ES2851123T1 - Receptores quiméricos de antígeno específicos de glipicano-3 para inmunoterapia adoptiva - Google Patents

Receptores quiméricos de antígeno específicos de glipicano-3 para inmunoterapia adoptiva Download PDF

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ES2851123T1
ES2851123T1 ES20196219T ES20196219T ES2851123T1 ES 2851123 T1 ES2851123 T1 ES 2851123T1 ES 20196219 T ES20196219 T ES 20196219T ES 20196219 T ES20196219 T ES 20196219T ES 2851123 T1 ES2851123 T1 ES 2851123T1
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seq
lymphocytes
cells
cancer
car
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Andras Heczey
Stephen M G Gottschalk
Leonid S Metelitsa
Gianpietro Dotti
Wenpeng Li
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Baylor College of Medicine
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Baylor College of Medicine
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Abstract

Linfocitos T que expresan un receptor quimérico de antígeno (CAR) que se dirige a glipicano-3 (GPC3) para su uso en un método de tratamiento de una enfermedad asociada con la proliferación y/o actividad de células GPC3 positivas en un individuo, comprendiendo el método la etapa de poner en contacto las células con una cantidad terapéuticamente eficaz de los linfocitos T y comprendiendo el CAR (i) un anticuerpo scFv distinto de 3E11, 2G9, 4G5, 3D8 o 2E10 y (ii) un dominio coestimulante de CD28, en donde: (a) los linfocitos T albergan un polinucleótido que codifica el CAR y comprende la SEQ ID NO: 19, SEQ ID NO: 33, SEQ ID NO: 12 o SEQ ID NO: 29, o una combinación de las mismas; y/o (b) la CAR comprende la secuencia de aminoácidos de la SEQ ID NO: 18, SEQ ID, SEQ ID NO: 32, SEQ ID NO: 10 o SEQ ID NO: 28, o una combinación de las mismas; en donde la enfermedad es cáncer o síndrome de Simpson-Golabi-Behmel.

Claims (8)

REIVINDICACIONES
1. Linfocitos T que expresan un receptor quimérico de antígeno (CAR) que se dirige a glipicano-3 (GPC3) para su uso en un método de tratamiento de una enfermedad asociada con la proliferación y/o actividad de células GPC3 positivas en un individuo, comprendiendo el método la etapa de poner en contacto las células con una cantidad terapéuticamente eficaz de los linfocitos T y comprendiendo el CAR (i) un anticuerpo scFv distinto de 3E11, 2G9, 4G5, 3D8 o 2E10 y (ii) un dominio coestimulante de CD28, en donde:
(a) los linfocitos T albergan un polinucleótido que codifica el CAR y comprende la SEQ ID NO: 19, SEQ ID NO: 33, s Eq ID NO: 12 o SEQ ID NO: 29, o una combinación de las mismas; y/o
(b) la CAR comprende la secuencia de aminoácidos de la SEQ ID NO: 18, SEQ ID, SEQ ID NO: 32, SEQ ID NO: 10 o SEQ ID NO: 28, o una combinación de las mismas;
en donde la enfermedad es cáncer o síndrome de Simpson-Golabi-Behmel.
2. Los linfocitos T para el uso de la reivindicación 1, en donde las células GPC3 positivas son células cancerosas y: (a) el cáncer es cáncer de hígado, sarcoma embrionario, tumor rabdoide, tumor de Wilms, coriocarcinoma o tumor del saco vitelino; o
(b) dichas células cancerosas no son células de carcinoma hepatocelular.
3. Los linfocitos T para el uso de la reivindicación 1 o 2, en donde:
(a) dicho contacto se realiza in vitro; o
(b) dicho contacto se realiza en cultivo celular.
4. Los linfocitos T para el uso de la reivindicación 1 o 2, en donde dicho contacto se realiza in vivo.
5. Los linfocitos T para el uso de la reivindicación 4, en donde:
(a) dichos linfocitos T son autólogos para el individuo; o
(b) dichos linfocitos T son alogénicos para el individuo.
6. Los linfocitos T para el uso de una cualquiera de las reivindicaciones 1, 3(b), 4 y 5, en donde las células GPC3 positivas son células cancerosas, en donde además el individuo ha recibido, está recibiendo o recibirá un tratamiento adicional contra el cáncer.
7. Los linfocitos T para el uso de la reivindicación 6, en donde el tratamiento adicional contra el cáncer comprende quimioterapia, inmunoterapia, radiación, cirugía, hormonoterapia o una combinación de las mismas.
8. Los linfocitos T para el uso de una cualquiera de las reivindicaciones anteriores, en donde el polinucleótido comprende además un gen suicida.
ES20196219T 2014-09-26 2015-09-25 Receptores quiméricos de antígeno específicos de glipicano-3 para inmunoterapia adoptiva Pending ES2851123T1 (es)

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US201462055979P 2014-09-26 2014-09-26

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ES15845117T Active ES2844700T3 (es) 2014-09-26 2015-09-25 Receptores quiméricos de antígeno específicos de glipicano-3 para inmunoterapia adoptiva
ES20196219T Pending ES2851123T1 (es) 2014-09-26 2015-09-25 Receptores quiméricos de antígeno específicos de glipicano-3 para inmunoterapia adoptiva

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US (1) US20170281683A1 (es)
EP (2) EP3858991A1 (es)
JP (1) JP2017529851A (es)
DE (1) DE20196219T1 (es)
ES (2) ES2844700T3 (es)
WO (1) WO2016049459A1 (es)

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