SG11201903282TA - Immunotherapy methods and compositions involving tryptophan metabolic pathway modulators - Google Patents

Immunotherapy methods and compositions involving tryptophan metabolic pathway modulators

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Publication number
SG11201903282TA
SG11201903282TA SG11201903282TA SG11201903282TA SG11201903282TA SG 11201903282T A SG11201903282T A SG 11201903282TA SG 11201903282T A SG11201903282T A SG 11201903282TA SG 11201903282T A SG11201903282T A SG 11201903282TA SG 11201903282T A SG11201903282T A SG 11201903282TA
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Singapore
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international
methods
cells
suite
dexter
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SG11201903282TA
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Michael Ports
Evan Paul Thomas
Hyam I Levitsky
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Juno Therapeutics Inc
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Publication of SG11201903282TA publication Critical patent/SG11201903282TA/en

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • A61K39/4643—Vertebrate antigens
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12Y113/00—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13)
    • C12Y113/11—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13) with incorporation of two atoms of oxygen (1.13.11)
    • C12Y113/11011—Tryptophan 2,3-dioxygenase (1.13.11.11), i.e. indolamine 2,3-dioxygenase 2
    • C—CHEMISTRY; METALLURGY
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    • C12Y113/11—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13) with incorporation of two atoms of oxygen (1.13.11)
    • C12Y113/11052—Indoleamine 2,3-dioxygenase (1.13.11.52), i.e. indoleamine 2,3-dioxygenase 1
    • C—CHEMISTRY; METALLURGY
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
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    • C12Y207/11001—Non-specific serine/threonine protein kinase (2.7.11.1), i.e. casein kinase or checkpoint kinase
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
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    • C12N2502/30—Coculture with; Conditioned medium produced by tumour cells
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    • C12N2510/00—Genetically modified cells
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
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    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • G—PHYSICS
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    • G01N2333/52—Assays involving cytokines
    • G01N2333/555—Interferons [IFN]
    • G01N2333/57—IFN-gamma

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD 1101111 0 DOI HIM 011101 0 101111H11 111111111111111 011111110 111 0111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2018/071873 A3 19 April 2018 (19.04.2018) WIP0 1 PCT (51) International Patent Classification: UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, A61K 35/17 (2015.01) C12Q 1/26 (2006.01) TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, A61K 45/06 (2006.01) Cl 2N 5/0783 (2010.01) EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, A61K 48/00 (2006.01) G01N 33/574 (2006.01) MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, A61K 31/4245 (2006.01) A61P 35/00 (2006.01) TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, C07K 14/725 (2006.01) KM, ML, MR, NE, SN, TD, TG). (21) International Application Number: PCT/US2017/056680 Declarations under Rule 4.17: — as to the applicant's entitlement to claim the priority of the (22) International Filing Date: earlier application (Rule 4.17(iii)) 13 October 2017 (13.10.2017) Published: (25) Filing Language: English — with international search report (Art. 21(3)) (26) Publication Language: English — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of (30) Priority Data: amendments (Rule 48.2(h)) 62/407,776 13 October 2016 (13.10.2016) US — with sequence listing part of description (Rule 5.2(a)) 62/514,767 02 June 2017 (02.06.2017) US (88) Date of publication of the international search report: (71) Applicant: JUNO THERAPEUTICS, INC. [US/US]; 400 04 October 2018 (04.10.2018) Dexter Ave. N, Suite 1200, Seattle, WA 98109 (US). Inventors: PORTS, Michael; c/o Juno Therapeutics, Inc., 400 Dexter Ave. N, Suite 1200, Seattle, WA 98109 (US). (72) THOMAS, Evan Paul; c/o Juno Therapeutics, Inc., 400 Dexter Ave. N, Suite 1200, Seattle, WA 98109 (US). LEV- ITSKY, Hyam I; c/o Juno Therapeutics, Inc., 400 Dexter Ave. N, Suite 1200, Seattle, WA 98109 (US). Agent: AHN, Sejin et al.; Morrison & Foerster LLP, 12531 (74) High Bluff Drive, Suite 100, San Diego, CA 92130-2040 (US). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (81) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (84) M ..! (54) Title: IMMUNOTHERAPY METHODS AND COMPOSITIONS INVOLVING TRYPTOPHAN METABOLIC PATHWAY M MODULATORS ir---- GC (57) : Provided are methods of treatment involving immunotherapy, such as T cell therapy, and administration of a tryptophan - metabolism and/or kynurenine pathway modulator. In some embodiments, the method includes a combination therapy that involves IN administration of engineered T cells, such as chimeric antigen receptor (CAR)-expressing cells, and a tryptophan metabolism and/ 0 --.... or kynurenine pathway modulator, such as an inhibitor of an enzyme. Also provided are engineered cells in which the expression X 1-1 ) of a molecule involved in the kynurenine pathway is modified. Also provided are methods of manufacturing engineered cells, cells, C compositions, methods of administration to subjects, nucleic acids and kits for use in the methods. In some aspects, features of the ei methods and cells provide for increased or improved activity, activity, outcome, function, response, persistence, expansion and/or 0 proliferation of cells for adoptive cell therapy.
SG11201903282TA 2016-10-13 2017-10-13 Immunotherapy methods and compositions involving tryptophan metabolic pathway modulators SG11201903282TA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662407776P 2016-10-13 2016-10-13
US201762514767P 2017-06-02 2017-06-02
PCT/US2017/056680 WO2018071873A2 (en) 2016-10-13 2017-10-13 Immunotherapy methods and compositions involving tryptophan metabolic pathway modulators

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US (1) US11896615B2 (en)
EP (2) EP3525803B1 (en)
JP (2) JP2019533676A (en)
KR (1) KR20190084053A (en)
CN (1) CN110381963A (en)
AU (1) AU2017343780B2 (en)
BR (1) BR112019006652A2 (en)
CA (1) CA3037387A1 (en)
ES (1) ES2939646T3 (en)
IL (1) IL265848A (en)
MA (2) MA46649A (en)
MX (1) MX2019004181A (en)
PH (1) PH12019500803A1 (en)
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WO (1) WO2018071873A2 (en)

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