BR112016029853A2 - compostos de indazol substituído como inibidores de irak4 - Google Patents

compostos de indazol substituído como inibidores de irak4

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Publication number
BR112016029853A2
BR112016029853A2 BR112016029853A BR112016029853A BR112016029853A2 BR 112016029853 A2 BR112016029853 A2 BR 112016029853A2 BR 112016029853 A BR112016029853 A BR 112016029853A BR 112016029853 A BR112016029853 A BR 112016029853A BR 112016029853 A2 BR112016029853 A2 BR 112016029853A2
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BR
Brazil
Prior art keywords
substituted indazole
indazole compounds
irak4 inhibitors
irak4
substituted
Prior art date
Application number
BR112016029853A
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English (en)
Inventor
Samajdar Susanta
Rao Gummadi Venkateshwar
Original Assignee
Aurigene Discovery Tech Ltd
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Publication date
Application filed by Aurigene Discovery Tech Ltd filed Critical Aurigene Discovery Tech Ltd
Publication of BR112016029853A2 publication Critical patent/BR112016029853A2/pt

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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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Abstract

a presente invenção apresenta composto de indazol substituído da fórmula (i) e seus sais farmaceuticamente aceitáveis e seu uso para inibir a irak4 e/ou para o tratamento de doenças ou distúrbios induzidos por irak4.
BR112016029853A 2014-06-20 2015-06-19 compostos de indazol substituído como inibidores de irak4 BR112016029853A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN3017CH2014 2014-06-20
PCT/IB2015/054620 WO2015193846A1 (en) 2014-06-20 2015-06-19 Substituted indazole compounds as irak4 inhibitors

Publications (1)

Publication Number Publication Date
BR112016029853A2 true BR112016029853A2 (pt) 2017-08-22

Family

ID=54934936

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016029853A BR112016029853A2 (pt) 2014-06-20 2015-06-19 compostos de indazol substituído como inibidores de irak4

Country Status (16)

