MA53020A - Protéine de fusion du fviii améliorée et utilisation associée - Google Patents
Protéine de fusion du fviii améliorée et utilisation associéeInfo
- Publication number
- MA53020A MA53020A MA053020A MA53020A MA53020A MA 53020 A MA53020 A MA 53020A MA 053020 A MA053020 A MA 053020A MA 53020 A MA53020 A MA 53020A MA 53020 A MA53020 A MA 53020A
- Authority
- MA
- Morocco
- Prior art keywords
- fusion protein
- associated use
- fviii fusion
- enhanced fviii
- enhanced
- Prior art date
Links
- 102100026735 Coagulation factor VIII Human genes 0.000 title 1
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 title 1
- 108020001507 fusion proteins Proteins 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810481941 | 2018-05-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA53020A true MA53020A (fr) | 2021-05-05 |
Family
ID=68539524
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA053020A MA53020A (fr) | 2018-05-18 | 2019-05-16 | Protéine de fusion du fviii améliorée et utilisation associée |
Country Status (9)
Country | Link |
---|---|
US (1) | US20210361775A1 (fr) |
EP (1) | EP3816181A4 (fr) |
JP (2) | JP2021530437A (fr) |
KR (1) | KR102575788B1 (fr) |
CN (2) | CN113039200B (fr) |
BR (1) | BR112020023168A2 (fr) |
MA (1) | MA53020A (fr) |
MX (1) | MX2020012103A (fr) |
WO (1) | WO2019219049A1 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023227015A1 (fr) * | 2022-05-25 | 2023-11-30 | 江苏晟斯生物制药有限公司 | Conjugué de protéine de fusion fviii ayant une demi-vie étendue et son utilisation |
CN116284411B (zh) * | 2023-02-03 | 2024-02-13 | 北京基科晟斯医药科技有限公司 | 抗培重组人凝血因子VIII-Fc融合蛋白的抗体及其应用 |
CN116036244B (zh) * | 2023-02-24 | 2023-09-19 | 北京基科晟斯医药科技有限公司 | 培重组人凝血因子VIII-Fc融合蛋白用于治疗含抑制物的血友病A的用途 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4818679A (en) | 1985-02-19 | 1989-04-04 | The Trustees Of Columbia University In The City Of New York | Method for recovering mutant cells |
AU8576298A (en) * | 1997-07-18 | 1999-02-10 | Chiron Corporation | Lentiviral vectors |
US7645860B2 (en) * | 2006-03-31 | 2010-01-12 | Baxter Healthcare S.A. | Factor VIII polymer conjugates |
EP2977055A1 (fr) * | 2010-02-16 | 2016-01-27 | Novo Nordisk A/S | Protéines de fusion de facteur viii |
CN102770449B (zh) * | 2010-02-16 | 2016-02-24 | 诺沃—诺迪斯克有限公司 | 具有降低的vwf结合的因子viii分子 |
CN103917554B (zh) * | 2011-10-18 | 2017-03-08 | 杰特有限公司 | 用于改善重构后纯化的因子viii的稳定性的方法 |
CN103172745A (zh) * | 2011-12-21 | 2013-06-26 | 北京韩美药品有限公司 | 包含免疫球蛋白Fc片段的长效人内皮抑素 |
WO2013106787A1 (fr) * | 2012-01-12 | 2013-07-18 | Biogen Idec Ma Inc. | Facteur viii chimérique et polypeptides et leurs utilisations |
US10023628B2 (en) * | 2012-07-06 | 2018-07-17 | Bioverativ Therapeutics Inc. | Cell line expressing single chain factor VIII polypeptides and uses thereof |
WO2014026954A1 (fr) * | 2012-08-13 | 2014-02-20 | Novo Nordisk A/S | Formulations liquides de facteur viii |
ES2657291T3 (es) * | 2013-04-22 | 2018-03-02 | Csl Ltd. | Un complejo covalente de factor de von Willebrand y factor VIII asociado por un puente disulfuro |
EP3400002B1 (fr) * | 2016-01-07 | 2022-02-02 | CSL Behring Lengnau AG | Facteur de von willebrand tronqué muté |
US11046749B2 (en) * | 2016-06-24 | 2021-06-29 | Mogam Institute For Biomedical Research | Chimera protein comprising FVIII and vWF factors, and use thereof |
CN106279437B (zh) * | 2016-08-19 | 2017-10-31 | 安源医药科技(上海)有限公司 | 高糖基化人凝血因子viii融合蛋白及其制备方法与用途 |
-
2019
- 2019-05-16 WO PCT/CN2019/087156 patent/WO2019219049A1/fr unknown
- 2019-05-16 US US17/055,403 patent/US20210361775A1/en active Pending
- 2019-05-16 MX MX2020012103A patent/MX2020012103A/es unknown
- 2019-05-16 JP JP2020564649A patent/JP2021530437A/ja active Pending
- 2019-05-16 EP EP19804136.0A patent/EP3816181A4/fr active Pending
- 2019-05-16 MA MA053020A patent/MA53020A/fr unknown
- 2019-05-16 CN CN201980033170.0A patent/CN113039200B/zh active Active
- 2019-05-16 CN CN202310860049.3A patent/CN117467019A/zh active Pending
- 2019-05-16 KR KR1020207034852A patent/KR102575788B1/ko active IP Right Grant
- 2019-05-16 BR BR112020023168-1A patent/BR112020023168A2/pt unknown
-
2023
- 2023-04-20 JP JP2023069317A patent/JP7492780B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
WO2019219049A1 (fr) | 2019-11-21 |
EP3816181A1 (fr) | 2021-05-05 |
EP3816181A4 (fr) | 2022-04-20 |
MX2020012103A (es) | 2021-01-29 |
US20210361775A1 (en) | 2021-11-25 |
JP2023093634A (ja) | 2023-07-04 |
KR102575788B1 (ko) | 2023-09-08 |
CN113039200A (zh) | 2021-06-25 |
CN117467019A (zh) | 2024-01-30 |
CN113039200B (zh) | 2023-07-25 |
KR20210005248A (ko) | 2021-01-13 |
JP7492780B2 (ja) | 2024-05-30 |
BR112020023168A2 (pt) | 2021-02-09 |
JP2021530437A (ja) | 2021-11-11 |
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