HK1078857A1 - Intermediates for the production of beraprost and its salts - Google Patents

Intermediates for the production of beraprost and its salts

Info

Publication number
HK1078857A1
HK1078857A1 HK05110705A HK05110705A HK1078857A1 HK 1078857 A1 HK1078857 A1 HK 1078857A1 HK 05110705 A HK05110705 A HK 05110705A HK 05110705 A HK05110705 A HK 05110705A HK 1078857 A1 HK1078857 A1 HK 1078857A1
Authority
HK
Hong Kong
Prior art keywords
beraprost
intermediates
salts
production
new
Prior art date
Application number
HK05110705A
Other languages
English (en)
Inventor
T Tibor Szabo
J Jozsef Bodi
G Gyula Dalmadi
Z Zsuzsanna Baloghne Kardos
Z Zoltan Szeverenzl
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Publication of HK1078857A1 publication Critical patent/HK1078857A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
HK05110705A 2001-07-30 2005-11-25 Intermediates for the production of beraprost and its salts HK1078857A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0103089A HU227157B1 (en) 2001-07-30 2001-07-30 Production of beraprost ester by selective oxidation

Publications (1)

Publication Number Publication Date
HK1078857A1 true HK1078857A1 (en) 2006-03-24

Family

ID=90001541

Family Applications (2)

Application Number Title Priority Date Filing Date
HK05101229A HK1068877A1 (en) 2001-07-30 2005-02-16 Process for the production of beraprost and its salts
HK05110705A HK1078857A1 (en) 2001-07-30 2005-11-25 Intermediates for the production of beraprost and its salts

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK05101229A HK1068877A1 (en) 2001-07-30 2005-02-16 Process for the production of beraprost and its salts

Country Status (26)

Country Link
US (1) US7005527B2 (xx)
EP (1) EP1412342B1 (xx)
JP (1) JP4440506B2 (xx)
KR (1) KR100604699B1 (xx)
CN (2) CN100347165C (xx)
AT (1) ATE407127T1 (xx)
AU (1) AU2002321670B8 (xx)
BR (1) BR0211514A (xx)
CA (1) CA2453649C (xx)
CU (1) CU23324B7 (xx)
DE (1) DE60228724D1 (xx)
ES (1) ES2314083T3 (xx)
HK (2) HK1068877A1 (xx)
HR (1) HRP20040198B1 (xx)
HU (1) HU227157B1 (xx)
IL (2) IL159814A0 (xx)
ME (2) MEP18708A (xx)
MX (1) MXPA04000847A (xx)
NO (1) NO328695B1 (xx)
NZ (1) NZ531264A (xx)
PL (1) PL216072B1 (xx)
RS (1) RS51314B (xx)
RU (1) RU2272033C2 (xx)
UA (1) UA75692C2 (xx)
WO (1) WO2003011849A1 (xx)
ZA (1) ZA200400748B (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0215757D0 (en) * 2002-07-08 2002-08-14 Cascade Biochem Ltd Benzoprostacyclin intermediates methods for their preparation and products derived therefrom
WO2012174407A1 (en) 2011-06-16 2012-12-20 Lung LLC Method of producing beraprost
CN102952107B (zh) * 2011-08-29 2015-10-07 上海天伟生物制药有限公司 一种高纯度的贝前列素钠及其制备方法和用途
WO2013040068A2 (en) * 2011-09-12 2013-03-21 Irix Pharmaceuticals, Inc. Process for preparing synthetic prostacyclins
CN103509044A (zh) * 2012-06-21 2014-01-15 上海天伟生物制药有限公司 贝前列素钠中间体及其制备方法
KR20150132440A (ko) * 2013-03-15 2015-11-25 젬머스 파마 인코포레이티드 바이러스 감염의 치료제로서의 베라프로스트 이성질체
CN103242274B (zh) * 2013-05-22 2014-11-05 孙威 一种贝前列素钠化合物及其制备方法
WO2015179427A1 (en) * 2014-05-20 2015-11-26 Lung Biotechnology Pbc Methods for producing beraprost and its derivatives
CN108463457B (zh) * 2015-08-12 2019-06-28 联合治疗学有限公司 制备贝前列素的方法
HU231080B1 (hu) * 2016-04-05 2020-07-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Eljárás optikailag aktív Beraprost előállítására
HU231212B1 (hu) * 2018-04-16 2021-11-29 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Eljárás iloprost előállítására
US10577340B1 (en) 2018-11-26 2020-03-03 Chirogate International Inc. Beraprost-314d crystals and methods for preparation thereof
TW202317527A (zh) * 2021-06-28 2023-05-01 日商大內新興化學工業股份有限公司 貝前列素或光學活性物之合成中間物及其製造方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5931510B2 (ja) * 1979-09-03 1984-08-02 東レ株式会社 ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体
JPS58124778A (ja) * 1982-01-20 1983-07-25 Toray Ind Inc ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体
JPS59134787A (ja) * 1983-01-19 1984-08-02 Toray Ind Inc ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体の製造法
HU197733B (en) * 1985-05-29 1989-05-29 Chinoin Gyogyszer Es Vegyeszet Process for producing ephedrin-salts of 7-oxo-prosta-cyclin derivatives
CA1284642C (en) * 1986-03-31 1991-06-04 Hikozo Iwakura Prostacyclin (pgi ) analogues
JP2594118B2 (ja) * 1987-07-01 1997-03-26 塩野義製薬株式会社 ベンゾジオキサンプロスタサイクリン類縁体
JP2542429B2 (ja) * 1987-10-27 1996-10-09 三共株式会社 オクタヒドロナフタリン置換オキシム誘導体
GB8929059D0 (en) * 1989-12-22 1990-02-28 Leo Pharm Prod Ltd Chemical compounds
JP3025056B2 (ja) * 1991-03-12 2000-03-27 財団法人微生物化学研究会 ２，６−ジデオキシ−２−フルオロ−ｌ−タロピラノース誘導体の製造法
JP3024298B2 (ja) * 1991-09-13 2000-03-21 住友化学工業株式会社 シクロペンテンエステル類及びその利用
JPH09132589A (ja) * 1995-09-08 1997-05-20 Microbial Chem Res Found 糖部分の水酸基をモノ−または−ジ−ｏ−アミノアルカノイル化された含フッ素アンスラサイクリン誘導体

Also Published As

Publication number Publication date
EP1412342B1 (en) 2008-09-03
IL159814A (en) 2008-08-07
DE60228724D1 (de) 2008-10-16
HUP0103089A2 (hu) 2003-07-28
HRP20040198B1 (en) 2012-02-29
CN1235896C (zh) 2006-01-11
WO2003011849A8 (en) 2004-03-11
WO2003011849A1 (en) 2003-02-13
HUP0103089D0 (en) 2001-10-28
ME00089B (me) 2010-10-10
BR0211514A (pt) 2004-09-14
CN1537107A (zh) 2004-10-13
NZ531264A (en) 2005-09-30
MXPA04000847A (es) 2004-03-26
RU2272033C2 (ru) 2006-03-20
RU2004105959A (ru) 2005-03-27
HK1068877A1 (en) 2005-05-06
CA2453649A1 (en) 2003-02-13
NO20040388L (no) 2004-01-29
PL216072B1 (pl) 2014-02-28
AU2002321670B8 (en) 2008-09-11
AU2002321670B2 (en) 2008-08-14
RS51314B (sr) 2010-12-31
MEP18708A (en) 2010-06-10
KR100604699B1 (ko) 2006-07-31
HUP0103089A3 (en) 2005-01-28
US20040209945A1 (en) 2004-10-21
EP1412342A1 (en) 2004-04-28
KR20040043169A (ko) 2004-05-22
JP4440506B2 (ja) 2010-03-24
IL159814A0 (en) 2004-06-20
HU227157B1 (en) 2010-09-28
RS8604A (xx) 2007-02-05
CU23324B7 (es) 2008-11-27
CA2453649C (en) 2009-12-22
ATE407127T1 (de) 2008-09-15
HRP20040198A2 (en) 2005-04-30
ES2314083T3 (es) 2009-03-16
JP2003055368A (ja) 2003-02-26
UA75692C2 (uk) 2006-05-15
US7005527B2 (en) 2006-02-28
NO328695B1 (no) 2010-04-26
PL367298A1 (en) 2005-02-21
ZA200400748B (en) 2005-01-26
CN100347165C (zh) 2007-11-07
CN1680351A (zh) 2005-10-12

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Legal Events

Date Code Title Description
PE Patent expired

Effective date: 20220724