ES8306767A1 - Androstene 17 alpha -carbonate 17 beta -carboxylates (and carbothioates) - Google Patents

Androstene 17 alpha -carbonate 17 beta -carboxylates (and carbothioates)

Info

Publication number
ES8306767A1
ES8306767A1 ES514633A ES514633A ES8306767A1 ES 8306767 A1 ES8306767 A1 ES 8306767A1 ES 514633 A ES514633 A ES 514633A ES 514633 A ES514633 A ES 514633A ES 8306767 A1 ES8306767 A1 ES 8306767A1
Authority
ES
Spain
Prior art keywords
beta
alpha
carbothioates
androstene
carboxylates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES514633A
Other languages
Spanish (es)
Other versions
ES514633A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of ES514633A0 publication Critical patent/ES514633A0/en
Publication of ES8306767A1 publication Critical patent/ES8306767A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel anti-inflammatory agents based on a glucocortico-steroid structure having a general formula I < IMAGE > the groups R1 to R5, and Z being defined X is O or S. One example is based on the inactive metabolite cortienic acid which is activated by the introduction of non-toxic substituents at positions 17 alpha - and 17 beta -.
ES514633A 1980-07-10 1982-08-02 Androstene 17 alpha -carbonate 17 beta -carboxylates (and carbothioates) Expired ES8306767A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16845380A 1980-07-10 1980-07-10
US26578581A 1981-05-21 1981-05-21

Publications (2)

Publication Number Publication Date
ES514633A0 ES514633A0 (en) 1983-06-16
ES8306767A1 true ES8306767A1 (en) 1983-06-16

Family

ID=26864131

Family Applications (2)

Application Number Title Priority Date Filing Date
ES504340A Expired ES8300785A1 (en) 1980-07-10 1981-07-10 Androstene 17 alpha -carbonate 17 beta -carboxylates (and carbothioates)
ES514633A Expired ES8306767A1 (en) 1980-07-10 1982-08-02 Androstene 17 alpha -carbonate 17 beta -carboxylates (and carbothioates)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES504340A Expired ES8300785A1 (en) 1980-07-10 1981-07-10 Androstene 17 alpha -carbonate 17 beta -carboxylates (and carbothioates)

Country Status (17)

Country Link
KR (2) KR860000266B1 (en)
AT (1) AT379816B (en)
AU (1) AU540898B2 (en)
CA (1) CA1174667A (en)
CH (1) CH648856A5 (en)
DE (1) DE3126732C2 (en)
DK (1) DK165837C (en)
ES (2) ES8300785A1 (en)
FI (1) FI71748C (en)
FR (1) FR2486529A1 (en)
GB (1) GB2079755B (en)
IT (1) IT1205446B (en)
NL (1) NL192343C (en)
NO (1) NO163285C (en)
PH (1) PH25874A (en)
PT (1) PT73348B (en)
SE (1) SE449106B (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2137206B (en) * 1980-02-15 1985-04-03 Glaxo Group Ltd Androstane 17-carbothioc acid derivatives
JPS6041607A (en) * 1983-08-12 1985-03-05 Otsuka Pharmaceut Co Ltd Ointment base
IL78144A0 (en) * 1985-04-04 1986-07-31 Draco Ab Novel androstane-17beta-carboxylic acid esters
SE8501693D0 (en) * 1985-04-04 1985-04-04 Draco Ab NOVEL 16,17-ACETALSUBSTITUTED ANDROSTANE-17BETA-CARBOXYLIC ACID ESTERS
WO1989003390A1 (en) * 1987-10-13 1989-04-20 Bodor Nicholas S Soft steroids having anti-inflammatory activity
DE4025342A1 (en) * 1990-08-10 1992-02-13 Hoechst Ag CORTICOID-17-ALKYLCARBONATE SUBSTITUTED IN 17-POSITION, METHOD FOR THE PRODUCTION THEREOF, AND MEDICINAL PRODUCTS CONTAINING THE SAME
AU8439998A (en) * 1997-06-30 1999-01-25 Glaxo Group Limited Compounds
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
US6858593B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
DZ3468A1 (en) 2000-08-05 2002-02-14 Glaxo Group Ltd 6.ALPHA., 9.ALPHA.-DIFLUORO-17.ALPHA.-`(2-FURANYLCARBOXYLE) OXY! -11.BETA.-HYDROXY-16.ALPHA.-METHYLE-3-OXO-ANDROST-1,4, -DIENE-17-CARBOTHIOIC ACID S-FLUOROMETHYL ESTER USED AS ANTI-INFLAMMATORY AGENT
GB0019172D0 (en) 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6777400B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6858596B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6750210B2 (en) 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
US6787532B2 (en) 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
UA77656C2 (en) 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
UA82323C2 (en) * 2002-08-09 2008-04-10 Меда Фарма Гмбх & Ко. Кг Novel combination of a glucocorticoid and pde-inhibitor for the treatment of respiratory diseases, allergic diseases, asthma and chronic obstructive pulmonary diseases
GB0316290D0 (en) 2003-07-11 2003-08-13 Glaxo Group Ltd Novel compounds
ATE517908T1 (en) 2005-01-10 2011-08-15 Glaxo Group Ltd ANDROSTAN-17-ALPHA-CARBONATE DERIVATIVES FOR USE IN THE TREATMENT OF ALLERGIC AND INFLAMMATORY CONDITIONS
TWI374147B (en) * 2006-01-27 2012-10-11 Sun Pharma Advance Res Company Ltd Novel 11β-hydroxyandrosta-4-ene-3-ones
US7691811B2 (en) * 2006-05-25 2010-04-06 Bodor Nicholas S Transporter-enhanced corticosteroid activity and methods and compositions for treating dry eye
US7687484B2 (en) * 2006-05-25 2010-03-30 Bodor Nicholas S Transporter enhanced corticosteroid activity
CN101942001B (en) * 2010-08-24 2013-02-06 山东省医药工业研究所 Purification method of loteprednol etabonate
CN103183714A (en) * 2011-12-29 2013-07-03 山东方明药业集团股份有限公司 Synthetic method for loteprednol

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1384372A (en) * 1971-01-20 1975-02-19 Glaxo Lab Ltd Dereivatives of 17alpha-hydroxyandrost-4-ene-17beta-carboxylic acids
GB1438940A (en) * 1972-07-19 1976-06-09 Glaxo Lab Ltd 17beta-haloalkoxycarbonyl-17alpha-oxysteroids
GB1514476A (en) * 1974-08-30 1978-06-14 Glaxo Lab Ltd Alkyl and haloalkyl androst-4-ene and androsta-1,4-diene-17beta-carboxylates
DE2735110A1 (en) * 1977-08-04 1979-02-15 Hoechst Ag CORTICOID-17-ALKYLCARBONATE AND METHOD FOR THE PRODUCTION THEREOF
IT1114534B (en) * 1978-02-08 1986-01-27 Glaxo Group Ltd ANTI-INFLAMMATORY STEROID OF THE ANDROSTANE SERIES COMPOSITIONS THAT CONTAIN IT AND PROCEDURE TO PRODUCE IT
US4188385A (en) * 1978-04-05 1980-02-12 Syntex (U.S.A.) Inc. Thioetianic acid derivatives
DE2817988A1 (en) * 1978-04-25 1979-11-08 Hoechst Ag CORTICOID 17-ALKYLCARBONATE AND METHOD FOR THE PRODUCTION THEREOF

Also Published As

Publication number Publication date
GB2079755A (en) 1982-01-27
KR830006327A (en) 1983-09-24
NL192343C (en) 1997-06-04
ATA307081A (en) 1985-07-15
DK302181A (en) 1982-01-11
SE8104132L (en) 1982-01-11
ES514633A0 (en) 1983-06-16
NO163285C (en) 1990-05-02
KR860000452B1 (en) 1986-04-26
PT73348B (en) 1982-09-23
PH25874A (en) 1991-12-02
NO812344L (en) 1982-01-11
GB2079755B (en) 1985-01-30
FI812175L (en) 1982-01-11
FR2486529B1 (en) 1985-01-04
NO163285B (en) 1990-01-22
NL192343B (en) 1997-02-03
CH648856A5 (en) 1985-04-15
SE449106B (en) 1987-04-06
DE3126732C2 (en) 1987-04-30
CA1174667A (en) 1984-09-18
PT73348A (en) 1981-08-01
DE3126732A1 (en) 1982-03-25
FR2486529A1 (en) 1982-01-15
ES504340A0 (en) 1982-12-01
FI71748B (en) 1986-10-31
AT379816B (en) 1986-03-10
KR850002759A (en) 1985-05-15
IT1205446B (en) 1989-03-23
FI71748C (en) 1987-02-09
KR860000266B1 (en) 1986-03-22
IT8105186A0 (en) 1981-07-09
ES8300785A1 (en) 1982-12-01
NL8103315A (en) 1982-02-01
AU7259181A (en) 1982-01-14
AU540898B2 (en) 1984-12-06
DK165837B (en) 1993-01-25
DK165837C (en) 1993-06-21

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20030211