MX341148B - PROTEINAS DE ENLACE A ANTIGENOS HUMANAS QUE ENLAZAN ß-KLOTHO, RECEPTORES FGF Y COMPLEJOS DE LOS MISMOS. - Google Patents

PROTEINAS DE ENLACE A ANTIGENOS HUMANAS QUE ENLAZAN ß-KLOTHO, RECEPTORES FGF Y COMPLEJOS DE LOS MISMOS.

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Publication number
MX341148B
MX341148B MX2012006467A MX2012006467A MX341148B MX 341148 B MX341148 B MX 341148B MX 2012006467 A MX2012006467 A MX 2012006467A MX 2012006467 A MX2012006467 A MX 2012006467A MX 341148 B MX341148 B MX 341148B
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MX
Mexico
Prior art keywords
antigen binding
binding proteins
klotho
fgfric
fgfr3c
Prior art date
Application number
MX2012006467A
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English (en)
Other versions
MX2012006467A (es
Inventor
Sylvia Hu Shaw-Fen
Foltz Ian
Li Yang
Terence King Chadwick
Arora Taruna
Original Assignee
Amgen Inc *
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Application filed by Amgen Inc * filed Critical Amgen Inc *
Publication of MX2012006467A publication Critical patent/MX2012006467A/es
Publication of MX341148B publication Critical patent/MX341148B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K49/00—Preparations for testing in vivo
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    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/16—Antibodies; Immunoglobulins; Fragments thereof
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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Abstract

La presente invención se refiere a composiciones y métodos relacionados con o derivados de proteínas de enlace a antígenos que activan la señalización mediada por FGF21. En modalidades, las proteínas de enlace a antígenos enlazan específicamente a (i) ß-Klotho; (ii) FGFR1c, FGFR2c, FGFR3c o FGFR4; o (iii) un complejo que comprende ß-Klotho y uno de FGFR1c, FGFR2c, FGFR3c, y FGFR4. En algunas modalidades las proteínas de enlace a antígenos inducen señalización del tipo FGF21. En algunas modalidades, las proteínas de enlace a antígenos son anticuerpos completamente humanos, humanizados, o quiméricos, fragmentos de enlace y derivados de tales anticuerpos, y polipéptidos que enlazan específicamente a (i) ß-Klotho; (ii) FGFR1c, FGFR2c, FGFR3c o FGFR4; o (iii) un complejo que comprende ß-Klotho y uno de FGFR1c, FGFR2c, FGFR3c, y FGFR4. Otras modalidades proporcionan ácidos nucleicos que codifican tales proteínas de enlace a antígenos, y fragmentos y derivados de las mismas, y polipéptidos, células que comprenden tales polinucleótidos, métodos de elaboración de tales proteínas de enlace a antígenos, y fragmentos y derivados de las mismas, y polipéptidos, y métodos de uso de tales proteínas de enlace a antígenos, fragmentos y derivados de las mismas, y polipéptidos, que incluyen métodos de tratamiento o diagnóstico de sujetos que padecen de diabetes tipo 2, obesidad, NASH, síndrome metabólico y trastornos o condiciones relacionadas.
MX2012006467A 2009-12-07 2010-12-03 PROTEINAS DE ENLACE A ANTIGENOS HUMANAS QUE ENLAZAN ß-KLOTHO, RECEPTORES FGF Y COMPLEJOS DE LOS MISMOS. MX341148B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26732109P 2009-12-07 2009-12-07
US38184610P 2010-09-10 2010-09-10
PCT/US2010/058984 WO2011071783A1 (en) 2009-12-07 2010-12-03 Human antigen binding proteins that bind beta-klotho, fgf receptors and complexes thereof

Publications (2)

Publication Number Publication Date
MX2012006467A MX2012006467A (es) 2012-09-12
MX341148B true MX341148B (es) 2016-08-09

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ID=43545013

Family Applications (2)

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MX2016010041A MX360487B (es) 2009-12-07 2010-12-03 PROTEÍNAS DE ENLACE A ANTÍGENOS HUMANAS QUE ENLAZAN ß-KLOTHO, RECEPTORES FGF Y COMPLEJOS DE LOS MISMOS.
MX2012006467A MX341148B (es) 2009-12-07 2010-12-03 PROTEINAS DE ENLACE A ANTIGENOS HUMANAS QUE ENLAZAN ß-KLOTHO, RECEPTORES FGF Y COMPLEJOS DE LOS MISMOS.

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MX2016010041A MX360487B (es) 2009-12-07 2010-12-03 PROTEÍNAS DE ENLACE A ANTÍGENOS HUMANAS QUE ENLAZAN ß-KLOTHO, RECEPTORES FGF Y COMPLEJOS DE LOS MISMOS.

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US (4) US9284378B2 (es)
EP (4) EP2711375B1 (es)
JP (4) JP5840619B2 (es)
KR (3) KR102121678B1 (es)
CN (2) CN108586602A (es)
AR (1) AR079274A1 (es)
AU (1) AU2010328444B2 (es)
BR (1) BR112012013876B1 (es)
CA (2) CA2782420C (es)
CL (1) CL2012001504A1 (es)
CR (2) CR20180020A (es)
CY (1) CY1119000T1 (es)
DK (1) DK2711375T3 (es)
EA (2) EA026129B1 (es)
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HR (1) HRP20170882T1 (es)
HU (1) HUE034727T2 (es)
IL (2) IL220048A0 (es)
LT (1) LT2711375T (es)
MA (1) MA33854B1 (es)
ME (1) ME02807B (es)
MX (2) MX360487B (es)
MY (2) MY173097A (es)
NZ (2) NZ717847A (es)
PE (1) PE20121686A1 (es)
PL (1) PL2711375T3 (es)
PT (1) PT2711375T (es)
RS (1) RS56016B1 (es)
SG (2) SG10201708609PA (es)
SI (1) SI2711375T1 (es)
TN (1) TN2012000268A1 (es)
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UA (1) UA109888C2 (es)
UY (2) UY33089A (es)
WO (1) WO2011071783A1 (es)
ZA (1) ZA201204145B (es)

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WO2002077546A1 (fr) * 2001-03-14 2002-10-03 Sekisui Chemical Co., Ltd. Pompe de chaleur, et systeme de pompe de chaleur
EP1928905B1 (de) 2005-09-30 2015-04-15 AbbVie Deutschland GmbH & Co KG Bindungsdomänen von proteinen der repulsive guidance molecule (rgm) proteinfamilie und funktionale fragmente davon sowie deren verwendung
US8962803B2 (en) 2008-02-29 2015-02-24 AbbVie Deutschland GmbH & Co. KG Antibodies against the RGM A protein and uses thereof
JOP20190083A1 (ar) 2008-06-04 2017-06-16 Amgen Inc بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها
UA109888C2 (uk) 2009-12-07 2015-10-26 ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ
BR112012013734A2 (pt) * 2009-12-08 2017-01-10 Abbott Gmbh & Co Kg anticorpos monoclonais contra a proteína rgm a para uso no tratamento da degeneração da camada de fibras nervosas da retina.
EP2707718A1 (en) * 2011-05-10 2014-03-19 Amgen Inc. Method of identifying compounds that specifically modulate the interaction of fgfr1 and beta-klotho
CN103596980B (zh) 2011-05-16 2017-08-08 霍夫曼-拉罗奇有限公司 Fgfr1激动剂及使用方法
US9574002B2 (en) * 2011-06-06 2017-02-21 Amgen Inc. Human antigen binding proteins that bind to a complex comprising β-Klotho and an FGF receptor
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