AU540898B2 - 17-disubstituted-androst-4-en-3-one derivatives - Google Patents

17-disubstituted-androst-4-en-3-one derivatives

Info

Publication number
AU540898B2
AU540898B2 AU72591/81A AU7259181A AU540898B2 AU 540898 B2 AU540898 B2 AU 540898B2 AU 72591/81 A AU72591/81 A AU 72591/81A AU 7259181 A AU7259181 A AU 7259181A AU 540898 B2 AU540898 B2 AU 540898B2
Authority
AU
Australia
Prior art keywords
androst
disubstituted
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU72591/81A
Other versions
AU7259181A (en
Inventor
Nicholas Stephen Bodor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of AU7259181A publication Critical patent/AU7259181A/en
Application granted granted Critical
Publication of AU540898B2 publication Critical patent/AU540898B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
AU72591/81A 1980-07-10 1981-07-06 17-disubstituted-androst-4-en-3-one derivatives Expired AU540898B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16845380A 1980-07-10 1980-07-10
US168453 1980-07-10
US26578581A 1981-05-21 1981-05-21
US265785 1981-05-21

Publications (2)

Publication Number Publication Date
AU7259181A AU7259181A (en) 1982-01-14
AU540898B2 true AU540898B2 (en) 1984-12-06

Family

ID=26864131

Family Applications (1)

Application Number Title Priority Date Filing Date
AU72591/81A Expired AU540898B2 (en) 1980-07-10 1981-07-06 17-disubstituted-androst-4-en-3-one derivatives

Country Status (17)

Country Link
KR (2) KR860000266B1 (en)
AT (1) AT379816B (en)
AU (1) AU540898B2 (en)
CA (1) CA1174667A (en)
CH (1) CH648856A5 (en)
DE (1) DE3126732A1 (en)
DK (1) DK165837C (en)
ES (2) ES504340A0 (en)
FI (1) FI71748C (en)
FR (1) FR2486529A1 (en)
GB (1) GB2079755B (en)
IT (1) IT1205446B (en)
NL (1) NL192343C (en)
NO (1) NO163285C (en)
PH (1) PH25874A (en)
PT (1) PT73348B (en)
SE (1) SE449106B (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2137206B (en) * 1980-02-15 1985-04-03 Glaxo Group Ltd Androstane 17-carbothioc acid derivatives
JPS6041607A (en) * 1983-08-12 1985-03-05 Otsuka Pharmaceut Co Ltd Ointment base
IL78144A0 (en) * 1985-04-04 1986-07-31 Draco Ab Novel androstane-17beta-carboxylic acid esters
SE8501693D0 (en) * 1985-04-04 1985-04-04 Draco Ab NOVEL 16,17-ACETALSUBSTITUTED ANDROSTANE-17BETA-CARBOXYLIC ACID ESTERS
ATE90355T1 (en) * 1987-10-13 1993-06-15 Nicholas S Bodor SOFT STEROIDS WITH ANTI-INFLAMMATORY EFFECTS.
DE4025342A1 (en) * 1990-08-10 1992-02-13 Hoechst Ag CORTICOID-17-ALKYLCARBONATE SUBSTITUTED IN 17-POSITION, METHOD FOR THE PRODUCTION THEREOF, AND MEDICINAL PRODUCTS CONTAINING THE SAME
DE69822164T2 (en) * 1997-06-30 2005-04-14 Glaxo Group Ltd., Greenford METHOD OF IDENTIFYING COMPOUNDS WITH REDUCED SYSTEMIC ACTIVITY
GB0019172D0 (en) 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6777400B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
NZ523958A (en) 2000-08-05 2004-11-26 Glaxo Group Ltd 17.beta.-carbothioate 17.alpha.-arylcarbonyloxyloxy androstane derviative as anti-inflammatory agents
US6858596B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6858593B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6787532B2 (en) 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
US6750210B2 (en) 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
UA77656C2 (en) 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
UA82323C2 (en) * 2002-08-09 2008-04-10 Меда Фарма Гмбх & Ко. Кг Novel combination of a glucocorticoid and pde-inhibitor for the treatment of respiratory diseases, allergic diseases, asthma and chronic obstructive pulmonary diseases
GB0316290D0 (en) 2003-07-11 2003-08-13 Glaxo Group Ltd Novel compounds
WO2006072599A2 (en) 2005-01-10 2006-07-13 Glaxo Group Limited Androstane 17-alpha carbonate derivatives for use in the treatment of allergic and inflammatory conditions
TWI374147B (en) * 2006-01-27 2012-10-11 Sun Pharma Advance Res Company Ltd Novel 11β-hydroxyandrosta-4-ene-3-ones
US7691811B2 (en) * 2006-05-25 2010-04-06 Bodor Nicholas S Transporter-enhanced corticosteroid activity and methods and compositions for treating dry eye
US7687484B2 (en) * 2006-05-25 2010-03-30 Bodor Nicholas S Transporter enhanced corticosteroid activity
CN101942001B (en) * 2010-08-24 2013-02-06 山东省医药工业研究所 Purification method of loteprednol etabonate
CN103183714A (en) * 2011-12-29 2013-07-03 山东方明药业集团股份有限公司 Synthetic method for loteprednol

