NL195016C - Recombinant pokkenvirus, vaccin dat dit virus bevat, geïsoleerd nucleïnezuurmolecuul, geïsoleerd polypeptide, nucleïnezuurvector die dit nucleïnezuurmolecuul bevat en vaccin die deze vector bevat. - Google Patents
Recombinant pokkenvirus, vaccin dat dit virus bevat, geïsoleerd nucleïnezuurmolecuul, geïsoleerd polypeptide, nucleïnezuurvector die dit nucleïnezuurmolecuul bevat en vaccin die deze vector bevat. Download PDFInfo
- Publication number
- NL195016C NL195016C NL9020677A NL9020677A NL195016C NL 195016 C NL195016 C NL 195016C NL 9020677 A NL9020677 A NL 9020677A NL 9020677 A NL9020677 A NL 9020677A NL 195016 C NL195016 C NL 195016C
- Authority
- NL
- Netherlands
- Prior art keywords
- virus
- ehv
- vaccinia
- recombinant
- gene
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title claims description 89
- 239000013598 vector Substances 0.000 title claims description 31
- 229960005486 vaccine Drugs 0.000 title claims description 28
- 150000007523 nucleic acids Chemical class 0.000 title claims description 17
- 108020004707 nucleic acids Proteins 0.000 title claims description 14
- 102000039446 nucleic acids Human genes 0.000 title claims description 14
- 241000700647 Variola virus Species 0.000 title claims description 8
- 229920001184 polypeptide Polymers 0.000 title claims description 7
- 108090000765 processed proteins & peptides Proteins 0.000 title claims description 7
- 102000004196 processed proteins & peptides Human genes 0.000 title claims description 7
- 241000701081 Equid alphaherpesvirus 1 Species 0.000 claims description 276
- 101700012268 Holin Proteins 0.000 claims description 139
- 101710124413 Portal protein Proteins 0.000 claims description 139
- 101710112672 Probable tape measure protein Proteins 0.000 claims description 139
- 101710194975 Uncharacterized protein gp14 Proteins 0.000 claims description 139
- 241000700618 Vaccinia virus Species 0.000 claims description 94
- 101710099276 Probable metalloendopeptidase Proteins 0.000 claims description 92
- 241001529453 unidentified herpesvirus Species 0.000 claims description 74
- 108020004414 DNA Proteins 0.000 claims description 66
- 108090000288 Glycoproteins Proteins 0.000 claims description 63
- 102000003886 Glycoproteins Human genes 0.000 claims description 60
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 21
- 101001095863 Enterobacteria phage T4 RNA ligase 1 Proteins 0.000 claims description 19
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 14
- 241000178270 Canarypox virus Species 0.000 claims description 12
- 241001465754 Metazoa Species 0.000 claims description 9
- 244000144977 poultry Species 0.000 claims description 8
- 230000028993 immune response Effects 0.000 claims description 6
- 230000001939 inductive effect Effects 0.000 claims description 2
- 239000013612 plasmid Substances 0.000 description 114
- 239000012634 fragment Substances 0.000 description 103
- 206010046865 Vaccinia virus infection Diseases 0.000 description 97
- 208000007089 vaccinia Diseases 0.000 description 97
- 108090000623 proteins and genes Proteins 0.000 description 61
- 210000004027 cell Anatomy 0.000 description 44
- 108700026244 Open Reading Frames Proteins 0.000 description 38
- 150000001413 amino acids Chemical class 0.000 description 37
- 239000000047 product Substances 0.000 description 33
- 239000002773 nucleotide Substances 0.000 description 31
- 125000003729 nucleotide group Chemical group 0.000 description 31
- 230000006798 recombination Effects 0.000 description 29
- 238000005215 recombination Methods 0.000 description 26
- 238000010276 construction Methods 0.000 description 23
- 230000037431 insertion Effects 0.000 description 21
- 238000003780 insertion Methods 0.000 description 21
- 238000010367 cloning Methods 0.000 description 20
- 241000699800 Cricetinae Species 0.000 description 19
- 239000011543 agarose gel Substances 0.000 description 19
- 108020004705 Codon Proteins 0.000 description 18
- 238000000034 method Methods 0.000 description 18
- 210000002966 serum Anatomy 0.000 description 18
- 108091026890 Coding region Proteins 0.000 description 17
- 230000003472 neutralizing effect Effects 0.000 description 17
- 241000700198 Cavia Species 0.000 description 16
- 108091034117 Oligonucleotide Proteins 0.000 description 16
- 108091081024 Start codon Proteins 0.000 description 16
- 239000012528 membrane Substances 0.000 description 16
- 241000700584 Simplexvirus Species 0.000 description 14
- 230000014509 gene expression Effects 0.000 description 14
- 101150061732 M2L gene Proteins 0.000 description 13
- 230000029087 digestion Effects 0.000 description 13
- 102000004169 proteins and genes Human genes 0.000 description 13
- 241000588724 Escherichia coli Species 0.000 description 12
- 108010076504 Protein Sorting Signals Proteins 0.000 description 12
- 241000701093 Suid alphaherpesvirus 1 Species 0.000 description 12
- 238000012217 deletion Methods 0.000 description 12
- 230000037430 deletion Effects 0.000 description 12
- 238000004458 analytical method Methods 0.000 description 11
- 238000010166 immunofluorescence Methods 0.000 description 11
- 210000003501 vero cell Anatomy 0.000 description 11
- 230000036961 partial effect Effects 0.000 description 10
- 230000001681 protective effect Effects 0.000 description 10
- 101710154606 Hemagglutinin Proteins 0.000 description 9
- 101710093908 Outer capsid protein VP4 Proteins 0.000 description 9
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 9
- 101710176177 Protein A56 Proteins 0.000 description 9
- 108020005038 Terminator Codon Proteins 0.000 description 9
- 239000000185 hemagglutinin Substances 0.000 description 9
- 230000002209 hydrophobic effect Effects 0.000 description 9
- 238000002255 vaccination Methods 0.000 description 9
- 241000712469 Fowl plague virus Species 0.000 description 8
- 239000011324 bead Substances 0.000 description 8
- 108010005774 beta-Galactosidase Proteins 0.000 description 8
- 238000013519 translation Methods 0.000 description 8
- 101710104895 DNA replication protein 17 Proteins 0.000 description 7
- 108010054576 Deoxyribonuclease EcoRI Proteins 0.000 description 7
- 101710152616 Probable major capsid protein gp17 Proteins 0.000 description 7
- 102100030350 Prolactin-inducible protein Human genes 0.000 description 7
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 7
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 7
- 208000015181 infectious disease Diseases 0.000 description 7
- 238000002703 mutagenesis Methods 0.000 description 7
- 231100000350 mutagenesis Toxicity 0.000 description 7
- 239000002953 phosphate buffered saline Substances 0.000 description 7
- 238000011144 upstream manufacturing Methods 0.000 description 7
- 102000053602 DNA Human genes 0.000 description 6
- 101900120730 Equine herpesvirus 1 Envelope glycoprotein E Proteins 0.000 description 6
- 241000701085 Human alphaherpesvirus 3 Species 0.000 description 6
- 125000003412 L-alanyl group Chemical group [H]N([H])[C@@](C([H])([H])[H])(C(=O)[*])[H] 0.000 description 6
- 230000000890 antigenic effect Effects 0.000 description 6
- 239000002585 base Substances 0.000 description 6
- 230000003053 immunization Effects 0.000 description 6
- 238000002649 immunization Methods 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 230000003612 virological effect Effects 0.000 description 6
- 101150039660 HA gene Proteins 0.000 description 5
- 230000004988 N-glycosylation Effects 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 230000002068 genetic effect Effects 0.000 description 5
- 238000009396 hybridization Methods 0.000 description 5
- 238000000338 in vitro Methods 0.000 description 5
- 238000002955 isolation Methods 0.000 description 5
- 239000002609 medium Substances 0.000 description 5
- 229960004452 methionine Drugs 0.000 description 5
- 230000008488 polyadenylation Effects 0.000 description 5
- 230000002103 transcriptional effect Effects 0.000 description 5
- 230000014621 translational initiation Effects 0.000 description 5
- ANVAOWXLWRTKGA-NTXLUARGSA-N (6'R)-beta,epsilon-carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=CCCC1(C)C ANVAOWXLWRTKGA-NTXLUARGSA-N 0.000 description 4
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 4
- 241000701083 Bovine alphaherpesvirus 1 Species 0.000 description 4
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 4
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 4
- 239000013553 cell monolayer Substances 0.000 description 4
- 230000000295 complement effect Effects 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 239000012091 fetal bovine serum Substances 0.000 description 4
- 238000002169 hydrotherapy Methods 0.000 description 4
- 238000001114 immunoprecipitation Methods 0.000 description 4
- 239000002054 inoculum Substances 0.000 description 4
- 108020004999 messenger RNA Proteins 0.000 description 4
- OPIFSICVWOWJMJ-AEOCFKNESA-N 5-bromo-4-chloro-3-indolyl beta-D-galactoside Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1OC1=CNC2=CC=C(Br)C(Cl)=C12 OPIFSICVWOWJMJ-AEOCFKNESA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- 108010017826 DNA Polymerase I Proteins 0.000 description 3
- 102000004594 DNA Polymerase I Human genes 0.000 description 3
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 3
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 3
- 108010081175 Equid herpesvirus glycoprotein 13 Proteins 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 101710189078 Helicase Proteins 0.000 description 3
- 208000029433 Herpesviridae infectious disease Diseases 0.000 description 3
- 241000700588 Human alphaherpesvirus 1 Species 0.000 description 3
- 101710125418 Major capsid protein Proteins 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 101710118046 RNA-directed RNA polymerase Proteins 0.000 description 3
- 238000012300 Sequence Analysis Methods 0.000 description 3
- 101710172711 Structural protein Proteins 0.000 description 3
- 108020004440 Thymidine kinase Proteins 0.000 description 3
- 238000000137 annealing Methods 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 102000005936 beta-Galactosidase Human genes 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 210000004899 c-terminal region Anatomy 0.000 description 3
- 210000000170 cell membrane Anatomy 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 230000004186 co-expression Effects 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 101150036031 gD gene Proteins 0.000 description 3
- 230000013595 glycosylation Effects 0.000 description 3
- 238000006206 glycosylation reaction Methods 0.000 description 3
- 101150118312 gp63 gene Proteins 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 244000052769 pathogen Species 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 230000010076 replication Effects 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 230000002441 reversible effect Effects 0.000 description 3
- 238000012163 sequencing technique Methods 0.000 description 3
- 238000002741 site-directed mutagenesis Methods 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 2
- 108020004463 18S ribosomal RNA Proteins 0.000 description 2
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 2
- 101000583086 Bunodosoma granuliferum Delta-actitoxin-Bgr2b Proteins 0.000 description 2
- 241000283707 Capra Species 0.000 description 2
- 101710167800 Capsid assembly scaffolding protein Proteins 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 2
- 102100027723 Endogenous retrovirus group K member 6 Rec protein Human genes 0.000 description 2
- 101000686824 Enterobacteria phage N4 Virion DNA-directed RNA polymerase Proteins 0.000 description 2
- 101710121417 Envelope glycoprotein Proteins 0.000 description 2
- 101000644628 Escherichia phage Mu Tail fiber assembly protein U Proteins 0.000 description 2
- 108091029865 Exogenous DNA Proteins 0.000 description 2
- 241000701024 Human betaherpesvirus 5 Species 0.000 description 2
- 241000701044 Human gammaherpesvirus 4 Species 0.000 description 2
- 108020005350 Initiator Codon Proteins 0.000 description 2
- 241000699673 Mesocricetus auratus Species 0.000 description 2
- 101710113540 ORF2 protein Proteins 0.000 description 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 2
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 description 2
- 101710090523 Putative movement protein Proteins 0.000 description 2
- 101100173636 Rattus norvegicus Fhl2 gene Proteins 0.000 description 2
- 229920002684 Sepharose Polymers 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 241000282887 Suidae Species 0.000 description 2
- 108700026226 TATA Box Proteins 0.000 description 2
- 102000006601 Thymidine Kinase Human genes 0.000 description 2
- 239000007983 Tris buffer Substances 0.000 description 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 230000002238 attenuated effect Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 239000013592 cell lysate Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000003776 cleavage reaction Methods 0.000 description 2
