CN104271150A - 嵌合因子viii多肽及其用途 - Google Patents

嵌合因子viii多肽及其用途 Download PDF

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Publication number
CN104271150A
CN104271150A CN201380013452.7A CN201380013452A CN104271150A CN 104271150 A CN104271150 A CN 104271150A CN 201380013452 A CN201380013452 A CN 201380013452A CN 104271150 A CN104271150 A CN 104271150A
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China
Prior art keywords
fviii
vwf
seq
chimeric protein
hours
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CN201380013452.7A
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English (en)
Chinese (zh)
Inventor
伊克塔·赛思·切布拉
刘童瑶
罗伯特·彼得斯
江海燕
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Treatment Co
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Biogen Idec MA Inc
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Priority to CN201911266598.8A priority Critical patent/CN111499760A/zh
Priority to CN201810666645.7A priority patent/CN109111526A/zh
Priority to CN201911267518.0A priority patent/CN111499761A/zh
Publication of CN104271150A publication Critical patent/CN104271150A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201380013452.7A 2012-01-12 2013-01-12 嵌合因子viii多肽及其用途 Pending CN104271150A (zh)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN201911266598.8A CN111499760A (zh) 2012-01-12 2013-01-12 嵌合因子viii多肽及其用途
CN201810666645.7A CN109111526A (zh) 2012-01-12 2013-01-12 嵌合因子viii多肽及其用途
CN201911267518.0A CN111499761A (zh) 2012-01-12 2013-01-12 嵌合因子viii多肽及其用途

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201261586099P 2012-01-12 2012-01-12
US61/586,099 2012-01-12
US201261586654P 2012-01-13 2012-01-13
US61/586,654 2012-01-13
US201261667901P 2012-07-03 2012-07-03
US61/667,901 2012-07-03
US201261734954P 2012-12-07 2012-12-07
US61/734,954 2012-12-07
PCT/US2013/021330 WO2013106787A1 (en) 2012-01-12 2013-01-12 Chimeric factor viii polypeptides and uses thereof

Related Child Applications (3)

Application Number Title Priority Date Filing Date
CN201810666645.7A Division CN109111526A (zh) 2012-01-12 2013-01-12 嵌合因子viii多肽及其用途
CN201911266598.8A Division CN111499760A (zh) 2012-01-12 2013-01-12 嵌合因子viii多肽及其用途
CN201911267518.0A Division CN111499761A (zh) 2012-01-12 2013-01-12 嵌合因子viii多肽及其用途

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CN104271150A true CN104271150A (zh) 2015-01-07

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CN201380013452.7A Pending CN104271150A (zh) 2012-01-12 2013-01-12 嵌合因子viii多肽及其用途
CN201911266598.8A Pending CN111499760A (zh) 2012-01-12 2013-01-12 嵌合因子viii多肽及其用途
CN201911267518.0A Pending CN111499761A (zh) 2012-01-12 2013-01-12 嵌合因子viii多肽及其用途
CN201810666645.7A Pending CN109111526A (zh) 2012-01-12 2013-01-12 嵌合因子viii多肽及其用途

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CN201911266598.8A Pending CN111499760A (zh) 2012-01-12 2013-01-12 嵌合因子viii多肽及其用途
CN201911267518.0A Pending CN111499761A (zh) 2012-01-12 2013-01-12 嵌合因子viii多肽及其用途
CN201810666645.7A Pending CN109111526A (zh) 2012-01-12 2013-01-12 嵌合因子viii多肽及其用途

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US (2) US11370827B2 (enExample)
EP (2) EP2804623B1 (enExample)
JP (4) JP6255630B2 (enExample)
KR (1) KR102212098B1 (enExample)
CN (4) CN104271150A (enExample)
AU (2) AU2016202875B2 (enExample)
BR (1) BR112014017165B1 (enExample)
CA (1) CA2863328A1 (enExample)
CO (1) CO7010788A2 (enExample)
CY (1) CY1122509T1 (enExample)
DK (1) DK2804623T3 (enExample)
EA (2) EA028309B1 (enExample)
ES (1) ES2753124T3 (enExample)
HR (1) HRP20191920T1 (enExample)
HU (1) HUE046396T2 (enExample)
IL (2) IL233463B (enExample)
LT (1) LT2804623T (enExample)
MX (1) MX357403B (enExample)
MY (1) MY201293A (enExample)
NZ (1) NZ626945A (enExample)
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PL (1) PL2804623T3 (enExample)
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RS (1) RS59670B1 (enExample)
SG (2) SG11201403764XA (enExample)
SI (1) SI2804623T1 (enExample)
TW (3) TW201348253A (enExample)
WO (1) WO2013106787A1 (enExample)
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Cited By (11)

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CN106659771A (zh) * 2014-07-02 2017-05-10 杰特有限公司 修饰的von Willebrand因子
CN107921103A (zh) * 2015-08-12 2018-04-17 细胞机械股份有限公司 涉及长半衰期凝血复合物的方法和组合物
CN108472337A (zh) * 2015-08-03 2018-08-31 比奥贝拉蒂治疗公司 因子ix融合蛋白以及其制备和使用方法
CN109790529A (zh) * 2016-06-24 2019-05-21 财团法人牧岩生命科学研究所 包含FVIII和vWF因子的嵌合蛋白及其用途
WO2019219049A1 (zh) * 2018-05-18 2019-11-21 北京辅仁瑞辉生物医药研究院有限公司 改进的fviii融合蛋白及其应用
CN112175088A (zh) * 2019-07-02 2021-01-05 郑州晟斯生物科技有限公司 改进的fix融合蛋白、缀合物及其应用
CN112512555A (zh) * 2018-05-18 2021-03-16 比奥维拉迪维治疗股份有限公司 治疗血友病a的方法
CN113087803A (zh) * 2021-05-12 2021-07-09 苏州大学附属第一医院 抗人血管性血友病因子前导肽单克隆抗体sz176及其应用
CN113166271A (zh) * 2018-05-18 2021-07-23 郑州晟斯生物科技有限公司 具有延长半衰期的融合多肽缀合物
US12161696B2 (en) 2016-12-02 2024-12-10 Bioverativ Therapeutics Inc. Methods of treating hemophilic arthropathy using chimeric clotting factors
CN120757663A (zh) * 2025-07-04 2025-10-10 广州至善生物科技发展有限公司 一种神经干细胞及其在修复脊髓损伤中的应用

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KR102714760B1 (ko) * 2013-06-28 2024-10-11 바이오버라티브 테라퓨틱스 인크. Xten을 지닌 트롬빈 절단가능한 링커 및 이의 용도
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TWI851647B (zh) 2019-01-16 2024-08-11 日商武田藥品工業股份有限公司 用於a型血友病基因治療之編碼表現增加之重組fviii變異體的病毒載體
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JP2023537565A (ja) 2020-06-24 2023-09-04 バイオベラティブ セラピューティクス インコーポレイテッド タンパク質を発現するように改変されたレンチウイルスベクターの調製物から遊離第ｖｉｉｉ因子を除去する方法
WO2023159135A2 (en) * 2022-02-16 2023-08-24 University Of Miami Il-2 and tl1a fusion proteins and methods of use thereof

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