Country Link
US (1) US20170152263A1 (pt)
EP (1) EP3157521A4 (pt)
JP (1) JP2017518348A (pt)
KR (1) KR20170016500A (pt)
CN (1) CN106456609A (pt)
AU (1) AU2015275730A1 (pt)
BR (1) BR112016029853A2 (pt)
CA (1) CA2952188A1 (pt)
CU (1) CU20160188A7 (pt)
EA (1) EA201692418A1 (pt)
HK (1) HK1231411A1 (pt)
IL (1) IL249345A0 (pt)
MX (1) MX2016017147A (pt)
PH (1) PH12016502382A1 (pt)
SG (1) SG11201610009XA (pt)
WO (1) WO2015193846A1 (pt)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CU24389B1 (es) 2014-01-13 2019-04-04 Aurigene Discovery Tech Ltd Compuestos de heterociclilo bicíclico como inhibidores de irak4
JO3705B1 (ar) 2014-11-26 2021-01-31 Bayer Pharma AG إندازولات مستبدلة جديدة، عمليات لتحضيرها، مستحضرات دوائية تحتوي عليها واستخدامها في إنتاج أدوية
EP3195865A1 (de) 2016-01-25 2017-07-26 Bayer Pharma Aktiengesellschaft Kombinationen von irak4 inhibitoren und btk inhibitoren
WO2016174183A1 (en) 2015-04-30 2016-11-03 Bayer Pharma Aktiengesellschaft Combinations of inhibitors of irak4 with inhibitors of btk
BR112018000624A2 (pt) * 2015-07-15 2018-09-18 Aurigene Discovery Technologies Limited compostos de indazol e azaindazol como inibidores de irak-4
WO2017108723A2 (en) * 2015-12-22 2017-06-29 F. Hoffmann-La Roche Ag PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS
CN109153665B (zh) * 2016-03-03 2021-10-15 拜耳医药股份有限公司 新的2-取代的吲唑、其制备方法、包含其的药物制剂及其用于制备药物的用途
US20190125736A1 (en) * 2016-06-01 2019-05-02 Bayer Pharma Aktiengesellschaft Use of 2-substituted indazoles for the treatment and prophylaxis of autoimmune diseases
TW201811799A (zh) 2016-09-09 2018-04-01 美商英塞特公司 吡唑并嘧啶化合物及其用途
WO2018049214A1 (en) 2016-09-09 2018-03-15 Incyte Corporation Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer
AU2017322427B2 (en) 2016-09-09 2021-12-23 Incyte Corporation Pyrazolopyridine derivatives as HPK1 modulators and uses thereof for the treatment of cancer
JP7059268B2 (ja) 2016-11-02 2022-04-25 エフ．ホフマン－ラ ロシュ アーゲー ＩＲＡＫ４モデュレーターとしてのピラゾロ［１，５ａ］ピリミジン誘導体
WO2018152220A1 (en) 2017-02-15 2018-08-23 Incyte Corporation Pyrazolopyridine compounds and uses thereof
JOP20180011A1 (ar) 2017-02-16 2019-01-30 Gilead Sciences Inc مشتقات بيرولو [1، 2-b]بيريدازين
KR102633530B1 (ko) 2017-03-31 2024-02-02 오리진 온콜로지 리미티드 혈액 장애를 치료하기 위한 화합물 및 조성물
WO2018234343A1 (en) 2017-06-21 2018-12-27 F. Hoffmann-La Roche Ag BENZOFURANES AS MODULATORS OF IRAQ4
JP2020524691A (ja) 2017-06-21 2020-08-20 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ＩＲＡＫ４調節因子としてのピラゾロ［１，５ａ］ピリミジン誘導体
WO2018234342A1 (en) 2017-06-21 2018-12-27 F. Hoffmann-La Roche Ag ISOINDOLINONE DERIVATIVES AS MODULATORS OF IRAK4
WO2019051199A1 (en) 2017-09-08 2019-03-14 Incyte Corporation 6-CYANO-INDAZOLE COMPOUNDS AS HEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) MODULATORS
MX2020003190A (es) 2017-09-22 2020-11-11 Kymera Therapeutics Inc Degradadores de proteinas y usos de los mismos.
US11358948B2 (en) 2017-09-22 2022-06-14 Kymera Therapeutics, Inc. CRBN ligands and uses thereof
KR20200080254A (ko) * 2017-10-31 2020-07-06 쿠리스 인코퍼레이션 혈액학적 장애를 치료하기 위한 화합물 및 조성물
WO2019111218A1 (en) 2017-12-08 2019-06-13 Cadila Healthcare Limited Novel heterocyclic compounds as irak4 inhibitors
JP2021508703A (ja) 2017-12-26 2021-03-11 カイメラ セラピューティクス， インコーポレイテッド Ｉｒａｋ分解剤およびそれらの使用
US11485743B2 (en) 2018-01-12 2022-11-01 Kymera Therapeutics, Inc. Protein degraders and uses thereof
US11512080B2 (en) 2018-01-12 2022-11-29 Kymera Therapeutics, Inc. CRBN ligands and uses thereof
AU2019220632B2 (en) 2018-02-14 2024-02-22 Dana-Farber Cancer Institute, Inc. IRAK degraders and uses thereof
US10752635B2 (en) 2018-02-20 2020-08-25 Incyte Corporation Indazole compounds and uses thereof
KR20200133747A (ko) 2018-02-20 2020-11-30 인사이트 코포레이션 암을 치료하기 위한 hpk1 억제제로서의 n-(페닐)-2-(페닐)피리미딘-4-카복스아미드 유도체 및 관련 화합물
US10745388B2 (en) 2018-02-20 2020-08-18 Incyte Corporation Indazole compounds and uses thereof
US11873303B2 (en) * 2018-04-05 2024-01-16 Merck Patent Gmbh Substituted pyrazoles as type II IRAK inhibitors
US11299473B2 (en) 2018-04-13 2022-04-12 Incyte Corporation Benzimidazole and indole compounds and uses thereof
WO2020010177A1 (en) 2018-07-06 2020-01-09 Kymera Therapeutics, Inc. Tricyclic crbn ligands and uses thereof
TWI721483B (zh) 2018-07-13 2021-03-11 美商基利科學股份有限公司 吡咯并[1,2-b]嗒𠯤衍生物
US10899755B2 (en) 2018-08-08 2021-01-26 Incyte Corporation Benzothiazole compounds and uses thereof
CN110833559A (zh) * 2018-08-15 2020-02-25 广西梧州制药（集团）股份有限公司 吡唑并嘧啶衍生物在治疗急性肺损伤致肺纤维化的用途
CN112513027B (zh) 2018-08-17 2024-03-29 浙江海正药业股份有限公司 吲唑胺类衍生物及其制备方法和其在医药上的用途
WO2020048471A1 (zh) * 2018-09-06 2020-03-12 浙江海正药业股份有限公司 7-取代吲唑类衍生物及其制备方法和其在医药上的用途
WO2020068729A1 (en) 2018-09-25 2020-04-02 Incyte Corporation Pyrazolo[4,3-d]pyrimidine compounds as alk2 abd/or fgfr modulators
CA3119773A1 (en) 2018-11-30 2020-06-04 Kymera Therapeutics, Inc. Irak degraders and uses thereof
JP2022541265A (ja) * 2019-07-18 2022-09-22 ブリストル－マイヤーズ スクイブ カンパニー ＩＲＡＫ４阻害剤として有用なピラゾロ［３，４－ｄ］ピロロ［１，２－ｂ］ピリダジニル化合物
KR20220059480A (ko) 2019-08-06 2022-05-10 인사이트 코포레이션 고체 형태의 hpk1 억제제
WO2021047677A1 (zh) * 2019-09-12 2021-03-18 中国科学院上海药物研究所 一类irak4激酶抑制剂及其制备和应用
US11779578B2 (en) 2019-12-17 2023-10-10 Kymera Therapeutics, Inc. IRAK degraders and uses thereof
WO2021127283A2 (en) 2019-12-17 2021-06-24 Kymera Therapeutics, Inc. Irak degraders and uses thereof
WO2021174024A1 (en) 2020-02-28 2021-09-02 First Wave Bio, Inc. Methods of treating iatrogenic autoimmune colitis
TW202210483A (zh) 2020-06-03 2022-03-16 美商凱麥拉醫療公司 Irak降解劑之結晶型
US20230391776A1 (en) * 2020-12-25 2023-12-07 Medshine Discovery Inc. Amide oxazole compound
CN113402499B (zh) 2021-06-21 2022-05-13 上海勋和医药科技有限公司 一种亚磺酰亚胺取代的吲唑类irak4激酶抑制剂、制备方法及用途

