MX2024004993A - Agentes degradantes de la proteina tirosina cinasa 2 (tyk2) y usos de los mismos. - Google Patents

Agentes degradantes de la proteina tirosina cinasa 2 (tyk2) y usos de los mismos.

Info

Publication number
MX2024004993A
MX2024004993A MX2024004993A MX2024004993A MX2024004993A MX 2024004993 A MX2024004993 A MX 2024004993A MX 2024004993 A MX2024004993 A MX 2024004993A MX 2024004993 A MX2024004993 A MX 2024004993A MX 2024004993 A MX2024004993 A MX 2024004993A
Authority
MX
Mexico
Prior art keywords
tyk2
degraders
compositions
methods
compounds
Prior art date
Application number
MX2024004993A
Other languages
English (en)
Inventor
Eamon Comer
Isaac Marx
Xiao Zhu
Christopher Michael Yates
Lewis Dale Pennington
Melissa Ford
Original Assignee
Kymera Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kymera Therapeutics Inc filed Critical Kymera Therapeutics Inc
Publication of MX2024004993A publication Critical patent/MX2024004993A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención proporciona compuestos, composiciones de los mismos y métodos para usarlos. Los compuestos y las composiciones de los mismos que son útiles, por ejemplo, para dirigirse, inhibir y/o degradar TYK2. En determinadas modalidades, se proporcionan agentes inhibidores y/o degradantes de TYK2 y métodos para hacerlos. Más específicamente, se proporcionan agentes degradantes de TYK2, composiciones que comprenden agentes degradantes de TYK2 y métodos para tratar afecciones relacionadas con TYK2.
MX2024004993A 2021-10-25 2022-10-24 Agentes degradantes de la proteina tirosina cinasa 2 (tyk2) y usos de los mismos. MX2024004993A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163271648P 2021-10-25 2021-10-25
PCT/US2022/047570 WO2023076161A1 (en) 2021-10-25 2022-10-24 Tyk2 degraders and uses thereof

Publications (1)

Publication Number Publication Date
MX2024004993A true MX2024004993A (es) 2024-05-07

Family

ID=84361085

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2024004993A MX2024004993A (es) 2021-10-25 2022-10-24 Agentes degradantes de la proteina tirosina cinasa 2 (tyk2) y usos de los mismos.

Country Status (10)

Country Link
EP (1) EP4423086A1 (es)
KR (1) KR20240111312A (es)
AR (1) AR127443A1 (es)
AU (1) AU2022378463A1 (es)
CA (1) CA3236262A1 (es)
CO (1) CO2024004970A2 (es)
IL (1) IL312330A (es)
MX (1) MX2024004993A (es)
TW (1) TW202334151A (es)
WO (1) WO2023076161A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024020221A1 (en) * 2022-07-21 2024-01-25 Arvinas Operations, Inc. Modulators of tyk2 proteolysis and associated methods of use

