DE3878833T2 - Thieno(triazolo)diazepinverbindungen, und medizinische verwendung derselben. - Google Patents
Thieno(triazolo)diazepinverbindungen, und medizinische verwendung derselben.Info
- Publication number
- DE3878833T2 DE3878833T2 DE8888904639T DE3878833T DE3878833T2 DE 3878833 T2 DE3878833 T2 DE 3878833T2 DE 8888904639 T DE8888904639 T DE 8888904639T DE 3878833 T DE3878833 T DE 3878833T DE 3878833 T2 DE3878833 T2 DE 3878833T2
- Authority
- DE
- Germany
- Prior art keywords
- thieno
- triazolo
- medical use
- diazepine
- diazepine compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13205887 | 1987-05-28 | ||
JP13719587 | 1987-05-29 | ||
JP14969887 | 1987-06-16 | ||
PCT/JP1988/000506 WO1988009333A1 (en) | 1987-05-28 | 1988-05-25 | Thieno(triazolo)diazepine compound and medicinal application of the same |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3878833D1 DE3878833D1 (de) | 1993-04-08 |
DE3878833T2 true DE3878833T2 (de) | 1993-06-09 |
Family
ID=27316424
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8888904639T Expired - Fee Related DE3878833T2 (de) | 1987-05-28 | 1988-05-25 | Thieno(triazolo)diazepinverbindungen, und medizinische verwendung derselben. |
Country Status (6)
Country | Link |
---|---|
US (1) | US4960770A (de) |
EP (1) | EP0315698B1 (de) |
JP (1) | JP2531102B2 (de) |
AT (1) | ATE86256T1 (de) |
DE (1) | DE3878833T2 (de) |
WO (1) | WO1988009333A1 (de) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3502392A1 (de) * | 1985-01-25 | 1986-07-31 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen |
PH30676A (en) * | 1986-07-22 | 1997-09-16 | Boehringer Ingelhein Kg | Hetrazepine compounds which have useful pharmaceutical utility |
MC1999A1 (fr) * | 1987-12-18 | 1990-01-26 | Hoffmann La Roche | Composes tricycliques |
US4959361A (en) * | 1987-12-18 | 1990-09-25 | Hoffmann-La Roche Inc. | Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists |
CA1324863C (en) * | 1988-01-30 | 1993-11-30 | Minoru Moriwaki | Thienotriazolodiazepine compounds and pharmaceutical uses thereof |
US5382579A (en) * | 1988-10-31 | 1995-01-17 | Eisai Co., Ltd. | Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals |
US5221671A (en) * | 1988-10-31 | 1993-06-22 | Eisai Co., Ltd. | Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals |
US5468740A (en) * | 1988-10-31 | 1995-11-21 | Eisai Co., Ltd. | 1,4-diazepine derivative and its pharmaceutical use |
US5304553A (en) * | 1988-10-31 | 1994-04-19 | Eisai Co., Ltd. | 1,4-diazepine derivative and its pharmaceutical use |
EP0387613A1 (de) * | 1989-03-03 | 1990-09-19 | Boehringer Ingelheim Kg | Neue Thienodiazepine |
JP2959598B2 (ja) * | 1990-10-12 | 1999-10-06 | 吉富製薬株式会社 | 光学活性なチエノトリアゾロジアゼピン化合物 |
JPH10190985A (ja) * | 1996-12-26 | 1998-07-21 | Asahi Optical Co Ltd | カスケード走査光学系を備えた記録装置 |
WO2008067222A1 (en) * | 2006-11-28 | 2008-06-05 | Kalypsys, Inc. | Heterocyclic modulators of tgr5 |
KR101633742B1 (ko) * | 2008-10-30 | 2016-06-27 | 써코메드 엘엘씨 | 아포 a에 활성인 티에노트리아졸로디아제핀 유도체 |
CN103180318B (zh) * | 2010-05-14 | 2017-05-10 | 达那-法伯癌症研究所 | 雄性避孕组合物以及使用方法 |
CA2799403C (en) | 2010-05-14 | 2020-01-21 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating leukemia |
BR112012029005A2 (pt) | 2010-05-14 | 2016-07-26 | Dana Farber Cancer Inst Inc | composições e métodos de tratamento de neoplasia, doença inflamatória e outros distúrbios |
AR084070A1 (es) | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
US9249161B2 (en) | 2010-12-02 | 2016-02-02 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
EP2705039B1 (de) | 2011-05-04 | 2017-07-26 | Constellation Pharmaceuticals, Inc. | Bromodomainhemmer und ihre verwendung |
US9328117B2 (en) | 2011-06-17 | 2016-05-03 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
DE102011082013A1 (de) * | 2011-09-01 | 2013-03-07 | Bayer Pharma AG | 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine |
TWI602820B (zh) | 2012-06-06 | 2017-10-21 | 星宿藥物公司 | 溴域抑制劑及其用途 |
US9624244B2 (en) | 2012-06-06 | 2017-04-18 | Constellation Pharmaceuticals, Inc. | Benzo [B] isoxazoloazepine bromodomain inhibitors and uses thereof |
US9975896B2 (en) | 2013-07-25 | 2018-05-22 | Dana-Farber Cancer Institute, Inc. | Inhibitors of transcription factors and uses thereof |
CA2929652A1 (en) | 2013-11-08 | 2015-05-14 | Dana-Farber Cancer Institute, Inc. | Combination therapy for cancer using bromodomain and extra-terminal (bet) protein inhibitors |
JP2017504653A (ja) | 2014-01-31 | 2017-02-09 | ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド | ジアミノピリミジンベンゼンスルホン誘導体およびその使用 |
JP2017504651A (ja) | 2014-01-31 | 2017-02-09 | ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド | ジアゼパン誘導体の使用 |
US10925881B2 (en) | 2014-02-28 | 2021-02-23 | Tensha Therapeutics, Inc. | Treatment of conditions associated with hyperinsulinaemia |
US9969747B2 (en) | 2014-06-20 | 2018-05-15 | Constellation Pharmaceuticals, Inc. | Crystalline forms of 2-((4S)-6-(4-chlorophenyl)-1-methyl-4H-benzo[C]isoxazolo[4,5-e]azepin-4-yl)acetamide |
RU2017104898A (ru) | 2014-08-08 | 2018-09-10 | Дана-Фарбер Кэнсер Инститьют, Инк. | Дигидроптеридиноновые производные и их применения |
JP2017526741A (ja) | 2014-08-08 | 2017-09-14 | ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド | ジアゼパン誘導体およびその使用 |
SG11201703414VA (en) | 2014-10-27 | 2017-05-30 | Tensha Therapeutics Inc | Bromodomain inhibitors |
CA2986441A1 (en) | 2015-06-12 | 2016-12-15 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
SG10202007090UA (en) | 2015-09-11 | 2020-08-28 | Dana Farber Cancer Inst Inc | Cyano thienotriazolodiazepines and uses thereof |
RU2018112953A (ru) | 2015-09-11 | 2019-10-14 | Дана-Фарбер Кэнсер Инститьют, Инк. | Ацетамидтиенотриазолодиазепины и пути их применения |
KR20180081809A (ko) | 2015-11-25 | 2018-07-17 | 다나-파버 캔서 인스티튜트 인크. | 2가 브로모도메인 억제제 및 그의 용도 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE51012T1 (de) * | 1983-09-09 | 1990-03-15 | Shell Int Research | Biopolymerzusammensetzungen und verfahren zur herstellung derselben. |
DE3435973A1 (de) * | 1984-10-01 | 1986-04-10 | Boehringer Ingelheim KG, 6507 Ingelheim | Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung |
ES2037013T3 (es) * | 1986-01-21 | 1993-06-16 | Boehringer Ingelheim Kg | Procedimiento para preparar tieno-1,4-diazepinas. |
JPH06187623A (ja) * | 1992-12-15 | 1994-07-08 | Matsushita Electric Ind Co Ltd | 磁気記録再生装置 |
JPH06222718A (ja) * | 1993-01-27 | 1994-08-12 | Sekisui Chem Co Ltd | 装飾用粘着シートの貼り付け方法 |
-
1988