- 230000001086 cytosolic effect Effects 0.000 description 2
- 239000013604 expression vector Substances 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 230000002458 infectious effect Effects 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 231100000518 lethal Toxicity 0.000 description 2
- 230000001665 lethal effect Effects 0.000 description 2
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 229930182817 methionine Natural products 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000007918 pathogenicity Effects 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- YBYRMVIVWMBXKQ-UHFFFAOYSA-N phenylmethanesulfonyl fluoride Chemical compound FS(=O)(=O)CC1=CC=CC=C1 YBYRMVIVWMBXKQ-UHFFFAOYSA-N 0.000 description 2
- 239000013600 plasmid vector Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 208000023504 respiratory system disease Diseases 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 230000007017 scission Effects 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 238000010561 standard procedure Methods 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 239000007929 subcutaneous injection Substances 0.000 description 2
- 238000010254 subcutaneous injection Methods 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 230000002381 testicular Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 238000013518 transcription Methods 0.000 description 2
- 230000035897 transcription Effects 0.000 description 2
- 230000005030 transcription termination Effects 0.000 description 2
- 238000001890 transfection Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
- MIAKOEWBCMPCQR-YBXAARCKSA-N (2s,3r,4s,5r,6r)-2-(4-aminophenoxy)-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound C1=CC(N)=CC=C1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MIAKOEWBCMPCQR-YBXAARCKSA-N 0.000 description 1
- 101150078635 18 gene Proteins 0.000 description 1
- NKDFYOWSKOHCCO-YPVLXUMRSA-N 20-hydroxyecdysone Chemical compound C1[C@@H](O)[C@@H](O)C[C@]2(C)[C@@H](CC[C@@]3([C@@H]([C@@](C)(O)[C@H](O)CCC(C)(O)C)CC[C@]33O)C)C3=CC(=O)[C@@H]21 NKDFYOWSKOHCCO-YPVLXUMRSA-N 0.000 description 1
- 101150052384 50 gene Proteins 0.000 description 1
- 102100022524 Alpha-1-antichymotrypsin Human genes 0.000 description 1
- 229930091051 Arenine Natural products 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 101150044735 C7L gene Proteins 0.000 description 1
- 101100148606 Caenorhabditis elegans pst-1 gene Proteins 0.000 description 1
- 108091035707 Consensus sequence Proteins 0.000 description 1
- 238000001712 DNA sequencing Methods 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 239000006145 Eagle's minimal essential medium Substances 0.000 description 1
- 241000701089 Equid alphaherpesvirus 4 Species 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 241001524679 Escherichia virus M13 Species 0.000 description 1
- 108060002716 Exonuclease Proteins 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 102000002464 Galactosidases Human genes 0.000 description 1
- 108010093031 Galactosidases Proteins 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 102100036263 Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial Human genes 0.000 description 1
- 101000678026 Homo sapiens Alpha-1-antichymotrypsin Proteins 0.000 description 1
- 101001001786 Homo sapiens Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial Proteins 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- 238000012218 Kunkel's method Methods 0.000 description 1
- 125000000174 L-prolyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(*)=O 0.000 description 1
- 125000002842 L-seryl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])O[H] 0.000 description 1
- 208000032420 Latent Infection Diseases 0.000 description 1
- 108010086093 Mung Bean Nuclease Proteins 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 208000025966 Neurological disease Diseases 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 229930040373 Paraformaldehyde Natural products 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 208000001203 Smallpox Diseases 0.000 description 1
- 230000005867 T cell response Effects 0.000 description 1
- 101800000385 Transmembrane protein Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 101100382201 Vaccinia virus (strain Copenhagen) C7L gene Proteins 0.000 description 1
- 101900123149 Varicella-zoster virus Envelope glycoprotein E Proteins 0.000 description 1
- 108700005077 Viral Genes Proteins 0.000 description 1
- 230000010530 Virus Neutralization Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 238000003277 amino acid sequence analysis Methods 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 238000000211 autoradiogram Methods 0.000 description 1
- 108010058966 bacteriophage T7 induced DNA polymerase Proteins 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 208000015114 central nervous system disease Diseases 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003593 chromogenic compound Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 229940028617 conventional vaccine Drugs 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000004520 electroporation Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 108700004025 env Genes Proteins 0.000 description 1
- 101150030339 env gene Proteins 0.000 description 1
- 102000013165 exonuclease Human genes 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000005745 host immune response Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000010185 immunofluorescence analysis Methods 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 238000007901 in situ hybridization Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000006317 isomerization reaction Methods 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 230000006548 oncogenic transformation Effects 0.000 description 1
- 229920002866 paraformaldehyde Polymers 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000007030 peptide scission Effects 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 230000007505 plaque formation Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 235000010388 propyl gallate Nutrition 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000014493 regulation of gene expression Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 210000003705 ribosome Anatomy 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000005204 segregation Methods 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 229940035893 uracil Drugs 0.000 description 1
