ME02571B - Novi biciklički piridinoni - Google Patents
Novi biciklički piridinoniInfo
- Publication number
- ME02571B ME02571B MEP-2016-269A MEP2016269A ME02571B ME 02571 B ME02571 B ME 02571B ME P2016269 A MEP2016269 A ME P2016269A ME 02571 B ME02571 B ME 02571B
- Authority
- ME
- Montenegro
- Prior art keywords
- pharmaceutically acceptable
- alkyl
- acceptable salt
- compound according
- substituted
- Prior art date
Links
- -1 bicyclic pyridinones Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 35
- 150000003839 salts Chemical class 0.000 claims 27
- 229910052739 hydrogen Inorganic materials 0.000 claims 17
- 239000001257 hydrogen Substances 0.000 claims 17
- 125000000217 alkyl group Chemical group 0.000 claims 14
- 235000019000 fluorine Nutrition 0.000 claims 13
- 125000000753 cycloalkyl group Chemical group 0.000 claims 12
- 229910052736 halogen Inorganic materials 0.000 claims 12
- 150000002367 halogens Chemical class 0.000 claims 12
- 125000001424 substituent group Chemical group 0.000 claims 12
- 125000004093 cyano group Chemical group *C#N 0.000 claims 11
- 229910052731 fluorine Inorganic materials 0.000 claims 11
- 239000011737 fluorine Substances 0.000 claims 11
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 10
- 150000002431 hydrogen Chemical class 0.000 claims 9
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 9
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 229910052801 chlorine Inorganic materials 0.000 claims 4
- 239000000460 chlorine Substances 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 229910007161 Si(CH3)3 Inorganic materials 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 150000001602 bicycloalkyls Chemical group 0.000 claims 2
- CPPKAGUPTKIMNP-UHFFFAOYSA-N cyanogen fluoride Chemical compound FC#N CPPKAGUPTKIMNP-UHFFFAOYSA-N 0.000 claims 2
- 125000004639 dihydroindenyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 2
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 1
- XTFIVUDBNACUBN-UHFFFAOYSA-N 1,3,5-trinitro-1,3,5-triazinane Chemical compound [O-][N+](=O)N1CN([N+]([O-])=O)CN([N+]([O-])=O)C1 XTFIVUDBNACUBN-UHFFFAOYSA-N 0.000 claims 1
- PBCQGLLRQCGBRF-SZFUDVHCSA-N 2-[(1s)-1-[(2s,5r)-5-[3,5-difluoro-4-(trifluoromethyl)phenyl]oxolan-2-yl]ethyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione Chemical compound C1([C@H]2CC[C@H](O2)[C@H](C)N2C(C=3N(C(C(N4C=C(C)N=C4)=CC=3)=O)CC2)=O)=CC(F)=C(C(F)(F)F)C(F)=C1 PBCQGLLRQCGBRF-SZFUDVHCSA-N 0.000 claims 1
- KWLOJYBMOANZSC-JQOQJDEVSA-N 2-[(1s)-1-[(2s,5r)-5-[4,5-difluoro-2-(trifluoromethyl)phenyl]oxolan-2-yl]ethyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione Chemical compound C1([C@H]2CC[C@H](O2)[C@H](C)N2C(C=3N(C(C(N4C=C(C)N=C4)=CC=3)=O)CC2)=O)=CC(F)=C(F)C=C1C(F)(F)F KWLOJYBMOANZSC-JQOQJDEVSA-N 0.000 claims 1
- MUDLWRHYTYCFBR-UZQPLGKSSA-N 2-[(1s)-1-[(2s,5r)-5-[4-chloro-2-(trifluoromethyl)phenyl]oxolan-2-yl]ethyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione Chemical compound C1([C@H]2CC[C@H](O2)[C@H](C)N2C(C=3N(C(C(N4C=C(C)N=C4)=CC=3)=O)CC2)=O)=CC=C(Cl)C=C1C(F)(F)F MUDLWRHYTYCFBR-UZQPLGKSSA-N 0.000 claims 1
- SKHXUJLZBBPBLM-PNHOKKKMSA-N 2-[(1s)-1-[(2s,5r)-5-[4-chloro-3-fluoro-2-(trifluoromethyl)phenyl]oxolan-2-yl]ethyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione Chemical compound C1([C@H]2CC[C@H](O2)[C@H](C)N2C(C=3N(C(C(N4C=C(C)N=C4)=CC=3)=O)CC2)=O)=CC=C(Cl)C(F)=C1C(F)(F)F SKHXUJLZBBPBLM-PNHOKKKMSA-N 0.000 claims 1
- AKCDDYGYIGPEKL-JQOQJDEVSA-N 2-[(1s)-1-[(2s,5r)-5-[4-chloro-5-fluoro-2-(trifluoromethyl)phenyl]oxolan-2-yl]ethyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione Chemical compound C1([C@H]2CC[C@H](O2)[C@H](C)N2C(C=3N(C(C(N4C=C(C)N=C4)=CC=3)=O)CC2)=O)=CC(F)=C(Cl)C=C1C(F)(F)F AKCDDYGYIGPEKL-JQOQJDEVSA-N 0.000 claims 1
- HDGHLFQAIWQFDC-UZQPLGKSSA-N 2-[(1s)-1-[(2s,5r)-5-[4-fluoro-2-(trifluoromethyl)phenyl]oxolan-2-yl]ethyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione Chemical compound C1([C@H]2CC[C@H](O2)[C@H](C)N2C(C=3N(C(C(N4C=C(C)N=C4)=CC=3)=O)CC2)=O)=CC=C(F)C=C1C(F)(F)F HDGHLFQAIWQFDC-UZQPLGKSSA-N 0.000 claims 1
- CZCJRJMKFMFGOG-WQTXXOFMSA-N 7-(4-methylimidazol-1-yl)-2-[(1s)-1-[(2s,5r)-5-[4-(trifluoromethyl)phenyl]oxolan-2-yl]ethyl]-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione Chemical compound C1([C@H]2CC[C@H](O2)[C@H](C)N2C(C=3N(C(C(N4C=C(C)N=C4)=CC=3)=O)CC2)=O)=CC=C(C(F)(F)F)C=C1 CZCJRJMKFMFGOG-WQTXXOFMSA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000007930 Type C Niemann-Pick Disease Diseases 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000005048 dihydroisoxazolyl group Chemical group O1N(CC=C1)* 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000001786 isothiazolyl group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 208000020016 psychiatric disease Diseases 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000004192 tetrahydrofuran-2-yl group Chemical group [H]C1([H])OC([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261703969P | 2012-09-21 | 2012-09-21 | |
| PCT/IB2013/058347 WO2014045156A1 (en) | 2012-09-21 | 2013-09-06 | Novel bicyclic pyridinones |
| EP13792085.6A EP2897956B1 (en) | 2012-09-21 | 2013-09-06 | Novel bicyclic pyridinones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME02571B true ME02571B (me) | 2017-06-20 |
Family
ID=49585452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2016-269A ME02571B (me) | 2012-09-21 | 2013-09-06 | Novi biciklički piridinoni |
Country Status (46)
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA110688C2 (uk) | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
| CA2889249C (en) | 2012-12-20 | 2021-02-16 | Francois Paul Bischoff | Tricyclic 3,4-dihydro-2h-pyrido[1,2-a]pyrazine-1,6-dione derivatives as gamma secretase modulators |
| CA2891755C (en) | 2013-01-17 | 2021-10-26 | Janssen Pharmaceutica Nv | Substituted pyrido-piperazinone derivatives as gamma secretase modulators |
| EP3052495B1 (en) * | 2013-10-04 | 2019-06-26 | Pfizer Inc | Novel bicyclic pyridinones as gamma-secretase modulators |
| US10562897B2 (en) | 2014-01-16 | 2020-02-18 | Janssen Pharmaceutica Nv | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators |
| DK3126361T3 (da) * | 2014-04-01 | 2020-01-02 | Pfizer | Chromen og 1,1a,2,7b-tetrahydrocyclopropa[c]chromen- pyridopyrazindioner som gamma-sekretase-modulatorer |
| AU2016214102B2 (en) | 2015-02-03 | 2018-09-27 | Pfizer Inc. | Novel cyclopropabenzofuranyl pyridopyrazinediones |
| US9802927B2 (en) | 2015-06-10 | 2017-10-31 | Denali Therapeutics, Inc. | Oxadiazine compounds and methods of use thereof |
| CN109311876B (zh) | 2016-06-16 | 2022-05-03 | 豪夫迈·罗氏有限公司 | 杂芳基雌激素受体调节剂及其用途 |
| RU2757276C2 (ru) | 2016-12-16 | 2021-10-12 | Пайплайн Терапьютикс, Инк. | Способы лечения кохлеарной синаптопатии |
| KR20210084484A (ko) | 2018-10-02 | 2021-07-07 | 프리퀀시 테라퓨틱스, 인크. | 귀 치료제를 포함하는 약제학적 조성물 및 관련 방법 |
| KR20220007050A (ko) | 2019-04-08 | 2022-01-18 | 프리퀀시 테라퓨틱스, 인크. | 난청을 치료하기 위한 chir99021과 발프로산의 조합 |
| JOP20220130A1 (ar) | 2019-12-06 | 2023-01-30 | Vertex Pharma | مجموعات تترا هيدروفيوران بها استبدال في صورة عوامل تعديل لقنوات الصوديوم |
| CN113402490B (zh) * | 2021-03-29 | 2023-01-03 | 白银京宇新药业有限公司 | 一种1，2，6，7-四氢-8H-茚并[5，4-b]呋喃-8-酮的制备方法 |
| TW202313593A (zh) | 2021-06-04 | 2023-04-01 | 美商維泰克斯製藥公司 | 作為鈉通道調節劑之ｎ—（羥基烷基（雜）芳基）四氫呋喃甲醯胺 |
