MX2019004181A - Métodos y composiciones de inmunoterapia que implican moduladores de la ruta metabólica de triptófano. - Google Patents
Métodos y composiciones de inmunoterapia que implican moduladores de la ruta metabólica de triptófano.Info
- Publication number
- MX2019004181A MX2019004181A MX2019004181A MX2019004181A MX2019004181A MX 2019004181 A MX2019004181 A MX 2019004181A MX 2019004181 A MX2019004181 A MX 2019004181A MX 2019004181 A MX2019004181 A MX 2019004181A MX 2019004181 A MX2019004181 A MX 2019004181A
- Authority
- MX
- Mexico
- Prior art keywords
- cells
- methods
- administration
- kynurenine pathway
- metabolic pathway
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 7
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 title abstract 3
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 title abstract 3
- 238000009169 immunotherapy Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000037353 metabolic pathway Effects 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 6
- YGPSJZOEDVAXAB-UHFFFAOYSA-N kynurenine Chemical compound OC(=O)C(N)CC(=O)C1=CC=CC=C1N YGPSJZOEDVAXAB-UHFFFAOYSA-N 0.000 abstract 6
- 230000037361 pathway Effects 0.000 abstract 3
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 230000004060 metabolic process Effects 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 238000011467 adoptive cell therapy Methods 0.000 abstract 1
- 238000002659 cell therapy Methods 0.000 abstract 1
- 238000002648 combination therapy Methods 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 230000002688 persistence Effects 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
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- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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- C12Y113/11011—Tryptophan 2,3-dioxygenase (1.13.11.11), i.e. indolamine 2,3-dioxygenase 2
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Abstract
Se proporcionan métodos de tratamiento que implica inmunoterapia, tal como terapia de células T, y administración de un modulador del metabolismo de triptófano y/o la ruta de quinurenina. En algunas modalidades, el método incluye una terapia de combinación que implica la administración de células T modificadas, tal como células que expresan el receptor de antígeno quimérico (CAR), y un modulador del metabolismo de triptófano y/o la ruta de quinurenina, tal como un inhibidor de una enzima. También se proporciona células modificadas en las cuales la expresión de una molécula implicada en la ruta de quinurenina se modifica. También se proporcionan métodos para fabricar células modificadas, células, composiciones, métodos de administración a sujetos, ácidos nucleicos, y kits para el uso en los métodos. En algunos aspectos, las características de los métodos y células proporcionan actividad incrementada y mejorada, actividad, resultado, función, respuesta, persistencia, expansión, y/o proliferación de células para terapia de células adoptivas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662407776P | 2016-10-13 | 2016-10-13 | |
US201762514767P | 2017-06-02 | 2017-06-02 | |
PCT/US2017/056680 WO2018071873A2 (en) | 2016-10-13 | 2017-10-13 | Immunotherapy methods and compositions involving tryptophan metabolic pathway modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019004181A true MX2019004181A (es) | 2019-10-30 |
Family
ID=60421838
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019004181A MX2019004181A (es) | 2016-10-13 | 2017-10-13 | Métodos y composiciones de inmunoterapia que implican moduladores de la ruta metabólica de triptófano. |
Country Status (15)
Country | Link |
---|---|
US (1) | US11896615B2 (es) |
EP (2) | EP3525803B1 (es) |
JP (2) | JP2019533676A (es) |
KR (1) | KR20190084053A (es) |
CN (1) | CN110381963A (es) |
AU (1) | AU2017343780B2 (es) |
BR (1) | BR112019006652A2 (es) |
CA (1) | CA3037387A1 (es) |
ES (1) | ES2939646T3 (es) |
IL (1) | IL265848A (es) |
MA (2) | MA46649A (es) |
MX (1) | MX2019004181A (es) |
PH (1) | PH12019500803A1 (es) |
SG (1) | SG11201903282TA (es) |
WO (1) | WO2018071873A2 (es) |
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MA42895A (fr) | 2015-07-15 | 2018-05-23 | Juno Therapeutics Inc | Cellules modifiées pour thérapie cellulaire adoptive |
GB201701332D0 (en) * | 2017-01-26 | 2017-03-15 | Tc Biopharm Ltd | Immune cells with modified metabolism and their use thereof |
KR20200026805A (ko) * | 2017-05-01 | 2020-03-11 | 주노 쎄러퓨티크스 인코퍼레이티드 | 세포 요법 및 면역조절 화합물의 조합 |
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WO2019138114A1 (en) * | 2018-01-15 | 2019-07-18 | Universität Heidelberg | Nfat binding polynucleotides |
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KR20210030883A (ko) * | 2019-09-10 | 2021-03-18 | 고려대학교 세종산학협력단 | 인돌아민 2,3-이산소화 효소를 포함하는 전립선암 진단용 마커 |
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US20220010028A1 (en) * | 2020-07-09 | 2022-01-13 | The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | Compositions and methods for treating fibroids |
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CN114306601A (zh) * | 2020-09-28 | 2022-04-12 | 中国科学院上海营养与健康研究所 | 一种l型氨基酸转运蛋白抑制剂或拮抗剂有效干预糖尿病的方法 |
GB202018554D0 (en) * | 2020-11-25 | 2021-01-06 | Cancer Research Tech Ltd | Nucleic acid constructs and cells |
EP4334718A1 (en) * | 2021-05-06 | 2024-03-13 | Mayo Foundation for Medical Education and Research | Assessing and treating cancer |
WO2023080788A1 (en) * | 2021-11-05 | 2023-05-11 | Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis | Tryptophan depletion induces production and presentation of tryptophan to phenylalanine substitutions |
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KR20190034588A (ko) | 2016-07-28 | 2019-04-02 | 노파르티스 아게 | 키메라 항원 수용체 및 pd-1 억제제의 조합 요법 |
WO2018102786A1 (en) | 2016-12-03 | 2018-06-07 | Juno Therapeutics, Inc. | Methods for modulation of car-t cells |
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MA50839A (fr) | 2019-08-21 |
EP3525803A2 (en) | 2019-08-21 |
WO2018071873A9 (en) | 2018-12-20 |
EP4190335A1 (en) | 2023-06-07 |
ES2939646T3 (es) | 2023-04-25 |
RU2019113778A3 (es) | 2021-07-15 |
AU2017343780B2 (en) | 2023-08-31 |
KR20190084053A (ko) | 2019-07-15 |
EP3525803B1 (en) | 2022-12-07 |
WO2018071873A2 (en) | 2018-04-19 |
BR112019006652A2 (pt) | 2019-07-02 |
CN110381963A (zh) | 2019-10-25 |
US11896615B2 (en) | 2024-02-13 |
RU2019113778A (ru) | 2020-11-13 |
SG11201903282TA (en) | 2019-05-30 |
MA46649A (fr) | 2019-08-21 |
US20200054673A1 (en) | 2020-02-20 |
AU2017343780A1 (en) | 2019-04-04 |
CA3037387A1 (en) | 2018-04-19 |
PH12019500803A1 (en) | 2019-07-15 |
IL265848A (en) | 2019-06-30 |
JP2019533676A (ja) | 2019-11-21 |
WO2018071873A3 (en) | 2018-10-04 |
JP2022166232A (ja) | 2022-11-01 |
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