- 108700026220 vif Genes Proteins 0.000 description 1
- 230000017613 viral reproduction Effects 0.000 description 1
- 210000002845 virion Anatomy 0.000 description 1
- 239000005723 virus inoculator Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/02—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using fungi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
- C12N2710/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16211—Lymphocryptovirus, e.g. human herpesvirus 4, Epstein-Barr Virus
- C12N2710/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
- C12N2710/16722—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24041—Use of virus, viral particle or viral elements as a vector
- C12N2710/24043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
- C12N2760/18122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
- C12N2760/20111—Lyssavirus, e.g. rabies virus
- C12N2760/20122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Plant Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL9900034A NL195085C (nl) | 1989-04-17 | 2003-07-02 | Herpesvirus recombinant pokkenvirus. |
| NL9900035A NL195086C (nl) | 1989-04-17 | 2003-07-02 | Herpesvirus recombinant pokkenvirus. |
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33900489A | 1989-04-17 | 1989-04-17 | |
| US33900489 | 1989-04-17 | ||
| US39448889A | 1989-08-16 | 1989-08-16 | |
| US39448889 | 1989-08-16 | ||
| US07/502,834 US5338683A (en) | 1981-12-24 | 1990-04-04 | Vaccinia virus containing DNA sequences encoding herpesvirus glycoproteins |
| US50283490 | 1990-04-04 | ||
| US9002094 | 1990-04-16 | ||
| PCT/US1990/002094 WO1990012882A1 (en) | 1989-04-17 | 1990-04-16 | Herpes virus recombinant poxvirus vaccine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NL9020677A NL9020677A (nl) | 1992-02-03 |
| NL195016C true NL195016C (nl) | 2003-06-10 |
Family
ID=27407304
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL9020677A NL195016C (nl) | 1989-04-17 | 1990-04-16 | Recombinant pokkenvirus, vaccin dat dit virus bevat, geïsoleerd nucleïnezuurmolecuul, geïsoleerd polypeptide, nucleïnezuurvector die dit nucleïnezuurmolecuul bevat en vaccin die deze vector bevat. |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US5338683A (enExample) |
| JP (2) | JP3083839B2 (enExample) |
| KR (1) | KR920700289A (enExample) |
| AT (1) | AT405184B (enExample) |
| AU (1) | AU625623B2 (enExample) |
| BE (1) | BE1004369A5 (enExample) |
| CA (1) | CA2014465C (enExample) |
| CH (1) | CH682671A5 (enExample) |
| DE (2) | DE4090565C2 (enExample) |
| DK (1) | DK176464B1 (enExample) |
| FR (1) | FR2647808B1 (enExample) |
| GB (1) | GB2246784B (enExample) |
| IE (1) | IE61098B1 (enExample) |
| IT (1) | IT1241119B (enExample) |
| LU (1) | LU88018A1 (enExample) |
| NL (1) | NL195016C (enExample) |
| WO (1) | WO1990012882A1 (enExample) |
Families Citing this family (163)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4603112A (en) * | 1981-12-24 | 1986-07-29 | Health Research, Incorporated | Modified vaccinia virus |
| US5505941A (en) * | 1981-12-24 | 1996-04-09 | Health Research, Inc. | Recombinant avipox virus and method to induce an immune response |
| US7767449B1 (en) | 1981-12-24 | 2010-08-03 | Health Research Incorporated | Methods using modified vaccinia virus |
| US7045313B1 (en) | 1982-11-30 | 2006-05-16 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant vaccinia virus containing a chimeric gene having foreign DNA flanked by vaccinia regulatory DNA |
| US5674735A (en) * | 1990-07-06 | 1997-10-07 | University Court Of The University Of Glasgow | DNA encoding the EHV-4 gH or gC glycoprotein |
| GB9014950D0 (en) * | 1990-07-06 | 1990-08-29 | Univ Glasgow | Ehv-4 glycoprotein vaccine |
| US7374768B1 (en) * | 1990-09-25 | 2008-05-20 | Xenova Research Limited | Viral vaccines |
| ATE194657T1 (de) * | 1990-09-25 | 2000-07-15 | Cantab Pharma Res | Bei einer transkomplementenden zellinie erzeugter defektiver virenimpfstoff |
| US5759552A (en) * | 1991-03-07 | 1998-06-02 | Virogenetics Corporation | Marek's disease virus recombinant poxvirus vaccine |
| US5997878A (en) | 1991-03-07 | 1999-12-07 | Connaught Laboratories | Recombinant poxvirus-cytomegalovirus, compositions and uses |
| GB9105383D0 (en) * | 1991-03-14 | 1991-05-01 | Immunology Ltd | An immunotherapeutic for cervical cancer |
| ATE181108T1 (de) * | 1991-08-26 | 1999-06-15 | Immuno Ag | Direkt molekuläre klonierung eines modifizierten genoms eines chordopocken-virus |
| DE69133333T2 (de) * | 1991-08-26 | 2004-07-29 | Baxter Healthcare S.A. | Ein intaktes FPV-tk-Gen enthaltender rekombinanter Virus der Vogelpocken |
| US5869312A (en) * | 1992-01-13 | 1999-02-09 | Syntro Corporation | Recombinant swinepox virus |
| WO1994019015A1 (en) * | 1993-02-26 | 1994-09-01 | Syntro Corporation | Recombinant fowlpox viruses and uses thereof |
| US6136318A (en) * | 1993-02-26 | 2000-10-24 | Cochran; Mark D. | Recombinant fowlpox viruses and uses thereof |
| US5925358A (en) * | 1993-02-26 | 1999-07-20 | Syntro Corporation | Recombinant fowlpox viruses and uses thereof |
| US6010703A (en) * | 1993-07-26 | 2000-01-04 | Board Of Trustees Operating Michigan State University | Recombinant poxvirus vaccine against feline rhinotracheitis |
| WO1995026751A1 (en) * | 1994-03-30 | 1995-10-12 | Virogenetics Corporation | NUCLEOTIDE AND AMINO ACID SEQUENCES OF CANINE HERPESVIRUS gB, gC and gD AND USES THEREFOR |
| EP0758397B1 (en) * | 1994-04-29 | 2005-06-22 | Baxter Healthcare S.A. | Recombinant poxviruses with foreign polynucleotides in essential regions |
| AU737243B2 (en) | 1996-07-03 | 2001-08-16 | Merial, Inc. | Recombinant canine adenovirus (CAV) containing exogenous DNA |
| US6183752B1 (en) * | 1997-02-05 | 2001-02-06 | Pasteur Merieux Serums Et Vaccins | Restenosis/atherosclerosis diagnosis, prophylaxis and therapy |
| US6517843B1 (en) | 1999-08-31 | 2003-02-11 | Merial | Reduction of porcine circovirus-2 viral load with inactivated PCV-2 |
| US6224882B1 (en) | 1997-11-07 | 2001-05-01 | Protein Science Corp. | Insect cells or fractions as adjuvant for antigens |
| AU2873999A (en) | 1998-02-24 | 1999-09-06 | Sisters Of Providence In Oregon | Compositions containing an OX-40 receptor binding agent or nucleic acid encoding the same and methods for enhancing antigen-specific immune response |
| MXPA00008352A (es) | 1998-02-27 | 2002-10-17 | Univ Pennsylvania | Vacunas, composiciones inmunoterapeuticas y metodos para usar las mismas. |
| WO2000049049A1 (en) | 1999-02-19 | 2000-08-24 | Michigan State University | An antigen test to detect equine protozoal myeloencephalitis in horse serum and cerebrospinal fluid |
| KR20010103788A (ko) | 1999-03-03 | 2001-11-23 | 멕코나시 에블린 에이치. | 백신 및 유전자요법 조성물 및 이들의 제조 및 사용방법 |
| US7446189B1 (en) | 1999-04-30 | 2008-11-04 | Institut De Recherches Cliniques De Montreal | Nucleic acids encoding mutant human CD80 and compositions comprising the same |
| BR0011732B1 (pt) * | 1999-06-10 | 2014-02-04 | Vacinas de dna para animais de companhia e de esporte | |
| AU5329300A (en) | 1999-06-10 | 2001-01-02 | Michigan State University | Feline calicivirus isolated from cat urine and vaccines thereof |
| AU7108700A (en) | 1999-09-02 | 2001-03-26 | Michigan State University | Vaccine to control equine protozoal myeloencephalitis in horses |
| US7419668B1 (en) | 1999-09-02 | 2008-09-02 | Board Of Trustees Of Michigan State University | Vaccine to control equine protozoal myeloencephalitis in horses |
| ATE385808T1 (de) * | 1999-12-21 | 2008-03-15 | Merial Sas | Mindestens ein cryptosporidium parvum-antigen und mindestens ein antigen eines anderen darmkrankheitserregers enthaltende zusammensetzungen und impfstoffe |
| CN1312171C (zh) * | 2000-07-14 | 2007-04-25 | 宾夕法尼亚州立大学托管会 | 可编码hiv辅助蛋白的dna疫苗 |
| CA2424216A1 (en) * | 2000-10-04 | 2002-04-11 | The Trustees Of The University Of Pennsylvania | Compositions and methods of using capsid protein from flaviviruses and pestiviruses |
| US7097842B2 (en) * | 2000-11-23 | 2006-08-29 | Bavarian Nordic A/S | Modified vaccinia virus ankara for the vaccination of neonates |
| US7628980B2 (en) * | 2000-11-23 | 2009-12-08 | Bavarian Nordic A/S | Modified vaccinia virus ankara for the vaccination of neonates |
| DE20122302U1 (de) | 2000-11-23 | 2005-02-24 | Bavarian Nordic A/S | Variante des Modifizierten Vaccinia-Ankara-Virus |
| US20020108132A1 (en) * | 2001-02-02 | 2002-08-08 | Avigenics Inc. | Production of a monoclonal antibody by a transgenic chicken |
| US7176300B2 (en) * | 2001-03-30 | 2007-02-13 | Avigenics, Inc. | Avian lysozyme promoter |
| US7541512B2 (en) * | 2001-03-30 | 2009-06-02 | Synageva Biopharma Corp. | Avians containing a lysozyme promoter transgene |
| EP1478751A4 (en) * | 2001-03-30 | 2005-10-19 | Avigenics Inc | LYSOZYM PROMOTER IN BIRDS |
| US20040037848A1 (en) * | 2001-04-06 | 2004-02-26 | Audonnet Jean-Christophe Francis | Recombinant vaccine against West Nile Virus |
| US7740863B2 (en) * | 2001-04-06 | 2010-06-22 | Merial | Recombinant vaccine against West Nile Virus |
| FR2823222B1 (fr) | 2001-04-06 | 2004-02-06 | Merial Sas | Vaccin contre le virus de la fievre du nil |
| US8216585B2 (en) * | 2001-05-25 | 2012-07-10 | The Trustees Of The University Of Pennsylvania | Targeted particles and methods of using the same |
| US7550650B2 (en) * | 2001-09-18 | 2009-06-23 | Synageva Biopharma Corp. | Production of a transgenic avian by cytoplasmic injection |
| US7335761B2 (en) * | 2001-11-30 | 2008-02-26 | Avigenics, Inc. | Avian gene expression controlling regions |
| US7294507B2 (en) * | 2001-11-30 | 2007-11-13 | Avigenics, Inc. | Ovomucoid promoters and methods of use |
| US6875588B2 (en) | 2001-11-30 | 2005-04-05 | Avigenics, Inc. | Ovomucoid promoter and methods of use |
| US20100333219A1 (en) * | 2001-11-30 | 2010-12-30 | Synageva Biopharma Corp. | Methods of protein production using ovomucoid regulatory regions |
| US7135562B2 (en) * | 2002-03-14 | 2006-11-14 | University Of Cincinnati | Avian iFABP gene expression controlling region |
| US20040241723A1 (en) * | 2002-03-18 | 2004-12-02 | Marquess Foley Leigh Shaw | Systems and methods for improving protein and milk production of dairy herds |
| JP4801880B2 (ja) * | 2002-04-19 | 2011-10-26 | バヴァリアン・ノルディック・アクティーゼルスカブ | 新生仔予防接種用変異ワクシニアウイルスアンカラ |
| EP2253709B1 (en) * | 2002-05-16 | 2018-04-11 | Bavarian Nordic A/S | Recombinant poxvirus expressing homologous genes inserted into the poxviral genome |
| UA85543C2 (ru) * | 2002-09-05 | 2009-02-10 | Бавариан Нордик А/С | Способ культивирования первичных клеток и амплификации вирусов в условиях безсывороточной среды, композиция и ее применение, и способ лечения или вакцинации животных |
| CA2510229A1 (en) * | 2002-12-13 | 2004-07-08 | Aventis Pasteur, Inc. | Production of alvac on avian embryonic stem cells |
| CN1980571A (zh) * | 2003-01-24 | 2007-06-13 | 阿维季尼克斯股份有限公司 | 禽类及禽蛋中表达的外源蛋白质 |
| US7262027B2 (en) * | 2003-03-14 | 2007-08-28 | Medical College Of Ohio | Polypeptide and DNA immunization against Coccidioides spp. infections |
| EP2390352A1 (en) | 2003-03-18 | 2011-11-30 | Quantum Genetics Ireland Limited | Systems and methods for improving protein and milk production of dairy herds |
| US7468273B2 (en) | 2003-05-01 | 2008-12-23 | Meial Limited | Canine GHRH gene, polypeptides and methods of use |
| NZ570709A (en) | 2003-06-13 | 2010-04-30 | Univ Pennsylvania | Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same |
| AU2004249191B2 (en) | 2003-06-13 | 2011-01-06 | The Trustees Of The University Of Pennsylvania | Vaccines, immunotherapeutics and methods for using the same |
| EP1689858B1 (en) | 2003-11-13 | 2013-05-15 | University Of Georgia Research Foundation, Inc. | Methods of characterizing infectious bursal disease virus |
| MXPA06009452A (es) | 2004-02-19 | 2007-03-15 | Univ Alberta | Polimorfismos del promotor de leptin y sus usos. |
| US20080274140A1 (en) * | 2004-11-19 | 2008-11-06 | David B Weiner | Vaccines and Methods for Using the Same |
| US20090042805A1 (en) * | 2004-11-24 | 2009-02-12 | David Chauvier | Peptides Useful As Dual Caspase-2/-6 Inhibitors And Their Biological Applications |
| SI1881845T1 (sl) | 2005-04-25 | 2010-06-30 | Merial Ltd | Cepiva proti virusu Nipah |
| DE602006019878D1 (de) * | 2005-07-28 | 2011-03-10 | Pfizer Prod Inc | Impfstoff gegen felines calicivirus (fcv), der ein fcv kapsid protein oder ein isoliertes fcv kapsid protein mit der protein sequenz seq id no: 13 oder mit einer protein sequenz, die zumindestens zu 95% identisch zur seq id no: 13 ist enthält. |
| US20080241184A1 (en) | 2005-08-25 | 2008-10-02 | Jules Maarten Minke | Canine influenza vaccines |
| EP1951751B1 (en) | 2005-11-14 | 2017-11-01 | Merial, Inc. | Gene therapy for renal failure |
| US7771995B2 (en) | 2005-11-14 | 2010-08-10 | Merial Limited | Plasmid encoding human BMP-7 |
| US7745158B2 (en) * | 2005-12-14 | 2010-06-29 | Kimberly-Clark Worldwide, Inc. | Detection of secreted aspartyl proteases from Candida species |
| DK1976871T3 (da) * | 2006-01-13 | 2011-12-12 | Univ Pennsylvania | Vacciner og immunterapeutika under anvendelse af codonoptimerede IL-15 og fremgangsmåder til anvendelse deraf |
| US9259463B2 (en) | 2006-01-16 | 2016-02-16 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Chlamydia vaccine |
| AU2007233252C1 (en) | 2006-03-29 | 2013-05-23 | Boehringer Ingelheim Animal Health USA Inc. | Vaccine against Streptococci |
| CA2670804A1 (en) * | 2006-05-19 | 2007-11-29 | Sanofi Pasteur Inc. | Immunological composition |
| US7862821B2 (en) | 2006-06-01 | 2011-01-04 | Merial Limited | Recombinant vaccine against bluetongue virus |
| KR101710981B1 (ko) | 2006-07-28 | 2017-02-28 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 개선된 백신 및 이의 사용 방법 |
| US8202967B2 (en) | 2006-10-27 | 2012-06-19 | Boehringer Ingelheim Vetmedica, Inc. | H5 proteins, nucleic acid molecules and vectors encoding for those, and their medicinal use |
| EP2126071A4 (en) * | 2007-01-26 | 2010-12-08 | Synageva Biopharma Corp | TRANSGENEXPRESSION IN BIRDS |
| KR101445903B1 (ko) | 2007-05-02 | 2014-09-29 | 메리얼 리미티드 | 향상된 발현 및 안정성을 갖는 ｄｎａ 플라스미드 |
| TW200907058A (en) * | 2007-05-30 | 2009-02-16 | Wyeth Corp | Raccoon poxvirus expressing rabies glycoproteins |
| US20090246226A1 (en) * | 2008-03-28 | 2009-10-01 | Zeon Corporation | Avian vaccines possessing a positive marker gene |
| WO2009124312A2 (en) * | 2008-04-04 | 2009-10-08 | The Trustees Of The University Of Pennsylvania | Consensus sequences of chikungunya viral proteins, nucleic acid molecules encoding the same, and compositions and methods for using the same |
| AU2009231598B2 (en) | 2008-04-04 | 2015-03-12 | The Trustees Of The University Of Pennsylvania | Vaccines and immunotherapeutics using IL-28 and compositions and methods of using the same |
| EP2283035B1 (en) | 2008-05-08 | 2015-07-29 | Merial Limited | Leishmania vaccine using sand fly salivary immunogen |
| US8829174B2 (en) | 2008-10-29 | 2014-09-09 | The Trustees Of The University Of Pennsylvania | HCV vaccines and methods for using the same |
| US8921536B2 (en) | 2008-10-29 | 2014-12-30 | The Trustees Of The University Of Pennsylvania | HCV vaccines and methods for using the same |
| US9050287B2 (en) | 2009-01-23 | 2015-06-09 | The Trustees Of The University Of Pennsylvania | Vaccines for human papilloma virus and methods for using the same |
| CA2653478A1 (en) * | 2009-01-23 | 2010-07-23 | Gregg Martin | Automated wash system for industrial vehicles |
| US20100192236A1 (en) * | 2009-01-28 | 2010-07-29 | University Of South Carolina | Modulation of Delta Opioid Receptor Expression |
| JP5797636B2 (ja) | 2009-04-03 | 2015-10-21 | メリアル リミテッド | ニューカッスル病ウイルスをベクターとするトリワクチン |
| US20100284977A1 (en) * | 2009-04-28 | 2010-11-11 | University Of South Carolina | Expression of Anti-Nociceptive Compounds from Endogenously Regulated Promoters |
| CA2760315C (en) | 2009-04-30 | 2019-05-28 | Centre Hospitalier Universitaire Vaudois Lausanne (Chuv) | Modified immunization vectors |
| AR078253A1 (es) | 2009-09-02 | 2011-10-26 | Boehringer Ingelheim Vetmed | Metodos para reducir la actividad antivirica en composiciones pcv-2 y composiciones pcv-2 con mejor inmunogenicidad |
| WO2011032179A1 (en) | 2009-09-14 | 2011-03-17 | The Trustees Of The University Of Pennsylvania | Vaccines and immunotherapeutics comprising il-15 receptor alpha and/or nucleic acid molecules encoding the same, and methods for using the same |
| CN102712931A (zh) | 2009-11-02 | 2012-10-03 | 宾夕法尼亚大学托管会 | 口蹄疫病毒病毒(fmdv)共有蛋白质、其编码序列及由其制备的疫苗 |
| US8298820B2 (en) | 2010-01-26 | 2012-10-30 | The Trustees Of The University Of Pennsylvania | Influenza nucleic acid molecules and vaccines made therefrom |
| WO2011097640A1 (en) | 2010-02-08 | 2011-08-11 | The Trustees Of The University Of Pennsylvania | Nucleic acid molecules encoding rantes, and compositions comprising and methods of using the same |
| US9109007B2 (en) | 2010-08-18 | 2015-08-18 | Purdue Pharma L.P. | MHC-I restricted epitopes containing non-natural amino acid residues |
| JP5913316B2 (ja) * | 2010-08-31 | 2016-04-27 | メリアル リミテッド | ニューカッスル病ウイルスをベクターとするヘルペスウイルスワクチン |
| AR083533A1 (es) | 2010-10-22 | 2013-03-06 | Boehringer Ingelheim Vetmed | Proteinas de hemaglutinina 5 (h5) para el tratamiento y prevencion de las infecciones de gripe |
| KR101939150B1 (ko) | 2010-11-12 | 2019-01-17 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 공통 전립선 항원, 이것을 암호화하는 핵산 분자, 그리고 이것을 포함하는 백신 및 용도 |
| WO2012090073A2 (en) | 2010-12-30 | 2012-07-05 | The Netherlands Cancer Institute | Methods and compositions for predicting chemotherapy sensitivity |
| WO2012106377A2 (en) | 2011-01-31 | 2012-08-09 | The Trustees Of The University Of Pennsylvania | Nucleic acid molecules encoding novel herpes antigens, vaccine comprising the same, and methods of use thereof |
| US9238679B2 (en) | 2011-02-11 | 2016-01-19 | The Trustees Of The University Of Pennslyvania | Nucleic acid molecule encoding hepatitis B virus core protein and surface antigen protein and vaccine comprising the same |
| KR101942372B1 (ko) | 2011-02-11 | 2019-04-12 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | B형 간염 바이러스 코어 단백질을 암호화하는 핵산 분자 및 이를 포함하는 백신 |
| AU2012240246A1 (en) | 2011-04-04 | 2013-05-09 | Netherlands Cancer Institute | Methods and compositions for predicting resistance to anticancer treatment with protein kinase inhibitors |
| EP2694677A2 (en) | 2011-04-04 | 2014-02-12 | Netherland Cancer Institute | Methods and compositions for predicting resistance to anticancer treatment with protein kinase inhibitors |
| US9216213B2 (en) | 2011-04-20 | 2015-12-22 | Merial, Inc. | Adjuvanted rabies vaccine with improved viscosity profile |
| KR102007444B1 (ko) | 2011-04-25 | 2019-08-06 | 어드밴스드 바이오사이언스 라보라토리즈, 인코포레이티드 | 절단형 hiv 피막 단백질(env), 이와 관련된 방법 및 조성물 |
| ES2674439T3 (es) | 2011-06-01 | 2018-06-29 | Merial, Inc. | Administración sin aguja de vacunas contra el VSRRP |
| ES2758713T3 (es) | 2011-07-11 | 2020-05-06 | Inovio Pharmaceuticals Inc | Vacuna de ADN contra el virus de Lassa |
| RS58289B1 (sr) | 2011-07-20 | 2019-03-29 | Merial Ltd | Rekombinantna vakcina protiv virusa mačje leukemije koja sadrži optimizovani gen omotača virusa mačje leukemije |
| US10166188B2 (en) | 2011-08-12 | 2019-01-01 | Merial, Inc. | Method for vacuum-assisted preservation of biologics including vaccines |
| AR088028A1 (es) | 2011-08-15 | 2014-05-07 | Boehringer Ingelheim Vetmed | Proteinas h5, de h5n1 para un uso medicinal |
| WO2013033092A2 (en) | 2011-09-03 | 2013-03-07 | Boehringer Ingelheim Vetmedica Gmbh | Streptococcus suis pilus antigens |
| EP2750703B1 (en) | 2011-10-12 | 2018-07-04 | The Trustees Of The University Of Pennsylvania | Vaccines for human papilloma virus and methods for using the same |
| KR101868954B1 (ko) | 2011-10-24 | 2018-07-20 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 개선된 hcv 백신 및 이것을 사용하는 방법 |
| AU2012352455B2 (en) | 2011-12-12 | 2016-01-21 | The Trustees Of The University Of Pennsylvania | Proteins comprising MRSA PBP2a and fragments thereof, nucleic acids encoding the same, and compositions and their use to prevent and treat MRSA infections |
| KR102445129B1 (ko) | 2011-12-12 | 2022-09-20 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 개선된 il-12 유전적 컨스트럭트 및 백신을 포함하는 조성물, 면역치료제 및 이를 이용하는 방법 |
| WO2013093629A2 (en) | 2011-12-20 | 2013-06-27 | Netherlands Cancer Institute | Modular vaccines, methods and compositions related thereto |
| WO2013138776A1 (en) | 2012-03-16 | 2013-09-19 | Merial Limited | Novel methods for providing long-term protective immunity against rabies in animals, based upon administration of replication-deficient flavivirus expressing rabies g |
| BR112014023414B1 (pt) * | 2012-03-20 | 2022-08-30 | Boehringer Ingelheim Animal Health USA Inc. | Vacina de herpesvirus-1 equino recombinante contendo uma glicoproteína c mutante e seus usos |
| EP3511337A1 (en) | 2012-04-10 | 2019-07-17 | The Trustees of The University of Pennsylvania | Human respiratory syncytial virus concensus antigens, nucleic acid constructs and vaccines made thereform, and methods of using same |
| EP2958586B1 (en) | 2013-02-21 | 2018-09-05 | Boehringer Ingelheim Vetmedica GmbH | H5 proteins of h5n1 influenza virus for use as a medicament |
| HK1216006A1 (zh) | 2013-03-12 | 2016-10-07 | Boehringer Ingelheim Animal Health USA Inc. | 反向遺傳學施馬倫貝格病毒疫苗組合物，和其使用方法 |
| KR20220140025A (ko) | 2013-03-12 | 2022-10-17 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | 인간 파밀로마 바이러스용 개선된 백신 및 이것을 사용하는 방법 |
| KR20150130284A (ko) | 2013-03-15 | 2015-11-23 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 암 백신 및 이를 이용한 치료 방법 |
| CN114045295A (zh) | 2013-03-15 | 2022-02-15 | 宾夕法尼亚大学理事会 | 口蹄疫病毒(fmdv)共有蛋白、其编码序列以及由其制造的疫苗 |
| WO2015153425A1 (en) | 2014-04-03 | 2015-10-08 | Boehringer Ingelheim Vetmedica, Inc. | Porcine epidemic diarrhea virus vaccine |
| US10010499B2 (en) | 2014-11-03 | 2018-07-03 | Merial Inc. | Methods of using microneedle vaccine formulations to elicit in animals protective immunity against rabies virus |
| WO2016210094A1 (en) | 2015-06-23 | 2016-12-29 | Merial, Inc. | Prrsv minor protein-containing recombinant viral vectors and methods of making and use thereof |
| BR112017028224A2 (pt) | 2015-08-31 | 2018-09-11 | Boehringer Ingelheim Vetmedica Gmbh | composição, e, método para proteger um leitão contra uma doença associada a pestivírus. |
| AU2016323106A1 (en) | 2015-09-16 | 2018-03-29 | Boehringer Ingelheim Animal Health USA Inc. | Salmonella Choleraesuis-Salmonella Typhimurium vaccines |
| JP7187448B2 (ja) | 2016-09-20 | 2022-12-12 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー | 新しいプロモーター |
| EA201990718A1 (ru) | 2016-09-20 | 2019-10-31 | Векторы аденовируса собачьих | |
| BR112019005415A2 (pt) | 2016-09-20 | 2019-10-22 | Boehringer Ingelheim Vetmedica Gmbh | nova vacina contra influenza suína |
| CA3036291A1 (en) | 2016-09-20 | 2018-03-29 | Boehringer Ingelheim Vetmedica Gmbh | New ehv insertion site orf70 |
| CN109922825B (zh) | 2016-11-03 | 2024-01-12 | 勃林格殷格翰动物保健有限公司 | 抗猪细小病毒及猪生殖与呼吸道综合征病毒的疫苗及其制造方法 |
| MX381132B (es) | 2016-11-03 | 2025-03-12 | Boehringer Ingelheim Vetmedica Gmbh | Vacuna contra parvovirus porcino. |
| CA3046684A1 (en) | 2017-01-30 | 2018-08-02 | Boehringer Ingelheim Animal Health USA Inc. | Porcine coronavirus vaccines |
| JP7083362B2 (ja) | 2017-07-12 | 2022-06-10 | ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド | セネカウイルスａ免疫原性組成物およびその方法 |
| KR20200057742A (ko) | 2017-09-23 | 2020-05-26 | 베링거잉겔하임베트메디카게엠베하 | 파라믹소바이러스과 발현 시스템 |
| WO2019092027A1 (en) | 2017-11-09 | 2019-05-16 | Boehringer Ingelheim Vetmedica Gmbh | Sapelovirus immunogenic compositions and uses thereof |
| KR102756354B1 (ko) | 2017-12-13 | 2025-01-21 | 이노비오 파마수티컬즈, 인크. | Prame를 표적으로 하는 암 백신 및 이의 용도 |
| BR112020010499A2 (pt) | 2017-12-13 | 2020-11-24 | Inovio Pharmaceuticals, Inc. | vacinas de câncer de alvo de mesotelina e usos das mesmas |
| CN111741772A (zh) | 2017-12-13 | 2020-10-02 | 艾诺奥医药品有限公司 | 靶向muc16的癌症疫苗和其用途 |
| EP3723798A4 (en) | 2017-12-13 | 2021-11-17 | Inovio Pharmaceuticals, Inc. | CANCER VACCINES TARGETING BORIS AND RELATED USES |
| RU2711907C2 (ru) * | 2017-12-22 | 2020-01-23 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт вакцин и сывороток им. И.И. Мечникова" (ФГБНУ НИИВС им. И.И. Мечникова) | Рекомбинантный белок, содержащий антигенно-значимые фрагменты белков вируса гепатита Е, используемый в тест-системах для серодиагностики гепатита Е (варианты) |
| CA3088646A1 (en) | 2018-02-23 | 2019-08-29 | Boehringer Ingelheim Vetmedica Gmbh | Recombinant viral vector systems expressing exogenous feline paramyxovirus genes and vaccines made therefrom |
| KR20200132958A (ko) | 2018-03-19 | 2020-11-25 | 베링거잉겔하임베트메디카게엠베하 | 불활성화된 ul18 및/또는 ul8을 갖는 신규한 ehv |
| AU2019239552A1 (en) | 2018-03-19 | 2020-09-10 | Boehringer Ingelheim Vetmedica Gmbh | EHV insertion site UL43 |
| CN112088013B (zh) | 2018-03-26 | 2024-12-06 | 勃林格殷格翰动物保健美国有限公司 | 制备免疫原性组合物的方法 |
| EP3852797A1 (en) | 2018-09-20 | 2021-07-28 | Boehringer Ingelheim Vetmedica GmbH | Modified pedv spike protein |
| CN112867506B (zh) | 2018-09-20 | 2025-08-05 | 勃林格殷格翰动物保健有限公司 | 抗猪流行性腹泻的鼻内载体疫苗 |
| JP2023513135A (ja) | 2020-02-06 | 2023-03-30 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー | 抗ラブドウイルス抗体を検出するのに有用なポリペプチド |
| BR112023006274A2 (pt) | 2020-10-05 | 2023-05-09 | Boehringer Ingelheim Vetmedica Gmbh | Proteína de fusão útil para vacinação contra rotavírus |
| EP4225361A1 (en) | 2020-10-05 | 2023-08-16 | Boehringer Ingelheim Animal Health USA Inc. | Fusion protein comprising circoviridae capsid protein, and chimeric virus-like particles composed thereof |