| CN114034792B (zh) * | 2021-11-09 | 2024-06-25 | 山东新华制药股份有限公司 | 检测氯酮含量的液相色谱分析方法 |
Family Cites Families (134)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1419789A (en) | 1972-08-02 | 1975-12-31 | Pfizer | 2-trifluoromethyl-4-quinolinols |
| WO1992000075A1 (en) | 1990-06-29 | 1992-01-09 | Pfizer Inc. | Pyridopyrazine derivatives for treating substance abuse and addiction |
| US5482967A (en) | 1992-09-04 | 1996-01-09 | Takeda Chemical Industries, Ltd. | Condensed heterocyclic compounds, their production and use |
| EP1308461A3 (en) | 1993-01-25 | 2004-02-11 | Takeda Chemical Industries, Ltd. | Antibodies to beta-amyloids or their derivatives and use thereof |
| ATE242243T1 (de) | 1995-03-24 | 2003-06-15 | Takeda Chemical Industries Ltd | Zyklische verbindungen, ihre herstellung und ihre verwendung als tachykininrezeptorantagonisten |
| DE19709877A1 (de) | 1997-03-11 | 1998-09-17 | Bayer Ag | 1,5-Dihydro-pyrazolo[3,4-d]-pyrimidinon-derivate |
| DK0994728T3 (da) | 1997-04-09 | 2008-12-01 | Intellect Neurosciences Inc | Rekombinante antistoffer, som er specifikke for beta-amyloide ender, DNA, der koder derfor, samt fremgangsmåder til anvendelse heraf |
| US8173127B2 (en) | 1997-04-09 | 2012-05-08 | Intellect Neurosciences, Inc. | Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof |
| GB9722520D0 (en) | 1997-10-24 | 1997-12-24 | Pfizer Ltd | Compounds |
| US6743427B1 (en) | 1997-12-02 | 2004-06-01 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| CA2322156A1 (en) | 1998-03-03 | 1999-09-10 | Ppg Industries Ohio, Inc. | Impregnated glass fiber strands and products including the same |
| US20020132817A1 (en) | 1998-03-19 | 2002-09-19 | Hideaki Natsugari | Heterocyclic compounds, their production and use |
| CA2352612A1 (en) | 1998-11-27 | 2000-06-08 | Hideo Fukui | Pharmaceuticals |
| HRP20020693B1 (hr) | 2000-02-24 | 2012-01-31 | Washington University | HUMANIZIRANA PROTUTIJELA KOJA SADRŽE PEPTID Aß |
| DE10045112A1 (de) | 2000-09-11 | 2002-03-21 | Merck Patent Gmbh | Verwendung von Indolderivaten zur Behandlung von Erkrankungen des zentralen Nervensystems |
| CA2427661C (en) | 2000-11-03 | 2013-05-28 | Proteotech, Inc. | Methods of isolating amyloid-inhibiting compounds and use of compounds isolated from uncaria tomentosa and related plants |
| JP2005503789A (ja) | 2001-08-17 | 2005-02-10 | イーライ・リリー・アンド・カンパニー | 抗Ａβ抗体 |
| US20030195205A1 (en) | 2001-11-02 | 2003-10-16 | Pfizer Inc. | PDE9 inhibitors for treating cardiovascular disorders |
| DE10238724A1 (de) | 2002-08-23 | 2004-03-04 | Bayer Ag | Alkyl-substituierte Pyrazolpyrimidine |
| DE10238723A1 (de) | 2002-08-23 | 2004-03-11 | Bayer Ag | Phenyl-substituierte Pyrazolyprimidine |
| WO2004024078A2 (en) | 2002-09-11 | 2004-03-25 | Merck & Co., Inc. | Dihydroxypyridopyrazine-1,6-dione compounds useful as hiv integrase inhibitors |
| US20040146512A1 (en) | 2002-10-09 | 2004-07-29 | Arnon Rosenthal | Methods of treating Alzheimer's disease using antibodies directed against amyloid beta peptide and compositions thereof |
| CA2501799C (en) | 2002-10-09 | 2008-06-17 | Pfizer Products Inc. | Pyrazole compounds for treatment of neurodegenerative disorders |
| AU2003301439A1 (en) | 2002-10-16 | 2004-05-04 | Gilead Sciences, Inc. | Pre-organized tricyclic integrase inhibitor compounds |
| US20040220186A1 (en) | 2003-04-30 | 2004-11-04 | Pfizer Inc. | PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease |
| CA2528652A1 (en) | 2003-06-19 | 2004-12-23 | Pfizer Products Inc. | Nk1 antagonist |
| WO2005020991A1 (en) | 2003-08-21 | 2005-03-10 | Pfizer Products, Inc. | Compounds for the treatment of neurodegenerative disorders |
| EP1666061A1 (en) | 2003-09-09 | 2006-06-07 | Takeda Pharmaceutical Company Limited | Use of antibody |
| US7572799B2 (en) | 2003-11-24 | 2009-08-11 | Pfizer Inc | Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors |
| GB0327319D0 (en) | 2003-11-24 | 2003-12-24 | Pfizer Ltd | Novel pharmaceuticals |
| US20070155731A1 (en) | 2004-01-28 | 2007-07-05 | Gabor Butora | Aminocyclopentyl pyridopyrazinone modulators of chemokine receptor activity |
| BRPI0507374A (pt) | 2004-02-02 | 2007-07-10 | Pfizer Prod Inc | moduladores do receptor de histamina-3 |
| EP1725102A4 (en) | 2004-03-09 | 2009-04-29 | Merck & Co Inc | HIV integrase |
| BRPI0509069B8 (pt) | 2004-03-23 | 2021-05-25 | Pfizer Prod Inc | compostos de imidazol e composição farmacêutica que os compreende para o tratamento de distúrbios neurodegenerativos |
| PL1742642T3 (pl) | 2004-04-14 | 2009-06-30 | Gilead Sciences Inc | Analogi fosfonianowe związków inhibitorów integrazy HIV |
| US7456164B2 (en) | 2004-05-07 | 2008-11-25 | Pfizer, Inc | 3- or 4-monosubtituted phenol and thiophenol derivatives useful as H3 ligands |
| EP1595881A1 (en) | 2004-05-12 | 2005-11-16 | Pfizer Limited | Tetrahydronaphthyridine derivates useful as histamine H3 receptor ligands |
| BRPI0513959A (pt) | 2004-07-30 | 2008-05-20 | Rinat Neuroscience Corp | anticorpos dirigidos contra o peptìdeo beta-amilóide, suas composições farmacêuticas, kit e métodos de fabricação dos mesmos |
| FR2877015B1 (fr) | 2004-10-21 | 2007-10-26 | Commissariat Energie Atomique | Revetement nanostructure et procede de revetement. |
| GB0423356D0 (en) | 2004-10-21 | 2004-11-24 | Merck Sharp & Dohme | Therapeutic agents |
| EP1827493A4 (en) | 2004-12-22 | 2009-09-30 | Univ St Louis | USE OF ANTI-ABETA ANTIBODIES FOR THE TREATMENT OF BRAIN TRAUMA |
| UY29504A1 (es) | 2005-04-29 | 2006-10-31 | Rinat Neuroscience Corp | Anticuerpos dirigidos contra el péptido amiloide beta y métodos que utilizan los mismos. |
| EP1881825B1 (en) | 2005-05-10 | 2013-07-24 | Merck Sharp & Dohme Corp. | Hiv integrase inhibitors |
| DE602006019231D1 (en) | 2005-05-12 | 2011-02-10 | Pfizer | Wasserfreie kristalline formen von n-ä1,2-ethoxyethyl)-5-(n-ethyl-n-methylaminoü-7-(4-methylpyridin-2-yl-aminoü-1h-pyrazoloä4,3-düpyrimidin-3-carbonylümethansulfonsäureamid |
| CA2603830A1 (en) | 2005-05-24 | 2006-11-30 | Pharmacia & Upjohn Co Llc | PYRIDINE [2,3-B] PYRAZINONES |
| WO2006126082A2 (en) | 2005-05-24 | 2006-11-30 | Pharmacia & Upjohn Company Llc | Pyridine [3,4-b] pyrazinones as pde-5 inhibitors |
| WO2006126083A1 (en) | 2005-05-24 | 2006-11-30 | Pharmacia & Upjohn Company Llc | Pyridine [3 , 4-b] pyrazinone compounds as pde-5 inhibitors |
| DE602006018301D1 (de) | 2005-06-22 | 2010-12-30 | Pfizer Prod Inc | Histamin-3-rezeptorantagonisten |
| US20070060534A1 (en) | 2005-06-30 | 2007-03-15 | Threshold Pharmaceuticals, Inc. | Anthracycline analogs |
| US8158673B2 (en) | 2005-10-27 | 2012-04-17 | Pfizer Inc. | Histamine-3 receptor antagonists |
| WO2007052124A1 (en) | 2005-11-04 | 2007-05-10 | Pfizer Limited | Tetrahydronaphthyridine derivative |
| WO2007061923A2 (en) | 2005-11-18 | 2007-05-31 | Takeda San Diego, Inc. | Glucokinase activators |
| US20080275251A1 (en) | 2005-11-18 | 2008-11-06 | Glaxo Group Limited | Novel Intermediates and Their Use |
| US20070117839A1 (en) | 2005-11-24 | 2007-05-24 | Eisai R&D Management Co., Ltd. | Two cyclic cinnamide compound |
| EP1953154A4 (en) | 2005-11-24 | 2013-11-20 | Eisai R&D Man Co Ltd | CINNAMIDE COMPOUNDS OF MORPHOLINE TYPE |
| WO2007063385A2 (en) | 2005-12-01 | 2007-06-07 | Pfizer Products Inc. | Spirocyclic amine histamine-3 receptor antagonists |