Family Cites Families (173)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5516931A (en) 1982-02-01 1996-05-14 Northeastern University Release tag compounds producing ketone signal groups
US4709016A (en) 1982-02-01 1987-11-24 Northeastern University Molecular analytical release tags and their use in chemical analysis
US4650750A (en) 1982-02-01 1987-03-17 Giese Roger W Method of chemical analysis employing molecular release tag compounds
US5650270A (en) 1982-02-01 1997-07-22 Northeastern University Molecular analytical release tags and their use in chemical analysis
WO2002020740A2 (en) 2000-09-08 2002-03-14 California Institute Of Technology Proteolysis targeting chimeric pharmaceutical
MY159449A (en) 2005-12-13 2017-01-13 Incyte Holdings Corp Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors
WO2007078990A2 (en) 2005-12-23 2007-07-12 Zealand Pharma A/S Modified lysine-mimetic compounds
CN102112879B (zh) 2008-06-30 2015-05-13 生物科技研究有限公司 Stat3和tyk2作为神经退行性疾病的药物靶点
DE102009001438A1 (de) 2009-03-10 2010-09-16 Bayer Schering Pharma Aktiengesellschaft Carbonylamino-substituierte Anilino-Pyrimidinderivate als Tyk-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
DE102009015070A1 (de) 2009-03-30 2010-10-14 Bayer Schering Pharma Aktiengesellschaft Aminocabonylamino-substituierte Anilino-Pyrimidinderivate als Tyk-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
AR076687A1 (es) 2009-05-18 2011-06-29 Infinity Pharmaceuticals Inc Isoxazolinas como inhibidores de la amidahidrolasa de acidos grasos y com-posiciones farmaceuticas que los contienen
MX2012010265A (es) 2010-03-17 2012-10-01 Hoffmann La Roche Compuestos de imidazopiridina, composiciones y metodos de uso.
US9765019B2 (en) 2010-06-30 2017-09-19 Brandeis University Small-molecule-targeted protein degradation
WO2012000970A1 (en) 2010-07-01 2012-01-05 Cellzome Limited Triazolopyridines as tyk2 inhibitors
JP2014500254A (ja) 2010-11-09 2014-01-09 セルゾーム リミティッド Ｔｙｋ２阻害剤としてのピリジン化合物およびそのアザ類似体
BR112013011520A2 (pt) 2010-11-19 2019-09-24 Hoffmann La Roche pirazolo piridinas e pirazolo piridinas e seu uso como inibidores de tyk2
CN103502275A (zh) 2010-12-07 2014-01-08 耶鲁大学 融合蛋白的小分子疏水性标记和引起的其降解
EP3608317A1 (en) 2012-01-12 2020-02-12 Yale University Compounds & methods for the enhanced degradation of targeted proteins & other polypeptides by an e3 ubiquitin ligase
WO2013106646A2 (en) 2012-01-12 2013-07-18 Yale University Compounds and methods for the inhibition of vcb e3 ubiquitin ligase
JPWO2013125543A1 (ja) 2012-02-20 2015-07-30 武田薬品工業株式会社 複素環化合物
DK2634185T3 (en) 2012-03-02 2016-03-21 Sareum Ltd Tyk2 kinase inhibitors
JPWO2013146963A1 (ja) 2012-03-28 2015-12-14 武田薬品工業株式会社 複素環化合物
KR20150013554A (ko) 2012-05-24 2015-02-05 셀좀 리미티드 Tyk2 억제제로서의 헤테로시클릴 피리미딘 유사체
US9422331B2 (en) 2012-09-19 2016-08-23 Hoffmann-La Roche Inc. 2-oxo-2,3,4,5-tetrahydro-1 H-benzo[B]diazepines and their use in the treatment of cancer
USRE48175E1 (en) 2012-10-19 2020-08-25 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged small molecules as inducers of protein degradation
BR112015010244A8 (pt) 2012-11-08 2019-10-01 Bristol Myers Squibb Co compostos de piridila substituída por alquil-amida úteis como moduladores de il-12, il-23 e/ou respostas de ifnalfa, sua composição farmacêutica e seu uso
MX2015005731A (es) 2012-11-08 2015-09-16 Bristol Myers Squibb Co Compuestos heterciclicos sustituidos con amida utiles como moduladores de las respuestas de interleucina 12(il-12), interleucina 23 (il-23) y/o interferon alfa (ifnalfa).
US9540333B2 (en) 2012-11-08 2017-01-10 Bristol-Myers Squibb Company Alkyl amide-substituted pyrimidine compounds useful in the modulation of IL-12, IL-23 and/or IFNα
GB201311910D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel Compounds
US20160159773A1 (en) 2013-07-30 2016-06-09 Takeda Pharmaceutical Company Limited Heterocyclic compound
CN105793245B (zh) 2013-09-03 2018-03-20 萨勒姆有限公司 药物化合物
AR094537A1 (es) 2013-11-07 2015-08-12 Bristol Myers Squibb Co COMPUESTOS DE PIRIDILO SUSTITUIDOS CON ALQUILAMIDA ÚTILES COMO MODULADORES DE LAS RESPUESTAS DE IL-12, IL-23 Y/O IFNa
WO2015071393A1 (en) 2013-11-18 2015-05-21 F. Hoffmann-La Roche Ag Tetrahydro-benzodiazepinones
JP6458038B2 (ja) 2013-12-10 2019-01-23 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ ＩＬ−１２、ＩＬ−２３および／またはＩＦＮα応答のモジュレーターとして有用なイミダゾピリダジン化合物
WO2015091584A1 (en) 2013-12-18 2015-06-25 F. Hoffmann-La Roche Ag Thiazolopyridine compounds, compositions and their use as tyk2 kinase inhibitors
CN106661039B (zh) 2014-02-28 2019-09-13 林伯士拉克许米公司 酪氨酸蛋白质激酶2(tyk2)抑制剂和其用途
KR20240038809A (ko) 2014-04-14 2024-03-25 아비나스 오퍼레이션스, 인코포레이티드 단백질분해의 이미드-기초된 조절인자 및 연관된 이용 방법
US20160022642A1 (en) 2014-07-25 2016-01-28 Yale University Compounds Useful for Promoting Protein Degradation and Methods Using Same
NO2721710T3 (es) 2014-08-21 2018-03-31
JP2016065023A (ja) 2014-09-25 2016-04-28 武田薬品工業株式会社 複素環化合物
WO2016047678A1 (ja) 2014-09-25 2016-03-31 武田薬品工業株式会社 複素環化合物
CN107257800B (zh) 2014-12-23 2020-06-30 达纳-法伯癌症研究所股份有限公司 通过双功能分子诱导靶蛋白降解的方法
JP6817962B2 (ja) 2015-01-20 2021-01-20 アルビナス・オペレーションズ・インコーポレイテッドＡｒｖｉｎａｓ Ｏｐｅｒａｔｉｏｎｓ， Ｉｎｃ． ターゲティングされたアンドロゲン受容体分解のための化合物および方法
EP3262049B1 (en) 2015-02-27 2022-07-20 Nimbus Lakshmi, Inc. Tyk2 inhibitors and uses thereof
CN108601764A (zh) 2015-03-18 2018-09-28 阿尔维纳斯股份有限公司 用于靶蛋白的增强降解的化合物和方法
GB201506871D0 (en) 2015-04-22 2015-06-03 Glaxosmithkline Ip Dev Ltd Novel compounds
ES2862469T3 (es) 2015-06-04 2021-10-07 Arvinas Operations Inc Moduladores de proteólisis a base de imidas y métodos de uso asociados
EP3302482A4 (en) 2015-06-05 2018-12-19 Arvinas, Inc. Tank-binding kinase-1 protacs and associated methods of use
WO2017007612A1 (en) 2015-07-07 2017-01-12 Dana-Farber Cancer Institute, Inc. Methods to induce targeted protein degradation through bifunctional molecules
KR20180035828A (ko) 2015-07-10 2018-04-06 아비나스 인코포레이티드 단백질 분해의 mdm2계 조절인자 및 관련된 이용 방법
WO2017011590A1 (en) 2015-07-13 2017-01-19 Arvinas, Inc. Alanine-based modulators of proteolysis and associated methods of use
EP3344624B8 (en) 2015-09-02 2023-11-29 Takeda Pharmaceutical Company Limited Tyk2 inhibitors and uses thereof
