (en) 1986-07-31
HK75792A (en) 1992-10-09
DK46292A (da) 1992-04-06
US5082839A (en) 1992-01-21
FI860296A (fi) 1986-07-26
US4968794A (en) 1990-11-06
YU44280B (en) 1990-04-30
IE860209L (en) 1986-07-25
JPH02191281A (ja) 1990-07-27
NZ214926A (en) 1989-04-26
DD265799A5 (de) 1989-03-15
JPS61176591A (ja) 1986-08-08
HUT40441A (en) 1986-12-28
NO894640L (no) 1986-07-28
JPH0633278B2 (ja) 1994-05-02
FI860296A0 (fi) 1986-01-22
DD265899A5 (de) 1989-03-15
ES8802523A1 (es) 1988-07-16
YU79987A (en) 1988-06-30
KR860005822A (ko) 1986-08-13
NO166646B (no) 1991-05-13
SU1402265A3 (ru) 1988-06-07
IL77702A (en) 1989-02-28
DD263063A5 (de) 1988-12-21
DK165323C (da) 1993-03-29
SG44292G (en) 1992-09-04
PT81898B (pt) 1988-05-27
YU46049B (sh) 1992-12-21
GR860189B (en) 1986-05-26

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