| WO2007069053A1 (en) | 2005-12-14 | 2007-06-21 | Pfizer Products Inc. | Benzimidazole antagonists of the h-3 receptor |
| AU2007207481B2 (en) * | 2006-01-20 | 2012-08-23 | Merck Sharp & Dohme Corp. | Carbocyclic and heterocyclic arylsulfones as gamma secretase inhibitors |
| WO2007088462A1 (en) | 2006-02-01 | 2007-08-09 | Pfizer Products Inc. | Spirochromane antagonists of the h-3 receptor |
| WO2007088450A2 (en) | 2006-02-01 | 2007-08-09 | Pfizer Products Inc. | Chromane antagonist of the h-3 receptor |
| WO2007099423A1 (en) | 2006-03-02 | 2007-09-07 | Pfizer Products Inc. | 1-pyrrolidine indane derivatives as histamine-3 receptor antagonists |
| TWI378091B (en) | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
| JP2009539762A (ja) | 2006-03-13 | 2009-11-19 | ファイザー・プロダクツ・インク | Ｈ３受容体のテトラリン拮抗薬 |
| ATE513831T1 (de) | 2006-04-21 | 2011-07-15 | Pfizer Prod Inc | Pyridinä3,4-büpyrazinone |
| CA2651153C (en) | 2006-05-15 | 2014-04-29 | Merck & Co., Inc. | Antidiabetic bicyclic compounds |
| NZ572367A (en) | 2006-05-16 | 2011-09-30 | Gilead Sciences Inc | Fused cyclic compounds as integrase inhibitors |
| CA2651396A1 (en) | 2006-05-19 | 2007-11-29 | Eisai R&D Management Co., Ltd. | Urea type cinnamide derivative |
| WO2007138431A2 (en) | 2006-05-30 | 2007-12-06 | Pfizer Products Inc. | Azabicyclic ether histamine-3 antagonists |
| MX2009007782A (es) | 2007-01-22 | 2009-07-31 | Pfizer Prod Inc | Sal de tosilato de un compuesto terapeutico y composiciones farmaceuiticas de la misma. |
| CA2676920A1 (en) | 2007-02-12 | 2008-08-21 | Merck & Co., Inc. | Piperidine derivatives |
| WO2008099210A2 (en) | 2007-02-12 | 2008-08-21 | Merck & Co., Inc. | Piperazine derivatives for treatment of ad and related conditions |
| PE20081791A1 (es) | 2007-02-28 | 2009-02-07 | Eisai Randd Man Co Ltd | Dos derivados ciclicos de oxomorfolina |
| WO2008137102A2 (en) | 2007-05-04 | 2008-11-13 | Torreypines Therapeutics, Inc. | Methods of modulating amyloid beta and compounds useful therefor |
| US8357682B2 (en) | 2007-05-07 | 2013-01-22 | Zhaoning Zhu | Gamma secretase modulators |
| MX2009012163A (es) | 2007-05-11 | 2009-12-01 | Hoffmann La Roche | Hetarilanilinas como moduladores para beta-amiloide. |
| CL2008001540A1 (es) | 2007-05-29 | 2009-05-22 | Sgx Pharmaceuticals Inc | Compuestos derivados de pirrolopiridinas y pirazolopiridinas; composicion farmaceutica; y uso en el tratamiento del cancer. |
| AR066151A1 (es) | 2007-06-01 | 2009-07-29 | Schering Corp | Moduladores de gama secretasa |
| US8426403B2 (en) | 2007-06-01 | 2013-04-23 | Zhaoning Zhu | Gamma secretase modulators |
| WO2008156580A1 (en) | 2007-06-13 | 2008-12-24 | Merck & Co., Inc. | Triazole derivatives for treating alzheimer's disease and related conditions |
| CL2008001914A1 (es) | 2007-06-29 | 2009-07-17 | Schering Corp | Compuestos heterociclicos de nitrogeno y oxigeno,moduladores de gama secretasa, composicion farmaceutica de dichos compuestos; kit farmaceutico y su uso para prevenir o tratar enfermedades asociadas al sistema nervioso central como alzheimer, sindrome de down, enfermedades neurodegenerativas, inhibir el deposito de proteina amiloide. |
| EP2185522A1 (en) | 2007-08-06 | 2010-05-19 | Schering Corporation | Gamma secretase modulators |
| ES2529648T3 (es) | 2007-08-31 | 2015-02-24 | Eisai R&D Management Co., Ltd. | Compuesto policíclico |
| US7935815B2 (en) | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
| EP2200990A1 (en) | 2007-09-06 | 2010-06-30 | Schering Corporation | Gamma secretase modulators |
| MX2010003397A (es) | 2007-09-28 | 2010-04-09 | Schering Corp | Moduladores de la gamma secretasa. |
