BR112018000635A2 - compostos aza substituídos como inibidores irak-4 - Google Patents
compostos aza substituídos como inibidores irak-4Info
- Publication number
- BR112018000635A2 BR112018000635A2 BR112018000635A BR112018000635A BR112018000635A2 BR 112018000635 A2 BR112018000635 A2 BR 112018000635A2 BR 112018000635 A BR112018000635 A BR 112018000635A BR 112018000635 A BR112018000635 A BR 112018000635A BR 112018000635 A2 BR112018000635 A2 BR 112018000635A2
- Authority
- BR
- Brazil
- Prior art keywords
- irak
- inhibitors
- compounds substituted
- aza compounds
- aza
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
a presente invenção provê compostos aza substituídos de fórmula (i) ou (ii) e seus sais farmaceuticamente aceitáveis e seu uso para inibir irak-4 e/ou para o tratamento de doenças ou distúrbios induzidos por irak-4.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN3632CH2015 | 2015-07-15 | ||
IN3631CH2015 | 2015-07-15 | ||
PCT/IB2016/054229 WO2017009806A1 (en) | 2015-07-15 | 2016-07-15 | Substituted aza compounds as irak-4 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018000635A2 true BR112018000635A2 (pt) | 2018-09-18 |
Family
ID=57757045
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018000635A BR112018000635A2 (pt) | 2015-07-15 | 2016-07-15 | compostos aza substituídos como inibidores irak-4 |
Country Status (14)
Country | Link |
---|---|
US (1) | US20180208605A1 (pt) |
EP (1) | EP3322409A4 (pt) |
JP (1) | JP2018524365A (pt) |
KR (1) | KR20180026537A (pt) |
CN (1) | CN108024971A (pt) |
AU (1) | AU2016293446A1 (pt) |
BR (1) | BR112018000635A2 (pt) |
CA (1) | CA2992408A1 (pt) |
EA (1) | EA201890308A1 (pt) |
HK (1) | HK1249435A1 (pt) |
IL (1) | IL256581A (pt) |
MX (1) | MX2018000396A (pt) |
PH (1) | PH12018500041A1 (pt) |
WO (1) | WO2017009806A1 (pt) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CU24389B1 (es) | 2014-01-13 | 2019-04-04 | Aurigene Discovery Tech Ltd | Compuestos de heterociclilo bicíclico como inhibidores de irak4 |
BR112018000624A2 (pt) * | 2015-07-15 | 2018-09-18 | Aurigene Discovery Technologies Limited | compostos de indazol e azaindazol como inibidores de irak-4 |
AU2017322427B2 (en) | 2016-09-09 | 2021-12-23 | Incyte Corporation | Pyrazolopyridine derivatives as HPK1 modulators and uses thereof for the treatment of cancer |
WO2018049191A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridone derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
WO2018049214A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
TW201811799A (zh) | 2016-09-09 | 2018-04-01 | 美商英塞特公司 | 吡唑并嘧啶化合物及其用途 |
JP7059268B2 (ja) * | 2016-11-02 | 2022-04-25 | エフ.ホフマン-ラ ロシュ アーゲー | IRAK4モデュレーターとしてのピラゾロ[1,5a]ピリミジン誘導体 |
WO2018152220A1 (en) | 2017-02-15 | 2018-08-23 | Incyte Corporation | Pyrazolopyridine compounds and uses thereof |
JOP20180011A1 (ar) | 2017-02-16 | 2019-01-30 | Gilead Sciences Inc | مشتقات بيرولو [1، 2-b]بيريدازين |
KR102633530B1 (ko) * | 2017-03-31 | 2024-02-02 | 오리진 온콜로지 리미티드 | 혈액 장애를 치료하기 위한 화합물 및 조성물 |
