DE20196219T1 - Glypican-3-Spezifische Chimäre Antigenrezeptoren für adoptive Immuntherapie - Google Patents

Glypican-3-Spezifische Chimäre Antigenrezeptoren für adoptive Immuntherapie Download PDF

Info

Publication number
DE20196219T1
DE20196219T1 DE20196219.8T DE20196219T DE20196219T1 DE 20196219 T1 DE20196219 T1 DE 20196219T1 DE 20196219 T DE20196219 T DE 20196219T DE 20196219 T1 DE20196219 T1 DE 20196219T1
Authority
DE
Germany
Prior art keywords
cells
seq
cancer
car
contacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE20196219.8T
Other languages
English (en)
Inventor
Andras HECZEY
Stephen M. G. GOTTSCHALK
Leonid S. METELITSA
Gianpietro Dotti
Wenpeng Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor College of Medicine
Original Assignee
Baylor College of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor College of Medicine filed Critical Baylor College of Medicine
Publication of DE20196219T1 publication Critical patent/DE20196219T1/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4613—Natural-killer cells [NK or NK-T]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4631—Chimeric Antigen Receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464469—Tumor associated carbohydrates
    • A61K39/464471—Gangliosides, e.g. GM2, GD2 or GD3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464474—Proteoglycans, e.g. glypican, brevican or CSPG4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/53—Liver
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/56—Kidney
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

T-Zellen, die einen chimären Antigen-Rezeptor (CAR) exprimieren, der auf Glypican-3 (GPC3) abzielt, zur Verwendung in einem Verfahren zur Behandlung einer Krankheit, welche mit der Proliferation und/oder Aktivität von GPC3-positiven Zellen in einem Individuum assoziiert ist, wobei das Verfahren den Schritt des Inkontaktbringens der Zellen mit einer therapeutisch wirksamen Menge der T-Zellen umfasst, und wobei der CAR (i) einen scFv-Antikörper, bei dem es nicht um 3E11, 2G9, 4G5, 3D8 oder 2E10 handelt, und (ii) eine kostimulatorische CD28-Domäne umfasst, wobei:(a) die T-Zellen ein Polynukleotid beherbergen, welches den CAR kodiert und SEQ ID NO: 19, SEQ ID NO: 33, SEQ ID NO: 12 oder SEQ ID NO: 29, oder eine Kombination davon umfasst; und/oder(b) der CAR die Aminosäuresequenz von SEQ ID NO: 18, SEQ ID NO: 32, SEQ ID NO: 10 oder SEQ ID NO: 28, oder eine Kombination davon umfasst; wobei es sich bei der Krankheit um Krebs oder das Simpson-Golabi-Behmel-Syndrom handelt.

Claims (8)

  1. T-Zellen, die einen chimären Antigen-Rezeptor (CAR) exprimieren, der auf Glypican-3 (GPC3) abzielt, zur Verwendung in einem Verfahren zur Behandlung einer Krankheit, welche mit der Proliferation und/oder Aktivität von GPC3-positiven Zellen in einem Individuum assoziiert ist, wobei das Verfahren den Schritt des Inkontaktbringens der Zellen mit einer therapeutisch wirksamen Menge der T-Zellen umfasst, und wobei der CAR (i) einen scFv-Antikörper, bei dem es nicht um 3E11, 2G9, 4G5, 3D8 oder 2E10 handelt, und (ii) eine kostimulatorische CD28-Domäne umfasst, wobei: (a) die T-Zellen ein Polynukleotid beherbergen, welches den CAR kodiert und SEQ ID NO: 19, SEQ ID NO: 33, SEQ ID NO: 12 oder SEQ ID NO: 29, oder eine Kombination davon umfasst; und/oder (b) der CAR die Aminosäuresequenz von SEQ ID NO: 18, SEQ ID NO: 32, SEQ ID NO: 10 oder SEQ ID NO: 28, oder eine Kombination davon umfasst; wobei es sich bei der Krankheit um Krebs oder das Simpson-Golabi-Behmel-Syndrom handelt.
  2. Die T-Zellen zur Verwendung nach Anspruch 1, wobei die GPC3-positiven Zellen Krebszellen sind und: (a) es sich bei dem Krebs um Leberkrebs, embryonales Sarkom, rhabdoider Tumor, Wilms-Tumor, Choriokarzinom, oder Dottersack-Tumor handelt; oder (b) es sich bei den Krebszellen nicht um hepatozelluläre Karzinomzellen handelt.
  3. Die T-Zellen zur Verwendung nach Anspruch 1 oder 2, wobei: (a) das Inkontaktbringen in vitro durchgeführt wird; oder (b) das Inkontaktbringen in einer Zellkultur durchgeführt wird.
  4. Die T-Zellen zur Verwendung nach Anspruch 1 oder 2, wobei das Inkontaktbringen in vivo durchgeführt wird.
  5. Die T-Zellen zur Verwendung nach Anspruch 4, wobei: (a) die T-Zellen autolog zu dem Individuum sind; oder (b) die T-Zellen für das Individuum allogen sind.
  6. Die T-Zellen zur Verwendung nach einem der Ansprüche 1, 3(b), 4 und 5, wobei die GPC3-positiven Zellen Krebszellen sind, ferner wobei das Individuum eine zusätzliche Krebsbehandlung erhalten hat, erhält oder erhalten wird.
  7. Die T-Zellen zur Verwendung nach Anspruch 6, wobei die zusätzliche Krebsbehandlung eine Chemotherapie, Immuntherapie, Bestrahlung, Operation, Hormontherapie, oder eine Kombination davon umfasst.
  8. Die T-Zellen zur Verwendung nach einem der vorhergehenden Ansprüche, wobei das Polynukleotid weiterhin ein Suizidgen umfasst.
DE20196219.8T 2014-09-26 2015-09-25 Glypican-3-Spezifische Chimäre Antigenrezeptoren für adoptive Immuntherapie Pending DE20196219T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462055979P 2014-09-26 2014-09-26
US201462055979P 2014-09-26
EP20196219.8A EP3858991A1 (de) 2014-09-26 2015-09-25 Glypican-3-spezifische chimäre antigenrezeptoren für adoptive immuntherapie

Publications (1)

Publication Number Publication Date
DE20196219T1 true DE20196219T1 (de) 2021-10-28

Family

ID=55582053

Family Applications (1)

Application Number Title Priority Date Filing Date
DE20196219.8T Pending DE20196219T1 (de) 2014-09-26 2015-09-25 Glypican-3-Spezifische Chimäre Antigenrezeptoren für adoptive Immuntherapie

Country Status (6)

Country Link
US (1) US20170281683A1 (de)
EP (2) EP3858991A1 (de)
JP (1) JP2017529851A (de)
DE (1) DE20196219T1 (de)
ES (2) ES2844700T3 (de)
WO (1) WO2016049459A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108699153B (zh) 2016-02-25 2022-09-23 细胞医学瑞士公司 Pd-l1的结合成员
CN109414512A (zh) 2016-04-22 2019-03-01 科济生物医药（上海）有限公司 用于细胞免疫疗法的组合物和方法
JP2019530431A (ja) 2016-07-26 2019-10-24 テッサ・セラピューティクス・プライベート・リミテッド キメラ抗原受容体
JP2018093823A (ja) * 2016-12-15 2018-06-21 Ｈｅａｒｔｓｅｅｄ株式会社 未分化幹細胞除去剤及び未分化幹細胞除去方法
CA3049189A1 (en) 2017-01-10 2018-07-19 Yamaguchi University Anti-gpc3 antibody
EP3615574A4 (de) * 2017-04-26 2021-02-24 Eureka Therapeutics, Inc. Spezifisch glypican 3 erkennende konstrukte und deren verwendung
EP3441461A1 (de) * 2017-08-11 2019-02-13 Baylor College of Medicine Cd1d-restringierte nkt-zellen als plattform für gebrauchsfertige krebsimmuntherapie
US20220403001A1 (en) 2018-06-12 2022-12-22 Obsidian Therapeutics, Inc. Pde5 derived regulatory constructs and methods of use in immunotherapy
BR112020025804A2 (pt) 2018-06-22 2021-03-23 Kite Pharma, Inc. proteínas transmembranares quiméricas e usos das mesmas
US20210261646A1 (en) * 2018-07-03 2021-08-26 Sotio, LLC Chimeric receptors in combination with trans metabolism molecules enhancing glucose import and therapeutic uses thereof
EP3825404A4 (de) * 2018-07-17 2022-04-13 Noile-Immune Biotech, Inc. Einkettiger anti-gpc3-antikörper mit car
WO2020037066A1 (en) 2018-08-14 2020-02-20 Unum Therapeutics Inc. Chimeric antigen receptor polypeptides in combination with trans metabolism molecules modulating krebs cycle and therapeutic uses thereof
US20210388109A1 (en) 2018-10-01 2021-12-16 Adicet Bio, Inc. Compositions and methods regarding engineered and non-engineered gamma delta t-cells for treatment of solid tumors
EP3870600A1 (de) 2018-10-24 2021-09-01 Obsidian Therapeutics, Inc. Er-abstimmbare proteinregulierung
JP2022512958A (ja) * 2018-11-07 2022-02-07 ソティオ，リミティド ライアビリティ カンパニー トランス共刺激分子と組み合わされた抗ｇｐｃ３キメラ抗原受容体（ｃａｒ）及びその治療的用途
EP3894011A1 (de) 2018-12-11 2021-10-20 Obsidian Therapeutics, Inc. Membrangebundene il12-zusammensetzungen und verfahren zur abstimmbaren regulierung
AU2020235865A1 (en) 2019-03-08 2021-09-23 Obsidian Therapeutics, Inc. Human carbonic anhydrase 2 compositions and methods for tunable regulation
KR20210150446A (ko) * 2019-04-04 2021-12-10 상하이 파마슈티컬스 홀딩 컴퍼니 리미티드 종양 항원 인식 수용체를 함유하는 면역 세포 및 이의 적용
EP3983537A1 (de) 2019-06-12 2022-04-20 Obsidian Therapeutics, Inc. Ca2-zusammensetzungen und verfahren zur abstimmbaren regulierung
CN114450308A (zh) 2019-06-12 2022-05-06 黑曜石疗法公司 用于调节性调控的ca2组合物和方法
WO2021046451A1 (en) 2019-09-06 2021-03-11 Obsidian Therapeutics, Inc. Compositions and methods for dhfr tunable protein regulation
WO2021186397A1 (en) * 2020-03-18 2021-09-23 Eutilex Co., Ltd. Gpc3 car-t cell compositions and methods of making and using the same
WO2021186395A1 (en) * 2020-03-18 2021-09-23 Eutilex Co., Ltd. Gpc3 car- t cells secreting il-18 and methods of making and using the same
JP2023535371A (ja) 2020-07-17 2023-08-17 シミュレックス インコーポレイテッド 免疫抑制シグナル伝達をリダイレクトするためのキメラＭｙＤ８８受容体ならびに関連する組成物および方法
EP4263600A1 (de) 2020-12-18 2023-10-25 Century Therapeutics, Inc. Chimäre antigenrezeptorsysteme mit anpassbarer rezeptorspezifität
WO2022214089A1 (zh) 2021-04-08 2022-10-13 克莱格医学有限公司 细胞免疫治疗的应用
CA3237201A1 (en) * 2021-11-16 2023-05-25 Sotio Biotech Inc. Treatment of myxoid/round cell liposarcoma patients

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
US5928906A (en) 1996-05-09 1999-07-27 Sequenom, Inc. Process for direct sequencing during template amplification
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
CN101313063B (zh) * 2005-08-09 2013-04-03 肿瘤疗法·科学股份有限公司 用于hla-a2阳性人群的来自磷脂酰肌醇蛋白聚糖-3(gpc3)的癌症排斥抗原肽以及含有该肽的药物
CN105968209B (zh) * 2011-04-19 2021-08-03 美国政府(由卫生和人类服务部的部长所代表) 对磷脂酰肌醇蛋白聚糖3特异的人单克隆抗体及其用途
EP3692794A1 (de) * 2011-09-16 2020-08-12 Baylor College of Medicine Gegen die tumormikroumgebung gerichtete manipulierte nkt-zellen
US20140322216A1 (en) * 2011-11-08 2014-10-30 The Trustees Of The University Of Pennsylvania Glypican-3-specific antibody and uses thereof
JP2016512199A (ja) * 2013-03-05 2016-04-25 ベイラー カレッジ オブ メディスンＢａｙｌｏｒ Ｃｏｌｌｅｇｅ Ｏｆ Ｍｅｄｉｃｉｎｅ 腫瘍溶解性ウイルス
CN104140974B (zh) * 2013-05-08 2017-09-29 科济生物医药（上海）有限公司 编码gpc‑3嵌合抗原受体蛋白的核酸及表达gpc‑3嵌合抗原受体蛋白的t淋巴细胞
JP2018522564A (ja) * 2015-08-03 2018-08-16 カースゲン セラピューティクス リミテッドＣａｒｓｇｅｎ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ 抗グリピカン３抗体およびその使用

Also Published As

Publication number Publication date
EP3198010A1 (de) 2017-08-02
ES2844700T3 (es) 2021-07-22
EP3858991A1 (de) 2021-08-04
WO2016049459A1 (en) 2016-03-31
JP2017529851A (ja) 2017-10-12
ES2851123T1 (es) 2021-09-03
EP3198010B1 (de) 2020-11-04
EP3198010A4 (de) 2018-06-06
US20170281683A1 (en) 2017-10-05

Similar Documents

Publication Publication Date Title
DE20196219T1 (de) Glypican-3-Spezifische Chimäre Antigenrezeptoren für adoptive Immuntherapie
Lee et al. Double‐edged sword of mesenchymal stem cells: cancer‐promoting versus therapeutic potential
BR112018070097A2 (pt) anticorpo, hibridoma, composição farmacêutica, método para tratar câncer em um indivíduo, método para inibir a proliferação de células cancerígenas, método para diagnosticar o câncer em um indivíduo, método para tratar um paciente humano, método para fazer imagens de um indivíduo, conjugado de fármaco-anticorpo (adc), método para tratar câncer, anticorpo biespecífico e método para preparar uma população de anticorpos homogêneos
Seifert et al. Role of Hox genes in stem cell differentiation
NZ756678A (en) Anti-lag-3 antibodies and uses thereof
Wystrychowski et al. Multipotency and cardiomyogenic potential of human adipose-derived stem cells from epicardium, pericardium, and omentum
MY198034A (en) Tumor-targeted agonistic cd28 antigen binding molecules
EA201891092A1 (ru) Способы и композиции для редактирования генов в гемопоэтических стволовых клетках
MX2019006438A (es) Produccion de celulas modificadas para terapia de celulas adoptivas.
PH12019502561A1 (en) Novel monoclonal antibodies to cytotoxic t-lymphocyte-associated protein 4 (ctla-4)
EA034770B8 (ru) Человеческие антитела к pd-1
CN105473731B (zh) 自身癌抗原特异性cd8+ t细胞的分离及增殖方法
JP2017529851A5 (de)
MX2019002867A (es) Metodos de tratamiento de trastornos inmunologicos usando proteinas de union a pd-1.
EP4289944A3 (de) Verfahren zur herstellung genetisch modifizierter, chimären antigenrezeptor exprimierender t-zellen
AR106949A1 (es) Polipéptidos biparatópicos que antagonizan la señalización wnt en células tumorales
RU2017134270A (ru) Способы лечения рака с применением активированных t-клеток
BR112017001513A2 (pt) molécula de ligação biespecífica, polinucleotídeo, vetor, célula ex vivo, método de produção de uma molécula de ligação biespecífica, mistura de polinucleotídeos, composição farmacêutica, método de tratamento de um câncer, método de preparação de uma célula
EA201790087A1 (ru) Ковалентно связанные диатела, обладающие иммунореактивностью с pd-1 и lag-3, и способы их применения
Liadaki et al. β4 integrin marks interstitial myogenic progenitor cells in adult murine skeletal muscle
Simmen et al. The Krüppel-like factors in female reproductive system pathologies
MX2020001491A (es) Metodos y composiciones para preparar celulas geneticamente modificadas.
Kang et al. Talin1 targeting potentiates anti-angiogenic therapy by attenuating invasion and stem-like features of glioblastoma multiforme
PH12020551187A1 (en) Bispecific antigen-binding molecules and methods of use
US20190112578A1 (en) Derivation and Self-Renewal of Multipotent Cells and Uses Thereof