AU2016349781A1 (en) 2015-11-02 2018-05-10 Yale University Proteolysis targeting chimera compounds and methods of preparing and using same
KR20180081584A (ko) 2015-11-18 2018-07-16 브리스톨-마이어스 스큅 컴퍼니 Il-12, il-23 및/또는 ifn 알파 반응의 조정제로서 유용한 이미다조피리다진 화합물
US20200216454A1 (en) 2015-12-30 2020-07-09 Dana-Farber Cancer Institute, Inc. Bifunctional molecules for her3 degradation and methods of use
WO2017117474A1 (en) 2015-12-30 2017-07-06 Dana-Farber Cancer Institute, Inc. Bifunctional compounds for her3 degradation and methods of use
PT3419978T (pt) 2016-02-24 2020-06-01 Pfizer Derivados de pirazolo[1,5-a]pirazin-4-ilo como inibidores de jak
MX2018011216A (es) 2016-03-16 2019-08-29 H Lee Moffitt Cancer Ct & Res Moléculas pequeñas contra cereblon para mejorar la función efectora de los linfocitos t.
US20170281784A1 (en) 2016-04-05 2017-10-05 Arvinas, Inc. Protein-protein interaction inducing technology
UA123786C2 (uk) 2016-04-06 2021-06-02 Дзе Ріджентс Оф Дзе Юніверсіті Оф Мічіган Деструктори білка mdm2
JP7001614B2 (ja) 2016-04-06 2022-02-03 ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン リガンド依存性の標的タンパク質分解のための単官能性中間体
WO2017197036A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Spirocyclic degronimers for target protein degradation
CN109562107A (zh) 2016-05-10 2019-04-02 C4医药公司 用于靶蛋白降解的杂环降解决定子体
WO2017197056A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Bromodomain targeting degronimers for target protein degradation
CN109641874A (zh) 2016-05-10 2019-04-16 C4医药公司 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体
CN109790143A (zh) 2016-05-10 2019-05-21 C4医药公司 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体
WO2017201069A1 (en) 2016-05-18 2017-11-23 Biotheryx, Inc. Oxoindoline derivatives as protein function modulators
CN110036015B (zh) 2016-10-07 2022-07-19 百时美施贵宝公司 可用作IL-12、IL-23和/或IFNα应答的调节剂的咪唑并哒嗪化合物
ES2930198T3 (es) 2016-10-14 2022-12-07 Nimbus Lakshmi Inc Inhibidores de TYK2 y usos de los mismos
WO2018075937A1 (en) 2016-10-21 2018-04-26 Nimbus Lakshmi, Inc. Tyk2 inhibitors and uses thereof
CN110191887B (zh) 2016-11-17 2022-02-18 百时美施贵宝公司 IL-12、IL-23和/或IFN-α的咪唑并哒嗪调节剂
US10294256B2 (en) 2016-12-13 2019-05-21 Bristol-Myers Squibb Company Phosphine oxide alkyl amide substituted heteroaryl compounds as modulators of IL-12, IL-23 and/or IFN alpha responses
CN108322937B (zh) 2017-01-18 2020-08-11 上海诺基亚贝尔股份有限公司 无线接入网中用于网络切片的资源分配方法和编排器
TWI783978B (zh) 2017-03-08 2022-11-21 美商林伯士拉克許米公司 Tyk2抑制劑、其用途及生產方法
WO2018237026A1 (en) 2017-06-20 2018-12-27 C4 Therapeutics, Inc. N / O-LINKED DEGRONS AND DEGRONIMERS FOR DEGRADATION OF PROTEINS
US11046698B2 (en) 2017-07-28 2021-06-29 Nimbus Lakshmi, Inc. TYK2 inhibitors and uses thereof
WO2019081488A1 (en) 2017-10-24 2019-05-02 Telefonaktiebolaget Lm Ericsson (Publ) RANDOM FREQUENCY HOPE ACCESS
CA3074034A1 (en) 2017-10-27 2019-05-02 Theravance Biopharma R&D Ip, Llc Pyrimidine compound as jak kinase inhibitor
WO2019099868A2 (en) 2017-11-16 2019-05-23 C4 Therapeutics, Inc. Degraders and degrons for targeted protein degradation
AU2018396142A1 (en) * 2017-12-26 2020-07-16 Kymera Therapeutics, Inc. IRAK degraders and uses thereof
US11802132B2 (en) 2018-02-23 2023-10-31 Dana-Farber Cancer Institute, Inc. Small molecules for inducing selective protein degradation and uses thereof
UY38144A (es) 2018-03-12 2019-10-31 Abbvie Inc Inhibidores de la señalización mediada por tirosina cinasa
ES2944733T3 (es) 2018-03-22 2023-06-23 Bristol Myers Squibb Co Compuestos heterocíclicos que comprenden piridina, útiles como moduladores de las respuestas a IL-12, IL-23 y/o IFN alfa
EP3578561A1 (en) 2018-06-04 2019-12-11 F. Hoffmann-La Roche AG Spiro compounds
CA3102996A1 (en) 2018-07-20 2020-01-23 Dana-Farber Cancer Institute, Inc. Degraders that target proteins via keap1
CN110818641B (zh) 2018-08-07 2022-10-14 北京诺诚健华医药科技有限公司 哒嗪-3-甲酰胺类化合物、其制备方法及其在医药学上的应用
PL3842431T3 (pl) 2018-08-23 2024-05-20 Zhuhai United Laboratories Co., Ltd. Związek [1,2,4]triazolo[1,5-a]pirydyny jako inhibitor jak i jego zastosowanie
GB201816369D0 (en) 2018-10-08 2018-11-28 Sareum Ltd Pharmaceutical compounds
EP3866789A4 (en) 2018-10-15 2022-07-06 Nimbus Lakshmi, Inc. TYK2 INHIBITORS AND USES THEREOF
SG11202104017VA (en) 2018-10-22 2021-05-28 Esker Therapeutics Inc Tyk2 inhibitors and uses thereof
CN113227071B (zh) 2018-10-30 2024-06-25 百时美施贵宝公司 治疗与IL-12、IL-23和/或IFN-α的调节相关的病症的酰胺取代的杂环化合物
CN113271938A (zh) 2018-11-30 2021-08-17 林伯士拉克许米公司 Tyk2抑制剂和其用途
CN113348021A (zh) 2019-01-23 2021-09-03 林伯士拉克许米公司 Tyk2抑制剂和其用途
CN117263918A (zh) 2019-01-28 2023-12-22 江苏豪森药业集团有限公司 一种哒嗪类衍生物抑制剂、其制备方法和应用
SG11202108162SA (en) 2019-01-30 2021-08-30 Bristol Myers Squibb Co Amide-disubstituted pyridine or pyridazine compounds
CN113677347A (zh) 2019-02-07 2021-11-19 温缇克斯生物科学公司 Tyk2假激酶配体
BR112021017996A2 (pt) 2019-03-11 2021-11-16 Esker Therapeutics Inc Inibidores de tyk2 e seus usos
SG11202110523XA (en) 2019-03-26 2021-10-28 Ventyx Biosciences Inc Tyk2 pseudokinase ligands
CN113710661B (zh) * 2019-04-02 2022-11-22 上海睿跃生物科技有限公司 治疗癌症的化合物和方法
CA3135802A1 (en) * 2019-04-05 2020-10-08 Kymera Therapeutics, Inc. Stat degraders and uses thereof
AU2020256720B2 (en) 2019-04-12 2022-09-01 PrimeGene (Beijing) Co. Ltd. Pyrazolopyrazine derived compounds, pharmaceutical composition and use thereof
CN111909140A (zh) 2019-04-12 2020-11-10 明慧医药（杭州）有限公司 作为tyk2抑制剂的杂环化合物及合成和使用方法
CA3138473A1 (en) 2019-04-30 2020-11-05 Celgene Corporation Combination therapies comprising apremilast and tyk2 inhibitors
WO2020251969A1 (en) * 2019-06-10 2020-12-17 Kymera Therapeutics, Inc. Smarca degraders and uses thereof
CN112142743A (zh) 2019-06-28 2020-12-29 广州诺诚健华医药科技有限公司 杂环类化合物、其制备方法及其在医药学上的应用
EP4011865A4 (en) 2019-08-09 2022-11-02 The National Institutes of Pharmaceutical R&D Co., Ltd BRIDGED HETEROCYCLYL SUBSTITUTED PYRIMIDINE COMPOUND, METHOD FOR PREPARATION AND PHARMACEUTICAL USE
KR20220062038A (ko) 2019-09-13 2022-05-13 오리제니스 게엠베하 예를 들어 자가면역 질환의 치료를 위한 lrrk2, nuak1 및/또는 tyk2 키나제 조정제로서의 1,4-디히드로벤조[d]피라졸로[3,4-f][1,3]디아제핀 유도체 및 관련 화합물
