MY201293A - Chimeric factor viii polypeptides and uses thereof - Google Patents
Chimeric factor viii polypeptides and uses thereofInfo
- Publication number
- MY201293A MY201293A MYPI2018001814A MYPI2018001814A MY201293A MY 201293 A MY201293 A MY 201293A MY PI2018001814 A MYPI2018001814 A MY PI2018001814A MY PI2018001814 A MYPI2018001814 A MY PI2018001814A MY 201293 A MY201293 A MY 201293A
- Authority
- MY
- Malaysia
- Prior art keywords
- vwf
- vwf fragment
- fviii
- protein
- fragment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261586099P | 2012-01-12 | 2012-01-12 | |
| US201261586654P | 2012-01-13 | 2012-01-13 | |
| US201261667901P | 2012-07-03 | 2012-07-03 | |
| US201261734954P | 2012-12-07 | 2012-12-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY201293A true MY201293A (en) | 2024-02-15 |
Family
ID=48781968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI2018001814A MY201293A (en) | 2012-01-12 | 2013-01-12 | Chimeric factor viii polypeptides and uses thereof |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US11370827B2 (enExample) |
| EP (2) | EP2804623B1 (enExample) |
| JP (4) | JP6255630B2 (enExample) |
| KR (1) | KR102212098B1 (enExample) |
| CN (4) | CN104271150A (enExample) |
| AU (2) | AU2016202875B2 (enExample) |
| BR (1) | BR112014017165B1 (enExample) |
| CA (1) | CA2863328A1 (enExample) |
| CO (1) | CO7010788A2 (enExample) |
| CY (1) | CY1122509T1 (enExample) |
| DK (1) | DK2804623T3 (enExample) |
| EA (2) | EA028309B1 (enExample) |
| ES (1) | ES2753124T3 (enExample) |
| HR (1) | HRP20191920T1 (enExample) |
| HU (1) | HUE046396T2 (enExample) |
| IL (2) | IL233463B (enExample) |
| LT (1) | LT2804623T (enExample) |
| MX (1) | MX357403B (enExample) |
| MY (1) | MY201293A (enExample) |
| NZ (1) | NZ626945A (enExample) |
| PH (2) | PH12014501602B1 (enExample) |
| PL (1) | PL2804623T3 (enExample) |
| PT (1) | PT2804623T (enExample) |
| RS (1) | RS59670B1 (enExample) |
| SG (2) | SG11201403764XA (enExample) |
| SI (1) | SI2804623T1 (enExample) |
| TW (3) | TW201348253A (enExample) |
| WO (1) | WO2013106787A1 (enExample) |
| ZA (1) | ZA201405094B (enExample) |
Families Citing this family (67)
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| US20100256062A1 (en) | 2004-12-06 | 2010-10-07 | Howard Tommy E | Allelic Variants of Human Factor VIII |
| PL2291523T3 (pl) | 2008-06-24 | 2015-05-29 | Csl Behring Gmbh | Czynnik VIII, czynnik von Willebranda lub ich kompleksy o wydłużonym okresie półtrwania in vivo |
| EP2470559B1 (en) | 2009-08-24 | 2017-03-22 | Amunix Operating Inc. | Coagulation factor ix compositions and methods of making and using same |
| RS59670B1 (sr) | 2012-01-12 | 2020-01-31 | Bioverativ Therapeutics Inc | Himerni polipeptidi faktora viii i njihove upotrebe |
| HUE043537T2 (hu) | 2012-02-15 | 2019-08-28 | Bioverativ Therapeutics Inc | Rekombináns VIII faktor fehérjék |
| PT2814840T (pt) | 2012-02-15 | 2020-01-28 | Bioverativ Therapeutics Inc | Composições de fator viii e métodos de produção e utilização das mesmas |
