NL192343C - 17Ó-gesubstitueerde androsta-(1,)4-(di)een-3-on-17ß-carbonzuurverbindingen met een ontstekingswerende werkzaamheid en farmaceutische preparaten, die deze verbindingen bevatten. - Google Patents

17Ó-gesubstitueerde androsta-(1,)4-(di)een-3-on-17ß-carbonzuurverbindingen met een ontstekingswerende werkzaamheid en farmaceutische preparaten, die deze verbindingen bevatten. Download PDF

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Publication number
NL192343C
NL192343C NL8103315A NL8103315A NL192343C NL 192343 C NL192343 C NL 192343C NL 8103315 A NL8103315 A NL 8103315A NL 8103315 A NL8103315 A NL 8103315A NL 192343 C NL192343 C NL 192343C
Authority
NL
Netherlands
Prior art keywords
formula
hydroxy
carboxylate
chloromethyl
compound
Prior art date
Application number
NL8103315A
Other languages
English (en)
Dutch (nl)
Other versions
NL192343B (nl
NL8103315A (nl
Original Assignee
Nicholas Stephen Bodor Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicholas Stephen Bodor Dr filed Critical Nicholas Stephen Bodor Dr
Publication of NL8103315A publication Critical patent/NL8103315A/nl
Publication of NL192343B publication Critical patent/NL192343B/xx
Application granted granted Critical
Publication of NL192343C publication Critical patent/NL192343C/nl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NL8103315A 1980-07-10 1981-07-10 17Ó-gesubstitueerde androsta-(1,)4-(di)een-3-on-17ß-carbonzuurverbindingen met een ontstekingswerende werkzaamheid en farmaceutische preparaten, die deze verbindingen bevatten. NL192343C (nl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16845380A 1980-07-10 1980-07-10
US16845380 1980-07-10
US26578581A 1981-05-21 1981-05-21
US26578581 1981-05-21

Publications (3)

Publication Number Publication Date
NL8103315A NL8103315A (nl) 1982-02-01
NL192343B NL192343B (nl) 1997-02-03
NL192343C true NL192343C (nl) 1997-06-04

Family

ID=26864131

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8103315A NL192343C (nl) 1980-07-10 1981-07-10 17Ó-gesubstitueerde androsta-(1,)4-(di)een-3-on-17ß-carbonzuurverbindingen met een ontstekingswerende werkzaamheid en farmaceutische preparaten, die deze verbindingen bevatten.

Country Status (17)

