DE69838172D1 - Oxindolylchinazolinderivate als angiogenesehemmer - Google Patents
Oxindolylchinazolinderivate als angiogenesehemmerInfo
- Publication number
- DE69838172D1 DE69838172D1 DE69838172T DE69838172T DE69838172D1 DE 69838172 D1 DE69838172 D1 DE 69838172D1 DE 69838172 T DE69838172 T DE 69838172T DE 69838172 T DE69838172 T DE 69838172T DE 69838172 D1 DE69838172 D1 DE 69838172D1
- Authority
- DE
- Germany
- Prior art keywords
- oxindolylchinazole
- angiogenesehemmer
- derivatives
- salts
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 abstract 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97401972 | 1997-08-22 | ||
EP97401973 | 1997-08-22 | ||
EP97401973 | 1997-08-22 | ||
EP97401974 | 1997-08-22 | ||
EP97401972 | 1997-08-22 | ||
EP97401974 | 1997-08-22 | ||
PCT/GB1998/002493 WO1999010349A1 (en) | 1997-08-22 | 1998-08-19 | Oxindolylquinazoline derivatives as angiogenesis inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69838172D1 true DE69838172D1 (de) | 2007-09-13 |
DE69838172T2 DE69838172T2 (de) | 2008-04-10 |
Family
ID=27238731
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69838172T Expired - Lifetime DE69838172T2 (de) | 1997-08-22 | 1998-08-19 | Oxindolylchinazolinderivate als angiogenesehemmer |
Country Status (8)
Country | Link |
---|---|
US (1) | US6294532B1 (de) |
EP (1) | EP1005470B1 (de) |
JP (2) | JP4959049B2 (de) |
AT (1) | ATE368665T1 (de) |
AU (1) | AU8816298A (de) |
DE (1) | DE69838172T2 (de) |
ES (1) | ES2289791T3 (de) |
WO (1) | WO1999010349A1 (de) |
Families Citing this family (132)
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AU733551B2 (en) | 1996-09-25 | 2001-05-17 | Astrazeneca Ab | Qinoline derivatives inhibiting the effect of growth factors such as VEGF |
GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
AU8816298A (en) * | 1997-08-22 | 1999-03-16 | Zeneca Limited | Oxindolylquinazoline derivatives as angiogenesis inhibitors |
HU228964B1 (en) * | 1999-02-10 | 2013-07-29 | Astrazeneca Ab | Quinazoline derivatives as angiogenesis inhibitors, process for their preparation and medicaments containing them |
ATE398120T1 (de) | 1999-11-05 | 2008-07-15 | Astrazeneca Ab | Neue quinazolin-derivate |
UA74803C2 (uk) | 1999-11-11 | 2006-02-15 | Осі Фармасьютікалз, Інк. | Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування |
JP2003525897A (ja) * | 2000-03-06 | 2003-09-02 | アストラゼネカ アクチボラグ | 治 療 |
GB0008269D0 (en) * | 2000-04-05 | 2000-05-24 | Astrazeneca Ab | Combination chemotherapy |
EP1274692B1 (de) * | 2000-04-07 | 2006-08-02 | AstraZeneca AB | Chinazolinverbindungen |
ATE448226T1 (de) | 2000-09-01 | 2009-11-15 | Novartis Vaccines & Diagnostic | Aza heterocyclische derivate und ihre therapeutische verwendung |
WO2002022598A1 (en) | 2000-09-11 | 2002-03-21 | Chiron Corporation | Quinolinone derivatives as tyrosine kinase inhibitors |
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US7105530B2 (en) * | 2000-12-21 | 2006-09-12 | Smithkline Beecham Corporation | Pyrimidineamines as angiogenesis modulators |
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WO2002094809A1 (en) * | 2001-05-24 | 2002-11-28 | Yamanouchi Pharmaceutical Co., Ltd. | 3-quinoline-2-(1h)-ylideneindolin-2-one derivatives |
AU2002345792A1 (en) | 2001-06-21 | 2003-01-08 | Pfizer Inc. | Thienopyridine and thienopyrimidine anticancer agents |
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SE0104341D0 (sv) * | 2001-12-20 | 2001-12-20 | Astrazeneca Ab | New use |
SE0104340D0 (sv) | 2001-12-20 | 2001-12-20 | Astrazeneca Ab | New compounds |
EP1458711B1 (de) * | 2001-12-21 | 2007-07-18 | AstraZeneca AB | Verwendung von oxindolderivaten zur behandlung von mit demenz in zusammenhang stehenden krankheiten, alzheimer-krankheit und mit glycogensynthasekinase-3 assoziierten leiden |
TW200301123A (en) * | 2001-12-21 | 2003-07-01 | Astrazeneca Uk Ltd | New use |
CA2473572C (en) * | 2002-02-01 | 2011-05-10 | Astrazeneca Ab | Quinazoline compounds |
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- 1998-08-19 AU AU88162/98A patent/AU8816298A/en not_active Abandoned
- 1998-08-19 EP EP98939756A patent/EP1005470B1/de not_active Expired - Lifetime
- 1998-08-19 US US09/486,051 patent/US6294532B1/en not_active Expired - Fee Related
- 1998-08-19 ES ES98939756T patent/ES2289791T3/es not_active Expired - Lifetime
- 1998-08-19 JP JP2000507677A patent/JP4959049B2/ja not_active Expired - Fee Related
- 1998-08-19 DE DE69838172T patent/DE69838172T2/de not_active Expired - Lifetime
- 1998-08-19 AT AT98939756T patent/ATE368665T1/de not_active IP Right Cessation
- 1998-08-19 WO PCT/GB1998/002493 patent/WO1999010349A1/en active IP Right Grant
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2009
- 2009-09-24 JP JP2009219619A patent/JP2010043091A/ja active Pending
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ES2289791T3 (es) | 2008-02-01 |
JP2010043091A (ja) | 2010-02-25 |
JP4959049B2 (ja) | 2012-06-20 |
AU8816298A (en) | 1999-03-16 |
EP1005470A1 (de) | 2000-06-07 |
WO1999010349A1 (en) | 1999-03-04 |
EP1005470B1 (de) | 2007-08-01 |
US6294532B1 (en) | 2001-09-25 |
ATE368665T1 (de) | 2007-08-15 |
JP2001514182A (ja) | 2001-09-11 |
DE69838172T2 (de) | 2008-04-10 |
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