ME00089B - Postupak za produkciju beraprosta i njegovih soli - Google Patents

Postupak za produkciju beraprosta i njegovih soli

Info

Publication number
ME00089B
ME00089B MEP-2008-187A MEP2008187A ME00089B ME 00089 B ME00089 B ME 00089B ME P2008187 A MEP2008187 A ME P2008187A ME 00089 B ME00089 B ME 00089B
Authority
ME
Montenegro
Prior art keywords
beraprost
salts
production
formula
preparation
Prior art date
Application number
MEP-2008-187A
Other languages
English (en)
Inventor
Tibor Szabo
József Bódi
Gyula Dalmadi
Kardos Zsuzsanna Baloghne
Zoltán Szeverenyi
Original Assignee
Chinoin Gyógyszer Es Vegyeszeti Termekek Gyára Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyógyszer Es Vegyeszeti Termekek Gyára Zrt filed Critical Chinoin Gyógyszer Es Vegyeszeti Termekek Gyára Zrt
Publication of ME00089B publication Critical patent/ME00089B/me

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Furan Compounds (AREA)
  • Error Detection And Correction (AREA)

Abstract

Predmetni pronalazak odnosi se na postupak za pripremanje beraprosta formule (l)korišćenjem novih intermedijera. Predmetni pronalazak odnosi se na postupak za pripremanje beraprosta formule (l)korišćenjem novih intermedijera.
MEP-2008-187A 2001-07-30 2002-07-25 Postupak za produkciju beraprosta i njegovih soli ME00089B (me)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0103089A HU227157B1 (en) 2001-07-30 2001-07-30 Production of beraprost ester by selective oxidation
PCT/HU2002/000074 WO2003011849A1 (en) 2001-07-30 2002-07-25 Process for the production of beraprost and its salts

Publications (1)

Publication Number Publication Date
ME00089B true ME00089B (me) 2010-10-10

Family

ID=90001541

Family Applications (2)

Application Number Title Priority Date Filing Date
MEP-2008-187A ME00089B (me) 2001-07-30 2002-07-25 Postupak za produkciju beraprosta i njegovih soli
MEP-187/08A MEP18708A (en) 2001-07-30 2002-07-25 Process for the production of beraprost and its salts

Family Applications After (1)

Application Number Title Priority Date Filing Date
MEP-187/08A MEP18708A (en) 2001-07-30 2002-07-25 Process for the production of beraprost and its salts

Country Status (26)

