CO6660490A2 - Composiciones solidas - Google Patents

Composiciones solidas

Info

Publication number
CO6660490A2
CO6660490A2 CO12234723A CO12234723A CO6660490A2 CO 6660490 A2 CO6660490 A2 CO 6660490A2 CO 12234723 A CO12234723 A CO 12234723A CO 12234723 A CO12234723 A CO 12234723A CO 6660490 A2 CO6660490 A2 CO 6660490A2
Authority
CO
Colombia
Prior art keywords
pyrrolidin
methyl
compound
bis
oxobutan
Prior art date
Application number
CO12234723A
Other languages
English (en)
Inventor
Bernd Liepold
Tina Jung
Peter Hoilg
Rudolf Schroeder
Nancy E Sever
Justin Lafountaine
Brent D Sinclair
Yi Gao
Jianwei Wu
Bryan K Erickson
Simon Kullmann
Ulrich Westedt
Mirko Paul
Tanja Heitermann
Renato Koenig
Madlen Thiel
Gerd Woehrle
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44317041&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6660490(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US12/813,301 external-priority patent/US8691938B2/en
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of CO6660490A2 publication Critical patent/CO6660490A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

La presente invención se refiere a una composición sólida que comprende (1) un compuesto, o una sal farmacéuticamente aceptable de éste, en una forma amorfa; (2) un polímero hidrofilico farmacéuticamente aceptable, y opcionalmente; (3) un agente tensioactivo farmacéuticamente aceptable, en donde dicho compuesto se selecciona del grupo que consiste en el (2S,2 S)- 1,1 - ((2S, 2 S) -2,2 -(4,4 - ((2S, 5S)- 1- (4-ter-butilfenil)pirrolidin-2, 5-diil) bis (4, 1 -fenileno) ) bis (azanodiil) bis (oxometileno) bis (pirrolidin-2, 1-diil))bis(3-metil-1-oxobutan-2, 1-diiI)dicarbamato de dimetilo (compuesto lA), el [(2S) -1 -{(2S) -2-[4- (4-{5-(4-{2-[(2S)- 1 -{(2S)-2-[(metoxicarbonil)amino]-3-metilbutanoíljpirrolidin-2-iI]-1H-imidazol-4-iI-feniil)-1-[6-(piperidin-1-il)piridin-3-iI]-1H-pirrol-2-il}fenil)-1H-imidazol-2-il]pirrolidin- 1- il}-3-metil-1-oxobutan-2-il]carbamato de metilo (compuesto I), el {(2S,3R)-1-[(2S)-2-{6-[(2R, 5R)- 1 -(4-ter-butilfenil)-5-(2-{(2S)- 1 -[N-(metoxicarbonil)-O-metil-Ltreonil]pirrolidin-2-il}- 1H-benzimidazol-6-iI)pirrolidin-2-il]- 1H-benzimidazol-2-iI} pirrolidin- 1 -il]-3-metoxi- 1 -oxobutan-2-il}carbamato de metilo (compuesto l) y el {(2S) -1-[(2S) -2-{5-[(2R, 5R) -7-[2, 5-difluoro-4-(trifluorometil) feniil]-5-{2-[(2S) -1 -{(2S) - 2-[(metoxicarbonil)amino]-3-metilbutanoílpirrolidin-2-il]- 1H-benzimidazol-5-iI}pirrolidin-2-iI]- 1H-benzimidazol-2-il}pirrolidin-1-il]-3-metil-1-oxobutan-2-il)carbamato de metilo (compuesto I) .
CO12234723A 2010-06-10 2012-12-27 Composiciones solidas CO6660490A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35355310P 2010-06-10 2010-06-10
US12/813,301 US8691938B2 (en) 2009-06-11 2010-06-10 Anti-viral compounds

Publications (1)

Publication Number Publication Date
CO6660490A2 true CO6660490A2 (es) 2013-04-30

Family

ID=44317041

Family Applications (1)

Application Number Title Priority Date Filing Date
CO12234723A CO6660490A2 (es) 2010-06-10 2012-12-27 Composiciones solidas

Country Status (41)

Country Link
US (2) US8686026B2 (es)
EP (3) EP2954892B1 (es)
JP (1) JP5814356B2 (es)
KR (3) KR101481395B1 (es)
CN (1) CN103209686B (es)
AR (1) AR083240A1 (es)
AU (1) AU2011264823B2 (es)
BR (2) BR212012031500U2 (es)
CA (1) CA2802180C (es)
CL (1) CL2012003470A1 (es)
CO (1) CO6660490A2 (es)
CR (1) CR20120650A (es)
CY (2) CY1116748T1 (es)
DK (2) DK2954892T3 (es)
DO (1) DOP2012000307A (es)
EA (1) EA024538B1 (es)
EC (1) ECSP13012382A (es)
ES (2) ES2546767T5 (es)
GT (1) GT201200332A (es)
HK (1) HK1184068A1 (es)
HR (2) HRP20150926T4 (es)
HU (2) HUE039719T2 (es)
IL (1) IL223535A (es)
LT (1) LT2954892T (es)
ME (1) ME02201B (es)
MX (1) MX2012014384A (es)
MY (1) MY164607A (es)
NZ (1) NZ605440A (es)
PE (1) PE20131036A1 (es)
PL (2) PL2954892T3 (es)
PT (2) PT2579854E (es)
RS (2) RS57982B1 (es)
SG (1) SG186251A1 (es)
SI (2) SI2954892T1 (es)
SM (1) SMT201500263B (es)
TR (1) TR201815161T4 (es)
TW (1) TWI487700B (es)
UA (1) UA105434C2 (es)
UY (1) UY33446A (es)
WO (1) WO2011156578A1 (es)
ZA (1) ZA201300112B (es)

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