ME02807B - HUMANI ANTIGEN-VEZUJUĆI PROTEINI KOJI SE VEZUJU ZA BETA-KLOTHO, FGF RECEPTORE l NJIHOVE KOMPLEKSE - Google Patents

HUMANI ANTIGEN-VEZUJUĆI PROTEINI KOJI SE VEZUJU ZA BETA-KLOTHO, FGF RECEPTORE l NJIHOVE KOMPLEKSE

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Publication number
ME02807B
ME02807B MEP-2017-108A MEP10817A ME02807B ME 02807 B ME02807 B ME 02807B ME P10817 A MEP10817 A ME P10817A ME 02807 B ME02807 B ME 02807B
Authority
ME
Montenegro
Prior art keywords
seq
isolated antibody
fragment
amino acid
acid sequence
Prior art date
Application number
MEP-2017-108A
Other languages
German (de)
English (en)
French (fr)
Inventor
Shaw-Fen Sylvia Hu
Ian Foltz
Chadwick T King
Yang Li
Taruna Arora
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43545013&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME02807(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of ME02807B publication Critical patent/ME02807B/me

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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
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    • A61K38/18—Growth factors; Growth regulators
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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    • A61K49/10—Organic compounds
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K2317/52—Constant or Fc region; Isotype
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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Claims (9)

1. Izolovano antitelo ili njegov fragment koje je sposobno da se vezuje za kompleks koji sadrži β-Klotho i FGFR1c i indukuje FGF21-posredovani prenos signala i sadrži sledeće CDR regione:a) CDRH1: SEQ ID NO: 122;b) CDRH2: SEQ ID NO: 133;c) CDRH3: SEQ ID NO: 148;d) CDRL1: SEQ ID NO: 166;e) CDRL2: SEQ ID NO: 176; if) CDRL3: SEQ ID NO: 188.
2. Izolovano antitelo ili njegov fragment koje je sposobno da se vezuje za kompleks koji sadrži β-Klotho i FGFR1c i indukuje FGF21-posredovani prenos signala, pri čemu navedeno izolovano antitelo ili njegov fragment sadrži aminokiselinsku sekvencu 90% identičnu sa SEQ ID NO: 50 i sadrži aminokiselinsku sekvencu 90% identičnu sa SEQ ID NO: 68.
3. Izolovano antitelo ili njegov fragment prema patentnom zahtevu 2, naznačeno time što navedeno izolovano antitelo ili njegov fragment sadrži aminokiselinsku sekvencu 95% identičnu sa SEQ ID NO: 50 i sadrži aminokiselinsku sekvencu 95% identičnu sa SEQ ID NO: 68.
4. Izolovano antitelo ili njegov fragment prema patentnom zahtevu 3, naznačeno time što navedeno izolovano antitelo ili njegov fragment sadrži SEQ ID NO: 50 i SEQ ID NO: 68.
5. Izolovano antitelo ili njegov fragment koje je sposobno da se vezuje za kompleks koji sadrži β-Klotho i FGFR1c i indukuje FGF21-posredovani prenos signala, pri čemu navedeno izolovano antitelo ili njegov fragment sadrži aminokiselinsku sekvencu 90% identičnu sa SEQ ID NO: 14 i sadrži aminokiselinsku sekvencu 90% identičnu sa SEQ ID NO: 32.
6. Izolovano antitelo ili njegov fragment prema patentnom zahtevu 5, naznačeno time što navedeno izolovano antitelo ili njegov fragment sadrži aminokiselinsku sekvencu 95% identičnu sa SEQ ID NO: 14 i sadrži aminokiselinsku sekvencu 95% identičnu sa SEQ ID NO: 32.
7. Izolovano antitelo ili njegov fragment prema patentnom zahtevu 6, naznačeno time što navedeno izolovano antitelo ili njegov fragment sadrži aminokiselinsku sekvencu 98% identičnu sa SEQ ID NO: 14 i sadrži aminokiselinsku sekvencu 98% identičnu sa SEQ ID NO: 32.
8. Izolovano antitelo ili njegov fragment prema patentnom zahtevu 1, naznačeno time što navedeno antitelo ili njegov fragment sadrži SEQ ID NO: 14 i SEQ ID NO: 32.
9. Farmaceutska kompozicija koja sadrži izolovano antitelo ili njegov fragment prema bilo kom od prethodnih patentnih zahteva pomešano sa njegovim farmaceutski prihvatljivim nosačem.
MEP-2017-108A 2009-12-07 2010-12-03 HUMANI ANTIGEN-VEZUJUĆI PROTEINI KOJI SE VEZUJU ZA BETA-KLOTHO, FGF RECEPTORE l NJIHOVE KOMPLEKSE ME02807B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26732109P 2009-12-07 2009-12-07
US38184610P 2010-09-10 2010-09-10
EP13183846.8A EP2711375B1 (en) 2009-12-07 2010-12-03 Human antigen binding proteins that bind beta-klotho, fgf receptors and complexes thereof

Publications (1)

Publication Number Publication Date
ME02807B true ME02807B (me) 2018-01-20

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MEP-2017-108A ME02807B (me) 2009-12-07 2010-12-03 HUMANI ANTIGEN-VEZUJUĆI PROTEINI KOJI SE VEZUJU ZA BETA-KLOTHO, FGF RECEPTORE l NJIHOVE KOMPLEKSE

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US (5) US9284378B2 (me)
EP (4) EP2711375B1 (me)
JP (4) JP5840619B2 (me)
KR (3) KR102121678B1 (me)
CN (2) CN102858802B (me)
AR (1) AR079274A1 (me)
AU (1) AU2010328444B2 (me)
BR (1) BR112012013876B1 (me)
CA (2) CA2981687C (me)
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CR (2) CR20180020A (me)
CY (1) CY1119000T1 (me)
DK (1) DK2711375T3 (me)
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MA (1) MA33854B1 (me)
ME (1) ME02807B (me)
MX (2) MX360487B (me)
MY (2) MY191950A (me)
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PE (1) PE20121686A1 (me)
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SG (2) SG10201708609PA (me)
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UY (2) UY33089A (me)
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JPWO2002077546A1 (ja) * 2001-03-14 2004-07-15 積水化学工業株式会社 ヒートポンプ及びヒートポンプシステム
WO2007039256A2 (de) 2005-09-30 2007-04-12 Abbott Gmbh & Co. Kg Bindungsdomänen von proteinen der repulsive guidance molecule (rgm) proteinfamilie und funktionale fragmente davon sowie deren verwendung
US8962803B2 (en) 2008-02-29 2015-02-24 AbbVie Deutschland GmbH & Co. KG Antibodies against the RGM A protein and uses thereof
JOP20190083A1 (ar) 2008-06-04 2017-06-16 Amgen Inc بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها
UA109888C2 (uk) * 2009-12-07 2015-10-26 ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ
BR112012013734A2 (pt) * 2009-12-08 2017-01-10 Abbott Gmbh & Co Kg anticorpos monoclonais contra a proteína rgm a para uso no tratamento da degeneração da camada de fibras nervosas da retina.
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