| AR128992A1 (es) | 2022-04-05 | 2024-07-03 | Boehringer Ingelheim Vetmedica Gmbh | Composición inmunógena útil para la vacunación contra el rotavirus |
| WO2025184411A1 (en) | 2024-02-27 | 2025-09-04 | Calidi Biotherapeutics (Nevada), Inc. | Serum-resistant eev viruses and uses thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1061898A (en) | 1963-03-07 | 1967-03-15 | Philips Electronic Pharma | Method for protecting dogs against canine distemper |
| US4603112A (en) * | 1981-12-24 | 1986-07-29 | Health Research, Incorporated | Modified vaccinia virus |
| US4722848A (en) * | 1982-12-08 | 1988-02-02 | Health Research, Incorporated | Method for immunizing animals with synthetically modified vaccinia virus |
| US4769330A (en) * | 1981-12-24 | 1988-09-06 | Health Research, Incorporated | Modified vaccinia virus and methods for making and using the same |
| AU570940B2 (en) * | 1982-11-30 | 1988-03-31 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Process for producing poxvirus recombinants for expression offoreign genes |
| EP0162738A1 (en) | 1984-04-09 | 1985-11-27 | MOLECULAR GENETICS RESEARCH & DEVELOPMENT LIMITED PARTNERSHIP | Production of pseudorabies virus subunit vaccines |
| EP0261940A3 (en) * | 1986-09-23 | 1989-07-05 | Applied Biotechnology, Inc. | Pseudorabies vaccines and dna vectors for recombination with pox viruses |
| US5242829A (en) * | 1986-09-23 | 1993-09-07 | Therion Biologics Corporation | Recombinant pseudorabies virus |
| EP0284416B1 (en) * | 1987-03-27 | 1995-02-22 | Nippon Zeon Co., Ltd. | Recombinant avipoxyvirus |
| EP0297924A3 (en) * | 1987-07-01 | 1990-07-11 | City Of Hope | Recombinant vaccinia virus expressing hsv 1 gb |
| DE10399032I1 (de) * | 1987-08-28 | 2004-01-29 | Health Research Inc | Rekombinante Viren. |
| WO1990001546A1 (en) * | 1988-08-05 | 1990-02-22 | Applied Biotechnology, Inc. | Equine herpesvirus-1 vaccine |
| IE68404B1 (en) | 1990-11-20 | 1996-06-12 | Virogenetics Corp | Measles virus recombinant poxvirus vaccine |
-
1990
- 1990-04-04 US US07/502,834 patent/US5338683A/en not_active Expired - Lifetime
- 1990-04-12 CA CA002014465A patent/CA2014465C/en not_active Expired - Lifetime
- 1990-04-16 NL NL9020677A patent/NL195016C/nl not_active IP Right Cessation
- 1990-04-16 CH CH3982/90A patent/CH682671A5/fr not_active IP Right Cessation
- 1990-04-16 WO PCT/US1990/002094 patent/WO1990012882A1/en not_active Ceased
- 1990-04-16 JP JP02507078A patent/JP3083839B2/ja not_active Expired - Lifetime
- 1990-04-16 DE DE4090565A patent/DE4090565C2/de not_active Expired - Lifetime
- 1990-04-16 AT AT0902590A patent/AT405184B/de active
- 1990-04-16 DE DE19904090565 patent/DE4090565T/de active Pending
- 1990-04-16 AU AU55520/90A patent/AU625623B2/en not_active Expired
- 1990-04-16 KR KR1019900702630A patent/KR920700289A/ko not_active Withdrawn
- 1990-04-17 FR FR9004910A patent/FR2647808B1/fr not_active Expired - Lifetime
- 1990-04-17 IT IT20063A patent/IT1241119B/it active IP Right Grant
- 1990-04-17 BE BE9000425A patent/BE1004369A5/fr not_active IP Right Cessation
- 1990-04-18 IE IE138090A patent/IE61098B1/en not_active IP Right Cessation
-
1991
- 1991-09-27 GB GB9120655A patent/GB2246784B/en not_active Expired - Lifetime
- 1991-10-15 DK DK199101743A patent/DK176464B1/da not_active IP Right Cessation
- 1991-10-16 LU LU88018A patent/LU88018A1/fr unknown
-
1993
- 1993-09-21 US US08/124,668 patent/US5482713A/en not_active Expired - Lifetime
-
1995
- 1995-06-07 US US08/476,500 patent/US6183750B1/en not_active Expired - Lifetime
-
1999
- 1999-12-28 JP JP37276499A patent/JP3246735B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE4090565C2 (de) | 2000-03-09 |
| DK174391D0 (da) | 1991-10-15 |
| LU88018A1 (fr) | 1992-03-11 |
| ATA902590A (de) | 1998-10-15 |
| CH682671A5 (fr) | 1993-10-29 |
| JP3246735B2 (ja) | 2002-01-15 |
| JP3083839B2 (ja) | 2000-09-04 |
| DE4090565T (enExample) | 1992-05-14 |
| US6183750B1 (en) | 2001-02-06 |
| IE901380L (en) | 1990-10-17 |
| IT9020063A1 (it) | 1991-10-17 |
| JP2000157292A (ja) | 2000-06-13 |
| FR2647808B1 (fr) | 1995-03-03 |
| AU625623B2 (en) | 1992-07-16 |
| IT1241119B (it) | 1993-12-29 |
| US5482713A (en) | 1996-01-09 |
| DK176464B1 (da) | 2008-03-31 |
| IT9020063A0 (it) | 1990-04-17 |
| BE1004369A5 (fr) | 1992-11-10 |
| GB9120655D0 (en) | 1991-11-27 |
| GB2246784B (en) | 1993-04-28 |
| JPH04505248A (ja) | 1992-09-17 |
| AU5552090A (en) | 1990-11-16 |
| IE61098B1 (en) | 1994-09-21 |
| AT405184B (de) | 1999-06-25 |
| WO1990012882A1 (en) | 1990-11-01 |
| US5338683A (en) | 1994-08-16 |
| CA2014465C (en) | 1999-06-15 |
| GB2246784A (en) | 1992-02-12 |
| FR2647808A1 (fr) | 1990-12-07 |
| KR920700289A (ko) | 1992-02-19 |
| NL9020677A (nl) | 1992-02-03 |
| DK174391A (da) | 1991-12-12 |
| CA2014465A1 (en) | 1990-10-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NL195016C (nl) | Recombinant pokkenvirus, vaccin dat dit virus bevat, geïsoleerd nucleïnezuurmolecuul, geïsoleerd polypeptide, nucleïnezuurvector die dit nucleïnezuurmolecuul bevat en vaccin die deze vector bevat. | |
| Guo et al. | Expression in recombinant vaccinia virus of the equine herpesvirus 1 gene encoding glycoprotein gp13 and protection of immunized animals | |
| LU88000A1 (fr) | Systeme de selection d'hotes de poxvirus du recombinaision | |
| DE69233158T2 (de) | Gentechnologisch hergestellter stamm für impfstoffe | |
| US5688920A (en) | Nucleotide and amino acid sequences for canine herpesvirus GB, GC and GD and uses therefor | |
| Guo et al. | Coexpression by vaccinia virus recombinants of equine herpesvirus 1 glycoproteins gp13 and gp14 results in potentiated immunity | |
| JP2001520507A (ja) | 組換えポックスウイルス−サイトメガロウイルス組成物および使用 | |
| US6248333B1 (en) | Isolated nucleic acid sequence of equine herpesvirus type 1 glycoprotein D (EHV-1 gD) | |
| DE69535561T2 (de) | NUKLEOTID- UND AMINOSÄURESEQUENZEN gB, gC UND gD DES HERPESVIRUS DES HUNDES UND IHRE VERWENDUNGEN | |
| NL195085C (nl) | Herpesvirus recombinant pokkenvirus. | |
| CA2259047C (en) | Innoculation kits for avoiding maternal immunity |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BA | A request for search or an international-type search has been filed | ||
| BB | A search report has been drawn up | ||
| BC | A request for examination has been filed | ||
| BX | A request for additional search has been filed | ||
| BY | An additional search report has been drawn up | ||
| NP1 | Patent granted (not automatically) | ||
| V4 | Discontinued because of reaching the maximum lifetime of a patent |
Effective date: 20100416 |