| GB0720444D0 (en) | 2007-10-18 | 2007-11-28 | Glaxo Group Ltd | Novel compounds |
| MX2010005028A (es) | 2007-11-05 | 2010-05-27 | Schering Corp | Moduladores de gamma secretasa. |
| WO2009073779A1 (en) * | 2007-12-06 | 2009-06-11 | Schering Corporation | Gamma secretase modulators |
| US8426595B2 (en) | 2007-12-11 | 2013-04-23 | Xianhai Huang | Gamma secretase modulators |
| CN101970433A (zh) | 2007-12-11 | 2011-02-09 | 先灵公司 | γ分泌酶调节剂 |
| US20110166132A1 (en) | 2007-12-13 | 2011-07-07 | Amgen Inc. | Gamma Secretase Modulators |
| ATE535515T1 (de) | 2008-01-11 | 2011-12-15 | Hoffmann La Roche | Modulatoren für amyloid beta |
| CN101952275B (zh) | 2008-02-22 | 2014-06-18 | 弗·哈夫曼-拉罗切有限公司 | β-淀粉样蛋白的调节剂 |
| CA2716747A1 (en) | 2008-02-29 | 2009-09-03 | Schering Corporation | Gamma secretase modulators for the treatment of alzheimer's disease |
| US20100137320A1 (en) | 2008-02-29 | 2010-06-03 | Schering Corporation | Gamma secretase modulators |
| CA2722606A1 (en) | 2008-05-05 | 2009-11-12 | Amgen Inc. | Urea compounds as gamma secretase modulators |
| FR2933700B1 (fr) * | 2008-07-08 | 2010-07-30 | Sanofi Aventis | Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique |
| TW201006801A (en) | 2008-07-18 | 2010-02-16 | Lilly Co Eli | Imidazole carboxamides |
| US20110251172A1 (en) | 2008-08-13 | 2011-10-13 | Rivkin Alexey A | Purine derivatives for treatment of alzheimer's disease |
| US8685972B2 (en) | 2008-08-13 | 2014-04-01 | Merck Sharp & Dohme Corp. | Pyrimidine derivatives for treatment of alzheimer's disease |
| CA2733606A1 (en) | 2008-08-27 | 2010-03-04 | Eisai R&D Management Co., Ltd. | Process for preparing certain cinnamide compounds |
| BRPI0920651A2 (pt) | 2008-10-09 | 2016-01-12 | Hoffmann La Roche | moduladores para amiloide beta |
| AU2009313524A1 (en) | 2008-11-06 | 2010-05-14 | Merck Sharp & Dohme Corp. | Gamma secretase modulators |
| JP2012507512A (ja) | 2008-11-06 | 2012-03-29 | アストラゼネカ・アクチエボラーグ | アミロイドβのモジュレーター |
| EP2356115A1 (en) | 2008-11-06 | 2011-08-17 | Schering Corporation | Gamma secretase modulators |
| MX2011004954A (es) | 2008-11-10 | 2011-05-30 | Hoffmann La Roche | Moduladores heterociclicos de gamma-secretasa. |
| WO2010071741A1 (en) | 2008-12-16 | 2010-06-24 | Merck Sharp & Dohme Corp. | Triazole derivatives for treatment of alzheimer's disease |
| WO2010077582A1 (en) | 2008-12-16 | 2010-07-08 | Merck Sharp & Dohme Corp. | Triazole derivatives for treatment of alzheimer's disease |
| PA8854101A1 (es) | 2008-12-18 | 2010-07-27 | Ortho Mcneil Janssen Pharm | Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa |
| PL2379525T3 (pl) | 2008-12-19 | 2016-01-29 | Centrexion Therapeutics Corp | Cykliczne pirymidyno-4-karboksamidy jako antagoniści receptora CCR2 do leczenia stanów zapalnych, astmy oraz COPD |
| AU2009330233A1 (en) | 2008-12-22 | 2011-07-07 | Merck Sharp & Dohme Corp. | Gamma secretase modulators |
| CA2747750A1 (en) | 2008-12-22 | 2010-07-01 | Theodros Asberom | Gamma secretase modulators |
| TW201030002A (en) | 2009-01-16 | 2010-08-16 | Bristol Myers Squibb Co | Bicyclic compounds for the reduction of beta-amyloid production |
| EP2393804B1 (en) | 2009-02-06 | 2014-04-16 | Janssen Pharmaceuticals, Inc. | Novel substituted bicyclic heterocyclic compounds as gamma secretase modulators |
| TWI461425B (zh) | 2009-02-19 | 2014-11-21 | Janssen Pharmaceuticals Inc | 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類 |
| CN102333778B (zh) | 2009-02-26 | 2015-05-13 | 卫材R&D管理有限公司 | 四氢三唑并吡啶衍生物的盐及其晶体 |
| JP2012051805A (ja) | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | テトラヒドロトリアゾロピリジン誘導体の製造方法 |
| JP2012121809A (ja) | 2009-02-26 | 2012-06-28 | Eisai R & D Management Co Ltd | 多環式化合物の製造法およびその中間体 |
| JP2012051806A (ja) | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | イミダゾリルピラジン誘導体 |
| JP2012051807A (ja) | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | アリールイミダゾール化合物 |
| US20120053165A1 (en) | 2009-03-03 | 2012-03-01 | Pfizer Inc. | Novel Phenyl Imidazoles and Phenyl Triazoles As Gamma-Secretase Modulators |
| AP3534A (en) | 2009-08-07 | 2016-01-13 | Dow Agrosciences Llc | Pesticidal compositions |
| CA2776480A1 (en) * | 2009-10-20 | 2011-04-28 | Pfizer Inc. | Novel heteroaryl imidazoles and heteroaryl triazoles as gamma-secretase modulators |
| CA2785499C (en) * | 2009-12-22 | 2017-05-02 | Vertex Pharmaceuticals Incorporated | Isoindolinone inhibitors of phosphatidylinositol 3-kinase |
| EP2691393B1 (en) | 2011-03-31 | 2016-09-14 | Pfizer Inc | Novel bicyclic pyridinones |
| JP6106745B2 (ja) | 2012-05-16 | 2017-04-05 | ヤンセン ファーマシューティカルズ，インコーポレーテッド | （特に）アルツハイマー病の治療に有用な置換３，４−ジヒドロ−２Ｈ−ピリド［１，２−ａ］ピラジン−１，６−ジオン誘導体 |
| TWI614238B (zh) | 2012-09-21 | 2018-02-11 | 必治妥美雅史谷比公司 | 雙（氟烷基）－１，４－苯并二氮呯酮化合物及其前藥 |
| UA110688C2 (uk) | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
| CA2889249C (en) | 2012-12-20 | 2021-02-16 | Francois Paul Bischoff | Tricyclic 3,4-dihydro-2h-pyrido[1,2-a]pyrazine-1,6-dione derivatives as gamma secretase modulators |
| CA2891755C (en) | 2013-01-17 | 2021-10-26 | Janssen Pharmaceutica Nv | Substituted pyrido-piperazinone derivatives as gamma secretase modulators |
| EP3052495B1 (en) | 2013-10-04 | 2019-06-26 | Pfizer Inc | Novel bicyclic pyridinones as gamma-secretase modulators |
| CN115068134B (zh) | 2014-03-21 | 2024-11-19 | 阿莱恩技术有限公司 | 具有弹性体的分段的正畸矫正器 |
| DK3126361T3 (da) | 2014-04-01 | 2020-01-02 | Pfizer | Chromen og 1,1a,2,7b-tetrahydrocyclopropa[c]chromen- pyridopyrazindioner som gamma-sekretase-modulatorer |
-
2013
- 2013-06-09 UA UAA201501621A patent/UA110688C2/uk unknown
- 2013-09-05 MA MA37886A patent/MA37886B1/fr unknown
- 2013-09-06 IN IN1119DEN2015 patent/IN2015DN01119A/en unknown
- 2013-09-06 MY MYPI2015700772A patent/MY181891A/en unknown
- 2013-09-06 SI SI201330390T patent/SI2897956T1/sl unknown
- 2013-09-06 PE PE2015000380A patent/PE20150686A1/es not_active Application Discontinuation
- 2013-09-06 AU AU2013319845A patent/AU2013319845B2/en not_active Ceased
- 2013-09-06 MD MDA20150023A patent/MD4583B1/ro not_active IP Right Cessation
- 2013-09-06 JP JP2015532539A patent/JP5844018B2/ja not_active Expired - Fee Related
- 2013-09-06 SG SG11201501074WA patent/SG11201501074WA/en unknown
- 2013-09-06 PL PL13792085T patent/PL2897956T3/pl unknown
- 2013-09-06 ME MEP-2016-269A patent/ME02571B/me unknown
- 2013-09-06 KR KR1020157006971A patent/KR101725696B1/ko not_active Expired - Fee Related
- 2013-09-06 CN CN201380048982.5A patent/CN104662021B/zh not_active Expired - Fee Related
- 2013-09-06 BR BR112015006436A patent/BR112015006436A2/pt not_active Application Discontinuation
- 2013-09-06 EA EA201590319A patent/EA026668B1/ru not_active IP Right Cessation
- 2013-09-06 AP AP2015008277A patent/AP2015008277A0/xx unknown
- 2013-09-06 PT PT137920856T patent/PT2897956T/pt unknown
- 2013-09-06 HU HUE13792085A patent/HUE031248T2/en unknown
- 2013-09-06 DK DK13792085.6T patent/DK2897956T3/en active
- 2013-09-06 HR HRP20161558TT patent/HRP20161558T1/hr unknown
- 2013-09-06 ES ES13792085.6T patent/ES2609987T3/es active Active
- 2013-09-06 NZ NZ704863A patent/NZ704863A/en not_active IP Right Cessation
- 2013-09-06 LT LTEP13792085.6T patent/LT2897956T/lt unknown
- 2013-09-06 RS RS20161058A patent/RS55426B1/sr unknown