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1181327A (en) * 1915-08-10 1916-05-02 Michael F Mcandrew Basket construction and guard therefor.
US1301085A (en) * 1916-11-06 1919-04-15 Charles R Hadley Company Loose-leaf binder.
HU222234B1 (hu) * 1990-05-18 2003-05-28 Aventis Pharma Deutschland Gmbh. Eljárás izoxazol-4-karbonsav-amidok és hidroxi-alkilidén-cián-ecetsav-amidok, a vegyületeket tartalmazó gyógyászati készítmények és az ismert vegyületeket tartalmazó rákellenes hatású gyógyszerkészítmények előállítására
DE10023486C1 (de) * 2000-05-09 2002-03-14 Schering Ag Ortho substituierte Anthranilsäureamide und deren Verwendung als Arzneimittel
US20030134836A1 (en) * 2001-01-12 2003-07-17 Amgen Inc. Substituted arylamine derivatives and methods of use
DE10162375A1 (de) * 2001-12-19 2003-07-10 Bayer Ag Bicyclische N-Aryl-amide
RU2342365C2 (ru) * 2003-05-01 2008-12-27 Бристол-Маерс Сквибб Компани Арилзамещенные пиразоламиды в качестве ингибиторов киназ
WO2004103954A1 (ja) * 2003-05-20 2004-12-02 Ajinomoto Co., Inc. アミド誘導体
WO2004108133A2 (en) * 2003-06-05 2004-12-16 Vertex Pharmaceuticals Incorporated Modulators of vr1 receptor
BRPI0415167A (pt) * 2003-10-07 2006-11-28 Renovis Inc composto de amina como ligandos de canal de ìon e usos dos mesmos
US7820821B2 (en) * 2006-02-10 2010-10-26 Transtech Pharma, Inc. Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors
WO2008030584A2 (en) * 2006-09-07 2008-03-13 Biogen Idec Ma Inc. Indazole derivatives as modulators of interleukin- 1 receptor-associated kinase
JP4785881B2 (ja) * 2007-02-27 2011-10-05 大塚製薬株式会社 医薬
CN101754955A (zh) * 2007-07-16 2010-06-23 雅培制药有限公司 作为蛋白激酶抑制剂的吲唑、苯并异*唑和苯并异噻唑化合物
US20090221612A1 (en) * 2008-02-13 2009-09-03 Mitchell Scott A Certain substituted amides, method of making, and method of use thereof
PL2488486T3 (pl) * 2009-10-13 2020-01-31 Ligand Pharmaceuticals Inc. Małocząsteczkowe związki mimetyczne hematopoetycznego czynnika wzrostu i ich zastosowania
CN102939283B (zh) * 2010-04-22 2015-06-03 詹森药业有限公司 可用作己酮糖激酶抑制剂的吲唑化合物
CA2793697A1 (en) * 2010-04-30 2011-11-03 Merck Sharp & Dohme Corp. Inhibitors of phosphoinositide dependent kinase 1 (pdk1)
SI2585064T1 (sl) * 2010-06-24 2017-08-31 Chemocentryx, Inc. Antagonisti C5AR
US9957271B2 (en) * 2011-10-20 2018-05-01 Glaxosmithkline Llc Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators
GB201119401D0 (en) * 2011-11-10 2011-12-21 Ucb Pharma Sa Therapeutic agents
BR112016015983A2 (pt) * 2014-01-10 2017-08-08 Aurigene Discovery Tech Ltd Compostos de indazol como inibidores de irak4, seus usos, e composição farmacêutica
BR112016017996A2 (pt) * 2014-02-06 2017-08-08 Abbvie Inc 6-heteroariloxi- or 6-ariloxi-quinolina-2-carboxamidas e método de uso

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