WO2018195155A1 (en) * | 2017-04-18 | 2018-10-25 | Celgene Quanticel Research, Inc. | Therapeutic compounds |
BR112020001714A2 (pt) | 2017-07-28 | 2020-07-21 | Nimbus Lakshmi, Inc. | inibidores de tyk2 e usos dos mesmos |
WO2019051199A1 (en) | 2017-09-08 | 2019-03-14 | Incyte Corporation | 6-CYANO-INDAZOLE COMPOUNDS AS HEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) MODULATORS |
US11358948B2 (en) | 2017-09-22 | 2022-06-14 | Kymera Therapeutics, Inc. | CRBN ligands and uses thereof |
MX2020003190A (es) | 2017-09-22 | 2020-11-11 | Kymera Therapeutics Inc | Degradadores de proteinas y usos de los mismos. |
KR20200080254A (ko) | 2017-10-31 | 2020-07-06 | 쿠리스 인코퍼레이션 | 혈액학적 장애를 치료하기 위한 화합물 및 조성물 |
JP2021508703A (ja) | 2017-12-26 | 2021-03-11 | カイメラ セラピューティクス, インコーポレイテッド | Irak分解剤およびそれらの使用 |
US11512080B2 (en) | 2018-01-12 | 2022-11-29 | Kymera Therapeutics, Inc. | CRBN ligands and uses thereof |
US11485743B2 (en) | 2018-01-12 | 2022-11-01 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
KR20200133747A (ko) | 2018-02-20 | 2020-11-30 | 인사이트 코포레이션 | 암을 치료하기 위한 hpk1 억제제로서의 n-(페닐)-2-(페닐)피리미딘-4-카복스아미드 유도체 및 관련 화합물 |
US10752635B2 (en) | 2018-02-20 | 2020-08-25 | Incyte Corporation | Indazole compounds and uses thereof |
US10745388B2 (en) | 2018-02-20 | 2020-08-18 | Incyte Corporation | Indazole compounds and uses thereof |
US11299473B2 (en) | 2018-04-13 | 2022-04-12 | Incyte Corporation | Benzimidazole and indole compounds and uses thereof |
WO2020010177A1 (en) | 2018-07-06 | 2020-01-09 | Kymera Therapeutics, Inc. | Tricyclic crbn ligands and uses thereof |
TWI721483B (zh) | 2018-07-13 | 2021-03-11 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒𠯤衍生物 |
US10899755B2 (en) | 2018-08-08 | 2021-01-26 | Incyte Corporation | Benzothiazole compounds and uses thereof |
WO2020068729A1 (en) | 2018-09-25 | 2020-04-02 | Incyte Corporation | Pyrazolo[4,3-d]pyrimidine compounds as alk2 abd/or fgfr modulators |
CA3119773A1 (en) | 2018-11-30 | 2020-06-04 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
KR20220059480A (ko) | 2019-08-06 | 2022-05-10 | 인사이트 코포레이션 | 고체 형태의 hpk1 억제제 |
AU2020360000B2 (en) * | 2019-10-02 | 2023-04-20 | Kainos Medicine, Inc. | N-(1H-imidazol-2-yl)benzamide compound and pharmaceutical composition comprising the same as active ingredient |
WO2021127283A2 (en) | 2019-12-17 | 2021-06-24 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
US11779578B2 (en) | 2019-12-17 | 2023-10-10 | Kymera Therapeutics, Inc. | IRAK degraders and uses thereof |
WO2021204589A1 (en) | 2020-04-07 | 2021-10-14 | Bayer Aktiengesellschaft | Substituted thiazolopyridines, salts thereof and their use as herbicidally active substances |
US20230322754A1 (en) * | 2020-04-28 | 2023-10-12 | Kymera Therapeutics, Inc. | Irak inhibitors and uses thereof |
TW202210483A (zh) | 2020-06-03 | 2022-03-16 | 美商凱麥拉醫療公司 | Irak降解劑之結晶型 |
US11767321B2 (en) | 2020-10-05 | 2023-09-26 | Enliven Inc. | 5- and 6-azaindole compounds for inhibition of BCR-ABL tyrosine kinases |
JP2023550739A (ja) * | 2020-11-18 | 2023-12-05 | キュリス,インコーポレイテッド | 疾患及び障害を治療する方法 |
