MXPA04003929A

MXPA04003929A - Formulacion de una forma de dosis oral de retencion gastrica, desgastable, mediante el uso de datos de prueba de desintegracion in vitro.

Formulacion de una forma de dosis oral de retencion gastrica, desgastable, mediante el uso de datos de prueba de desintegracion in vitro.

Info

Publication number: MXPA04003929A
Authority: MX; Mexico
Prior art keywords: dosage form; active agent; further characterized; form according; drug
Prior art date: 2001-10-25

Application number

MXPA04003929A

Other languages

English (en)

Spanish (es)

Inventor

Bret Berner

Original Assignee

Depomed Inc

Priority date

2001-10-25

Filing date

2002-10-25

Publication date

2004-11-29

2002-10-25 Application filed by Depomed Inc filed Critical Depomed Inc

2004-11-29 Publication of MXPA04003929A publication Critical patent/MXPA04003929A/es

Links

238000012360 testing method Methods 0.000 title claims abstract description 76
238000000338 in vitro Methods 0.000 title claims abstract description 38
230000002496 gastric effect Effects 0.000 title claims description 44
239000000203 mixture Substances 0.000 title claims description 34
239000006186 oral dosage form Substances 0.000 title claims description 7
238000009472 formulation Methods 0.000 title description 15
239000003814 drug Substances 0.000 claims abstract description 241
229940079593 drug Drugs 0.000 claims abstract description 239
239000002552 dosage form Substances 0.000 claims abstract description 229
239000013543 active substance Substances 0.000 claims abstract description 94
238000001727 in vivo Methods 0.000 claims abstract description 40
229920001477 hydrophilic polymer Polymers 0.000 claims abstract description 26
238000013270 controlled release Methods 0.000 claims abstract description 25
239000002775 capsule Substances 0.000 claims abstract description 11
229920000642 polymer Polymers 0.000 claims description 135
210000002784 stomach Anatomy 0.000 claims description 69
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XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 38
239000011159 matrix material Substances 0.000 claims description 33
210000001035 gastrointestinal tract Anatomy 0.000 claims description 27
230000014759 maintenance of location Effects 0.000 claims description 27
238000010521 absorption reaction Methods 0.000 claims description 25
238000000034 method Methods 0.000 claims description 25
239000012530 fluid Substances 0.000 claims description 21
229920000233 poly(alkylene oxides) Polymers 0.000 claims description 14
229920001577 copolymer Polymers 0.000 claims description 13
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210000000813 small intestine Anatomy 0.000 claims description 13
239000002934 diuretic Substances 0.000 claims description 12
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IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 claims description 4
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229960004329 metformin hydrochloride Drugs 0.000 claims description 4
OETHQSJEHLVLGH-UHFFFAOYSA-N metformin hydrochloride Chemical compound Cl.CN(C)C(=N)N=C(N)N OETHQSJEHLVLGH-UHFFFAOYSA-N 0.000 claims description 4
XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin hydrochloride Natural products CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims description 4
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OTVAEFIXJLOWRX-NXEZZACHSA-N thiamphenicol Chemical compound CS(=O)(=O)C1=CC=C([C@@H](O)[C@@H](CO)NC(=O)C(Cl)Cl)C=C1 OTVAEFIXJLOWRX-NXEZZACHSA-N 0.000 claims description 4
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SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 claims description 3
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LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 claims description 3
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