| HK1207591A1 (en) | 2012-06-08 | 2016-02-05 | Biogen Ma Inc. | Chimeric clotting factors |
| WO2013185113A1 (en) | 2012-06-08 | 2013-12-12 | Biogen Idec Ma Inc. | Procoagulant compounds |
| US10023628B2 (en) | 2012-07-06 | 2018-07-17 | Bioverativ Therapeutics Inc. | Cell line expressing single chain factor VIII polypeptides and uses thereof |
| RS59876B1 (sr) | 2012-07-11 | 2020-03-31 | Bioverativ Therapeutics Inc | Kompleks faktora viii sa xten i proteinom fon vilebrandovog faktora, i njihova primena |
| WO2014089541A2 (en) | 2012-12-07 | 2014-06-12 | Haplomics, Inc. | Factor viii mutation repair and tolerance induction |
| HUE063051T2 (hu) | 2013-02-15 | 2023-12-28 | Bioverativ Therapeutics Inc | Optimalizált VIII. faktor gén |
| TWI788044B (zh) | 2013-03-15 | 2022-12-21 | 美商百歐維拉提夫治療公司 | 因子ｉｘ多肽調配物 |
| DK2796145T3 (da) | 2013-04-22 | 2018-01-29 | Csl Ltd | Et kovalent kompleks af von Willebrand-faktor og faktor VIII linket af en disulfidbro |
| EP3013358A4 (en) * | 2013-06-28 | 2017-03-22 | Biogen MA Inc. | Thrombin cleavable linker with xten and its uses thereof |
| HK1223303A1 (zh) * | 2013-06-28 | 2017-07-28 | Bioverativ Therapeutics Inc. | 凝血酶可裂解连接子 |
| US10947269B2 (en) | 2013-08-08 | 2021-03-16 | Bioverativ Therapeutics Inc. | Purification of chimeric FVIII molecules |
| TW202003554A (zh) | 2013-08-14 | 2020-01-16 | 美商百歐維拉提夫治療公司 | 因子ｖｉｉｉ－ｘｔｅｎ融合物及其用途 |
| ES2900425T3 (es) | 2013-09-25 | 2022-03-16 | Bioverativ Therapeutics Inc | Métodos de inactivación vírica en columna |
| EP3091997B1 (en) * | 2014-01-10 | 2022-07-06 | Bioverativ Therapeutics Inc. | Factor viii chimeric proteins and uses thereof |
| WO2016004113A1 (en) | 2014-06-30 | 2016-01-07 | Biogen Ma Inc. | Optimized factor ix gene |
| ES2844232T3 (es) * | 2014-07-02 | 2021-07-21 | CSL Behring Lengnau AG | Factor de Von Willebrand modificado |
| US10626164B2 (en) | 2014-07-25 | 2020-04-21 | Csl Limited | Purification of VWF |
| CN107531774B (zh) * | 2015-02-06 | 2021-12-14 | 北卡罗来纳大学查珀尔希尔分校 | 优化的人类凝血因子viii基因表达盒及其用途 |
| US10688157B2 (en) | 2015-05-22 | 2020-06-23 | CSL Behring Lengnau AG | Truncated von Willebrand factor polypeptides for treating hemophilia |
| AU2016267539B2 (en) | 2015-05-22 | 2019-12-05 | CSL Behring Lengnau AG | Methods for preparing modified von willebrand factor |
| JP6909203B2 (ja) * | 2015-08-03 | 2021-07-28 | バイオベラティブ セラピューティクス インコーポレイテッド | 第ｉｘ因子融合タンパク質及びそれらの製造方法及び使用方法 |
| AU2016304842A1 (en) * | 2015-08-12 | 2018-02-22 | Cell Machines, Inc. | Methods and compositions related to long half-life coagulation complexes |
| PH12018500927B1 (en) | 2015-10-28 | 2024-07-03 | Sangamo Therapeutics Inc | Liver-specific constructs, factor viii expression cassettes and methods of use thereof |
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| CN110290798B (zh) * | 2017-02-27 | 2024-04-05 | 沙塔克实验室有限公司 | 基于vsig8的嵌合蛋白 |
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