Country Link
US (1) US7005527B2 (me)
EP (1) EP1412342B1 (me)
JP (1) JP4440506B2 (me)
KR (1) KR100604699B1 (me)
CN (2) CN100347165C (me)
AT (1) ATE407127T1 (me)
AU (1) AU2002321670B8 (me)
BR (1) BR0211514A (me)
CA (1) CA2453649C (me)
CU (1) CU23324B7 (me)
DE (1) DE60228724D1 (me)
ES (1) ES2314083T3 (me)
HK (2) HK1068877A1 (me)
HR (1) HRP20040198B1 (me)
HU (1) HU227157B1 (me)
IL (2) IL159814A0 (me)
ME (2) ME00089B (me)
MX (1) MXPA04000847A (me)
NO (1) NO328695B1 (me)
NZ (1) NZ531264A (me)
PL (1) PL216072B1 (me)
RS (1) RS51314B (me)
RU (1) RU2272033C2 (me)
UA (1) UA75692C2 (me)
WO (1) WO2003011849A1 (me)
ZA (1) ZA200400748B (me)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0215757D0 (en) * 2002-07-08 2002-08-14 Cascade Biochem Ltd Benzoprostacyclin intermediates methods for their preparation and products derived therefrom
CN105418567B (zh) 2011-06-16 2019-09-06 琅歌生物技术股份有限公司 贝前列素的生产方法
CN102952107B (zh) * 2011-08-29 2015-10-07 上海天伟生物制药有限公司 一种高纯度的贝前列素钠及其制备方法和用途
WO2013040068A2 (en) * 2011-09-12 2013-03-21 Irix Pharmaceuticals, Inc. Process for preparing synthetic prostacyclins
CN103509044A (zh) * 2012-06-21 2014-01-15 上海天伟生物制药有限公司 贝前列素钠中间体及其制备方法
KR20150132440A (ko) * 2013-03-15 2015-11-25 젬머스 파마 인코포레이티드 바이러스 감염의 치료제로서의 베라프로스트 이성질체
CN103242274B (zh) * 2013-05-22 2014-11-05 孙威 一种贝前列素钠化合物及其制备方法
CN106573904B (zh) * 2014-05-20 2019-11-08 朗格生物技术公共公益股份有限公司 用于产生贝前列素及其衍生物的方法
US9765047B2 (en) * 2015-08-12 2017-09-19 United Therapeutics Corporation Process for making beraprost
HU231080B1 (hu) * 2016-04-05 2020-07-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Eljárás optikailag aktív Beraprost előállítására
HU231212B1 (hu) * 2018-04-16 2021-11-29 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Eljárás iloprost előállítására
US10577340B1 (en) * 2018-11-26 2020-03-03 Chirogate International Inc. Beraprost-314d crystals and methods for preparation thereof
US12042503B2 (en) 2020-02-12 2024-07-23 Cytoagents, Inc. Compositions and methods for treating coronavirus infections
WO2023276983A1 (ja) * 2021-06-28 2023-01-05 大内新興化学工業株式会社 ベラプロストまたは光学活性体の合成中間体およびその製造方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5931510B2 (ja) * 1979-09-03 1984-08-02 東レ株式会社 ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体
JPS58124778A (ja) * 1982-01-20 1983-07-25 Toray Ind Inc ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体
JPS59134787A (ja) * 1983-01-19 1984-08-02 Toray Ind Inc ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体の製造法
HU197733B (en) * 1985-05-29 1989-05-29 Chinoin Gyogyszer Es Vegyeszet Process for producing ephedrin-salts of 7-oxo-prosta-cyclin derivatives
CA1284642C (en) * 1986-03-31 1991-06-04 Hikozo Iwakura Prostacyclin (pgi ) analogues
JP2594118B2 (ja) * 1987-07-01 1997-03-26 塩野義製薬株式会社 ベンゾジオキサンプロスタサイクリン類縁体
JP2542429B2 (ja) * 1987-10-27 1996-10-09 三共株式会社 オクタヒドロナフタリン置換オキシム誘導体
GB8929059D0 (en) * 1989-12-22 1990-02-28 Leo Pharm Prod Ltd Chemical compounds
JP3025056B2 (ja) * 1991-03-12 2000-03-27 財団法人微生物化学研究会 ２，６−ジデオキシ−２−フルオロ−ｌ−タロピラノース誘導体の製造法
JP3024298B2 (ja) * 1991-09-13 2000-03-21 住友化学工業株式会社 シクロペンテンエステル類及びその利用
JPH09132589A (ja) * 1995-09-08 1997-05-20 Microbial Chem Res Found 糖部分の水酸基をモノ−または−ジ−ｏ−アミノアルカノイル化された含フッ素アンスラサイクリン誘導体

