ME02201B - Pripravci u krutom stanju - Google Patents
Pripravci u krutom stanjuInfo
- Publication number
- ME02201B ME02201B MEP-2015-155A MEP15515A ME02201B ME 02201 B ME02201 B ME 02201B ME P15515 A MEP15515 A ME P15515A ME 02201 B ME02201 B ME 02201B
- Authority
- ME
- Montenegro
- Prior art keywords
- preparation according
- compound
- solid dispersion
- methyl
- surfactant
- Prior art date
Links
- 239000008247 solid mixture Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 9
- 239000007962 solid dispersion Substances 0.000 claims 8
- 239000004094 surface-active agent Substances 0.000 claims 5
- 229940125890 compound Ia Drugs 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- -1 4,1-phenylene Chemical group 0.000 claims 3
- 125000004485 2-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])C1([H])* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical group [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 claims 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 1
- 229940123066 Polymerase inhibitor Drugs 0.000 claims 1
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims 1
- RWRDLPDLKQPQOW-AMVILDFXSA-N [2H]C1N(CCC1)[2H] Chemical compound [2H]C1N(CCC1)[2H] RWRDLPDLKQPQOW-AMVILDFXSA-N 0.000 claims 1
- 125000001821 azanediyl group Chemical group [H]N(*)* 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 229920001531 copovidone Polymers 0.000 claims 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N formaldehyde Natural products O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 1
- 229920001519 homopolymer Polymers 0.000 claims 1
- 229920001477 hydrophilic polymer Polymers 0.000 claims 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 1
- 239000008180 pharmaceutical surfactant Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 229940113116 polyethylene glycol 1000 Drugs 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000006104 solid solution Substances 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Claims (16)
1.Kruti pripravak koji sadržava(l) spoj ili njegovu farmaceutsku prihvatljivu sol, u amorfnom obliku,(2) farmaceutski prihvatljiv hidrofilni polimer i(3) po izboru, farmaceutski prihvatljiv surfaktant,naznačen time, da je navedeni spoj odabran iz skupine koju čine :dimetil (2S,2'S )-1,1'-( (2S,2'S)-2,2'-( 4,4'-( (2S,SS)-I-( 4-tert-butilfenil )pirolidin-2,5-diil)bis( 4,1-fenilen) )bis( azanediil )bis( oksometilen )bis(pirolidin-2,1-d iii) )bis(3-metil-l-oksobutan-2,1-diil)dikarbamat(Spoj IA),metil [(2S)-l- {(2S)-2-[ 4-( 4-{5-( 4-{2-[ (2S )-1-{ (2S)- 2-[ (metoksikarbonil )amino]-3-metilbutanoil}pirolid in-2-il]-1 H-imidazol-4-il}fenil)-1-[ 6-(piperidin-1-il)piridin- 3-il]-1 H-pirol-2-il}fenil)-1 H-imidazol-2-il] pirolidin-1-il}-3-metil-1-oksobutan-2-il] karbamat (Spoj IB),metil { (2S,3R)-l-[ (2S)-2-{ 6-[ ( 2R,SR)-l-( 4-tert-butilfenil )-5-(2-{ (2S)-l-[N-(metoksikarbonil)-O-metil-L -treoni l] pirolidin-2 -il} -l H-benzim i dazol-6-i l )pirolidin-2 -il] -l H -benz i m i dazol-2-il}pirolidin-1-il]-3-metoksi-1-oksobutan-2-il}karbamat (Spoj IC) imetil { ( 2S )-l-[ (2S )-2-{5-[ ( 2R,SR)-l- [2,5-difluoro-4-(trifluormetil )fenil]-5-{2-[ (2S)-l { (2S)-2-[ (metoksi ka rb on i l )a m i no]-3-meti l buta noi l} pi roi id in-2 -i l] -l H-ben zi m id a zoi-5 -i l} piro l id in-2- i l]lH-benzimidazol-2-il}pirolidin-1-il]-3-metil-1-oksobutan-2-il}karbamat (Spoj ID ) ipri čemu su navedeni spoj ili sol i navedeni polimer u obliku čvrste disperzije
2.Pripravak u skladu s patentnim zahtjevom 1, naznačen time, da spomenuti polimer ima vrijednost Tg barem 50 °C.
3.Pripravak u skladu s patentnim zahtjevom 2, naznačen time, da dodatno sadržava navedeni surfaktant.
4.Pripravak u skladu s patentnim zahtjevom 3, naznačen time, da navedena kruta disperzija sadržava navedeni surfaktant.
5.Pripravak u skladu s patentnim zahtjevom 3, naznačen time, da je navedeni polimer homopolimer ili kopolimer N-vinil pirolidona.
6.Pripravak u skladu s patentnim zahtjevom 3, naznačen time, da je navedeni polimer kopovidon.
7.Pripravak u skladu s patentnim zahtjevom 6, naznačen time, da je navedeni surfaktant D- alfa-tokoferil polietilenglikol 1000 sukcinat.
8.Pripravak u skladu s patentnim zahtjevom 3, naznačen time, da je navedena čvrsta disperzija amorfna kruta disperzija.
9.Pripravak u skladu s patentnim zahtjevom 3, naznačen time, da je navedena kruta disperzija čvrsta otopina koja sadržava navedeni surfaktant.
10.Pripravak u skladu s patentnim zahtjevom 1, naznačen time, da dodatno sadržava drugi anti-HCV agens.
11.Pripravak u skladu s patentnim zahtjevom 1, naznačen time, da dodatno sadržava inhibitor proteaze za HCV.
12.Pripravak u skladu s patentnim zahtjevom 1, naznačen time, da dodatno sadržava inhibitor polimeraze za HCV.
13. Pripravak u skladu s patentnim zahtjevom 3, naznačen time, da je navedeni spoj spoj IA.
14. Pripravak u skladu s jednim od patentnih zahtjeva 1 do 12, naznačen time, da je navedeni spoj spoj IA.
15. Pripravak u skladu s patentnim zahtjevom 7, naznačen time, da navedena kruta disperzija sadržava navedeni surfaktant, a navedeni spoj je spoj IA.
16. Pripravak u skladu s patentnim zahtjevom 15, naznačen time, da je navedena čvrsta disperzija amorfna kruta disperzija
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35355310P | 2010-06-10 | 2010-06-10 | |
| US12/813,301 US8691938B2 (en) | 2009-06-11 | 2010-06-10 | Anti-viral compounds |
| PCT/US2011/039769 WO2011156578A1 (en) | 2010-06-10 | 2011-06-09 | Solid compositions |
| EP11727080.1A EP2579854B2 (en) | 2010-06-10 | 2011-06-09 | Solid compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME02201B true ME02201B (me) | 2016-02-20 |
Family
ID=44317041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2015-155A ME02201B (me) | 2010-06-10 | 2011-06-09 | Pripravci u krutom stanju |
Country Status (41)
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8546405B2 (en) | 2008-12-23 | 2013-10-01 | Abbott Laboratories | Anti-viral compounds |
| RU2505540C2 (ru) | 2008-12-23 | 2014-01-27 | Эббви Инк. | Антивирусные соединения |
| CA2758484A1 (en) | 2009-04-15 | 2010-10-21 | David A. Degoey | Anti-viral compounds |
| PL2628481T3 (pl) | 2009-06-11 | 2016-08-31 | Abbvie Bahamas Ltd | Tripodstawione heterocykle jako inhibitory replikacji wirusa HCV zapalenia wątroby typu C |
| US8937150B2 (en) | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
| NZ605440A (en) | 2010-06-10 | 2014-05-30 | Abbvie Bahamas Ltd | Solid compositions comprising an hcv inhibitor |
| US8552047B2 (en) | 2011-02-07 | 2013-10-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US9546160B2 (en) | 2011-05-12 | 2017-01-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
| BR112014000563A2 (pt) | 2011-07-09 | 2019-12-10 | Sunshine Lake Pharma Co., Ltd | composto, composição farmacêutica, e, uso do composto |
| EP2742047B1 (en) | 2011-08-10 | 2021-05-12 | Janssen Sciences Ireland Unlimited Company | Antibacterial piperidinyl substituted 3,4-dihydro-1h-[1,8]naphthyridinones |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| SE1450130A1 (sv) | 2011-10-21 | 2014-05-07 | Abbvie Inc | Förfaranden för att behandla hcv innefattande minst två direktverkande antivirala agenser, ribavirin men inte interferon |
| US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| AU2013201758B2 (en) * | 2011-10-21 | 2014-11-27 | Abbvie Ireland Unlimited Company | Methods for treating HCV |
| SE1450131A1 (sv) | 2011-10-21 | 2014-05-07 | Abbvie Inc | DAA-kombinationsbehandling (t.ex. med ABT-072 eller ABT-333)för användning vid behandling av HCV |
| AU2015100285B4 (en) * | 2011-10-21 | 2015-06-11 | Abbvie Ireland Unlimited Company | Methods for treating HCV |
