EA201270634A1 - АНТИГЕНСВЯЗЫВАЮЩИЕ БЕЛКИ ЧЕЛОВЕКА, КОТОРЫЕ СВЯЗЫВАЮТСЯ С β-КЛОТО, РЕЦЕПТОРАМИ FGF И ИХ КОМПЛЕКСАМИ - Google Patents

АНТИГЕНСВЯЗЫВАЮЩИЕ БЕЛКИ ЧЕЛОВЕКА, КОТОРЫЕ СВЯЗЫВАЮТСЯ С β-КЛОТО, РЕЦЕПТОРАМИ FGF И ИХ КОМПЛЕКСАМИ

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EA201270634A1
EA201270634A1 EA201270634A EA201270634A EA201270634A1 EA 201270634 A1 EA201270634 A1 EA 201270634A1 EA 201270634 A EA201270634 A EA 201270634A EA 201270634 A EA201270634 A EA 201270634A EA 201270634 A1 EA201270634 A1 EA 201270634A1
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binding proteins
antigen binding
cloto
fgfr3c
fgfr1c
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EA201270634A
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EA026129B1 (ru
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Шо-Фэнь Ху
Ян Фольтц
Чэдвик Теренс Кинг
Ян ЛИ
Таруна Арора
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Амген Инк.
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Abstract

Изобретение предоставляет композиции и способы, относящиеся к антигенсвязывающим белкам, активирующим FGF21-опосредованную передачу сигнала, или производным от этих белков. В различных вариантах воплощения антигенсвязывающие белки специфично связываются с (i) β-Клото; (ii) FGFR1c, FGFR2c, FGFR3c или FGFR4; или (iii) комплексом, содержащим β-Клото и одну из молекул FGFR1c, FGFR2c, FGFR3c и FGFR4. В некоторых вариантах воплощения антигенсвязывающие белки индуцируют FGF 21-подобный сигналлинг. В некоторых вариантах воплощения антигенсвязывающие белки являются полностью принадлежащими человеку, гуманизированными или химерными антителами, связывающими фрагментами и производными таких антител, и полипептидами, которые специфично связываются с (i) β-Клото; (ii) FGFR1c, FGFR2c, FGFR3c или FGFR4; или (iii) комплексом, содержащим β-Клото и одну из молекул FGFR1c, FGFR2c, FGFR3c и FGFR4. В других вариантах воплощения предложены нуклеиновые кислоты, кодирующие такие антигенсвязывающие белки и их фрагменты, а также производные и полипептиды, клетки, содержащие такие полинуклеотиды, способы получения таких антигенсвязывающих белков, их фрагментов и производных и полипептидов, и способы применения таких антигенсвязывающих белков, их фрагментов и производных и полипептидов, включая способы лечения или диагностики у субъектов, страдающих диабетом 2 типа, ожирением, НАСГ, метаболическим синдромом и родственными нарушениями или состояниями.
EA201270634A 2009-12-07 2010-12-03 АНТИГЕНСВЯЗЫВАЮЩИЕ БЕЛКИ ЧЕЛОВЕКА, КОТОРЫЕ СВЯЗЫВАЮТСЯ С β-КЛОТО, РЕЦЕПТОРАМИ FGF И ИХ КОМПЛЕКСАМИ EA026129B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26732109P 2009-12-07 2009-12-07
US38184610P 2010-09-10 2010-09-10
PCT/US2010/058984 WO2011071783A1 (en) 2009-12-07 2010-12-03 Human antigen binding proteins that bind beta-klotho, fgf receptors and complexes thereof

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EA201270634A1 true EA201270634A1 (ru) 2013-02-28
EA026129B1 EA026129B1 (ru) 2017-03-31

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EA201270634A EA026129B1 (ru) 2009-12-07 2010-12-03 АНТИГЕНСВЯЗЫВАЮЩИЕ БЕЛКИ ЧЕЛОВЕКА, КОТОРЫЕ СВЯЗЫВАЮТСЯ С β-КЛОТО, РЕЦЕПТОРАМИ FGF И ИХ КОМПЛЕКСАМИ
EA201691176A EA033405B1 (ru) 2009-12-07 2010-12-03 Изолированное антитело, которое индуцирует опосредованную фактором роста фибробластов 21 (fgf21) передачу сигнала

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