AU2016202875B2 - Chimeric Factor VIII Polypeptides and Uses Thereof - Google Patents

Chimeric Factor VIII Polypeptides and Uses Thereof Download PDF

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Publication number
AU2016202875B2
AU2016202875B2 AU2016202875A AU2016202875A AU2016202875B2 AU 2016202875 B2 AU2016202875 B2 AU 2016202875B2 AU 2016202875 A AU2016202875 A AU 2016202875A AU 2016202875 A AU2016202875 A AU 2016202875A AU 2016202875 B2 AU2016202875 B2 AU 2016202875B2
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AU2016202875A1 (en
Inventor
Ekta Seth Chhabra
Haiyan Jiang
Tongyao Liu
Robert Peters
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Bioverativ Therapeutics Inc
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Bioverativ Therapeutics Inc
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Priority claimed from AU2013205647A external-priority patent/AU2013205647B8/en
Application filed by Bioverativ Therapeutics Inc filed Critical Bioverativ Therapeutics Inc
Priority to AU2016202875A priority Critical patent/AU2016202875B2/en
Publication of AU2016202875A1 publication Critical patent/AU2016202875A1/en
Assigned to BIOVERATIV THERAPEUTICS INC. reassignment BIOVERATIV THERAPEUTICS INC. Request for Assignment Assignors: BIOGEN MA INC.
Priority to AU2018201163A priority patent/AU2018201163B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2016202875A 2012-01-12 2016-05-04 Chimeric Factor VIII Polypeptides and Uses Thereof Active AU2016202875B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2016202875A AU2016202875B2 (en) 2012-01-12 2016-05-04 Chimeric Factor VIII Polypeptides and Uses Thereof
AU2018201163A AU2018201163B2 (en) 2012-01-12 2018-02-16 Chimeric Factor VIII Polypeptides and Uses Thereof

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201261586099P 2012-01-12 2012-01-12
US61/586,099 2012-01-12
US201261586654P 2012-01-13 2012-01-13
US61/586,654 2012-01-13
US201261667901P 2012-07-03 2012-07-03
US61/667,901 2012-07-03
US201261734954P 2012-12-07 2012-12-07
US61/734,954 2012-12-07
PCT/US2013/021330 WO2013106787A1 (en) 2012-01-12 2013-01-12 Chimeric factor viii polypeptides and uses thereof
AU2013205647A AU2013205647B8 (en) 2012-01-12 2013-01-12 Chimeric factor VIII polypeptides and uses thereof
AU2016202875A AU2016202875B2 (en) 2012-01-12 2016-05-04 Chimeric Factor VIII Polypeptides and Uses Thereof

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
AU2013205647A Division AU2013205647B8 (en) 2012-01-12 2013-01-12 Chimeric factor VIII polypeptides and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2018201163A Division AU2018201163B2 (en) 2012-01-12 2018-02-16 Chimeric Factor VIII Polypeptides and Uses Thereof

Publications (2)

Publication Number Publication Date
AU2016202875A1 AU2016202875A1 (en) 2016-05-26
AU2016202875B2 true AU2016202875B2 (en) 2018-03-08

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AU2016202875A Active AU2016202875B2 (en) 2012-01-12 2016-05-04 Chimeric Factor VIII Polypeptides and Uses Thereof
AU2018201163A Active AU2018201163B2 (en) 2012-01-12 2018-02-16 Chimeric Factor VIII Polypeptides and Uses Thereof

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US (2) US11370827B2 (enExample)
EP (2) EP3505179A1 (enExample)
JP (4) JP6255630B2 (enExample)
KR (1) KR102212098B1 (enExample)
CN (4) CN104271150A (enExample)
AU (2) AU2016202875B2 (enExample)
BR (1) BR112014017165B1 (enExample)
CA (1) CA2863328A1 (enExample)
CO (1) CO7010788A2 (enExample)
CY (1) CY1122509T1 (enExample)
DK (1) DK2804623T3 (enExample)
EA (2) EA035323B1 (enExample)
ES (1) ES2753124T3 (enExample)
HR (1) HRP20191920T1 (enExample)
HU (1) HUE046396T2 (enExample)
IL (2) IL233463B (enExample)
LT (1) LT2804623T (enExample)
MX (1) MX357403B (enExample)
MY (1) MY201293A (enExample)
NZ (1) NZ626945A (enExample)
PH (2) PH12014501602B1 (enExample)
PL (1) PL2804623T3 (enExample)
PT (1) PT2804623T (enExample)
RS (1) RS59670B1 (enExample)
SG (2) SG10201610193RA (enExample)
SI (1) SI2804623T1 (enExample)
TW (3) TWI826778B (enExample)
WO (1) WO2013106787A1 (enExample)
ZA (1) ZA201405094B (enExample)

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CN109111526A (zh) 2019-01-01
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