Country Link
KR (2) KR860000266B1 (ko)
AT (1) AT379816B (ko)
AU (1) AU540898B2 (ko)
CA (1) CA1174667A (ko)
CH (1) CH648856A5 (ko)
DE (1) DE3126732C2 (ko)
DK (1) DK165837C (ko)
ES (2) ES8300785A1 (ko)
FI (1) FI71748C (ko)
FR (1) FR2486529A1 (ko)
GB (1) GB2079755B (ko)
IT (1) IT1205446B (ko)
NL (1) NL192343C (ko)
NO (1) NO163285C (ko)
PH (1) PH25874A (ko)
PT (1) PT73348B (ko)
SE (1) SE449106B (ko)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2137206B (en) * 1980-02-15 1985-04-03 Glaxo Group Ltd Androstane 17-carbothioc acid derivatives
JPS6041607A (ja) * 1983-08-12 1985-03-05 Otsuka Pharmaceut Co Ltd 軟膏基剤
IL78144A0 (en) * 1985-04-04 1986-07-31 Draco Ab Novel androstane-17beta-carboxylic acid esters
SE8501693D0 (sv) * 1985-04-04 1985-04-04 Draco Ab Novel 16,17-acetalsubstituted androstane-17beta-carboxylic acid esters
DE3786174T2 (de) * 1987-10-13 1993-10-21 Nicholas S Bodor Weiche steroide mit anti-entzündungswirkung.
DE4025342A1 (de) * 1990-08-10 1992-02-13 Hoechst Ag In 17-stellung substituierte corticoid-17-alkylcarbonate, verfahren zu deren herstellung und diese enthaltende arzneimittel
DE69822164T2 (de) * 1997-06-30 2005-04-14 Glaxo Group Ltd., Greenford Verfahren zur identifizierung von verbindungen mit verminderter systemischer aktivität
BRPI0113042B8 (pt) 2000-08-05 2021-05-25 Glaxo Group Ltd composto da fórmula ou um seu solvato fisiologicamente aceitável, uso do mesmo, composição farmacêutica, formulação farmacêutica, método para o tratamento de um indivíduo humano ou animal com uma condição inflamatória e/ou alérgica, e, processo para preparar um composto ou um seu solvato
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6787532B2 (en) 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
US6750210B2 (en) 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
GB0019172D0 (en) 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6858593B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6858596B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6777400B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
UA77656C2 (en) 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
UA82323C2 (uk) * 2002-08-09 2008-04-10 Меда Фарма Гмбх & Ко. Кг Нова комбінація глюкокортикоїду та pde-інгібітору для лікування респіраторних захворювань, алергічних захворювань, астми та хронічних обструктивних легеневих захворювань
GB0316290D0 (en) * 2003-07-11 2003-08-13 Glaxo Group Ltd Novel compounds
US7579335B2 (en) 2005-01-10 2009-08-25 Glaxo Group Limited Androstane 17α-carbonate derivatives for use in the treatment of allergic and inflammatory conditions
TWI374147B (en) * 2006-01-27 2012-10-11 Sun Pharma Advance Res Company Ltd Novel 11β-hydroxyandrosta-4-ene-3-ones
US7687484B2 (en) * 2006-05-25 2010-03-30 Bodor Nicholas S Transporter enhanced corticosteroid activity
US7691811B2 (en) * 2006-05-25 2010-04-06 Bodor Nicholas S Transporter-enhanced corticosteroid activity and methods and compositions for treating dry eye
CN101942001B (zh) * 2010-08-24 2013-02-06 山东省医药工业研究所 一种氯替泼诺的提纯方法
CN103183714A (zh) * 2011-12-29 2013-07-03 山东方明药业集团股份有限公司 一种氯替泼诺的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1384372A (en) * 1971-01-20 1975-02-19 Glaxo Lab Ltd Dereivatives of 17alpha-hydroxyandrost-4-ene-17beta-carboxylic acids
GB1438940A (en) * 1972-07-19 1976-06-09 Glaxo Lab Ltd 17beta-haloalkoxycarbonyl-17alpha-oxysteroids
GB1514476A (en) * 1974-08-30 1978-06-14 Glaxo Lab Ltd Alkyl and haloalkyl androst-4-ene and androsta-1,4-diene-17beta-carboxylates
DE2735110A1 (de) * 1977-08-04 1979-02-15 Hoechst Ag Corticoid-17-alkylcarbonate und verfahren zu ihrer herstellung
IT1114534B (it) * 1978-02-08 1986-01-27 Glaxo Group Ltd Steroide anti-infiammatorio della serie dell'androstano composizioni che lo contengono e procedimento per produrlo
US4188385A (en) * 1978-04-05 1980-02-12 Syntex (U.S.A.) Inc. Thioetianic acid derivatives
DE2817988A1 (de) * 1978-04-25 1979-11-08 Hoechst Ag Corticoid 17-alkylcarbonate und verfahren zu deren herstellung

Also Published As

Publication number Publication date
ES8306767A1 (es) 1983-06-16
KR830006327A (ko) 1983-09-24
FI812175L (fi) 1982-01-11
NL192343B (nl) 1997-02-03
FR2486529B1 (ko) 1985-01-04
IT1205446B (it) 1989-03-23
FR2486529A1 (fr) 1982-01-15
DE3126732C2 (de) 1987-04-30
GB2079755B (en) 1985-01-30
SE8104132L (sv) 1982-01-11
CH648856A5 (de) 1985-04-15
ES504340A0 (es) 1982-12-01
NO812344L (no) 1982-01-11
ATA307081A (de) 1985-07-15
DE3126732A1 (de) 1982-03-25
ES8300785A1 (es) 1982-12-01
NO163285C (no) 1990-05-02
CA1174667A (en) 1984-09-18
GB2079755A (en) 1982-01-27
NL8103315A (nl) 1982-02-01
AU540898B2 (en) 1984-12-06
AT379816B (de) 1986-03-10
AU7259181A (en) 1982-01-14
KR860000266B1 (ko) 1986-03-22
KR860000452B1 (ko) 1986-04-26
PH25874A (en) 1991-12-02
DK165837C (da) 1993-06-21
SE449106B (sv) 1987-04-06
DK302181A (da) 1982-01-11
DK165837B (da) 1993-01-25
PT73348A (en) 1981-08-01
ES514633A0 (es) 1983-06-16
PT73348B (en) 1982-09-23
IT8105186A0 (it) 1981-07-09
NO163285B (no) 1990-01-22
FI71748B (fi) 1986-10-31
FI71748C (fi) 1987-02-09
KR850002759A (ko) 1985-05-15

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BA A request for search or an international-type search has been filed
BB A search report has been drawn up
A85 Still pending on 85-01-01
BC A request for examination has been filed
CNR Transfer of rights (patent application after its laying open for public inspection)

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V4 Discontinued because of reaching the maximum lifetime of a patent

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