DE69116788T2 - 4-substituierte Dihydropyrido [4,3-d] pyrimidine als Analgetika und entzündungshemmende Mittel zur topischen Anwendung bei der Behandlung von Hauterkrankungen - Google Patents

4-substituierte Dihydropyrido [4,3-d] pyrimidine als Analgetika und entzündungshemmende Mittel zur topischen Anwendung bei der Behandlung von Hauterkrankungen

Info

Publication number
DE69116788T2
DE69116788T2 DE69116788T DE69116788T DE69116788T2 DE 69116788 T2 DE69116788 T2 DE 69116788T2 DE 69116788 T DE69116788 T DE 69116788T DE 69116788 T DE69116788 T DE 69116788T DE 69116788 T2 DE69116788 T2 DE 69116788T2
Authority
DE
Germany
Prior art keywords
analgesics
treatment
pyrimidines
inflammatory agents
skin diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69116788T
Other languages
English (en)
Other versions
DE69116788D1 (de
Inventor
Richard Charles Effland
Joseph Thomas Klein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Publication of DE69116788D1 publication Critical patent/DE69116788D1/de
Application granted granted Critical
Publication of DE69116788T2 publication Critical patent/DE69116788T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
DE69116788T 1990-08-27 1991-08-27 4-substituierte Dihydropyrido [4,3-d] pyrimidine als Analgetika und entzündungshemmende Mittel zur topischen Anwendung bei der Behandlung von Hauterkrankungen Expired - Fee Related DE69116788T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/573,414 US5059602A (en) 1990-08-27 1990-08-27 4-substituted dihydropyrido(4,3-d)pyrimidines as analgesics and topical antiinflammatory agents for the treatment of skin disorders

Publications (2)

Publication Number Publication Date
DE69116788D1 DE69116788D1 (de) 1996-03-14
DE69116788T2 true DE69116788T2 (de) 1996-07-18

Family

ID=24291905

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69116788T Expired - Fee Related DE69116788T2 (de) 1990-08-27 1991-08-27 4-substituierte Dihydropyrido [4,3-d] pyrimidine als Analgetika und entzündungshemmende Mittel zur topischen Anwendung bei der Behandlung von Hauterkrankungen

Country Status (22)

Country Link
US (1) US5059602A (de)
EP (1) EP0480155B1 (de)
JP (1) JP3083180B2 (de)
KR (1) KR100218562B1 (de)
AT (1) ATE133670T1 (de)
AU (1) AU635150B2 (de)
CA (1) CA2049850C (de)
CZ (1) CZ280569B6 (de)
DE (1) DE69116788T2 (de)
DK (1) DK0480155T3 (de)
ES (1) ES2082894T3 (de)
FI (1) FI914007A (de)
GR (1) GR3019085T3 (de)
HU (1) HUT59923A (de)
IE (1) IE72086B1 (de)
IL (1) IL99305A (de)
NO (1) NO913331L (de)
NZ (1) NZ239516A (de)
PT (1) PT98773B (de)
SG (1) SG48250A1 (de)
YU (1) YU144391A (de)
ZA (1) ZA916738B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5095019A (en) * 1990-08-27 1992-03-10 Hoechst-Roussel Pharmaceuticals Inc. 4-substituted dihydropyrido(4,3-D)pyrimidines as analgesics and topical antiinflammatory agents for the treatment of skin disorders
US6031105A (en) * 1996-04-09 2000-02-29 Pfizer Inc Substituted pyridines
US6008361A (en) * 1996-04-09 1999-12-28 Pfizer Inc. Substituted pyridines
WO2001087154A1 (en) 2000-05-18 2001-11-22 Nuvasive, Inc. Tissue discrimination and applications in medical procedures
ATE445838T1 (de) 2001-07-25 2009-10-15 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
CA2789097C (en) 2005-04-28 2017-02-21 Proteus Digital Health, Inc. Pharma-informatics system
EP1879877B8 (de) * 2005-05-03 2013-02-13 Ranbaxy Laboratories Limited Antimikrobielle mittel
JP2009533315A (ja) * 2006-04-10 2009-09-17 ランバクシー ラボラトリーズ リミテッド 抗菌剤
WO2008036682A2 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
NZ616673A (en) 2009-02-20 2014-08-29 To Bbb Holding B V Glutathione-based drug delivery system
NZ596876A (en) 2009-05-06 2014-01-31 Lab Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1197466B (de) * 1962-03-22 1965-07-29 Thomae Gmbh Dr K Verfahren zur Herstellung von neuen 5, 6, 7, 8-Tetrahydropyrido-[4, 3-d]pyrimidinen
US3635973A (en) * 1969-11-20 1972-01-18 Sherwin Williams Co Method of preparing 3-substituted pyridopyrimidinediones and lumazines
US3962264A (en) * 1972-09-27 1976-06-08 Pfizer Inc. Process for making 2-amino nicotinonitrile
JPS5813550B2 (ja) * 1975-03-15 1983-03-14 ヒサミツセイヤク カブシキガイシヤ シンキナピリド （ ４，３−ｄ ） ピリミジンジオンユウドウタイノセイゾウホウ
DE3438351A1 (de) * 1984-10-19 1986-04-24 Gödecke AG, 1000 Berlin 4-alkoxy-pyrido(2,3-d)pyrimidin-derivate, verfahren zu deren herstellung und deren verwendung
DE3502590A1 (de) * 1985-01-26 1986-07-31 Gödecke AG, 1000 Berlin 5-alkoxy-pyrido(4,3-d)pyrimidin-derivate, verfahren zu deren herstellung und deren verwendung
DE3502742A1 (de) * 1985-01-28 1986-07-31 Gödecke AG, 1000 Berlin 5-oxo-pyrido(4,3-d)pyrimidin-derivate, verfahren zu deren herstellung und deren verwendung

Also Published As

Publication number Publication date
JPH04230684A (ja) 1992-08-19
ZA916738B (en) 1992-04-29
US5059602A (en) 1991-10-22
HUT59923A (en) 1992-07-28
NO913331L (no) 1992-02-28
ES2082894T3 (es) 1996-04-01
CZ280569B6 (cs) 1996-02-14
DE69116788D1 (de) 1996-03-14
DK0480155T3 (da) 1996-06-10
NZ239516A (en) 1994-04-27
IL99305A (en) 1997-02-18
IE913010A1 (en) 1992-03-11
EP0480155B1 (de) 1996-01-31
NO913331D0 (no) 1991-08-26
AU635150B2 (en) 1993-03-11
EP0480155A2 (de) 1992-04-15
ATE133670T1 (de) 1996-02-15
CS262491A3 (en) 1992-06-17
SG48250A1 (en) 1998-04-17
HU912786D0 (en) 1992-01-28
CA2049850C (en) 2002-03-05
EP0480155A3 (en) 1992-04-29
YU144391A (sh) 1995-03-27
GR3019085T3 (en) 1996-05-31
IE72086B1 (en) 1997-03-12
PT98773A (pt) 1992-07-31
KR920004387A (ko) 1992-03-27
FI914007A0 (fi) 1991-08-23
CA2049850A1 (en) 1992-02-28
PT98773B (pt) 1999-01-29
FI914007A (fi) 1992-02-28
KR100218562B1 (ko) 1999-09-01
JP3083180B2 (ja) 2000-09-04
IL99305A0 (en) 1992-07-15
AU8271991A (en) 1992-03-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee