DK3365368T3 - Tgfbeta1-bindende immunoglobuliner og anvendelse deraf - Google Patents

Tgfbeta1-bindende immunoglobuliner og anvendelse deraf Download PDF

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Publication number
DK3365368T3
DK3365368T3 DK17716332.6T DK17716332T DK3365368T3 DK 3365368 T3 DK3365368 T3 DK 3365368T3 DK 17716332 T DK17716332 T DK 17716332T DK 3365368 T3 DK3365368 T3 DK 3365368T3
Authority
DK
Denmark
Prior art keywords
tgfbeta1
binding immunoglobulins
immunoglobulins
binding
Prior art date
Application number
DK17716332.6T
Other languages
English (en)
Inventor
Thomas Schurpf
Gregory J Carven
Abhishek Datta
Kimberly Long
Original Assignee
Scholar Rock Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=58503696&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3365368(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Scholar Rock Inc filed Critical Scholar Rock Inc
Application granted granted Critical
Publication of DK3365368T3 publication Critical patent/DK3365368T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK17716332.6T 2016-03-11 2017-03-10 Tgfbeta1-bindende immunoglobuliner og anvendelse deraf DK3365368T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662307353P 2016-03-11 2016-03-11
US201762443615P 2017-01-06 2017-01-06
US201762452866P 2017-01-31 2017-01-31
PCT/US2017/021972 WO2017156500A1 (en) 2016-03-11 2017-03-10 Tgfb1-binding immunoglobulins and use thereof

Publications (1)

Publication Number Publication Date
DK3365368T3 true DK3365368T3 (da) 2023-06-26

Family

ID=58503696

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17716332.6T DK3365368T3 (da) 2016-03-11 2017-03-10 Tgfbeta1-bindende immunoglobuliner og anvendelse deraf

Country Status (19)

Country Link
US (2) US11643459B2 (da)
EP (2) EP3365368B1 (da)
JP (4) JP2019509737A (da)
KR (2) KR20180122397A (da)
CN (1) CN109071646A (da)
AU (2) AU2017230103A1 (da)
BR (1) BR112018068340A2 (da)
CA (1) CA3055555A1 (da)
DK (1) DK3365368T3 (da)
EA (1) EA201891909A1 (da)
ES (1) ES2951648T3 (da)
FI (1) FI3365368T3 (da)
HU (1) HUE062976T2 (da)
IL (2) IL307835A (da)
MX (1) MX2018010948A (da)
PL (1) PL3365368T3 (da)
PT (1) PT3365368T (da)
SG (1) SG11201807176XA (da)
WO (1) WO2017156500A1 (da)

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HUE063120T2 (hu) 2017-05-09 2023-12-28 Scholar Rock Inc LRRC33-inhibitorok és alkalmazásuk
US20200231682A1 (en) 2017-07-28 2020-07-23 Scholar Rock, Inc. Ltbp complex-specific inhibitors of tgf-beta 1 and uses thereof
US11230601B2 (en) 2017-10-10 2022-01-25 Tilos Therapeutics, Inc. Methods of using anti-lap antibodies
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EP3677278B1 (en) 2018-07-11 2021-11-10 Scholar Rock, Inc. Isoform selective tgfbeta1 inhibitors and use thereof
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AU2020340176A1 (en) * 2019-08-28 2022-04-14 Chugai Seiyaku Kabushiki Kaisha Cross-species anti-latent TGF-beta 1 antibodies and methods of use
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TW202135862A (zh) 2020-01-11 2021-10-01 美商供石公司 TGFβ抑制劑及其用途
EP4279509A1 (en) * 2021-01-18 2023-11-22 Shanghai Jemincare Pharmaceuticals Co., Ltd. Garp protein antibody and application thereof
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WO2022180764A1 (en) 2021-02-26 2022-09-01 Chugai Seiyaku Kabushiki Kaisha Uses of cross-species anti-latent tgf-beta 1 antibodies
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WO2022206753A1 (zh) * 2021-03-29 2022-10-06 山东先声生物制药有限公司 GARP/TGFβ1抗体及其应用
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Also Published As

Publication number Publication date
FI3365368T3 (fi) 2023-06-13
CA3055555A1 (en) 2017-09-14
WO2017156500A8 (en) 2018-01-25
US20190071493A1 (en) 2019-03-07
SG11201807176XA (en) 2018-09-27
WO2017156500A1 (en) 2017-09-14
AU2017230103A1 (en) 2018-09-06
EP4169942A1 (en) 2023-04-26
US11643459B2 (en) 2023-05-09
AU2024202692A1 (en) 2024-05-30
US20230348583A1 (en) 2023-11-02
JP2022031403A (ja) 2022-02-18
CN109071646A (zh) 2018-12-21
BR112018068340A2 (pt) 2019-01-15
IL261442A (en) 2018-10-31
KR20180122397A (ko) 2018-11-12
JP2019509737A (ja) 2019-04-11
MX2018010948A (es) 2019-06-20
IL307835A (en) 2023-12-01
JP2023108057A (ja) 2023-08-03
ES2951648T3 (es) 2023-10-24
HUE062976T2 (hu) 2023-12-28
EP3365368B1 (en) 2023-05-17
PT3365368T (pt) 2023-08-17
EA201891909A1 (ru) 2019-02-28
PL3365368T3 (pl) 2023-08-21
JP2022028680A (ja) 2022-02-16
EP3365368A1 (en) 2018-08-29
KR20230088508A (ko) 2023-06-19
WO2017156500A9 (en) 2018-02-22

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