CA3154131A1 (en) 2019-09-13 2021-03-18 Origenis Gmbh 1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds as lrrk2, nuak1 and/or tyk2 kinase modulators for the treatment of e.g. autoimmune disease
CN114727949A (zh) 2019-09-18 2022-07-08 百时美施贵宝公司 Tyk2抑制剂的剂型
CN110734428A (zh) 2019-10-24 2020-01-31 嘉兴特科罗生物科技有限公司 一种小分子化合物
CN110862380A (zh) 2019-10-24 2020-03-06 嘉兴特科罗生物科技有限公司 一种小分子化合物
CN110627775A (zh) 2019-10-24 2019-12-31 嘉兴特科罗生物科技有限公司 一种小分子化合物
MX2022005563A (es) 2019-11-08 2022-08-19 Ventyx Biosciences Inc Ligandos de la pseudoquinasa tyk2.
WO2021158634A1 (en) * 2020-02-03 2021-08-12 Kymera Therapeutics, Inc. Irak degraders and uses thereof
WO2021170046A1 (en) 2020-02-26 2021-09-02 Beigene, Ltd. Tyk-2 inhibitor
JP2023524361A (ja) 2020-03-11 2023-06-12 ベイジン・イノケア・ファーマ・テク・カンパニー・リミテッド Ｔｙｋ２活性を阻害する複素環式化合物
WO2021202652A1 (en) 2020-04-01 2021-10-07 Eternity Bioscience Inc. Tyrosine kinase 2 inhibitors, preparation methods and medicinal uses thereof
DE102020109343A1 (de) 2020-04-03 2021-10-07 Amazonen-Werke H. Dreyer SE & Co. KG Verteilmaschine
WO2021204626A1 (en) 2020-04-06 2021-10-14 Almirall, S.A. Aryl and heteroaryl-carboxamide substituted heteroaryl compounds as tyk2 inhibitors
WO2021211741A1 (en) 2020-04-14 2021-10-21 Gossamer Bio Services, Inc. Substituted pyridines for the treatment of inflammatory diseases
KR20230004771A (ko) 2020-04-28 2023-01-06 브리스톨-마이어스 스큅 컴퍼니 Il-12, il-23 및/또는 ifn알파 조정제로서의 치환된 n-(메틸-d3)피리다진-3-카르복스아미드 또는 n-(메틸-d3)-니코틴아미드 화합물
CN113563309A (zh) 2020-04-28 2021-10-29 浙江海正药业股份有限公司 吡啶类衍生物及其制备方法和用途
CN113666877A (zh) 2020-05-15 2021-11-19 正大天晴药业集团股份有限公司 含烷氧基及酰胺基的tyk2抑制剂化合物
WO2021237121A1 (en) 2020-05-21 2021-11-25 Gossamer Bio Services, Inc. Substituted pyridines
CN113698403B (zh) 2020-05-21 2022-06-28 南京亘泰医药技术有限公司 (1r,4r,7r)-7-氨基-2-氮杂双环[2,2,1]庚烷衍生物及制备方法
CN113735837B (zh) 2020-05-28 2023-09-01 江苏先声药业有限公司 哒嗪类化合物及其用途
CN113735836B (zh) 2020-05-28 2023-05-30 江苏先声药业有限公司 哒嗪类化合物及其应用
CN113773262B (zh) 2020-06-09 2024-08-09 江苏先声药业有限公司 哒嗪类化合物
IL299294A (en) 2020-06-22 2023-02-01 Beigene Ltd tyk-2 inhibitor
US20220002267A1 (en) 2020-06-24 2022-01-06 Eternity Bioscience Inc. Tyrosine kinase 2 inhibitors, preparation methods and medicinal uses thereof
WO2022011337A1 (en) 2020-07-10 2022-01-13 Origenis Gmbh Kinase modulators and methods of use thereof
US20220009910A1 (en) 2020-07-10 2022-01-13 Eternity Bioscience Inc. Tyrosine kinase 2 inhibitors, preparation methods and medicinal uses thereof
WO2022011338A2 (en) 2020-07-10 2022-01-13 Origenis Gmbh Kinase modulators and methods of use thereof
CN113968846A (zh) 2020-07-24 2022-01-25 上海翰森生物医药科技有限公司 一种哒嗪类衍生物的盐、晶型及其制备方法和应用
KR20230043887A (ko) 2020-07-24 2023-03-31 상하이 한서 바이오메디컬 컴퍼니 리미티드 피리다진 유도체 유리 염기의 결정 형태, 및 이의 제조 방법 및 이의 용도
CN114057651A (zh) 2020-07-31 2022-02-18 正大天晴药业集团股份有限公司 含酰胺基的tyk2抑制剂化合物
WO2022032484A1 (zh) 2020-08-11 2022-02-17 北京诺诚健华医药科技有限公司 哒嗪-3-甲酰胺类化合物、其制备方法及其在医药学上的应用
CN114075220A (zh) 2020-08-13 2022-02-22 广东东阳光药业有限公司 取代的杂芳基化合物及其组合物和用途
CN114075194B (zh) 2020-08-13 2024-08-23 广东东阳光药业股份有限公司 取代的杂芳基化合物及其组合物和用途