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1384372A (en) * 1971-01-20 1975-02-19 Glaxo Lab Ltd Dereivatives of 17alpha-hydroxyandrost-4-ene-17beta-carboxylic acids
GB1438940A (en) * 1972-07-19 1976-06-09 Glaxo Lab Ltd 17beta-haloalkoxycarbonyl-17alpha-oxysteroids
GB1514476A (en) * 1974-08-30 1978-06-14 Glaxo Lab Ltd Alkyl and haloalkyl androst-4-ene and androsta-1,4-diene-17beta-carboxylates
DE2735110A1 (en) * 1977-08-04 1979-02-15 Hoechst Ag CORTICOID-17-ALKYLCARBONATE AND METHOD FOR THE PRODUCTION THEREOF
IT1114534B (en) * 1978-02-08 1986-01-27 Glaxo Group Ltd ANTI-INFLAMMATORY STEROID OF THE ANDROSTANE SERIES COMPOSITIONS THAT CONTAIN IT AND PROCEDURE TO PRODUCE IT
US4188385A (en) * 1978-04-05 1980-02-12 Syntex (U.S.A.) Inc. Thioetianic acid derivatives
DE2817988A1 (en) * 1978-04-25 1979-11-08 Hoechst Ag CORTICOID 17-ALKYLCARBONATE AND METHOD FOR THE PRODUCTION THEREOF

Also Published As

Publication number Publication date
NO163285B (en) 1990-01-22
KR860000266B1 (en) 1986-03-22
ES8300785A1 (en) 1982-12-01
DE3126732C2 (en) 1987-04-30
FI71748C (en) 1987-02-09
ES504340A0 (en) 1982-12-01
DK165837C (en) 1993-06-21
NL8103315A (en) 1982-02-01
DK302181A (en) 1982-01-11
FR2486529B1 (en) 1985-01-04
IT1205446B (en) 1989-03-23
DK165837B (en) 1993-01-25
ES514633A0 (en) 1983-06-16
AT379816B (en) 1986-03-10
IT8105186A0 (en) 1981-07-09
NL192343B (en) 1997-02-03
FI812175L (en) 1982-01-11
ES8306767A1 (en) 1983-06-16
GB2079755B (en) 1985-01-30
NO163285C (en) 1990-05-02
NL192343C (en) 1997-06-04
CA1174667A (en) 1984-09-18
GB2079755A (en) 1982-01-27
SE8104132L (en) 1982-01-11
FI71748B (en) 1986-10-31
KR830006327A (en) 1983-09-24
NO812344L (en) 1982-01-11
SE449106B (en) 1987-04-06
ATA307081A (en) 1985-07-15
PT73348B (en) 1982-09-23
FR2486529A1 (en) 1982-01-15
KR860000452B1 (en) 1986-04-26
PH25874A (en) 1991-12-02
PT73348A (en) 1981-08-01
AU7259181A (en) 1982-01-14
DE3126732A1 (en) 1982-03-25
CH648856A5 (en) 1985-04-15
KR850002759A (en) 1985-05-15

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired