NO164029C - Analogifremgangsmaate for fremstilling av terapeutisk aktive tieno-triazolo-1,4-diazepino-2-karboksylsyre-amider. - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive tieno-triazolo-1,4-diazepino-2-karboksylsyre-amider.

Info

Publication number
NO164029C
NO164029C NO855260A NO855260A NO164029C NO 164029 C NO164029 C NO 164029C NO 855260 A NO855260 A NO 855260A NO 855260 A NO855260 A NO 855260A NO 164029 C NO164029 C NO 164029C
Authority
NO
Norway
Prior art keywords
carbon atoms
diazepino
triazolo
carboxylic acid
acid amides
Prior art date
Application number
NO855260A
Other languages
English (en)
Other versions
NO855260L (no
NO164029B (no
Inventor
Karl-Heinz Weber
Gerhard Walther
Albrecht Harreus
Jorge Casals-Stenzel
Gojki Muacevic
Wolfgang Troeger
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of NO855260L publication Critical patent/NO855260L/no
Priority to NO894640A priority Critical patent/NO166646C/no
Publication of NO164029B publication Critical patent/NO164029B/no
Publication of NO164029C publication Critical patent/NO164029C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO855260A 1985-01-25 1985-12-23 Analogifremgangsmaate for fremstilling av terapeutisk aktive tieno-triazolo-1,4-diazepino-2-karboksylsyre-amider. NO164029C (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO894640A NO166646C (no) 1985-01-25 1989-11-22 Nye tieno-triazolo-1,4-diazepino-2-karboksylsyrer.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853502392 DE3502392A1 (de) 1985-01-25 1985-01-25 Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen

Publications (3)

Publication Number Publication Date
NO855260L NO855260L (no) 1986-07-28
NO164029B NO164029B (no) 1990-05-14
NO164029C true NO164029C (no) 1990-08-22

Family

ID=6260695

Family Applications (2)

Application Number Title Priority Date Filing Date
NO855260A NO164029C (no) 1985-01-25 1985-12-23 Analogifremgangsmaate for fremstilling av terapeutisk aktive tieno-triazolo-1,4-diazepino-2-karboksylsyre-amider.
NO894640A NO166646C (no) 1985-01-25 1989-11-22 Nye tieno-triazolo-1,4-diazepino-2-karboksylsyrer.

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO894640A NO166646C (no) 1985-01-25 1989-11-22 Nye tieno-triazolo-1,4-diazepino-2-karboksylsyrer.

Country Status (28)

Country Link
US (3) US4968794A (no)
EP (1) EP0194416B1 (no)
JP (2) JPH0633278B2 (no)
KR (1) KR920010711B1 (no)
AT (1) ATE42556T1 (no)
AU (1) AU584663B2 (no)
CA (1) CA1269373A (no)
CS (1) CS254992B2 (no)
CZ (1) CZ410791A3 (no)
DD (3) DD265799A5 (no)
DE (2) DE3502392A1 (no)
DK (2) DK165323C (no)
ES (3) ES8704949A1 (no)
FI (1) FI86851C (no)
GR (1) GR860189B (no)
HK (1) HK75792A (no)
HU (2) HU195821B (no)
IE (1) IE58728B1 (no)
IL (1) IL77702A (no)
MX (1) MX9203258A (no)
NO (2) NO164029C (no)
NZ (1) NZ214926A (no)
PL (1) PL144948B1 (no)
PT (1) PT81898B (no)
SG (1) SG44292G (no)
SU (1) SU1402265A3 (no)
YU (2) YU44280B (no)
ZA (1) ZA86542B (no)

Families Citing this family (40)

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DE3502392A1 (de) * 1985-01-25 1986-07-31 Boehringer Ingelheim KG, 6507 Ingelheim Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen
EP0230942B1 (de) * 1986-01-21 1992-04-29 Boehringer Ingelheim Kg Thieno-1,4-diazepine
DE3610848A1 (de) * 1986-04-01 1987-10-15 Boehringer Ingelheim Kg Neue 1,4-diazepine
PH30676A (en) * 1986-07-22 1997-09-16 Boehringer Ingelhein Kg Hetrazepine compounds which have useful pharmaceutical utility
DE3745135C2 (de) * 1986-10-21 1999-05-12 Korth Ruth Verwendung von hydrophilen Triazolothieno-diazepinen zur Behandlung von Arteriosklerose
EP0268242B1 (en) * 1986-11-17 1992-03-18 Yoshitomi Pharmaceutical Industries, Ltd. Paf-antagonistic thienotriazolodiazepine compounds and pharmaceutical uses thereof
DE3725130C2 (de) * 1987-07-29 1996-12-12 Boehringer Ingelheim Kg Tritium-oder ·1··4·C-markiertes 4-(2-Chlorphenyl)-9-methyl-2-[3-(4-morpholinyl)-3-propanon-1-yl]-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin, Verfahren zu deren Herstellung und deren Verwendung als Radiorezeptorassay sowie zu diagnostischen Zwecken
US5895785A (en) * 1987-10-20 1999-04-20 Ruth Korth Treatment and prevention of disorders mediated by LA-paf or endothelial cells
US4959361A (en) * 1987-12-18 1990-09-25 Hoffmann-La Roche Inc. Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists
CA1324863C (en) * 1988-01-30 1993-11-30 Minoru Moriwaki Thienotriazolodiazepine compounds and pharmaceutical uses thereof
EP0338993A1 (en) * 1988-04-21 1989-10-25 Sandoz Ag 6-Aryl-substituted-4h-thieno[2,3-e][1,2,4]triazolo [3,4-c][1,4]diazepines
ATE84724T1 (de) * 1988-04-27 1993-02-15 Schering Corp Gewisse paf-antagonist/antihistamin-mischungen und verfahren.
US5334592A (en) * 1988-04-27 1994-08-02 Schering Corporation Certain PAF antagonist antihistamine combinations and methods
CA1322367C (en) * 1988-05-17 1993-09-21 Yoshitomi Pharmaceutical Industries Ltd. Thienotriazolodiazepine compounds and pharmaceutical uses thereof
FI95708C (fi) * 1988-10-31 1996-03-11 Eisai Co Ltd Analogiamenetelmä 1,4-diatsepiinijohdannaisen ja sen farmaseuttisesti sopivan suolan valmistamiseksi
US5468740A (en) * 1988-10-31 1995-11-21 Eisai Co., Ltd. 1,4-diazepine derivative and its pharmaceutical use
US5304553A (en) * 1988-10-31 1994-04-19 Eisai Co., Ltd. 1,4-diazepine derivative and its pharmaceutical use
US5382579A (en) * 1988-10-31 1995-01-17 Eisai Co., Ltd. Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals
US5221671A (en) * 1988-10-31 1993-06-22 Eisai Co., Ltd. Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals
RU2117670C1 (ru) * 1988-10-31 1998-08-20 Эйсай Ко., Лтд. Производные триазоло[1,4]диазепина и способы их получения
EP0387613A1 (de) * 1989-03-03 1990-09-19 Boehringer Ingelheim Kg Neue Thienodiazepine
DE4010528A1 (de) * 1990-04-02 1991-10-17 Boehringer Ingelheim Kg Praeparativ chromatographisches trennverfahren zur herstellung enantiomerenreiner hetrazepine
ES2095316T3 (es) * 1990-05-31 1997-02-16 Allergan Inc Uso de antagonistas del factor activador de plaquetas como agentes antipruriticos.
DE4027470A1 (de) * 1990-08-30 1992-03-05 Boehringer Ingelheim Kg Neue hetrazepinoide amide
DE4128579A1 (de) * 1991-08-28 1993-03-04 Boehringer Ingelheim Kg Verwendung von 4-(2-chlorphenyl)-9-methyl-2-(3(4-morpholinyl)-3-propanon-1-y1)-6h-thieno-(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepin zur behandlung der allergischen rhinitis
DE540767T1 (de) * 1991-11-04 2001-10-25 Korth Ruth Maria Behandlung und Vorbeugung von von erhöhten Lyso-PAF-Spiegel mediierten mentalen Erkrankungen mit PAF-Antagonisten
TW219935B (no) * 1991-12-25 1994-02-01 Mitsubishi Chemicals Co Ltd
DE4200619A1 (de) * 1992-01-13 1993-07-15 Boehringer Ingelheim Kg Verwendung von 4-(2-chlorphenyl)-9-methyl-2-/3(4-morpholinyl)-3-propanon-1-yl/-6h-thieno-/3,2-f//1,2,4/ triazolo/4,3-a//1,4/diazepin zur behandlung der dysmenorrhes
GB9207645D0 (en) * 1992-04-08 1992-05-27 Smithkline Beecham Corp Methods
EP0656004A1 (en) * 1992-08-20 1995-06-07 Cytomed, Inc. Dual functional anti-inflammatory and immunosuppressive agents
US5288514A (en) * 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5302590A (en) * 1992-12-18 1994-04-12 Hoffmann-La Roche Inc. Compounds useful as dual antagonists of platelet activating factor and leukotriene D4
AU699354B2 (en) * 1994-11-08 1998-12-03 Takeda Chemical Industries Ltd. Thienopyridine or thienopyrimidine derivatives useful as anti-inflammatory agents or in the treatment of osteoporosis
US6433167B1 (en) 1997-06-25 2002-08-13 Nikken Chemicals Co., Ltd. Triazolo-1,4-diazepine compounds and medicinal composition containing the same
WO2004106299A2 (en) 2003-05-30 2004-12-09 Ranbaxy Laboratories Limited Substituted pyrrole derivatives and their use as hmg-co inhibitors
US7223167B2 (en) * 2005-04-01 2007-05-29 Cnh America Llc Anti-wind wiper with adjustable extension
KR101329112B1 (ko) 2005-11-08 2013-11-14 랜박시 래보러터리스 리미티드 (3ｒ,5ｒ)-7-〔2-(4-플루오로페닐)-5-이소프로필-3-페닐-4-〔(4-히드록시 메틸 페닐 아미노)카르보닐〕-피롤-1-일〕-3,5-디히드록시 헵탄산 헤미 칼슘염의 제조 방법
US9638493B2 (en) 2011-11-26 2017-05-02 Orval E. Bowman Pointing devices, apparatus, systems and methods for high shock environments
CN116745300A (zh) 2020-11-16 2023-09-12 勃林格殷格翰国际有限公司 作为血小板活化因子受体拮抗剂的环戊烷并噻吩甲酰胺衍生物
US11992494B2 (en) 2021-12-22 2024-05-28 Boehringer Ingelheim International Gmbh Cyclopentathiophene carboxamide derivatives as platelet activating factor receptor antagonists

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
PH12303A (en) * 1973-02-08 1979-01-16 Hoffmann La Roche Thienotriazolodiazepine derivatives
DE2503235A1 (de) * 1975-01-27 1976-07-29 Boehringer Sohn Ingelheim Neues verfahren zur herstellung von 8-brom-thieno-triazolo-1,4-diazepinen
US4201712A (en) * 1975-07-16 1980-05-06 Boehringer Ingelheim Gmbh Process for preparation of 6-aryl-4H-s-triazolo-[3,4-c]-thieno-[2,3-e]-1,4-diazepines
AU518438B2 (en) * 1978-04-26 1981-10-01 Boehringer Ingelheim International Gmbh Substituted 6-aryl-4h-s-triazolo-3,4-c-thieno-2,3-e-1,4-diazepines
AU520063B2 (en) * 1978-07-13 1982-01-14 Boehringer Ingelheim International Gmbh Substituted 4h-s-triazolo(3,4-c)thieno(2,3-e)1,4-diazepines
DE3435973A1 (de) * 1984-10-01 1986-04-10 Boehringer Ingelheim KG, 6507 Ingelheim Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung
DE3502392A1 (de) * 1985-01-25 1986-07-31 Boehringer Ingelheim KG, 6507 Ingelheim Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen
EP0230942B1 (de) * 1986-01-21 1992-04-29 Boehringer Ingelheim Kg Thieno-1,4-diazepine
WO1988009333A1 (en) * 1987-05-28 1988-12-01 Yoshitomi Pharmaceutical Industries, Ltd. Thieno(triazolo)diazepine compound and medicinal application of the same
US4959361A (en) * 1987-12-18 1990-09-25 Hoffmann-La Roche Inc. Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists
US4914096A (en) * 1988-04-21 1990-04-03 Sandoz Pharmaceuticals Corp. 6-aryl-substituted-4H-thieno(2,3-e)(1,2,4)triazolo(3,4-c)(1,4)diazepines

Also Published As

Publication number Publication date
FI86851C (fi) 1992-10-26
IE860209L (en) 1986-07-25
DD265899A5 (de) 1989-03-15
IL77702A (en) 1989-02-28
YU79987A (en) 1988-06-30
ES8802523A1 (es) 1988-07-16
HUT40441A (en) 1986-12-28
KR860005822A (ko) 1986-08-13
NO894640D0 (no) 1989-11-22
DK36786D0 (da) 1986-01-24
JPH0633278B2 (ja) 1994-05-02
NO894640L (no) 1986-07-28
DE3663028D1 (en) 1989-06-01
PL257602A1 (en) 1987-05-04
YU46049B (sh) 1992-12-21
EP0194416B1 (de) 1989-04-26
EP0194416A1 (de) 1986-09-17
KR920010711B1 (ko) 1992-12-14
FI860296A (fi) 1986-07-26
CS254992B2 (en) 1988-02-15
AU584663B2 (en) 1989-06-01
HU193624B (en) 1987-11-30
AU5272886A (en) 1986-07-31
US5082839A (en) 1992-01-21
ES8704949A1 (es) 1987-04-16
ES557343A0 (es) 1988-06-01
FI86851B (fi) 1992-07-15
ES557344A0 (es) 1988-07-16
CA1269373A (en) 1990-05-22
GR860189B (en) 1986-05-26
NO855260L (no) 1986-07-28
YU44280B (en) 1990-04-30
JPH0651704B2 (ja) 1994-07-06
DE3502392A1 (de) 1986-07-31
DK46292A (da) 1992-04-06
ATE42556T1 (de) 1989-05-15
ZA86542B (en) 1987-09-30
DK46292D0 (da) 1992-04-06
ES8802426A1 (es) 1988-06-01
FI860296A0 (fi) 1986-01-22
NO166646C (no) 1991-08-21
DK36786A (da) 1986-07-26
ES551198A0 (es) 1987-04-16
PT81898A (de) 1986-02-01
HU195821B (en) 1988-07-28
US5155103A (en) 1992-10-13
DD265799A5 (de) 1989-03-15
CZ410791A3 (en) 1993-04-14
DK165323C (da) 1993-03-29
JPS61176591A (ja) 1986-08-08
JPH02191281A (ja) 1990-07-27
NO164029B (no) 1990-05-14
PT81898B (pt) 1988-05-27
YU7886A (en) 1987-10-31
SG44292G (en) 1992-09-04
PL144948B1 (en) 1988-07-30
DK165323B (da) 1992-11-09
IE58728B1 (en) 1993-11-03
NZ214926A (en) 1989-04-26
DD263063A5 (de) 1988-12-21
MX9203258A (es) 1992-07-01
NO166646B (no) 1991-05-13
SU1402265A3 (ru) 1988-06-07
US4968794A (en) 1990-11-06
HK75792A (en) 1992-10-09

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