MX357261B - Inhibidores de la proteina cinasa dependiente de acido desoxirribonucleico (adn-pk). - Google Patents

Inhibidores de la proteina cinasa dependiente de acido desoxirribonucleico (adn-pk).

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Publication number
MX357261B
MX357261B MX2014012960A MX2014012960A MX357261B MX 357261 B MX357261 B MX 357261B MX 2014012960 A MX2014012960 A MX 2014012960A MX 2014012960 A MX2014012960 A MX 2014012960A MX 357261 B MX357261 B MX 357261B
Authority
MX
Mexico
Prior art keywords
inhibitors
dna
compounds
compositions
disorders
Prior art date
Application number
MX2014012960A
Other languages
English (en)
Other versions
MX2014012960A (es
Inventor
Deng Hongbo
S Charifson Paul
P Duffy John
Gao Huai
M Kennedy Joseph
Michael Cottrell Kevin
Giroux Simon
Green Jeremy
Lee Jackson Katrina
Patick Maxwell John
A Morris Mark
Charles Pierce Albert
D Waal Nathan
J Lauffer David
Willem Ledeboer Mark
Li Pan
Xu Jinwang
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of MX2014012960A publication Critical patent/MX2014012960A/es
Publication of MX357261B publication Critical patent/MX357261B/es

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    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

La presente invención se refiere a compuestos de la fórmula siguiente: (ver Fórmula) que son útiles como inhibidores de la ADN-PK. La invención proporciona, además, composiciones farmacéuticamente aceptables que comprenden esos compuestos, y métodos para usar las composiciones en el tratamiento de diversas enfermedades, afecciones o trastornos, tales como el cáncer.
MX2014012960A 2012-04-24 2013-04-23 Inhibidores de la proteina cinasa dependiente de acido desoxirribonucleico (adn-pk). MX357261B (es)

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