CN114181199B (zh) 2020-09-15 2023-09-26 成都赜灵生物医药科技有限公司 2，4-二取代嘧啶衍生物及其制备方法和用途
EP4214215A1 (en) 2020-09-16 2023-07-26 Alumis Inc. Tyk2 inhibitors and uses thereof
CN111961037B (zh) 2020-09-17 2021-09-21 嘉兴特科罗生物科技有限公司 一种作为jak激酶抑制剂的药物化合物
CN112159394B (zh) 2020-10-09 2021-10-22 嘉兴特科罗生物科技有限公司 一种作为jak激酶抑制剂的小分子化合物及其用途
CN112142675B (zh) 2020-10-09 2021-11-30 嘉兴特科罗生物科技有限公司 一种作为jak激酶抑制剂的小分子化合物及其用途
WO2022083560A1 (zh) 2020-10-19 2022-04-28 南京药石科技股份有限公司 Tyk2选择性抑制剂及其用途
CN114437035A (zh) * 2020-11-06 2022-05-06 海思科医药集团股份有限公司 一种抑制并降解irak4的化合物及其药物组合物和药学上的应用
WO2022099431A1 (en) 2020-11-10 2022-05-19 Unity Biotechnology, Inc. Crystalline solid meglumine salt inhibitor of bcl and methods of making and using same
US20240059671A1 (en) * 2020-11-12 2024-02-22 Cullgen (Shanghai), Inc. Tyrosine kinase 2 (tyk2) degradation compounds and methods of use
TW202227430A (zh) 2020-11-17 2022-07-16 大陸商江蘇恆瑞醫藥股份有限公司 含氮雜環類衍生物、其製備方法及其在醫藥上的應用
WO2022109580A1 (en) 2020-11-20 2022-05-27 Janssen Pharmaceutica Nv Inhibition of tyk2 dependent signaling pathways
WO2022109492A1 (en) 2020-11-23 2022-05-27 Gossamer Bioservices, Inc. Pyrrolopyridazine compounds as kinase inhibitors
CN114591351B (zh) 2020-12-03 2023-12-05 成都科岭源医药技术有限公司 一种多环化合物及其制备方法和用途
CN112592345B (zh) 2020-12-07 2024-09-13 嘉兴特科罗生物科技有限公司 一种三氮唑并吡嗪类化合物及其用途
WO2022121868A1 (zh) 2020-12-08 2022-06-16 正大天晴药业集团股份有限公司 含酰胺基和杂环烷基的tyk2抑制剂化合物
CN114644633A (zh) 2020-12-18 2022-06-21 北京诺诚健华医药科技有限公司 杂环类jak抑制剂
CN115160297B (zh) 2020-12-22 2023-03-31 益方生物科技(上海)股份有限公司 杂芳基化合物及其制备方法和用途
US20240124440A1 (en) 2020-12-23 2024-04-18 Sudo Biosciences Limited Tyk2 inhibitors and uses thereof
WO2022150446A1 (en) 2021-01-07 2022-07-14 Biogen Ma Inc. Tyk2 inhibitors
CN114805438A (zh) 2021-01-18 2022-07-29 正大天晴药业集团股份有限公司 含磷酰基的tyk2抑制剂化合物
CN117043164A (zh) 2021-01-19 2023-11-10 安锐生物医药科技(广州)有限公司 咪唑并哒嗪或吡唑并嘧啶化合物和组合物
MX2023008651A (es) 2021-01-29 2023-08-01 Bristol Myers Squibb Co Forma cristalina de 6-(ciclopropanocarboxamido)-4-((2-metoxi-3-(1- metil-1h-1,2,4-triazol-3-il)fenil)amino)-n-(metil-d3)piridazina-3 -carboxamida.
TW202233600A (zh) 2021-02-06 2022-09-01 大陸商正大天晴藥業集團股份有限公司 含聯環的ｔｙｋ２抑制劑化合物、藥物組合物及其用途
CN114907326A (zh) 2021-02-06 2022-08-16 正大天晴药业集团股份有限公司 含酰胺基和联环的tyk2抑制剂化合物
TW202302583A (zh) 2021-02-19 2023-01-16 英商蘇多生物科學有限公司 Ｔｙｋ２抑制劑及其用途
EP4294808A1 (en) 2021-02-19 2023-12-27 Sudo Biosciences Limited Tyk2 inhibitors and uses thereof
IL305165A (en) 2021-02-19 2023-10-01 Sudo Biosciences Ltd TYK2 inhibitors and their uses
US20240189309A1 (en) 2021-02-19 2024-06-13 Sudo Biosciences Limited Tyk2 inhibitors and uses thereof
AU2022234495A1 (en) 2021-03-09 2024-06-27 Cspc Ouyi Pharmaceutical Co., Ltd. Use of tricyclic heteroaryl-containing compound
JP2024510274A (ja) 2021-03-16 2024-03-06 アンルイ バイオメディカル テクノロジー （グァンヂョウ） カンパニー リミテッド アミノヘテロアリール化合物および組成物
CN117177960A (zh) 2021-03-30 2023-12-05 浙江文达医药科技有限公司 作为tyk2假激酶结构域抑制剂的杂环化合物及合成方法和用途
CN116888125B (zh) 2021-04-07 2024-04-12 上海齐鲁制药研究中心有限公司 Tyk2抑制剂及其用途
CN113480543B (zh) 2021-07-07 2022-05-17 无锡市第二人民医院 2,6,8-多取代咪唑并[1,2-a]吡嗪及其合成方法和应用
CN113735859A (zh) 2021-08-12 2021-12-03 安徽医科大学 一种激酶抑制剂

Also Published As

Publication number Publication date
AR127443A1 (es) 2024-01-24
KR20240111312A (ko) 2024-07-16
AU2022378463A1 (en) 2024-05-09
WO2023076161A1 (en) 2023-05-04
IL312330A (en) 2024-06-01
TW202334151A (zh) 2023-09-01
CA3236262A1 (en) 2023-05-04
CO2024004970A2 (es) 2024-05-20
EP4423086A1 (en) 2024-09-04

Similar Documents

Publication Publication Date Title
MX2021014441A (es) Inhibidores del dominio asociado mejorador de la transcripcion (tead) y usos de los mismos.
MX2021014443A (es) Inhibidores del dominio asociado mejorador de la transcripcion (tead) y usos de los mismos.
MX2023004593A (es) Inhibidores de tirosina cinasa 2 (tyk2) y usos de los mismos.
MX2023012245A (es) Compuestos, composiciones y metodos para el tratamiento del cancer.
MX2022002877A (es) Antagonistas de cinasa progenitora hematopoyetica 1 (hpk1) y sus usos.
MX2020007799A (es) Inhibidores de cinasa no derrepresible de control de aminoacido general 2 (gcn2) y sus usos.
MX2022005216A (es) Piridazinonas como inhibidores de poli(adp-ribosa) polimerasa 7 (parp7).
MX2023008031A (es) Inhibidores de la cinasa 2 de control general no desrepresible (gcn2) y usos de los mismos.
MX2022007576A (es) Degradadores de cinasas asociadas al receptor de interleucina-1 (irak) y usos de los mismos.
MX2021012216A (es) Degradadores de transductores de señal y activadores de transcripción (stat) y usos de los mismos.
MX2017012738A (es) Inhibidores de indolamina 2.3-dioxigenasa (ido) para el tratamiento de cancer.
MX2022008395A (es) Inhibidores de sarm1.
MX2023007852A (es) Degradadores de cinasas asociadas al receptor de interleucina-1 (irak) y usos de los mismos.
MX2023002256A (es) Inhibidores de sarm1.
PH12021500008A1 (en) Transglutaminase 2 (tg2) inhibitors
MX2022010944A (es) Inhibidores del factor de iniciacion de traduccion eucariotica 4e (eif4e) y sus usos.
MX2023011933A (es) Moduladores del linfoma de linaje b de casitas de ligasa e3 b (cbl-b) y usos de estos.
MX2022001004A (es) Inhibidores de enzimas.
WO2020247701A3 (en) Inhibitors of sarm1
MX2022011437A (es) Degradadores de transductores de se?al y activadores de la transcripcion (stat) y usos de los mismos.
MX2022007841A (es) Degradadores del regulador dependiente de actina asociado a la matriz relacionado con el complejo switch/sacarosa no fermentable de la subfamilia a de la cromatina (smarca)y usos de los mismos.
PH12017502123A1 (en) Substituted benzamides and methods of use thereof
MX2017015923A (es) Inhibidores de indolamina-2,3-dioxigenasa (ido).
WO2021158635A8 (en) Anti-viral compositions and methods of use
MX2023013173A (es) Degradadores de cinasa 2 dependiente de ciclina (cdk2) y sus usos.