| EP2797594A1 (en) * | 2011-12-28 | 2014-11-05 | AbbVie Inc. | Methods for treating hcv |
| EP2907505A3 (en) * | 2011-12-29 | 2015-12-30 | Abbvie Inc. | Solid compositions comprising an HCV inhibitor |
| US9034832B2 (en) | 2011-12-29 | 2015-05-19 | Abbvie Inc. | Solid compositions |
| US9326973B2 (en) | 2012-01-13 | 2016-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| JP2015516421A (ja) * | 2012-05-07 | 2015-06-11 | ブリストル−マイヤーズ・スクイブ・ホールディングス・アイルランドＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｈｏｌｄｉｎｇｓ Ｉｒｅｌａｎｄ | １，１−ジメチルエチル［（１ｓ）−１−｛［（２ｓ，４ｒ）−４−（７−クロロ−４メトキシイソキノリン−１−イルオキシ）−２−（｛（１ｒ，２ｓ）−１−［（シクロプロピルスルホニル）カルバモイル］−２−エテニルシクロプロピル｝カルバモイル）ピロリジン−１−イル］カルボニル｝−２，２−ジメチルプロピル］カルバメートの経口固形製剤 |
| TWI610916B (zh) | 2012-08-03 | 2018-01-11 | 廣東東陽光藥業有限公司 | 作爲丙型肝炎抑制劑的橋環化合物及其在藥物中的應用 |
| WO2014082380A1 (en) | 2012-11-29 | 2014-06-05 | Sunshine Lake Pharma Co., Ltd. | Fused ring compounds as hepatitis c virus inhibitors, pharmaceutical compositions and uses thereof |
| WO2014082379A1 (en) | 2012-11-29 | 2014-06-05 | Sunshine Lake Pharma Co.,Ltd. | Spiro ring compound as hepatitis c virus (hcv) inhibitor and uses thereof field of the invention |
| EP2950786B1 (en) | 2013-01-31 | 2019-11-27 | Gilead Pharmasset LLC | Combination formulation of two antiviral compounds |
| US11484534B2 (en) | 2013-03-14 | 2022-11-01 | Abbvie Inc. | Methods for treating HCV |
| BR112015021692A2 (pt) * | 2013-03-15 | 2017-07-18 | Boehringer Ingelheim Int | formulação de dosagem oral sólida de inibidor de hcv no estado amorfo |
| US20150023913A1 (en) | 2013-07-02 | 2015-01-22 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| CA2916912A1 (en) | 2013-07-02 | 2015-01-08 | Abbvie Inc. | Methods for treating hcv |
| US9717712B2 (en) | 2013-07-02 | 2017-08-01 | Bristol-Myers Squibb Company | Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis C virus |
| US9775831B2 (en) | 2013-07-17 | 2017-10-03 | Bristol-Myers Squibb Company | Combinations comprising biphenyl derivatives for use in the treatment of HCV |
| CA3042642A1 (en) | 2013-08-12 | 2015-02-19 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
| JP2016529293A (ja) | 2013-08-27 | 2016-09-23 | ギリアド ファーマセット エルエルシー | ２つの抗ウイルス化合物の組合せ製剤 |
| AU2014346455A1 (en) * | 2013-11-11 | 2016-05-26 | Impax Laboratories, Inc. | Rapidly disintegrating formulations and methods of use |
| JP6232262B2 (ja) * | 2013-11-13 | 2017-11-15 | アクアス株式会社 | 徐放性を有する固形水処理剤、およびその製造方法 |
| KR101561964B1 (ko) | 2013-11-15 | 2015-10-20 | 한국과학기술연구원 | 옥사졸리디논 화합물 및 이를 포함하는 c형 간염 예방 또는 치료용 약학 조성물 |
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| WO2015110048A1 (en) | 2014-01-23 | 2015-07-30 | Sunshine Lake Pharma Co., Ltd. | Bridged ring compounds as hepatitis c virus inhibitors, pharmaceutical compositions and uses thereof |
| KR20230107902A (ko) | 2014-02-05 | 2023-07-18 | 머크 샤프 앤드 돔 엘엘씨 | Cgrp-활성 화합물에 대한 정제 제제 |
| US12168004B2 (en) | 2014-02-05 | 2024-12-17 | Merck Sharp & Dohme Llc | Treatment of migraine |
| WO2015171162A1 (en) * | 2014-05-09 | 2015-11-12 | Abbvie Inc. | Anti-viral compound |
| TWI721947B (zh) | 2014-06-11 | 2021-03-21 | 美商基利法瑪席特有限責任公司 | 抗病毒化合物的固態形式 |
| EP3169315B1 (en) | 2014-07-17 | 2020-06-24 | Pharmaceutical Manufacturing Research Services, Inc. | Immediate release abuse deterrent liquid fill dosage form |
| US20160106737A1 (en) | 2014-10-20 | 2016-04-21 | Pharmaceutical Manufacturing Research Services, Inc. | Extended Release Abuse Deterrent Liquid Fill Dosage Form |
| US20160193151A1 (en) * | 2015-01-06 | 2016-07-07 | Maria Del Pilar Noriega Escobar | Dosage form incorporating an amorphous drug solid solution |
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