Also Published As

Publication number Publication date
CN1235896C (zh) 2006-01-11
WO2003011849A1 (en) 2003-02-13
HRP20040198B1 (en) 2012-02-29
HUP0103089D0 (en) 2001-10-28
NZ531264A (en) 2005-09-30
RS8604A (en) 2007-02-05
KR100604699B1 (ko) 2006-07-31
RU2004105959A (ru) 2005-03-27
HRP20040198A2 (en) 2005-04-30
RS51314B (sr) 2010-12-31
HK1068877A1 (en) 2005-05-06
KR20040043169A (ko) 2004-05-22
CA2453649C (en) 2009-12-22
US7005527B2 (en) 2006-02-28
EP1412342A1 (en) 2004-04-28
RU2272033C2 (ru) 2006-03-20
PL216072B1 (pl) 2014-02-28
ZA200400748B (en) 2005-01-26
HUP0103089A3 (en) 2005-01-28
ES2314083T3 (es) 2009-03-16
IL159814A0 (en) 2004-06-20
US20040209945A1 (en) 2004-10-21
IL159814A (en) 2008-08-07
BR0211514A (pt) 2004-09-14
MXPA04000847A (es) 2004-03-26
AU2002321670B8 (en) 2008-09-11
WO2003011849A8 (en) 2004-03-11
ATE407127T1 (de) 2008-09-15
EP1412342B1 (en) 2008-09-03
MEP18708A (en) 2010-06-10
CN100347165C (zh) 2007-11-07
CA2453649A1 (en) 2003-02-13
CN1537107A (zh) 2004-10-13
PL367298A1 (en) 2005-02-21
CU23324B7 (es) 2008-11-27
JP2003055368A (ja) 2003-02-26
DE60228724D1 (de) 2008-10-16
NO328695B1 (no) 2010-04-26
AU2002321670B2 (en) 2008-08-14
HU227157B1 (en) 2010-09-28
CN1680351A (zh) 2005-10-12
NO20040388L (no) 2004-01-29
UA75692C2 (uk) 2006-05-15
JP4440506B2 (ja) 2010-03-24
HK1078857A1 (en) 2006-03-24
HUP0103089A2 (hu) 2003-07-28

Similar Documents

Publication Publication Date Title
HK1068877A1 (en) Process for the production of beraprost and its salts
HUP0302345A2 (hu) Új triazolo-pirimidin-vegyületek, ezek intermedierjei és eljárás az előállításukra
MEP14208A (en) Quinoline and isoquinoline derivatives, method for the production thereof and use thereof as anti-inflammatory agents
BR0206355A (pt) Composições abrilhantadoras ópticas, sua produção e seu uso
BR0214268A (pt) Aperfeiçoamentos em relação a abrilhantadores ópticos
HRP20050803B1 (hr) Novitetna kristalna modifikacija anhidrata boskalida
EA200600621A1 (ru) Производные тетрагидронафталина, способ их получения и их применение в качестве противовоспалительных средств
BRPI0416678A (pt) pirazolpirimidinas
ATE287889T1 (de) Cefalosporin-zwischenprodukte
DE60041001D1 (de) Substituierte homopiperidylbenzimidazolanaloga als fundusrelaxantien
NO20010265D0 (no) 3-(1-hydroksy-pentyliden)-5-nitro-3H-benzofuran-2-on, fremgangsmåte for fremstilling og anvendelse derav
PT1206452E (pt) Processo de preparacao de compostos benzoper-hidroisoindole
HRP20050450A2 (en) Method of preparing inhibitors of phosphodiesterase-4
JO2433B1 (en) Preparation of heterocyclic lindane landscapes
NO20033049D0 (no) Fremgangsmåte for fremstilling av (+/-) trans-4-p-fluorfenyl- 3-hydroksymetyl-1
GB0320738D0 (en) Novel process
YU74401A (sh) Postupak za dobijanje 2s-3-amino-3-arilpropionske kiseline i njenih derivata
HUP0303153A2 (hu) N-metil-paroxetin és intermedierjei előállítására
FI20030026A0 (fi) Menetelmä substituoitujen imidatsolijohdannaisten valmistamiseksi ja menetelmässä käytettäviä välituotteita
NO20024999L (no) Syntese av mellomprodukter for fremstilling av vitamin D- derivater
HU0001287D0 (en) New intermediate and process for its production
UY26778A1 (es) Derivados de ácido heteroarilalcanoico.