MX2019004181A - Métodos y composiciones de inmunoterapia que implican moduladores de la ruta metabólica de triptófano. - Google Patents

Métodos y composiciones de inmunoterapia que implican moduladores de la ruta metabólica de triptófano.

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Publication number
MX2019004181A
MX2019004181A MX2019004181A MX2019004181A MX2019004181A MX 2019004181 A MX2019004181 A MX 2019004181A MX 2019004181 A MX2019004181 A MX 2019004181A MX 2019004181 A MX2019004181 A MX 2019004181A MX 2019004181 A MX2019004181 A MX 2019004181A
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Mexico
Prior art keywords
cells
methods
administration
kynurenine pathway
metabolic pathway
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MX2019004181A
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English (en)
Inventor
I Levitsky Hyam
Ports Michael
Paul Thomas Evan
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Juno Therapeutics Inc
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Publication of MX2019004181A publication Critical patent/MX2019004181A/es

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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Abstract

Se proporcionan métodos de tratamiento que implica inmunoterapia, tal como terapia de células T, y administración de un modulador del metabolismo de triptófano y/o la ruta de quinurenina. En algunas modalidades, el método incluye una terapia de combinación que implica la administración de células T modificadas, tal como células que expresan el receptor de antígeno quimérico (CAR), y un modulador del metabolismo de triptófano y/o la ruta de quinurenina, tal como un inhibidor de una enzima. También se proporciona células modificadas en las cuales la expresión de una molécula implicada en la ruta de quinurenina se modifica. También se proporcionan métodos para fabricar células modificadas, células, composiciones, métodos de administración a sujetos, ácidos nucleicos, y kits para el uso en los métodos. En algunos aspectos, las características de los métodos y células proporcionan actividad incrementada y mejorada, actividad, resultado, función, respuesta, persistencia, expansión, y/o proliferación de células para terapia de células adoptivas.
MX2019004181A 2016-10-13 2017-10-13 Métodos y composiciones de inmunoterapia que implican moduladores de la ruta metabólica de triptófano. MX2019004181A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662407776P 2016-10-13 2016-10-13
US201762514767P 2017-06-02 2017-06-02
PCT/US2017/056680 WO2018071873A2 (en) 2016-10-13 2017-10-13 Immunotherapy methods and compositions involving tryptophan metabolic pathway modulators

Publications (1)

Publication Number Publication Date
MX2019004181A true MX2019004181A (es) 2019-10-30

Family

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Application Number Title Priority Date Filing Date
MX2019004181A MX2019004181A (es) 2016-10-13 2017-10-13 Métodos y composiciones de inmunoterapia que implican moduladores de la ruta metabólica de triptófano.

Country Status (15)

Country Link
US (1) US11896615B2 (es)
EP (2) EP3525803B1 (es)
JP (2) JP2019533676A (es)
KR (1) KR20190084053A (es)
CN (1) CN110381963A (es)
AU (1) AU2017343780B2 (es)
BR (1) BR112019006652A2 (es)
CA (1) CA3037387A1 (es)
ES (1) ES2939646T3 (es)
IL (1) IL265848A (es)
MA (2) MA46649A (es)
MX (1) MX2019004181A (es)
PH (1) PH12019500803A1 (es)
SG (1) SG11201903282TA (es)
WO (1) WO2018071873A2 (es)

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