US11866405B2 (en) | 2020-12-10 | 2024-01-09 | Astrazeneca Ab | Substituted indazoles as IRAK4 inhibitors |
US20230391776A1 (en) * | 2020-12-25 | 2023-12-07 | Medshine Discovery Inc. | Amide oxazole compound |
US20220331330A1 (en) * | 2021-04-08 | 2022-10-20 | Curis, Inc. | Combination therapies for the treatment of cancer |
TW202328151A (zh) | 2021-09-07 | 2023-07-16 | 德商拜耳廠股份有限公司 | 經取代之2,3-二氫[1,3]噻唑并[4,5-b]吡啶、其鹽及其作為除草活性物質之用途 |
TW202328150A (zh) | 2021-09-07 | 2023-07-16 | 德商拜耳廠股份有限公司 | 經取代之噻唑并吡啶、其鹽及其作為除草活性物質之用途 |
CN117177965B (zh) * | 2021-12-23 | 2024-04-30 | 杭州多域生物技术有限公司 | 一种五元并六元化合物、制备方法、药物组合物和应用 |
WO2023152349A1 (en) | 2022-02-14 | 2023-08-17 | Astrazeneca Ab | Irak4 inhibitors |
TW202400250A (zh) | 2022-04-12 | 2024-01-01 | 美商健臻公司 | Irak4調節劑於基因療法之用途(一) |
WO2023227703A1 (en) | 2022-05-26 | 2023-11-30 | Astrazeneca Ab | Solid forms of heterocyclylamides as irak4 inhibitors |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6878714B2 (en) * | 2001-01-12 | 2005-04-12 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
DE602005009021D1 (de) * | 2004-12-17 | 2008-09-25 | Lilly Co Eli | Neue mch-rezeptorantagonisten |
EP1674467A1 (en) * | 2004-12-22 | 2006-06-28 | 4Sc Ag | 2,5- and 2,6-disubstituted benzazole derivatives useful as protein kinase inhibitors |
GB0606429D0 (en) * | 2006-03-30 | 2006-05-10 | Novartis Ag | Organic compounds |
WO2007121154A2 (en) * | 2006-04-11 | 2007-10-25 | Janssen Pharmaceutica, N.V. | Substituted benzothiazole kinase inhibitors |
EP2640708A1 (en) * | 2010-11-19 | 2013-09-25 | Ligand Pharmaceuticals Inc. | Heterocycle amines and uses thereof |
WO2013042137A1 (en) * | 2011-09-19 | 2013-03-28 | Aurigene Discovery Technologies Limited | Bicyclic heterocycles as irak4 inhibitors |
KR101385603B1 (ko) * | 2012-05-17 | 2014-04-21 | 한국원자력의학원 | 벤조티아졸 유도체 및 암 치료를 위한 그의 용도 |
CU24389B1 (es) * | 2014-01-13 | 2019-04-04 | Aurigene Discovery Tech Ltd | Compuestos de heterociclilo bicíclico como inhibidores de irak4 |
-
2016
- 2016-07-15 CA CA2992408A patent/CA2992408A1/en not_active Abandoned
- 2016-07-15 KR KR1020187004447A patent/KR20180026537A/ko unknown
- 2016-07-15 WO PCT/IB2016/054229 patent/WO2017009806A1/en active Application Filing
- 2016-07-15 AU AU2016293446A patent/AU2016293446A1/en not_active Abandoned
- 2016-07-15 US US15/744,451 patent/US20180208605A1/en not_active Abandoned
- 2016-07-15 CN CN201680052322.8A patent/CN108024971A/zh active Pending
- 2016-07-15 EP EP16823970.5A patent/EP3322409A4/en not_active Withdrawn
- 2016-07-15 BR BR112018000635A patent/BR112018000635A2/pt not_active Application Discontinuation
- 2016-07-15 EA EA201890308A patent/EA201890308A1/ru unknown
- 2016-07-15 MX MX2018000396A patent/MX2018000396A/es unknown
- 2016-07-15 JP JP2018501261A patent/JP2018524365A/ja active Pending
-
2017
- 2017-12-26 IL IL256581A patent/IL256581A/en unknown
-
2018
- 2018-01-04 PH PH12018500041A patent/PH12018500041A1/en unknown
- 2018-07-13 HK HK18109083.9A patent/HK1249435A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
AU2016293446A1 (en) | 2018-02-15 |
