HK1249509A1 - 作為irak-4抑制劑的吲唑及氮雜吲唑化合物 - Google Patents

作為irak-4抑制劑的吲唑及氮雜吲唑化合物

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Publication number
HK1249509A1
HK1249509A1 HK18109038.5A HK18109038A HK1249509A1 HK 1249509 A1 HK1249509 A1 HK 1249509A1 HK 18109038 A HK18109038 A HK 18109038A HK 1249509 A1 HK1249509 A1 HK 1249509A1
Authority
HK
Hong Kong
Prior art keywords
irak
indazole
inhibitors
azaindazole compounds
azaindazole
Prior art date
Application number
HK18109038.5A
Other languages
English (en)
Inventor
Venkateshwar Rao Gummadi
Susanta Samajdar
Subhendu Mukherjee
Original Assignee
Aurigene Discovery Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aurigene Discovery Tech Ltd filed Critical Aurigene Discovery Tech Ltd
Publication of HK1249509A1 publication Critical patent/HK1249509A1/zh

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    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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HK18109038.5A 2015-07-15 2018-07-12 作為irak-4抑制劑的吲唑及氮雜吲唑化合物 HK1249509A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN3630CH2015 2015-07-15
PCT/IB2016/054203 WO2017009798A1 (en) 2015-07-15 2016-07-14 Indazole and azaindazole compounds as irak-4 inhibitors

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HK1249509A1 true HK1249509A1 (zh) 2018-11-02

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US (1) US20180201609A1 (zh)
EP (1) EP3322698A4 (zh)
JP (1) JP2018524372A (zh)
KR (1) KR20180025896A (zh)
CN (1) CN108026065A (zh)
AU (1) AU2016293441A1 (zh)
BR (1) BR112018000624A2 (zh)
CA (1) CA2992406A1 (zh)
CU (1) CU20180006A7 (zh)
EA (1) EA201890307A1 (zh)
HK (1) HK1249509A1 (zh)
IL (1) IL256584A (zh)
MX (1) MX2018000512A (zh)
PH (1) PH12018500040A1 (zh)
WO (1) WO2017009798A1 (zh)

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PT3466955T (pt) 2014-01-13 2021-01-29 Aurigene Discovery Tech Ltd Método de preparação de derivados de oxazolo[4,5-b] piridina e tiazolo[4,5-b] piridina como inibidores de irak-4 para o tratamento do cancro
CN108473498B (zh) * 2015-12-22 2021-11-02 豪夫迈·罗氏有限公司 作为IRAK4调节剂的吡唑并[1,5a]嘧啶衍生物
EP3423446B1 (de) 2016-03-03 2020-09-16 Bayer Pharma Aktiengesellschaft Neue 2-substituierte indazole, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln
MA44759B1 (fr) 2016-04-29 2024-01-31 Bayer Pharma AG Forme polymorphe de n-(6-(2-hydroxypropan-2-yl)-2-[2-(méthylsulfonyl)éthyl]-2h-indazol-5-yl)-6-(trifluorométhyl)pyridine-2-carboxamide
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