MX389700B - Derivados de pirazolopiridina como moduladores de cinasa 1 progenitora hematopoyetica (hpk1) y usos de los mismos para tratamiento de cancer. - Google Patents

Derivados de pirazolopiridina como moduladores de cinasa 1 progenitora hematopoyetica (hpk1) y usos de los mismos para tratamiento de cancer.

Info

Publication number
MX389700B
MX389700B MX2019002750A MX2019002750A MX389700B MX 389700 B MX389700 B MX 389700B MX 2019002750 A MX2019002750 A MX 2019002750A MX 2019002750 A MX2019002750 A MX 2019002750A MX 389700 B MX389700 B MX 389700B
Authority
MX
Mexico
Prior art keywords
hpk1
modulators
cancer treatment
hematopoietic progenitor
pyrazolopyridine derivatives
Prior art date
Application number
MX2019002750A
Other languages
English (en)
Other versions
MX2019002750A (es
Inventor
Alexander Sokolsky
Anlai Wang
Hai- Fen YE
Jun Pan
Kai Liu
Oleg Vechorkin
Qinda Ye
Wenqing Yao
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of MX2019002750A publication Critical patent/MX2019002750A/es
Publication of MX389700B publication Critical patent/MX389700B/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

Se describen compuestos de la formula (I), métodos para usar los compuestos para inhibir la actividad de HPK1 y composiciones farmacéuticamente que comprenden estos compuestos. Los compuestos son útiles en tratar, prevenir o aminorar enfermedades o trastornos asociados con la actividad de HPK1 tal como cáncer.
MX2019002750A 2016-09-09 2017-09-08 Derivados de pirazolopiridina como moduladores de cinasa 1 progenitora hematopoyetica (hpk1) y usos de los mismos para tratamiento de cancer. MX389700B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662385584P 2016-09-09 2016-09-09
PCT/US2017/050737 WO2018049200A1 (en) 2016-09-09 2017-09-08 Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer

Publications (2)

Publication Number Publication Date
MX2019002750A MX2019002750A (es) 2019-07-04
MX389700B true MX389700B (es) 2025-03-20

Family

ID=59901617

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019002750A MX389700B (es) 2016-09-09 2017-09-08 Derivados de pirazolopiridina como moduladores de cinasa 1 progenitora hematopoyetica (hpk1) y usos de los mismos para tratamiento de cancer.

Country Status (17)

Country Link
US (5) US10266530B2 (es)
EP (2) EP4119558A1 (es)
JP (2) JP7076432B2 (es)
KR (2) KR102507967B1 (es)
CN (2) CN109923114B (es)
AR (1) AR109596A1 (es)
AU (2) AU2017322427B2 (es)
BR (1) BR112019004586A2 (es)
EA (1) EA201990665A1 (es)
ES (1) ES2927104T3 (es)
IL (2) IL292977A (es)
MA (1) MA46191A (es)
MX (1) MX389700B (es)
PH (1) PH12019500521A1 (es)
TW (2) TWI771319B (es)
UA (1) UA125650C2 (es)
WO (1) WO2018049200A1 (es)

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