- 1988-05-25 US US07/304,989 patent/US4960770A/en not_active Expired - Fee Related
- 1988-05-25 WO PCT/JP1988/000506 patent/WO1988009333A1/ja active IP Right Grant
- 1988-05-25 DE DE8888904639T patent/DE3878833T2/de not_active Expired - Fee Related
- 1988-05-25 AT AT88904639T patent/ATE86256T1/de not_active IP Right Cessation
- 1988-05-25 EP EP88904639A patent/EP0315698B1/de not_active Expired - Lifetime
-
1993
- 1993-06-28 JP JP5185489A patent/JP2531102B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE3878833D1 (de) | 1993-04-08 |
US4960770A (en) | 1990-10-02 |
JPH06157316A (ja) | 1994-06-03 |
EP0315698B1 (de) | 1993-03-03 |
JP2531102B2 (ja) | 1996-09-04 |
WO1988009333A1 (en) | 1988-12-01 |
EP0315698A1 (de) | 1989-05-17 |
ATE86256T1 (de) | 1993-03-15 |
EP0315698A4 (de) | 1990-05-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE3878833T2 (de) | Thieno(triazolo)diazepinverbindungen, und medizinische verwendung derselben. | |
DE69838172D1 (de) | Oxindolylchinazolinderivate als angiogenesehemmer | |
DE68929372T2 (de) | Thieno[3,2-f] (1,2,4- triazolo)[4,3-a] 1,4- diazepinderivate als PAF-Antagonisten | |
NZ332645A (en) | use of a bis-indolylmaleimide derivative for treating VEGF related diseases | |
ATE80394T1 (de) | 6,11-dihydro-11-(4-piperidyliden)-5hbenzo(5,6>cyclohepta(1,2-b>-pyrridine und zusammensetzungen sowie verfahren zur verwendung. | |
ATE233242T1 (de) | Chinoline und chinazoline verbindungen und ihre therapeutische anwendung | |
ATE166353T1 (de) | 2-heteroaryl-5,11-dihydro-6h-dipyrido(3,2-b:2', '-e> (1,4>diazepine und ihre verwendung zur vorbeugung und behandlung von hiv-infektion | |
PT87160A (pt) | Verfahren zur herstellung von 3h-1,2,3-triazolo ]4,5-d" pyrimidinen | |
DE69116788T2 (de) | 4-substituierte Dihydropyrido [4,3-d] pyrimidine als Analgetika und entzündungshemmende Mittel zur topischen Anwendung bei der Behandlung von Hauterkrankungen | |
FI845102L (fi) | Imidazo/1,2-c/pyrimidiner. | |
DK0526588T3 (da) | Heterocykliske forbindelser, deres fremstilling og anvendelse | |
DE69213777D1 (de) | Pyridobenzodiazepine, Dipyrido-[3,2-b:2',3'-3] [1,4]-diazepine und deren Verwendung in der Vorbeugung und Behandlung von AIDS | |
DE3853704D1 (de) | Pyrrolo[1,2-a]imidazol- und Imidazo[1,2-a]pyridinderivate und ihre Anwendung als 5-Lipoxygenase Inhibitoren. | |
DK177191D0 (da) | Heterocyclic compounds and their preparation and use | |
FI912499A0 (fi) | Pyrido/3,4-b/pyrrolo/1,2-e//1,4,5/ oxadiazepiner och daermed naerbeslaektade analoger, foerfarande foer deras framstaellning och deras anvaendning som laekemedel. | |
ATE131482T1 (de) | Pyrido(2,3-b>(1,5>-benzoxazepin (und -thiazepin)- 5(6h)-one und -thione und ihre verwendung zur vorbeugung und behandlung von hiv-infektion | |
DK0461012T3 (da) | Derivater af ((1-arylpyrrolidin-2-yl)methyl)piperazin, fremstillingen heraf og deres terapeutiske anvendelse | |
GB2071093B (en) | Benzothiopyrano(2,3-c)pyridines | |
JPS6479185A (en) | Thieno(triazolo)diazepine compound | |
ES466054A1 (es) | Procedimiento de preparacion de compuestos del acido amino- espiro(oxa(o tia)cicloalcano-penam)-carboxilico | |
DE3777999D1 (de) | Substituierte piperidine oder azepine, ihre herstellung und therapeutische verwendung. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |