CR20180020A - PROTEÍNAS DE ENLACE A ANTIGENOS HUMANAS QUE ENLAZAN BETA-KLOTHO, RECEPTORES FGF Y COMPLEJOS DE LOS MISMOS. (Divisional 2012-0366) - Google Patents

PROTEÍNAS DE ENLACE A ANTIGENOS HUMANAS QUE ENLAZAN BETA-KLOTHO, RECEPTORES FGF Y COMPLEJOS DE LOS MISMOS. (Divisional 2012-0366)

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Publication number
CR20180020A
CR20180020A CR20180020A CR20180020A CR20180020A CR 20180020 A CR20180020 A CR 20180020A CR 20180020 A CR20180020 A CR 20180020A CR 20180020 A CR20180020 A CR 20180020A CR 20180020 A CR20180020 A CR 20180020A
Authority
CR
Costa Rica
Prior art keywords
antigen binding
binding proteins
klotho
fgfr3c
fgfr1c
Prior art date
Application number
CR20180020A
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English (en)
Inventor
Shaw-Fen Sylvia; Hu
Ian; Foltz
Chadwick Terence; King
Taruna; Arora
Yang; Li
Original Assignee
Amgen Inc
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Publication date
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Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CR20180020A publication Critical patent/CR20180020A/es

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/16—Antibodies; Immunoglobulins; Fragments thereof
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A—HUMAN NECESSITIES
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
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    • C07K2317/54—F(ab')2
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    • C07K2317/55—Fab or Fab'
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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Abstract

La descripción actual proporciona composiciones y métodos relacionados con o derivados de proteínas de enlace a antígenos que activan la señalización mediada por FGF21. En modalidades, las proteínas de enlace a antígenos enlazan específicamente a (i) ¿-Klotho; (ii) FGFR1c, FGFR2c, FGFR3c o FGFR4; o (iii) un complejo que comprende ¿-Klotho y uno de FGFR1c, FGFR2c, FGFR3c, y FGFR4. En algunas modalidades las proteínas de enlace a antígenos inducen señalización del tipo FGF21. En algunas modalidades, las proteínas de enlace a antígenos son anticuerpos completamente humanos, humanizados, o quiméricos, fragmentos de enlace y derivados de tales anticuerpos, y polipéptidos que enlazan específicamente a (i) ¿-Klotho; (ii) FGFR1c, FGFR2c, FGFR3c o FGFR4; o (iii) un complejo que comprende ¿-Klotho y uno de FGFR1c, FGFR2c, FGFR3c, y FGFR4¿ Otras modalidades proporcionan ácidos nucleicos que codifican tales proteínas de enlace a antígenos, y fragmentos y derivados de las mismas, y polipéptidos, células que comprenden tales polinucleótidos, métodos de elaboración de tales proteínas de enlace a antígenos, y fragmentos y derivados de las mismas, y polipéptidos, y métodos de uso de tales proteínas de enlace a antígenos, fragmentos y derivados de las mismas, y polipéptidos, que incluyen métodos de tratamiento o diagnóstico de sujetos que padecen de diabetes tipo 2, obesidad, NASH, síndrome metabólico y trastornos o condiciones relacionadas.
CR20180020A 2009-12-07 2010-12-03 PROTEÍNAS DE ENLACE A ANTIGENOS HUMANAS QUE ENLAZAN BETA-KLOTHO, RECEPTORES FGF Y COMPLEJOS DE LOS MISMOS. (Divisional 2012-0366) CR20180020A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26732109P 2009-12-07 2009-12-07
US38184610P 2010-09-10 2010-09-10
PCT/US2010/058984 WO2011071783A1 (en) 2009-12-07 2010-12-03 Human antigen binding proteins that bind beta-klotho, fgf receptors and complexes thereof

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CR20180020A true CR20180020A (es) 2018-07-20

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ID=43545013

Family Applications (2)

Application Number Title Priority Date Filing Date
CR20180020A CR20180020A (es) 2009-12-07 2010-12-03 PROTEÍNAS DE ENLACE A ANTIGENOS HUMANAS QUE ENLAZAN BETA-KLOTHO, RECEPTORES FGF Y COMPLEJOS DE LOS MISMOS. (Divisional 2012-0366)
CR20120366A CR20120366A (es) 2009-12-07 2012-07-06 Proteínas de enlace a antigenos humanas que enlazan beta-klotho, receptores fgf y complejos de los mismos

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CR20120366A CR20120366A (es) 2009-12-07 2012-07-06 Proteínas de enlace a antigenos humanas que enlazan beta-klotho, receptores fgf y complejos de los mismos

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JP (4) JP5840619B2 (es)
KR (3) KR101865974B1 (es)
CN (2) CN102858802B (es)
AR (1) AR079274A1 (es)
AU (1) AU2010328444B2 (es)
BR (1) BR112012013876B1 (es)
CA (2) CA2981687C (es)
CL (1) CL2012001504A1 (es)
CR (2) CR20180020A (es)
CY (1) CY1119000T1 (es)
DK (1) DK2711375T3 (es)
EA (2) EA026129B1 (es)
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