- 2013-09-06 WO PCT/IB2013/058347 patent/WO2014045156A1/en active Application Filing
- 2013-09-06 CA CA2882386A patent/CA2882386C/en active Active
- 2013-09-06 EP EP13792085.6A patent/EP2897956B1/en active Active
- 2013-09-06 GE GEAP201313766A patent/GEP201706659B/en unknown
- 2013-09-06 MX MX2015003637A patent/MX360599B/es active IP Right Grant
- 2013-09-17 TW TW102133670A patent/TWI500616B/zh not_active IP Right Cessation
- 2013-09-19 UY UY0001035039A patent/UY35039A/es not_active Application Discontinuation
- 2013-09-19 AR ARP130103367A patent/AR092628A1/es unknown
- 2013-09-19 US US14/031,163 patent/US8916564B2/en active Active
-
2014
- 2014-11-17 US US14/543,020 patent/US9193726B2/en active Active
-
2015
- 2015-02-05 CR CR20150053A patent/CR20150053A/es unknown
- 2015-02-09 IL IL237163A patent/IL237163A/en active IP Right Grant
- 2015-02-20 ZA ZA2015/01195A patent/ZA201501195B/en unknown
- 2015-02-20 PH PH12015500376A patent/PH12015500376A1/en unknown
- 2015-03-06 TN TNP2015000084A patent/TN2015000084A1/fr unknown
- 2015-03-06 CU CUP2015000021A patent/CU20150021A7/es unknown
- 2015-03-19 NI NI201500038A patent/NI201500038A/es unknown
- 2015-03-20 CL CL2015000717A patent/CL2015000717A1/es unknown
- 2015-03-20 DO DO2015000069A patent/DOP2015000069A/es unknown
- 2015-03-20 GT GT201500069A patent/GT201500069A/es unknown
- 2015-04-20 EC ECIEPI201515594A patent/ECSP15015594A/es unknown
- 2015-10-07 US US14/877,118 patent/US9751877B2/en active Active
-
2016
- 2016-12-14 CY CY20161101290T patent/CY1118662T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ME02571B (me) | Novi biciklički piridinoni | |
| RU2012126083A (ru) | Производные аминооксазина | |
| HRP20192336T1 (hr) | Derivati imidazotiadiazola i imidazopirazina kao inhibitori proteazom aktiviranog receptora 4 (par4) za liječenje agregacije trombocita | |
| MX2015003771A (es) | Formulacion farmaceutica que contiene compuestos de tienotriazolodiazepina. | |
| JP2013517278A5 (forum.php) | ||
| CA2647036A1 (en) | Tetrahydropyridothienopyrimidine compounds and methods of use thereof | |
| JP2016506369A5 (forum.php) | ||
| HRP20191268T1 (hr) | Derivati tieno[2,3-c]pirol-4-ona kao inhibitori erk | |
| JO2602B1 (en) | Derivatives of carboxamide N-heterocyclic triple aryl containing benzimidazole unit and its preparation and use in treatment | |
| JP2014505037A5 (forum.php) | ||
| JP2016501185A5 (forum.php) | ||
| GEP20156267B (en) | 1H-IMIDAZO[4,5-c]QUINOLINONE DERIVATIVES | |
| HRP20211728T1 (hr) | Rsv antivirusni pirazolo- i triazolo-pirimidinski spojevi | |
| JP2016506368A5 (forum.php) | ||
| EA200970656A1 (ru) | Вич-ингибирующие 5,6-замещенные пиримидины | |
| HRP20180483T1 (hr) | Spoj kinolona | |
| NZ603896A (en) | 3-amino-5,6-dihydro-1h-pyrazin-2-one derivatives useful for the treatement of alzheimer's disease and other forms of dementia | |
| ME02906B (me) | Derivati pirazolopirolidina i njihova upotreba u liječenju bolesti | |
| EA201591675A1 (ru) | Замещенные 7-азабициклы и их применение в качестве модуляторов рецепторов орексина | |
| HRP20151111T1 (hr) | Kinuklidinski spojevi kao ligandi nikotinskog acetilkolin alfa-7 receptora | |
| HRP20141171T1 (hr) | Derivati od amida-6,7-dihidro-5h-imidazo-[1,2-a]-imidazol-3-karboksilne kiseline | |
| RU2015101798A (ru) | НОВЫЕ СОДЕРЖАЩИЕ ЗАМЕЩЕННЫЙ МОРФОЛИН ПРОИЗВОДНЫЕ 2, 3-ДИГИДРО-1Н-ИМИДАЗО{ 1, 2-а} ПИРИМИДИН-5-ОНА И 1, 2, 3, 4-ТЕТРАГИДРОПИРИМИДО{ 1, 2-а} ПИРИМИДИН-6-ОНА, ИХ ПОЛУЧЕНИЕ И ИХ ФАРМАЦЕВТИЧЕСКОЕ ПРИМЕНЕНИЕ | |
| JP2020536116A5 (forum.php) | ||
| RU2015101102A (ru) | Гетероароматическое метильное производное циклического амина | |
| JP2013540712A5 (forum.php) |