IL256581A (en) | 2018-02-28 |
EA201890308A1 (ru) | 2018-08-31 |
CN108024971A (zh) | 2018-05-11 |
EP3322409A1 (en) | 2018-05-23 |
EP3322409A4 (en) | 2019-07-24 |
KR20180026537A (ko) | 2018-03-12 |
MX2018000396A (es) | 2018-05-02 |
PH12018500041A1 (en) | 2018-07-09 |
WO2017009806A1 (en) | 2017-01-19 |
US20180208605A1 (en) | 2018-07-26 |
JP2018524365A (ja) | 2018-08-30 |
HK1249435A1 (zh) | 2018-11-02 |
CA2992408A1 (en) | 2017-01-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112018000635A2 (pt) | compostos aza substituídos como inibidores irak-4 | |
BR112018000624A2 (pt) | compostos de indazol e azaindazol como inibidores de irak-4 | |
BR112016029853A2 (pt) | compostos de indazol substituído como inibidores de irak4 | |
BR112018074621A2 (pt) | derivados de pirazolopirimidina como inibidores de quinase | |
DOP2016000173A (es) | Heteroarilos y usos de estos | |
BR112014027236A2 (pt) | pirrolidinas substituídas como um fator inibidor de xia para o tratamento de doenças tromboembolíticas | |
CR20150472A (es) | USO DE DERIVADOS DE PIRAZOLOPIRIMIDINA PARA EL TRATAMIENTO DE TRANSTORNOS RELACIONADOS CON LA PI3Kd | |
BR112017006940A2 (pt) | triazolopirazinonas como inibidores de pde1 | |
BR112016018555A8 (pt) | Ciclopropilaminas como inibidores de lsd1, seu uso, composição farmacêutica que os compreende e método de inibição de lsd1 | |
BR112017013936A2 (pt) | inibidores de bace1 seletivos. | |
BR112017002942A2 (pt) | compostos e derivados de espiro[3h-indol-3,2´-pirrolidin]2(1h)-ona como inibidores de mdm2-p53 | |
BR112015020350A2 (pt) | derivados de 6-(5-hidroxi-1h-pirazol-1-il)nicotinamida e seu uso como inibidores de phd | |
BR112017008659A2 (pt) | ?métodos e compostos de agonista de gip? | |
BR112015007061A8 (pt) | composto, composição farmacêutica e uso do composto | |
BR112016024533A8 (pt) | derivados de amino pirazina como inibidores de fosfatidilinositol 3-cinase ou sal, seu uso, e composição e combinação farmacêuticas | |
ECSP16008797A (es) | Derivados de heterobicicloaril como inhibidores rorc2 y métodos de uso de los mismos | |
BR112018067922A2 (pt) | compostos antibacterianos e seus usos | |
BR112017009012A2 (pt) | derivados de anel benzo de seis membros como inibidor de dpp-4 e seu uso | |
BR112017004580A2 (pt) | composto, composição farmacêutica, produto de combinação, uso de um composto ou sal farmaceuticamente aceitável, e, método de tratamento. | |
BR112017003231A2 (pt) | compostos heterobicíclicos e seu uso para o tratamento da tuberculose | |
UY36081A (es) | Compuestos inhibidores de metaloenzima como fungicidas. | |
BR112019008415A2 (pt) | composto de piridona e inibidor de c-met, composição farmacêutica e uso dos mesmos | |
BR112017021583A2 (pt) | métodos para o tratamento de transtornos inflamatórios | |
BR112017005324A2 (pt) | inibidores de ssao derivados de imidazo[4,5-c]piridina | |
BR112015018442A2 (pt) | compostos de derivados de ciclohexeno biaril- ou heterocíclico biaril-substituído como inibidores de cetp |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |